KEGG   Bos taurus (cow): 281987
Entry
281987            CDS       T01008                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
bta  Bos taurus (cow)
Pathway
bta00562  Inositol phosphate metabolism
bta01100  Metabolic pathways
bta01521  EGFR tyrosine kinase inhibitor resistance
bta04012  ErbB signaling pathway
bta04014  Ras signaling pathway
bta04015  Rap1 signaling pathway
bta04020  Calcium signaling pathway
bta04062  Chemokine signaling pathway
bta04064  NF-kappa B signaling pathway
bta04066  HIF-1 signaling pathway
bta04070  Phosphatidylinositol signaling system
bta04072  Phospholipase D signaling pathway
bta04360  Axon guidance
bta04370  VEGF signaling pathway
bta04613  Neutrophil extracellular trap formation
bta04650  Natural killer cell mediated cytotoxicity
bta04658  Th1 and Th2 cell differentiation
bta04659  Th17 cell differentiation
bta04660  T cell receptor signaling pathway
bta04664  Fc epsilon RI signaling pathway
bta04666  Fc gamma R-mediated phagocytosis
bta04670  Leukocyte transendothelial migration
bta04722  Neurotrophin signaling pathway
bta04750  Inflammatory mediator regulation of TRP channels
bta04919  Thyroid hormone signaling pathway
bta04933  AGE-RAGE signaling pathway in diabetic complications
bta04935  Growth hormone synthesis, secretion and action
bta05012  Parkinson disease
bta05022  Pathways of neurodegeneration - multiple diseases
bta05135  Yersinia infection
bta05167  Kaposi sarcoma-associated herpesvirus infection
bta05170  Human immunodeficiency virus 1 infection
bta05171  Coronavirus disease - COVID-19
bta05200  Pathways in cancer
bta05205  Proteoglycans in cancer
bta05206  MicroRNAs in cancer
bta05214  Glioma
bta05223  Non-small cell lung cancer
bta05225  Hepatocellular carcinoma
bta05231  Choline metabolism in cancer
bta05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bta05417  Lipid and atherosclerosis
Module
bta_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    281987 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    281987 (PLCG1)
   04015 Rap1 signaling pathway
    281987 (PLCG1)
   04064 NF-kappa B signaling pathway
    281987 (PLCG1)
   04066 HIF-1 signaling pathway
    281987 (PLCG1)
   04070 Phosphatidylinositol signaling system
    281987 (PLCG1)
   04072 Phospholipase D signaling pathway
    281987 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    281987 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    281987 (PLCG1)
   04660 T cell receptor signaling pathway
    281987 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    281987 (PLCG1)
   04659 Th17 cell differentiation
    281987 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    281987 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    281987 (PLCG1)
   04670 Leukocyte transendothelial migration
    281987 (PLCG1)
   04062 Chemokine signaling pathway
    281987 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    281987 (PLCG1)
   04919 Thyroid hormone signaling pathway
    281987 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    281987 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    281987 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    281987 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    281987 (PLCG1)
   05206 MicroRNAs in cancer
    281987 (PLCG1)
   05205 Proteoglycans in cancer
    281987 (PLCG1)
   05231 Choline metabolism in cancer
    281987 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    281987 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    281987 (PLCG1)
   05214 Glioma
    281987 (PLCG1)
   05223 Non-small cell lung cancer
    281987 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    281987 (PLCG1)
   05171 Coronavirus disease - COVID-19
    281987 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    281987 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    281987 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    281987 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    281987 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    281987 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    281987 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    281987 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bta04131]
    281987 (PLCG1)
Enzymes [BR:bta01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     281987 (PLCG1)
Membrane trafficking [BR:bta04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    281987 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    281987 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 281987
