Bos taurus (cow): 408017 Help Entry 408017            CDS       T01008                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism bta  Bos taurus (cow) Pathway bta04010   MAPK signaling pathway bta04014   Ras signaling pathway bta04015   Rap1 signaling pathway bta04022   cGMP-PKG signaling pathway bta04066   HIF-1 signaling pathway bta04068   FoxO signaling pathway bta04072   Phospholipase D signaling pathway bta04081   Hormone signaling bta04150   mTOR signaling pathway bta04151   PI3K-Akt signaling pathway bta04152   AMPK signaling pathway bta04211   Longevity regulating pathway bta04213   Longevity regulating pathway - multiple species bta04520   Adherens junction bta04910   Insulin signaling pathway bta04913   Ovarian steroidogenesis bta04923   Regulation of lipolysis in adipocytes bta04930   Type II diabetes mellitus bta04931   Insulin resistance bta04932   Non-alcoholic fatty liver disease bta04960   Aldosterone-regulated sodium reabsorption bta05010   Alzheimer disease bta05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:bta00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     408017 (INSR)    04014 Ras signaling pathway     408017 (INSR)    04015 Rap1 signaling pathway     408017 (INSR)    04066 HIF-1 signaling pathway     408017 (INSR)    04068 FoxO signaling pathway     408017 (INSR)    04072 Phospholipase D signaling pathway     408017 (INSR)    04022 cGMP-PKG signaling pathway     408017 (INSR)    04151 PI3K-Akt signaling pathway     408017 (INSR)    04152 AMPK signaling pathway     408017 (INSR)    04150 mTOR signaling pathway     408017 (INSR)   09133 Signaling molecules and interaction    04081 Hormone signaling     408017 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     408017 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     408017 (INSR)    04923 Regulation of lipolysis in adipocytes     408017 (INSR)    04913 Ovarian steroidogenesis     408017 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     408017 (INSR)   09149 Aging    04211 Longevity regulating pathway     408017 (INSR)    04213 Longevity regulating pathway - multiple species     408017 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     408017 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     408017 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     408017 (INSR)    04932 Non-alcoholic fatty liver disease     408017 (INSR)    04931 Insulin resistance     408017 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bta01001]     408017 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:bta04090]     408017 (INSR) Enzymes [BR:bta01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      408017 (INSR) Protein kinases [BR:bta01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    408017 (INSR) CD molecules [BR:bta04090]  Proteins   408017 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Ig_DSCAM-DSCAML_C Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  408017 NCBI-ProteinID:  XP_002688878 BGD-bta:  BT11831 Ensembl:  ENSBTAG00000012687 VGNC:  30221 UniProt:  F1MV64 LinkDB All DBs Position 7:complement(16054185..16200493) Genome browser AA seq 1382 aa AA seqDB search MGAGGGRGAAAVLLMVVVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTSEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TIINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPTRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFIPRKSSSGPVAEDARPSRKRRALGDVGNVTAAVPTALGL PNTSSTSTPMSSEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGEEELHLCV SRRHYALERGCRLRGLLPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIG PLIFVFLFSVVIGSICLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR EKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKG FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN CPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEME FEDMESVPLDRASHAQREEAGGRDGGSALGLKRNYDEHIPYTHMNGGKKNGRILTLPRSN PS NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt atgggcgccgggggcgggaggggggcggcagccgtgctgctgatggtggtcgtcgccgcg ctgctggtgggcgccgcgggccacctgtaccctggagaagtgtgccccggtatggatatc