Bos taurus (cow): 100139857 Help Entry 100139857         CDS       T01008                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism bta  Bos taurus (cow) Pathway bta04020   Calcium signaling pathway bta04371   Apelin signaling pathway bta04713   Circadian entrainment bta04730   Long-term depression bta04921   Oxytocin signaling pathway bta05017   Spinocerebellar ataxia bta05020   Prion disease bta05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:bta00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100139857 (RYR1)    04020 Calcium signaling pathway     100139857 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100139857 (RYR1)   09156 Nervous system    04730 Long-term depression     100139857 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     100139857 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     100139857 (RYR1)    05020 Prion disease     100139857 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     100139857 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:bta01009]     100139857 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:bta04147]     100139857 (RYR1)    04040 Ion channels [BR:bta04040]     100139857 (RYR1) Protein phosphatases and associated proteins [BR:bta01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      100139857 (RYR1) Exosome [BR:bta04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    100139857 (RYR1) Ion channels [BR:bta04040]  Voltage-gated cation channels   Ryanodine receptor    100139857 (RYR1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 CDC45 Motif Other DBs NCBI-GeneID:  100139857 NCBI-ProteinID:  NP_001193706 BGD-bta:  BT12859 Ensembl:  ENSBTAG00000006999 VGNC:  34233 LinkDB All DBs Position 18:48236525..48365358 Genome browser AA seq 5040 aa AA seqDB search MGDGGEGEDEVQFLRTDDEVVLQCNATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPP DLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSGMYLSC LTTSRSMTDKLAFDVGLQEDAIGEACWWTTHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLFHGHMDECLTISPADSDD QRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALVEDQGLM VVDASKAHTKATSFCFRVSKEKLDTAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYA APDPKALRLGVLKKKAILHQEGHMDDALSLTRCQHEESQAARMIYSTAGLYNHFIKGLDS FSGKPRGSGSPAGTALPLEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQE EGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANCALF SNNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYL KWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLH LWTGHVPRLVTYPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPV VSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLV GPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDN KRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYM MSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPR LVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVESQSRWDRVRIFRAEKS YVVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADDLSYVFNGHRGQRWHLGSEPFG RPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFRDIEIGDGFLPVCSLGPGQVG HLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEAVPPEHPHYEVTRV DGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAE DEARAAEPDPDYENLRRSAGHWAEAEGNKEGTAKEGTPGSPAQAGVEAQPARAENEKDAT