Bos taurus (cow): 100300012 Help Entry 100300012         CDS       T01008                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism bta  Bos taurus (cow) Pathway bta04022   cGMP-PKG signaling pathway bta04068   FoxO signaling pathway bta04081   Hormone signaling bta04140   Autophagy - animal bta04152   AMPK signaling pathway bta04211   Longevity regulating pathway bta04213   Longevity regulating pathway - multiple species bta04910   Insulin signaling pathway bta04920   Adipocytokine signaling pathway bta04923   Regulation of lipolysis in adipocytes bta04930   Type II diabetes mellitus bta04931   Insulin resistance bta04932   Non-alcoholic fatty liver disease bta04935   Growth hormone synthesis, secretion and action bta05010   Alzheimer disease bta05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:bta00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     100300012 (IRS2)    04022 cGMP-PKG signaling pathway     100300012 (IRS2)    04152 AMPK signaling pathway     100300012 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     100300012 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     100300012 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     100300012 (IRS2)    04935 Growth hormone synthesis, secretion and action     100300012 (IRS2)   09149 Aging    04211 Longevity regulating pathway     100300012 (IRS2)    04213 Longevity regulating pathway - multiple species     100300012 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     100300012 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     100300012 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100300012 (IRS2)    04932 Non-alcoholic fatty liver disease     100300012 (IRS2)    04931 Insulin resistance     100300012 (IRS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  100300012 NCBI-ProteinID:  XP_024855938 VGNC:  30284 LinkDB All DBs Position 12:complement(84625081..84655639) Genome browser AA seq 1325 aa AA seqDB search MASPPEHGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA GAGGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE YFAVAAENEQEQEGWYRALTDLVSEGRAGAGDAPPAAAATSGSCSASLPGALGGSAGAAA ADDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVT LQLMSIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFE FRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSAC RVRTASEGDGGAAAAAAAGAGAGAAAGSPLSPGPVRAPLSRSHTLSGGRAGKAALAPAGG GLQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPHLQHPLHPQRPSSGSA SASGSPSDPGFMSLDEYGSSPGDLRVYCGHRSNTPESIAETPPARDGSAGELYGYMTMER PLSHCGGRAYRRVSGDGAPDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFS GSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGTDDGYVPMTPGVALLGTG SGSCKSDDYMPMSPTSVSAPKQILQPRPVPAALPPAGATVPTPASAAGRAFPGTAGSYKT GSPAESSPEDSGYMRMWCGSKLSMESADSKLLPNGDYLNMSPSDAGTAGTPPDFFSAAGE TLRCVPGYCYSSLPRSYKAPHACHGDSDQYVLMSSPVGRVLEEEQLEPPPGPAQPASAFP AAAAGSGHPQPLHPVVPSSGRPGGGGGSRPDGFLAQRCRAVRPTRLSLEGLPALPRMHEY PLPPEPRSPGEYINIDFGEAGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSG DSRQRSPLSDYMNLDFSSPKSPQPGAQGRDPVGSLDALLSPEASVYPPLPPRPAAPSSAL QPPPPPPPPGELYRLPAAPASQGPGAASSSSSDTGDNSDYTEMAFGVAATPPQPIAAPPK PDGARVSSPVSGLKRLSLMDQVSGVEAFLQAGQPPDPHRGAKVIRADPQGGRRRHSSETF SSTTTVTPVSPSFAHTPKRHNSASVENVCLRKGSEGGGAGGSVLGGGDEPPSSPRQLPPP TPQQARAWTPAQPGGGLVGCPGGSSSPMRRETSAGFQNGLNYIAIDVRDEPGLSPPLQQH PHAQMGDRSAWGRTRSLGGLISAVGAGSPAGVCGGPGPGALPAANAYASIDFLTHHLKEA TVVKE NT seq 3978 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccggagcacgggccccccgggccggcgggcggggacggccccaacctc aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgcgggcggcgacgaggcg ggcgcgggcgggggcccggcgccgcagccgccgcggctcgagtactacgagagcgagaag aagtggcggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgcctgaac atcaacaagcgcgccgacgccaagcacaagtacctgatcgccctctacaccaaggacgag