Bos taurus (cow): 505740 Help Entry 505740            CDS       T01008                                  Symbol ADCY5 Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism bta  Bos taurus (cow) Pathway bta00230   Purine metabolism bta01100   Metabolic pathways bta01522   Endocrine resistance bta04015   Rap1 signaling pathway bta04022   cGMP-PKG signaling pathway bta04024   cAMP signaling pathway bta04062   Chemokine signaling pathway bta04072   Phospholipase D signaling pathway bta04081   Hormone signaling bta04082   Neuroactive ligand signaling bta04114   Oocyte meiosis bta04211   Longevity regulating pathway bta04213   Longevity regulating pathway - multiple species bta04261   Adrenergic signaling in cardiomyocytes bta04270   Vascular smooth muscle contraction bta04371   Apelin signaling pathway bta04540   Gap junction bta04611   Platelet activation bta04713   Circadian entrainment bta04714   Thermogenesis bta04723   Retrograde endocannabinoid signaling bta04724   Glutamatergic synapse bta04725   Cholinergic synapse bta04726   Serotonergic synapse bta04727   GABAergic synapse bta04728   Dopaminergic synapse bta04750   Inflammatory mediator regulation of TRP channels bta04911   Insulin secretion bta04912   GnRH signaling pathway bta04913   Ovarian steroidogenesis bta04914   Progesterone-mediated oocyte maturation bta04915   Estrogen signaling pathway bta04916   Melanogenesis bta04918   Thyroid hormone synthesis bta04921   Oxytocin signaling pathway bta04923   Regulation of lipolysis in adipocytes bta04924   Renin secretion bta04925   Aldosterone synthesis and secretion bta04926   Relaxin signaling pathway bta04927   Cortisol synthesis and secretion bta04928   Parathyroid hormone synthesis, secretion and action bta04934   Cushing syndrome bta04935   Growth hormone synthesis, secretion and action bta04970   Salivary secretion bta04971   Gastric acid secretion bta04972   Pancreatic secretion bta04976   Bile secretion bta05012   Parkinson disease bta05030   Cocaine addiction bta05031   Amphetamine addiction bta05032   Morphine addiction bta05034   Alcoholism bta05163   Human cytomegalovirus infection bta05166   Human T-cell leukemia virus 1 infection bta05200   Pathways in cancer bta05207   Chemical carcinogenesis - receptor activation bta05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:bta00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     505740 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     505740 (ADCY5)    04371 Apelin signaling pathway     505740 (ADCY5)    04072 Phospholipase D signaling pathway     505740 (ADCY5)    04024 cAMP signaling pathway     505740 (ADCY5)    04022 cGMP-PKG signaling pathway     505740 (ADCY5)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     505740 (ADCY5)    04081 Hormone signaling     505740 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     505740 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     505740 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     505740 (ADCY5)    04062 Chemokine signaling pathway     505740 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     505740 (ADCY5)    04923 Regulation of lipolysis in adipocytes     505740 (ADCY5)    04912 GnRH signaling pathway     505740 (ADCY5)    04913 Ovarian steroidogenesis     505740 (ADCY5)    04915 Estrogen signaling pathway     505740 (ADCY5)    04914 Progesterone-mediated oocyte maturation     505740 (ADCY5)    04921 Oxytocin signaling pathway     505740 (ADCY5)    04926 Relaxin signaling pathway     505740 (ADCY5)    04935 Growth hormone synthesis, secretion and action     505740 (ADCY5)    04918 Thyroid hormone synthesis     505740 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     505740 (ADCY5)    04916 Melanogenesis     505740 (ADCY5)    04924 Renin secretion     505740 (ADCY5)    04925 Aldosterone synthesis and secretion     505740 (ADCY5)    04927 Cortisol synthesis and secretion     505740 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     505740 (ADCY5)    04270 Vascular smooth muscle contraction     505740 (ADCY5)   09154 Digestive system    04970 Salivary secretion     505740 (ADCY5)    04971 Gastric acid secretion     505740 (ADCY5)    04972 Pancreatic secretion     505740 (ADCY5)    04976 Bile secretion     505740 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     505740 (ADCY5)    04727 GABAergic synapse     505740 (ADCY5)    04725 Cholinergic synapse     505740 (ADCY5)    04728 Dopaminergic synapse     505740 (ADCY5)    04726 Serotonergic synapse     505740 (ADCY5)    04723 Retrograde endocannabinoid signaling     505740 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     505740 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     505740 (ADCY5)    04213 Longevity regulating pathway - multiple species     505740 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     505740 (ADCY5)    04714 Thermogenesis     505740 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     505740 (ADCY5)    05207 Chemical carcinogenesis - receptor activation     505740 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     505740 (ADCY5)    05163 Human cytomegalovirus infection     505740 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     505740 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     505740 (ADCY5)    05031 Amphetamine addiction     505740 (ADCY5)    05032 Morphine addiction     505740 (ADCY5)    05034 Alcoholism     505740 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     505740 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     505740 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     505740 (ADCY5) Enzymes [BR:bta01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      505740 (ADCY5) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  505740 NCBI-ProteinID:  NP_001178998 BGD-bta:  BT10413 Ensembl:  ENSBTAG00000018777 VGNC:  25646 UniProt:  E1BHU9 LinkDB All DBs Position 1:complement(67666355..67823121) Genome browser AA seq 1259 aa AA seqDB search MSSSKSVSPPGYAAQTAAAPASRGGPEHRSAWGEADSRANGYPQAPGGSARGSTKRPGGA VTPQQQQRLASRWRSDDEDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR GAAGGGSTRAPPAGSGGGSAAAAAAAGGTEVRPRSVELGLEERRGKGRAADDLEAGAVEE DEGSGDGGSSAGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSL TMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILVMAVLCNRAAFHQDHMGLAC YALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHL AIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQ RENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLA SQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGM DMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAG RIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQ RTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESSNPEDEVDEFLGR AIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITI VPHSVFMLSFYLTCFLLLTLVVFVSVIYSCVKLFPAPLQTLSRKIVRSKMNSTLVGVFTI TLVFLSAFVNMFTCNSKDLFGCLGDEHNISASQVNACHVVESAVNYSLGDEQGFCGSSWP NCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLVVEVPGVTLFDNADLLV TANAIDFNNNGTSQCPEHPTKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQA TEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSE FYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDK VGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNT VNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPPS NT seq 3780 nt NT seq  +upstreamnt  +downstreamnt atgtccagctccaaaagcgtgagccccccgggctacgcggcgcagacagcggcggcgccg gcgtcccggggaggcccggaacaccgctccgcgtggggagaggccgactcccgcgccaat