TEKNKKRGFLFKAKKAAMMTQPPATPTLPRLPHEVVPADDRDDPEIILNTTTYYYSVRVF AGQEPSCVWVGWVTPDYHQHDMNFDLSKVRAVTVTMGDEQGNIHSSLKCSNCYMVWGGDF VSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQN VIQFELGKQKNIMPLSAAMFLSERKNPTPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRA GERLGWAVQCQEPLTMMALHVPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNR VAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTP ETRAITLFPPGKRADNGPRRYGLPGVGVTTSLRPPHHFSAPCFVAALPAAGAAEAPARLS PSIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDV KQILKMIEPEVFTEEEEEEEEEEEGEEEEEDEEEKEEDEEEEAREKEDEEKEEEETAEGE KEDLEEGLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYA ILIKAFTMTAAETARRTREFRSPPQEQINMLLHFKTAEDEEDCPLPEEVRQDLLEFHRDL LTHCGIQLEGEEEEPEEEATLGSRLMSLLEKVRLVKKKEEKSEEEPPAEERKPQSLQELV SHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLEC LGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGG ESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAA SVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFA VFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLATIEEAIRISEDPARDGPGVR RDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILR SLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFL LHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIM VDSMLHTVYRLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFDVPILNEFAK MPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRM AMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKF AEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIA WEWTIEKAREGEEEKTEKKKTRKISQSAQTYDAREGYNPQPPDLSGVTLSRELQAMAEQL AENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVT RGLKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFF AKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFG TDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQA RTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTT RNPYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEE MCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPA GAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEATWMKRLAVFAQPIVSRARPELLHSHF IPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDN NRAHWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKM AKTGDVQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQELITLAKT RYALKDTDEEVREYLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQE VSAVLYHLEQIEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYK AAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDE DYLYIAYADIMAKSCHLEEGGENGEAEEEEVEVSFEEKEMEKQRLLYQQARLHTRGAAEM VLQMISACKGETGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQSIQALMQT CSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNND FQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVA KQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLD LQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQ DYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINCEEFANRFQEPARD IGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEIS ETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEMQIAAQISEPEGEP EEDEDEGVGAAEAGAESAEEGAAGPEGAAATAAAGATARLVAAANRAMRGLSYRSLRRRV RRLRRLTAREAATAVAALLWAVLAQGGAAGAGAAAGALRLLWGSLFGGGLVEGAKKVTVT ELLAGMPDPTSDEVHGEQPAGSGGDADGEGAGEGAGDAAEGAGDEEVADQEDPGVADGTV