cggaataatctcacccggctgcatgagctggccaactgctcagtcatcgaaggacatttg cagattctgttgatgttcaaaacgagacctgaggacttccgagacctcagtttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacttgttccccaacctcacagttatccgaggctcacgcctcttctttaattatgcactg gtcatctttgagatggttcacctgaaggagcttggcctctacaacctgatgaacatcacc cgggggtctgtccgcattgagaagaacaatgaactctgctacctggccaccatcgactgg tctcgcatcctggattccgtggaggataattatatcgtgctgaacaaagacgacaatgag gagtgtggggacatttgtccaggcaccgccaagggcaagaccaactgccctgccactgtc atcaacgggcaatttgtggagcggtgctggacacacagccactgccagaaagtgtgtccg accatctgcaagtcacatggctgcacctctgagggtctctgctgccacagcgagtgcttg ggcaactgctcagagcccgacgaccccaccaagtgtgtggcctgtcgcaacttctacctg gacggcaggtgtgtggagacctgcccgcccccttactaccacttccaagactggcgctgc gtgaacttcagcttctgccaggacctgcacaacaaatgcaagaactctcggaggcaaggc tgccaccagtatgtcattcacaataacaagtgcatccccgagtgcccctctggctacacg atgaattccagcaacttgatgtgtaccccttgcctgggcccctgtcccaaggtatgccac ctcctggaaggcgagaagaccatcgattcggtgacatctgcccaggagctccgaggctgc accatcatcaacggaagcttaatcatcaacattcgagggggcaacaacctggcagctgag ctagaggccaaccttggactcattgaagaaatttcaggatatctgaaaatccgccggtcc tatgccctggtgtcactttccttcttccggaagttacgtctgattcgaggggagaccttg gaaattgggaactactctttctacgccttggacaaccagaacctaaggcagctgtgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataaccccaaa ctctgcctgtcggaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag agaaatgacattgctctaaagaccaatggggaccaggcatcctgtgaaaatgaattactt aaattttcttacattcggacatcttacgacaagatcttgctaaaatgggagccgtattgg cctcctgacttccgagacctcctggggttcatgttgttctacaaagaggccccttaccag aacgtgacagaattcgatgggcaggatgcctgcggctccaacagctggacagtggtggat attgacccgcctacgaggtccaacgaccccaagtcacagaaccaccctgggtggctgatg cgtggtctcaagccctggacccagtatgccatctttgtcaagaccctggtcaccttttct gatgaacgccgtacatacggggccaagagtgacatcatctatgtccagacagacgccact aatccttccgtgcccctggatcccatctcagtttctaattcctcgtcccagattattctg aagtggaagcctccctccgaccccaatggcaatatcacacactacttggtgttctgggag agacaggcggaagacagtgagctgtatgaactggattattgcctcaaagggttgaagctg ccctcccggacctggtctccaccattcgagtcggagggctcccagaagcacaaccagagt gagtatgaggagtctgctggcgaatgctgctcctgcccaaagaccgactcgcagatcctc aaggagctggaggagtcctcgttcaggaaaacgtttgaagattacctgcacaacgtggtt ttcatccccagaaaatcatcttcaggccctgttgccgaggacgctaggccttcgaggaaa cgcagagcccttggtgatgtggggaatgtgacagcagccgtgcccactgctctggggctc cccaatacctcctccaccagcacgcccatgagctcggaggagcacagacccttcgagaaa gtggtgaacaaggagtcgctggtcatctccggcctgcgtcactttactggctatcgcatc gagcttcaggcttgcaaccaagattcccccgaggagaggtgtagcgtggctgcctatgtc agcgccaggaccatgcctgaagccaaggcagatgatattgtcggccccgtgacccatgaa atcttcgagaacaacgttgttcacttgatgtggcaggagcccaaggaacccaacggtctg attgtgctgtatgaagtgagttaccgacgatatggcgaggaggagctgcacctctgcgtc tcccgccgacattatgctctggagcgtggctgccggctgcgtgggctgctgcctgggaat tacagtgtgcgagttcgggccacctccctggcaggcaatgggtcttggacggaagccacc tatttctacgtgacagactatttagacgtgccatcaaatattgcaaaaatcatcatcggt cccctcatctttgtctttctcttcagtgttgtgattggaagtatttgtctattcctgaga aagaggcagccagatgggccattgggaccactgtatgcttcttcaaacccagagtacctc agtgccagcgatgtgtttccatgctctgtgtatgtgccggacgagtgggaggtgcctcga gagaagatcacactcctgcgagaattggggcaaggctcctttggcatggtgtacgagggc aacgccagggacattgtcaagggtgaggcggagacgcgcgtggcagtgaagacggtcaac gagtcagccagcctgcgagagcggatcgagtttctcaacgaggcttcggtcatgaagggc ttcacctgccaccatgtggtccgcctcctgggggtggtgtccaaaggccagccaacgctg gtggtgatggagttgatggctcacggagacctgaagagttacctccgttccctgcggcct gaggctgagaataaccccggccgccctccgcctaccctgcaagaaatgattcagatggcg gcagagatcgccgatgggatggcatacctgaacgctaagaagttcgtgcaccgggatctt gcagcccggaactgcatggttgcccacgactttacagtcaaaattggagactttggaatg acaagagacatctatgaaacggattactaccggaaagggggcaaaggtctgctccccgtg cggtggatggcacctgaatccctgaaggacggagtcttcaccacctcttcagacatgtgg tcttttggtgtggtcctttgggaaattaccagcttggcagaacagccttaccaaggtcta tcaaatgagcaggtgctgaaatttgtcatggatggagggtacctggatcaacctgacaat tgtccagagagagtcaccgacctgatgcggatgtgctggcagttcaaccccaagatgcgt ccaaccttcctggagatcgtggacctgctcaaggacgacctgcaccccagctttcccgaa gtgtccttcttccacagcgaggagaacaaggcgcccgagagcgaggagctggaaatggag tttgaggacatggagagcgtgcccctggaccgggcctcgcacgcgcagagagaggaggcc gggggccgggatggagggtcggcgctggggctaaagcgaaactatgacgagcacatcccc tacacccacatgaacgggggcaagaaaaacggacggattctgactttgccccggtcaaat ccttcctaa

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