ggctacccccaagcccccgggggttctgcccgcggctccaccaagagacctgggggggcg gtgaccccgcagcagcaacagcgcctggccagccgctggcgcagcgacgacgaagacgat cctccgctgagtggcgatgaccccctggccgggggcttcggcttcagcttccgttccaag tcggcctggcaggagcgcggcggcgacgactgcggtcgcggcagccggcggcagcggcgg ggcgcggccggcgggggcagcacccgggcgccccctgcgggcagcggcggcggttcggcg gctgcggccgccgcagcgggcgggacggaagtgcgcccccgttcggtggagctaggcctg gaggagcggcgtggcaagggccgcgcggccgacgatctggaggccggcgccgtcgaggaa gacgaagggtccggggatgggggcagctcggcaggctcgggcgcggggcctggcgcggtg ctgtcgctgggcgcctgctgcctggcactgctgcagatattccgctctaagaagttccca tcggacaagctggagcggctgtaccagcgctacttcttccgtctgaaccagagcagcctc acaatgctcatggctgtgctggtgctcgtgtgcctagtcatgttggccttccacgcggca cggcccccgctgcagctgccctacctggccgtcctagcggccgccgtgggtgtgatcctc gttatggccgtgctctgcaaccgtgccgccttccaccaggaccacatgggcctggcctgc tacgcgcttatcgccgtggtgctggccgtccaggtggtgggcctgttgctgccccagccg cgcagtgcctccgagggcatctggtggactgtgtttttcatctatacgatctacacgctc ctgcccgtgcgcatgcgggctgcggtactcagcggggtgctcctgtccgccctccacctg gccatcgccctgcgcaccaacgcccaggatcagttcctgctcaagcagctcgtctccaac gtcctcattttctcctgcaccaacattgtgggtgtgtgcacccactacccggctgaggtc tcgcagaggcaggccttccaggagacccgggagtgcatccaggctcggctccactcacag cgggagaaccagcagcaggagcggctcctgctgtctgtccttccccgtcacgttgccatg gagatgaaagccgacatcaacgccaaacaggaggatatgatgttccataagatttacatc cagaaacatgacaacgtgagcattctgtttgctgacatcgagggtttcaccagcctggca tcccagtgcactgcccaggagctggtcatgaccctcaacgagctcttcgcccgcttcgac aagctggctgcggagaatcactgtttacgtattaagatcctgggagattgttattactgt gtctcagggctgcctgaagccagggctgaccacgcccactgctgcgtggagatgggcatg gacatgatcgaggccatctcgctggtccgggaggtgacaggtgtgaacgtgaacatgcgt gtgggaattcacagcgggagagtgcactgcggtgtcctcggcctcaggaagtggcagttc gatgtctggtctaacgatgtcacactggccaaccacatggaggctggaggcaaggcggga cgcatccacatcaccaaggccactctcaactacttgaatggtgactacgaagtggagcca ggctgtgggggcgagcgcaacgcctacctcaaggagcacagtatcgagacctttctcatc ctgcgctgcacccagaagcggaaagaagagaaggccatgattgccaagatgaaccgtcag agaaccaactccatcgggcacaacccgccccactggggggccgagcgccccttctataac cacctggggggcaaccaggtgtccaaggagatgaagcggatgggctttgaagaccccaag gacaagaatgcccaggaaagttcgaaccctgaggatgaagtggatgaatttctgggccgt gccattgatgccaggagcatcgacaggctgcgatctgaacatgttcgcaagttcctcttg accttcagggagcctgacttagagaagaagtactccaagcaggtggatgaccgattcggt gcctacgtggcctgtgcctcgctcgtcttcctcttcatctgctttgtccagatcaccatt gtgccccactccgtgttcatgttgagtttctacctgacctgtttcctgctgctgaccttg gtggtgtttgtgtccgtgatctattcttgcgtgaagctcttcccagccccgctgcagacg ctctccaggaagatcgtgcggtccaagatgaacagcaccctggtgggggtgttcaccatc accctcgtgttcctgtcggctttcgtcaacatgttcacgtgcaactccaaggacctgttt ggctgcctgggggacgagcacaacatcagtgccagtcaggtcaatgcatgccacgtggtg gagtcggccgtcaactacagtctgggtgacgagcagggcttctgcggcagctcctggccc aactgcaacttccccgagtacttcacctatagcgtgctgctcagcctgctggcctgctcc gtgttcctgcagatcagctgcatcgggaagctggtgctcatgctggccatcgagctcatc tacgtgctcgtcgttgaggtgcccggtgtcacgctctttgacaatgccgacctactggtc acggccaacgccatagacttcaacaacaacgggacctcccagtgccctgagcatccaacc aaggtggcgctgaaggtggtgacgcccatcatcatctccgtcttcgtgctggccctgtac ctgcatgcccagcaggtggagtccactgcccgcctcgacttcctctggaaacttcaggcc acggaggagaaggaggagatggaggagctgcaggcctacaaccggcggctgctgcacaac attctgcccaaggacgtggccgcacacttcctggcccgcgaacggcgcaacgacgagctc tactatcagtcgtgcgagtgcgtggccgtcatgttcgcctccatcgccaacttctctgag ttctacgtggaactagaggccaacaacgagggcgtcgagtgcctgcggctgctcaacgag atcatcgcagactttgacgagatcattagtgaggaccggttcaggcagctggaaaagatc aagaccatcggcagcacctacatggccgcctccggcctcaatgactccacctacgacaag gtgggcaagacccacatcaaagccctggccgacttcgccatgaagttgatggaccaaatg aagtacatcaacgagcactctttcaacaacttccagatgaagatcgggctcaatattggc cccgtggtggcgggtgtgattggagcccgcaagcctcagtacgacatctggggcaatacg gtgaacgtggccagccgcatggacagcaccggtgtgcccgaccgcatccaggtcaccaca gacatgtaccaggtgctggccgccaatacgtaccagctggagtgccggggtgtggtcaag gtcaagggcaaaggcgagatgatgacctacttcctcaacggaggacccccgcccagttag

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