AVADGGPFRPEGAGLGDMGDTTPAEPPTPEGSPIIKRKLGVDGEEEELPPEPEPEPEPEP EKADAENGEKEEVPETPPEPPKKAAPPPPPPKKEGAGGAGLEFWGELEVQRVKFLNYLSR NFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGGLSGAGSGGGSGWGSGAGE EAEGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKEL ARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERI AELLGMDLATLEITAHNERKPEPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMV MSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFN FFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFD ITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFET HTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15123 nt NT seq  +upstreamnt  +downstreamnt atgggtgacggaggagagggcgaggatgaggtccagtttctgcggacggacgacgaggtg gtcctgcagtgcaacgccacggtgctcaaggagcagctcaagctctgcctggccgccgag ggcttcggcaaccgcctctgcttcctggagcccaccagcaacgcccagaatgtgcccccc gatctggccatctgttgctttgtcctggagcagtccctgtctgtccgagccctacaggag atgctggccaacaccgtggaggccggcgtggagtcgtcccagggtgggggacacaggaca ctcctgtatggccatgccatcctgctccggcacgcgcacagcggcatgtacctgagctgc ctcaccacctctcgctccatgactgacaagctggcctttgacgtaggacttcaggaggat gcaataggagaggcctgttggtggacgacgcacccagcctccaagcaaaggtcagaagga gagaaggtccgagttggcgatgacctcattcttgtcagtgtctcctccgagcgctacctg cacctgtcaacagccagtggggagctccaggttgacgcctctttcatgcagacactgtgg aacatgaaccccatctgctctggctgtgaagagggctatgtgaccggtggccatgtcctc cgcctctttcatggacacatggatgaatgtctgaccatttcccctgctgacagtgatgac cagcgcagacttgtctactatgaggggggatctgtgtgtacccacgcccgctccctctgg agactggaaccactgagaatcagttggagcgggagccacctgcgctggggccagccgctc cgcatccggcatgtcaccactgggcggtacctggcgctcgttgaggaccagggcctcatg gtggttgacgccagcaaggcccacaccaaggccacctccttctgcttccgcgtctccaag gagaaactggatacggctcccaagcgggacgtggagggcatgggccccccggaaatcaag tatggggagtcactgtgctttgtgcagcacgtggcctcaggcttgtggctcacctatgct gccccggaccccaaggccctgcgacttggtgtgctcaagaaaaaggccattctgcaccag gaaggccacatggacgacgcactgtcactgacccgctgtcagcacgaggagtctcaggct gcccgcatgatctacagtactgccggcctctacaaccacttcatcaagggcctggacagc ttcagcggaaagccgaggggctcggggtccccggcgggcacagcgctgcctctcgagggc gtcatcttgagcctgcaggacctcatcggctactttgagccgccctccgaggagctacag cacgaagagaagcagagcaagctgcgcagcctgcgcaaccgccagagcctcttccaggag gaggggatgctctccttggtcctgaattgcattgaccgcctaaatgtctacaccactgct gcccacttcgctgaatttgcaggggaggaggcagcagagtcctggaaagagattgtgaac ctgctctatgaaatcctggcctctctgatccgtggcaatcgtgccaactgtgccctcttc tccaacaacttggattggctggtcagcaagctggatcggctagaggcctcctcagggatc ctggaggtgctgtactgtgtcctgattgagagtccggaagtcctgaacatcatccaagag aaccacatcaagtccatcatctccctcctggacaagcatgggaggaaccacaaggtgctg gatgtgctatgttccctgtgtgtgtgcaatggcgtggccgtgcgctccaaccaagatctc atcactgagaacttgctccctggccgcgagcttctgctgcagacaaacctcatcaactat gtcaccagcatccgccccaacatctttgtgggccgagcagagggcaccacgcagtacctc aaatggtactttgaggtgatggtggacgaggtggttccgttcctgacggctcaggccacc cacctgagggtgggctgggccctcactgagggctacagcccctaccccgggggcggcgag ggctggggcggcaacggggtcggcgatgacctctattcctacggctttgacgggctgcac ctctggacaggacacgtgccacgcctggtcacttaccctgggcagcacctcctggccccc gaggacgtggtcagctgctgtctggacctcagtgtgccgtccatctctttccgcatcaat ggctgtcccgtgcagggggtcttcgaggccttcaatcttgatgggctcttcttccctgtt gtcagcttctcggctggtgtcaaagtgcggttcctccttggtggccgccatggagaattc aagttcctccctcctcctgggtatgccccttgccacgaggctgtgctcccacgagagcga ctccatctggaacccatcaaggagtaccggcgggaagggcctcgggggccccacctggtg