NCBI-ProteinID: NP_776850
BGD-bta: BT10117
Ensembl: ENSBTAG00000017584
VGNC: 32988
UniProt: P08487
Structure
LinkDB
Position
13:69790995..69822905
AA seq 1291 aa
MAGAASPCANGCGPSAPSDAEVVHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIRGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRTSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSIWNSQLDEVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAVRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSVMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEGL
ELASLLVKIDVFPAKQENGDLSPFGGASLRERSCDASGPLFHGRAREGSFEARYQQPFED
FRISQEHLADHFDGRDRRTPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaacggctgcgggcccagtgcgccctcggacgcc
gaggtggtgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgaggcgccgacaagatagagggggccattgacattcgtgaaatcaaggag
atccgcccagggaagacctcacgggacttcgatcgctaccaagaggatcctgcttttcga
ccggaccagtcccactgcttcgtcatcctgtatggaatggaattccgcctgaagaccctg
agcctccaagccacgtctgaggacgaagtgaacatgtggatcaggggcctgacttggctg
atggaggacacgttgcaggcagccacacccctgcagattgagaggtggctgcggaagcag
ttctactcagtggaccggaaccgtgaggaccggatatcggccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgggagcggctgacggac
ctggagcagcgcaccagtgacatcacctacgggcagtttgcacagctgtaccgcagcctc
atgtacagcgcccagaagacgatggaccttcctttcctggaagccagcgccctgagggcg
ggggagcggccggagctgtgccgggtgtcccttcctgagttccagcagttcctcctcgag
taccaaggggagctgtgggcggtggaccggctccaggtgcaggagttcatgctcagcttc
ctccgagaccccttgcgagagattgaggagccttacttcttcctggacgagttcgtcacc
ttcctgttctccaaggagaacagcatatggaactcgcagctagacgaggtgtgccccgac
accatgaacaaccccctgtcccactactggatctcctcctcgcacaacacgtacctgacc
ggggaccagttctccagcgagtcctccctggaagcctacgctcgctgcctgcggatgggc
tgccgttgcattgagttggactgctgggacggcccggatgggatgccggtcatttaccat
ggacacactctgaccaccaagatcaagttctcagacgtcctgcacaccatcaaggagcac
gcctttgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgcc
cagcagaggaacatggcccagtatttcaaaaaggtgcttggggacacactcctcaccaag
cccgtggatattgcagccgacgggctcccctcccccaaccagctcaagaggaagatcctt
atcaagcacaagaagttggctgagggcagtgcctacgaggaggtgccaacatcggtgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaagaccct
gtgaaccatgagtggtacccccactacttcgtcctgaccagcagcaagatctactactcg
gaggagaccagcagcgaccagggcaacgaggatgaggaggagcccaaggaggccagtggc
agcacagagctgcactccaacgagaagtggttccacgggaagcttggggcgggccgggat
gggcggcacatcgccgagcgcctgctcacggagtactgcattgagaccggggcccccgac
ggctccttccttgtgcgcgagagcgagacctttgtgggcgactacactctgtccttctgg
cggaatggcaaagtgcagcactgccggatccactcccggcaggacgcaggcacccccaag
ttcttcctgacggacaacctcgtcttcgactccctctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaacgaatttgagatgcgcctctcagagccggtcccgcagacc
aacgcgcacgagagcaaagagtggtaccacgccagcctgaccagagcgcaggccgagcac
atgctgatgcgtgtacccagggacggggccttcctggtgcggaaacggaacgagcccaac
tcctacgccatctccttccgggctgagggcaagatcaagcactgccgcgtccagcaggag
ggccagaccgtgatgctgggcaactcagagtttgacagccttgtcgacctcatcagctac
tacgagaagcacccactgtaccgcaagatgaagctgcgctaccccatcaacgaggaggct
ctggagaagatcggcacagctgagcctgactacggcgcgctgtacgagggccgcaaccct
ggcttctatgtggaggcgaaccccatgcccacgttcaagtgcgccgtcaaagctctcttc
gactacaaagcgcagcgggaggacgagctgacattcaccaagagtgccatcatccagaac
gtggagaagcaggagggaggctggtggcggggtgactacggcgggaagaagcagctgtgg
ttcccttcaaactatgtggaggaaatggtcagcccggcggccctggagcccgagagggag
cacttggacgagaacagcccactcggggacttgctccggggggtcctggatgtgccagct
tgtcagatagccgtccgtcccgagggcaagaacaaccggctgttcgtcttctccatcagc
atggcctcggtggcacactggtccctggatgtggctgccgactcgcaggaagagctgcag
gactgggtgaagaagatccgggaggtggcgcagacagcggatgccaggctcaccgagggc
aagatgatggagcggaggaagaagatcgccctagagctctcagagctcgtcgtctactgc
cggcctgtccctttcgacgaagagaagattggcaccgaacgggcctgctaccgcgacatg
tcgtccttcccggagaccaaggccgagaagtacgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccgcctgcagctctcccgcatctaccctaagggccagcggctggactcc
tccaattacgaccccctgcccatgtggatctgcggcagccagcttgtggccctcaacttc
cagaccccagacaaacccatgcagatgaaccaggccctgttcctggccggcgggcactgt
ggctatgtgctgcagcccagcgtcatgcgcgatgaggccttcgatccctttgacaagagc
agcctccgcgggctggagccgtgcgccatctgcatcgaggtgctgggggcccggcacctg
ccgaagaacggccgaggcatcgtgtgtccttttgtggagatcgaggtggccggagccgag
tatgacagcatcaagcagaagacagagtttgtggtggacaatggactgaaccccgtgtgg
ccagccaagcccttccacttccagattagtaaccccgagttcgccttcctgcgcttcgtg
gtctatgaggaggacatgtttagtgaccagaacttcctagctcaggctaccttcccagtg
aagggtctgaagacaggctacagagcggtgcctctgaagaacaactacagtgagggcctg
gagctggcctccctgctcgtcaagattgacgtgttccctgccaagcaggagaacggcgac
ctcagccccttcgggggtgcgtccctgcgggagcggagctgtgacgcctcgggcccgctg
ttccacggccgggcccgggagggctcctttgaagctcgctaccagcagccctttgaggac
ttccgcatctcccaggagcatctcgcagaccattttgacggtcgggatcgcaggacccca
cgcaggactcgggtcaacggagacaaccgcctgtag

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