tacttcgccgtggcagccgagaacgagcaggagcaggagggctggtaccgcgcgctcacc gacctggtcagcgagggccgcgcgggcgccggggacgcgccccccgccgccgccgccacc tccgggtcctgcagcgcctccctgcccggcgccctgggcggctcggcgggcgccgctgcg gccgatgacagctacgggctggtggcgcccgccacggccgcctaccgcgaggtgtggcag gtgaacctgaagcccaagggtctgggccagagcaagaacctgacgggcgtgtaccgcctg tgcctgtcggcgcgcaccatcggcttcgtgaagctcaactgcgagcagccgtcggtgacg ctgcagctcatgagcatccgccgctgcggccactcggacagcttcttcttcatcgaggtg ggccgctcggccgtgacgggccccggagagctgtggatgcaggcggatgactcggtggtg gcgcagaacatccacgagaccattctggaggccatgaaggcgctcaaggagctcttcgag ttccggccgcgcagcaagagccagtcgtccggctcgtcggctacgcaccccatcagcgtg cccggcgcgcgccgccaccaccacttggtcaacctgcccccgagccagacgggactggtg cgccgctcgcgcaccgacagcctggcggccaccccgcccgccgccaagtgcagcgcgtgc cgggtgcgcacagccagcgaaggcgacggcggcgccgcggcggcggcggcggcgggggcg ggggccggggcggcggcgggcagccccctgagcccgggcccggtgcgcgcgcccctgagc cgctcgcacacgctgagcggcggccgcgcgggcaaggcggcgctggcgccggcagggggc ggcctgcagcacagccgctccatgtccatgcccgtggcgcactcgcccccggcggccacc agccccggcagcctgtcgtccagcagcgggcacggctcgggctcctacccgccgcccccc ggcccgcacccgcacctgcagcaccccctgcacccccagcgcccctccagcggcagcgcc tcggcctcgggctcccccagcgaccccggcttcatgtccttggacgagtatggctccagc cccggggacctgcgggtctactgcggccaccggagcaacacgcccgagtccatcgctgag acgcccccggcgcgggacggcagcgcgggcgagctgtacggctacatgaccatggagcgg ccgctgagccactgcggcggccgcgcctaccgcagggtctctggggacggcgccccggac ttggaccgagggctgaggaagcggacttactcgctgaccacgcctgcccggcagcggccg gtgccccagccgtcctccgcgtccctggacgagtacaccttgatgcgggccaccttctcg ggcagctccggccgcctgtgcccatcctgccccgcctcttctcccaaagtggcctaccat ccttaccccgaggactacggcgacatcgagattggctcgcaccgcagctccagcagtaac ctgggcacggacgatggctacgtgcccatgacccccggcgtggccctcctggggacgggc agcgggagctgcaagagcgacgactacatgcccatgagccccaccagcgtgtcggccccg aaacagatactgcagccgcgccccgtgcccgccgccttgccccctgctggggccacggtg cccacgcccgcatcggcggccggcagggccttcccgggcaccgcgggcagctacaagacc ggctccccggccgagagctcccccgaggacagcgggtacatgcgcatgtggtgcggttcc aagctgtccatggagagcgccgacagcaagctgctgcccaacggggactacctcaacatg tcccccagcgatgcgggcacggcgggcaccccgcccgacttcttctcggccgcgggggag acgctgcggtgcgtgcccggctactgctacagctccttgccccgctcctacaaggcccct cacgcctgccacggcgacagtgaccagtacgtgctcatgagctcgccagtgggccgggtc ctggaggaggagcagctggagccaccccccggccccgcgcagccggccagtgccttcccg gccgcggcggctggcagcggccacccccagccacttcaccccgtcgtgccttcttctggg aggcctggcggtggcggaggcagccgccccgacggcttcctagcccagcgctgccgggca gtgcggcccacgcgcctgtccctggaggggctgccggccctgccccgcatgcacgagtac ccgctgccccccgagcccaggagtcctggcgagtacatcaacatcgacttcggggaggcc ggcgcgcgcctgtcaccccccgcgcccccgctcctggcctcggccgcctcgtcgtcctcg ctgttgtccgccagcagcccagcctcgtccctgggctccggcaccccgggcacaagcggg gacagccggcagcgctccccgctctccgactatatgaacctcgacttcagctcgcccaag tcgccgcagccaggcgcccagggccgggaccctgtgggctccttggacgccttgctgtcc cccgaggcctccgtgtacccgccgctgcccccgcgcccggccgccccctcctcggccctg cagccgccgcccccgccgcccccaccaggcgagctgtaccgcctgcctgcggcacccgcc tcccagggcccaggcgcggcctcctcctcgtcctcggacacgggggacaacagtgactac acagagatggccttcggcgtggccgccaccccgccacaaccgatcgcggcgcccccgaag cccgacggtgcccgcgtgagcagccctgtgtccggcctcaagaggctgagtctcatggat caggtgtcgggggtcgaggccttcctgcaggccggccagcccccagacccgcaccggggg gccaaggtcattcgtgcggacccccaggggggccgccgccgccacagctccgagaccttc tcctcgaccaccactgtgacccccgtgtccccatccttcgctcacacccccaagcgtcac aactcggcctcggtggagaacgtctgtctcaggaaaggcagcgaagggggcggggccggg ggcagcgtcctgggtgggggcgatgagcccccctcgtcgccccgccagttgcctccgcca acgcctcagcaagcgcgggcctggacgccggctcagcccggcggcggcctggttggctgt cccgggggcagcagctcaccgatgcgccgggagacctccgccggcttccagaacggcctc aactacatcgccatcgacgtgagggacgagccagggctgtcgccgcccctgcagcagcac ccgcacgcgcagatgggcgacaggagcgcctggggccgcacccgaagcctcgggggtctc atcagcgccgtgggtgccggtagccctgccggggtgtgcggagggccgggccccggcgcc ctgcccgcggccaacgcctacgccagcatcgacttcttgacgcatcacctgaaagaggcc acggtggtgaaagagtga

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