ggccccagtcgctgcctctcacacaccgactttgtgccctgccctgtggacactgtccag attgtcctgcctccccatctggagcgtattcgggagaagctggccgagaacatccatgaa ctctgggcactgactcgcatcgagcagggctggacctatggcccggttcgggatgacaat aagagactgcacccctgccttgtggattttcacagcctaccggagcccgagaggaattac aacctgcagatgtcgggggagacgctcaagactctactggcgctgggctgccacgtgggc atggcagatgagaaggcggaggacaacctgaagaagacaaaactccccaagacgtacatg atgagcaacgggtacaagccggcaccgctagacttgagccacgtgagactgacgcccgcg cagaccacgctggtggaccggctggcggagaacgggcacaacgtgtgggcccgagaccga gtggcccagggctggagctacagtgccgtgcaggacatccctgcccgccggaaccctcgc ctcgtgccctaccgcctgctggatgaggccaccaagcgcagcaaccgcgacagcctctgc caggccgtgcgcaccctgctgggctacggctacaacatcgagccgcccgaccaggagccc agtcaggtggagagccagtctcgctgggaccgggtgcgcatcttccgggcagagaaatcc tacgtggtgcagagtggccgctggtacttcgagttcgaggcagtcaccaccggcgagatg cgagtgggctgggctcggcctgagctgcgcccagacgtggagctgggagcggatgacctg tcctatgtcttcaacgggcaccgcggtcagcgctggcacctgggcagtgaaccgtttggg cgtccctggcagtcgggagacgttgtgggctgcatgatcgacctcacagagaacaccatc attttcaccctcaatggcgaggtcctcatgtccgattccggctcagaaacagccttccgc gatatcgagattggggatggcttcctgcctgtgtgcagcttgggacccggccaggtgggt cacttgaacctgggccaggacgtgagctccctgcggttctttgccatctgtggcctccag gaaggttttgagccatttgccatcaacatgcagcgcccggtcaccacctggttcagcaaa ggccttccgcaatttgaggccgtgcctcctgagcacccgcactatgaggtgactcgtgtg gatggcactgtagatacacccccctgcctgcgcctgacccaccgcacctggggctcccag aacagtctggtggagatgctgtttctccggctgagccttccagtccagttccaccagcac ttccggtgcaccgcaggggccaccccactggcaccccctggcctgcagcctcctgcggag gatgaggcccgggcagcggaacctgatcccgactatgaaaacctgcgccgctcagctggg cactgggccgaggctgaggggaacaaagaaggaactgccaaggaggggacacctgggagt cctgcccaggctggggtggaggcccagcctgccagggcagagaatgagaaggatgctacc acagagaagaacaagaagagagggttcttgttcaaggccaagaaggctgccatgatgacc cagccaccagccacacccactctgccccgactccctcatgaggtggtgcctgctgacgac cgtgatgaccctgagatcatcctcaataccaccacgtactattactctgtgagggtcttt gccggccaggagcccagctgcgtgtgggtgggctgggtcacccctgactaccaccagcac gacatgaacttcgacctcagcaaggtccgggcggtgacagtgaccatgggagatgagcaa ggcaacatccacagcagcctcaagtgtagtaactgctacatggtgtggggcggagacttc gtgagccctgggcagcagggccggatcagccacacggaccttgtcattggctgcctggtg gacttggccactggcctaatgacctttactgccaacggcaaagagagcaacacctttttc caggtggaacccaacacaaagctgttccctgccgtctttgtcctgcccacgcaccagaac gtgatccagtttgagctggggaaacagaagaacatcatgccgctgtcagccgccatgttt ttgagcgagcgcaagaaccccacgccgcagtgccctccgcggctggagatgcagatgctg atgcccgtgtcttggagccgcatgcccaaccacttcctgcaggtggagacgcggcgggcg ggcgagcggctcggctgggcagtgcagtgccaggagccgctcaccatgatggcgctgcac gtccccgaggagaaccgatgcatggacatcctggagttgtctgagcgcttggacctgcag cggttccattcgcacaccctccgcctctaccgggctgtgtgcgccctgggcaacaaccgc gtggcgcatgctctgtgcagccatgtggaccaggcgcagctgctgcacgccctggaggac gcgcacctgcccggccctctgcgggcaggctactacgacctcctcatcagcatccacctc gaaagtgcttgccgcagccgccgctccatgctctctgagtacatcgtgcccctcacgcct gagacccgcgccatcactctcttcccacccggaaagagagcggataacggtccccgccgc tacgggcttcctggcgtcggcgttaccacctcgctgcggcctccacaccatttctcagcc ccgtgtttcgtggccgccctgccagctgctggggcggcagaagccccggcccgcctcagc cccagcatccctctggaagctcttcgggacaaagcactcagaatgctgggggaggcggtg cgagatggtgggcagcacgctcgtgacccagtcgggggctccgtggagttccagtttgtg ccggtgctcaagctggtgtccaccctgctggtgatgggcatctttggcgatgaggatgta aaacagatcttgaagatgattgagcctgaagtattcactgaggaagaagaggaagaggag gaggaggaggaaggggaagaggaagaagaggatgaggaggagaaggaggaggacgaggag gaagaggcacgggagaaggaagatgaggaaaaagaggaggaggagacagcagagggggaa aaagaggacttggaggaggggctgctccagatgaagttgcccgagtctgtgaagttacag atgtgtaacctgctggagtatttctgtgaccaagagctacagcaccgtgtggaatctctg gcagcctttgcagagcgctatgtggacaaactccaggccaaccagagggaccgctacgcc atcctcataaaagccttcaccatgactgcagctgagacagcccgacgcactcgcgagttc cgctccccaccccaggagcagatcaacatgctattgcacttcaaaactgctgaggatgag gaagattgtcctctccctgaagaggtccgacaggatttgctcgaatttcatcgagacctg ctgacacactgcggaattcaactggagggggaagaggaggaaccagaggaagaagccacc ctgggcagtcgcctgatgagcctgttggagaaggtgcggctggtgaagaagaaggaggag aaatcagaggaggaaccacccgctgaggagcgcaaaccccagtcgctgcaagagctggtg tcccacacggtggtgcgttgggcccaagaggacttcgtgcagagcccggagctggtccgc gccatgttcagcctcctgcaccggcagtatgatgggctcggggagctgctgcgcgccctg ccccgggcctacaccatctccccctcctccgtggaggacaccatgagcctgctcgagtgc ctcggccagatccgctcactgctcatcgtgcagatgggcccccaggaagagaacctcatg atccagagcatcgggaacatcatgaacaacaaagtcttctaccaacacccgaacctgatg agggcactgggcatgcacgagacagtcatggaggtcatggtgaacgtccttgggggcggt gaatccaaggagatccgcttccccaagatggtgacaagctgctgccgcttcctctgctac ttctgccgcatcagccggcagaaccagcgctccatgttcgaccacctgagctacctgctg gagaacagcggcatcggcctgggcatgcagggctccactcccctggacgtggcagctgcc tctgtcatcgacaacaacgagctggccttggcgctgcaggagcaggatctggagaaggtg gtgtcctacttggctggctgtggcctccaaagctgccccatgctcctggccaaagggtac ccagacatcggctggaacccctgtggtggggagcgctacctggacttcctgcgcttcgct gtctttgtcaatggtgagagcgtagaggagaacgccaacgtggtggtgcggctgctgatc cgcaagcccgagtgctttgggcctgccctgcggggcgagggcggctcggggctgctggcc accatcgaagaggccatccgcatctccgaggaccccgcgcgggacggtccaggcgtccgt agggaccggcggcgcgagcacttcggggaggagccccctgaagaaaaccgggtgcatctg ggacacgccatcatgtccttctacgctgccttgattgacctgctgggacgctgtgcgcca gagatgcatctaattcaagccggcaagggtgaggccctgcggatccgtgccatcctgcgc tcccttgtacccttggatgacctcgtgggcatcatcagcctcccgctgcagatccccacc ctgggcaaagacggggctctggtgcaaccaaagatgtcagcatcctttgtgcccgaccac aaggcgtcaatggtgctcttcctggaccgggtatatggcattgagaaccaggacttcctg ttgcatgtgctggacgtggggttcctgcccgacatgcgggcggctgcctcgctggacacg gccactttcagcacgacggagatggcgctggcgctgaaccgctacctgtgcctagcggtg ctgccgctcatcaccaagtgtgcgcctctgtttgcgggaacggagcatcgtgccatcatg gtggactccatgcttcacacggtgtaccgcctgtcccgcggccgctcgctcaccaaggcg cagcgcgacgtcatcgaggaatgcctgatggcgctctgcaggtacatccgcccgtccatg ctgcagcacctgctgcggcgcctggtgttcgacgtgcctatcctcaacgagttcgccaag atgccgctcaagctcctcaccaaccactatgagcgctgttggaagtactactgcctcccc acaggttgggccaactttggggtcacctcggaggaagagctgcacctcactcgtaaactc ttctggggcatctttgactcgctggcccataagaaatatgatcaagagttgtaccgcatg gctatgccctgcctgtgtgccatcgcaggggccctgcccccggactacgtggatgcctca tactcatccaaggctgagaaaaaggccacggtggatgctgaaggcaactttgatcctcgg cctgtggagaccctcaatgtgatcatcccagagaagctggactccttcattaacaagttc gcggagtatacacacgagaagtgggccttcgacaagatccagaacaactggtcctatggg gagaacatagatgaggaactcaagacccatcccatgctgaggccctacaagaccttttca gagaaggacaaagagatttaccgctggcccataaaggagtccttgaaggccatgattgcc tgggaatggacgatagagaaagccagggagggtgaggaggagaagacggagaagaagaaa acccggaagatatcccaaagcgcccagacctatgatgcaagggaaggctacaacccacaa ccccccgatctcagtggagttaccctgtctcgggagctgcaagccatggcggaacaactg gcggaaaattaccacaacacatgggggcgcaaaaagaagcaggagctggaagccaagggt ggtgggacccatcccctgctggttccctacgacacgctcacggccaaggagaaggcacga gatcgggagaaggcccaggagctgttgaagttcctgcagatgaacggctacgcggtcacc agaggtcttaaggacatggaactggacacgtcttccattgagaaacggttcgccttcggc ttcctgcagcagttgctgcgctggatggacatttctcaagagttcatcgctcacctggag gccgtggtcagcagtggacgagtggaaaagtcccctcacgaacaggagattaaattcttt gccaagatcctgctccctttgatcaaccagtacttcaccaaccactgcctctatttcctg tccaccccggccaaagtgctgggcagtggtggccacgcctccaacaaggagaaggaaatg atcaccagcctcttctgcaagcttgcggctcttgtccgtcaccgagtctctctctttggc acggatgccccagctgtggtcaactgtcttcacatcctggcacgctccctggatgccagg accgtgatgaagtctggccccgagattgtgaaggctggcctccgttccttctttgagagt gcctcggaggacattgagaagatggtggagaacctgcggctcggcaaggtgtcacaggcg cgcacgcaggtgaagggcgtgggccagaacctcacctacaccactgtggccctgctgccg gtcctcaccaccctcttccagcacatcgcccagcatcagtttggagacgatgttatcctg gatgacgtccaggtctcttgctaccgaacactgtgcagtatctactctctggggaccacc aggaacccttacgtggaaaaattgcggccagccctgggcgagtgcctggcccgcctggca gcggccatgccagtggcattcctggagccgcagctgaatgaatacaatgcctgctcagtg tacaccaccaagtctccccgggagcgggccatcctggggctccccaacagtgtggaggaa atgtgtcctgacatcccagtgctggagcggctcatggctgacatcggggggctggctgag tcgggggcccgctacacggagatgccgcacgtcatcgagatcacgctgcccatgctgtgc agttacctgccccgctggtgggagcgcgggcccgaggcacccccacctgccctacctgcc ggggcccctccaccctgcacagccgtcacctccgaccacctcaactcgctgctggggaac atcctgcgaatcattgtcaacaacctgggcattgacgaggccacctggatgaagcggctg gctgtgtttgcccagcccattgtgagtcgggcccggccggagctcctgcactctcacttc atccccaccatcgggcggctgcgcaagcgggcagggaaggtggtggccgaggaggagcag ctgcgcctggaggccaaggcagaggccgaggagggcgagctcctggtgcgggatgagttc tctgtgctctgccgggatctgtacgccctttacccgctgctcatccgctacgtggacaac aacagggcacactggctgaccgagcccaaccccagcgcggaggagctgttcaggatggtg ggcgagatcttcatctactggtccaagtcccacaactttaagcgcgaggagcagaacttt gtggtccagaatgagatcaacaacatgtcatttctgacggccgacaacaagagcaaaatg gccaagacgggagatgtacagtcaggtggctcggaccaggagcgcaccaagaagaagcgc cggggtgaccggtactccgtgcagacgtcgctgattgtggccacgctcaagaagatgctg cccatcggcctgaacatgtgtgcccccactgaccaggagctcatcacactggccaagacc cgctatgccctgaaagacacagatgaggaggtccgggaatatctgcaaaacaaccttcac cttcagggaaaggtcgaaggctccccttctctgcgctggcaaatggccctgtaccggggc ctcccgggccgcgaggaggacgctgacgatccggagaaaatcgtgcgcagagttcaggaa gtgtccgccgtgctctaccatctggagcagatcgagcacccttacaagtccaagaaggcc gtgtggcacaagctcttatcgaagcagcgccggagggcagtcgtcgcctgtttccgcatg acccccctgtacaacctgcccacgcaccgggcctgtaatatgtttctggagagctacaag gcggcgtggatcttgacggaagaccacagttttgaggaccgcatgatagatgacctttca aaagctggggagcaggaggaggaggaggaggaggtggaagagaagaagccagaccccctg caccagctggtcctgcacttcagccgcaccgccctgactgaaaagagcaaactggatgaa gattacttgtatatagcgtatgctgatatcatggctaagagctgccacctggaggaggga ggggagaatggcgaagctgaagaagaggaggttgaggtttccttcgaggaaaaagagatg gagaagcagcgtctcctgtaccagcaggcgcggctacacacccggggggccgcggagatg gtgctgcagatgatcagtgcctgcaaaggagagacaggcgccatggtgtcctccaccctg aagctgggcatctccatcctaaatgggggcaatgctgatgtgcagcagaaaatgctggat tacctgaaggacaagaaggaagttggcttcttccagagtatccaggcactgatgcaaacc tgcagtgtcctggatctcaatgccttcgagaggcagaacaaggcagaggggctgggcatg gtgaatgaggatggaactgtcatcaatcgccagaacggagagaaggtcatggcagatgat gaattcacccaggacctgttccgattcctgcagttgctctgcgagggtcacaataatgat ttccaaaattacctacggacacagacagggaatacaaccactattaacatcatcatctgt actgtggactacctcctgcggctgcaggagtccatcagcgacttctactggtactactcc ggcaaggatgtcattgaggagcaaggcaagaggaacttttccaaggcaatgtcggtggct aaacaggtgttcaacagcctcaccgagtacatccagggcccctgcactgggaaccagcag agtctagcgcacagccgcctctgggacgccgtggtgggattcctgcacgtgtttgcccac atgatgatgaagctcgctcaggactcaagccagatcgagctgttgaaggagctgctggat ctgcagaaggacatggtggtgatgttgctgtcactactagaagggaacgtggtgaacggc atgattgcccggcagatggtggacatgcttgtggagtcctcatccaacgtggagatgatc ctcaagttctttgacatgttcctgaaactcaaggacatcgtgggctctgaggccttccag gactatgtcactgatccccgtggtctcatctccaagaaggacttccagaaggccatggac agtcagaagcagttcaccggtccggaaatccagttcctgctttcgtgctccgaagcggat gagaacgagatgatcaactgtgaggagttcgccaaccgcttccaggagccagcccgcgac atcggctttaacgtggcggtgctgctgaccaacctgtcagagcacgtgccgcacgacccg cgcctgcgcaacttcctcgagctcgcggagagcatcctcgagtacttccggccctacctg ggccgcatcgagatcatgggggcctcccgccgcatcgaacgtatctacttcgagatctcg gagaccaaccgcgctcagtgggagatgccccaggtgaaggagtcgaagcgtcagttcatc ttcgacgtggtgaacgagggcggcgagtcggagaagatggagctcttcgtgagcttctgc gaggacaccatcttcgagatgcagatcgccgcgcagatctcggagcccgagggcgagccg gaggaggacgaggacgagggcgtgggcgcggcggaggcgggcgcggagagcgcggaggag ggcgccgcggggcccgagggcgcggcggccacggcggcggcgggcgccacggcgcggctg gtggcggccgcgaaccgggccatgcggggcctcagctaccgcagcctgcggcggcgcgtg cgacggctgcggcggctcacggcgcgcgaggcggcgaccgcggtggccgcactcctctgg gccgtgctggcgcaagggggcgcggcgggcgcgggggccgcggcgggcgcgctgcgcctg ctctggggctctctcttcggcggcggcctggtggagggcgccaagaaggtgacggtgacc gagctcctggcgggcatgcccgaccccacgagcgacgaggtgcacggagagcagccggcc gggtccgggggcgacgcggacggcgagggcgcgggcgagggcgcgggcgatgccgccgag ggtgcgggcgacgaggaggtggcggaccaggaggacccgggagtcgccgacgggacggtg gctgtggccgatggggggcccttccgacccgaaggggccggcctcggggatatgggtgac acgacgccggcggagccgcccacgcccgagggctcgcccatcatcaagaggaagctgggg gtggacggagaggaagaagagctgcctccagagccggagccggagccggagcccgagccg gagaaagctgatgctgagaatggggagaaggaagaagtccctgagaccccaccagaaccc cccaaaaaggcagctcctcctccaccccctccaaagaaggagggagctggtggtgcaggc ctggaattctggggagaactggaagtacagcgggtgaagttcttgaactacctctcaagg aatttttacaccctgcgattccttgccctcttcttggcatttgccatcaacttcatcctg ctgttttataaggtctctgactctccacctggagaggatgatatggaggggtcagcagct gggggcctgtcaggagcagggtctggtggcggctccggctggggctcgggggctggagag gaagcagagggcgacgaggatgagaacatggtgtactacttcctggaggagagcacgggt tacatggagcctgccttgcggtgcttgagccttctgcatacgctggtggcctttctctgt atcattggctacaactgcctcaaggtgcccttggtgatctttaagcgggagaaggaactg gcccggaagctggagtttgatggcctctatatcacggagcagcctgaggatgatgacgtg aaaggccagtgggaccggctggtgctcaacactccgtctttccctagcaactactgggac aagtttgtcaagcggaaggtcttggacaagcacggggacatctatgggcgggagcggatc gccgagctgctgggcatggatctggccacgctggagatcacagcccacaacgagcgcaaa cctgaaccaccgccagggctgctcacctggcttatgtccatcgatgtgaagtaccagatc tggaagttcggggtcatcttcacagacaattctttcctgtacctgggctggtacatggtg atgtccctcctcgggcactacaacaacttcttctttgccgcccacctcctggacatcgcc atgggggtcaagacgctgcgcactatcctctcctccgtcacccacaatgggaagcagctg gtgatgaccgtgggcctcctggcagtggtggtctacctgtacaccgtggtggccttcaac ttcttccgcaagttctacaacaagagcgaggacgaggatgaacctgacatgaagtgtgac gacatgatgacatgttacctcttccacatgtacgtgggtgtccgagctggtgggggcatt ggggacgagatagaggacccagcaggcgatgaatacgagctgtaccgggtggtcttcgac atcaccttctttttcttcgtcatcgtcatcctgttggccattatccagggtctgatcatt gacgcttttggcgagctccgagaccaacaagagcaagtgaaggaagatatggagaccaag tgcttcatctgcggtatcggcagtgattactttgatacgacaccgcatgggttcgagact cacacactggaggaacacaacctggccaattacatgtttttcctgatgtatctgataaac aaggacgagacagaacacacgggccaggagtcttacgtctggaagatgtaccaagagaga tgttgggatttcttcccggctggcgattgtttccgcaagcagtatgaggaccagcttagc tga

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