Bos taurus (cow): 535017 Help Entry 535017            CDS       T01008                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism bta  Bos taurus (cow) Pathway bta00230   Purine metabolism bta01100   Metabolic pathways bta01522   Endocrine resistance bta04015   Rap1 signaling pathway bta04020   Calcium signaling pathway bta04022   cGMP-PKG signaling pathway bta04024   cAMP signaling pathway bta04062   Chemokine signaling pathway bta04072   Phospholipase D signaling pathway bta04081   Hormone signaling bta04082   Neuroactive ligand signaling bta04114   Oocyte meiosis bta04211   Longevity regulating pathway bta04213   Longevity regulating pathway - multiple species bta04261   Adrenergic signaling in cardiomyocytes bta04270   Vascular smooth muscle contraction bta04371   Apelin signaling pathway bta04540   Gap junction bta04611   Platelet activation bta04713   Circadian entrainment bta04714   Thermogenesis bta04720   Long-term potentiation bta04723   Retrograde endocannabinoid signaling bta04724   Glutamatergic synapse bta04725   Cholinergic synapse bta04727   GABAergic synapse bta04742   Taste transduction bta04750   Inflammatory mediator regulation of TRP channels bta04911   Insulin secretion bta04912   GnRH signaling pathway bta04913   Ovarian steroidogenesis bta04914   Progesterone-mediated oocyte maturation bta04915   Estrogen signaling pathway bta04916   Melanogenesis bta04918   Thyroid hormone synthesis bta04921   Oxytocin signaling pathway bta04923   Regulation of lipolysis in adipocytes bta04925   Aldosterone synthesis and secretion bta04926   Relaxin signaling pathway bta04927   Cortisol synthesis and secretion bta04928   Parathyroid hormone synthesis, secretion and action bta04934   Cushing syndrome bta04935   Growth hormone synthesis, secretion and action bta04970   Salivary secretion bta04971   Gastric acid secretion bta04972   Pancreatic secretion bta04976   Bile secretion bta05032   Morphine addiction bta05163   Human cytomegalovirus infection bta05166   Human T-cell leukemia virus 1 infection bta05200   Pathways in cancer bta05207   Chemical carcinogenesis - receptor activation bta05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:bta00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     535017 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     535017 (ADCY8)    04371 Apelin signaling pathway     535017 (ADCY8)    04020 Calcium signaling pathway     535017 (ADCY8)    04072 Phospholipase D signaling pathway     535017 (ADCY8)    04024 cAMP signaling pathway     535017 (ADCY8)    04022 cGMP-PKG signaling pathway     535017 (ADCY8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     535017 (ADCY8)    04081 Hormone signaling     535017 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     535017 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     535017 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     535017 (ADCY8)    04062 Chemokine signaling pathway     535017 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     535017 (ADCY8)    04923 Regulation of lipolysis in adipocytes     535017 (ADCY8)    04912 GnRH signaling pathway     535017 (ADCY8)    04913 Ovarian steroidogenesis     535017 (ADCY8)    04915 Estrogen signaling pathway     535017 (ADCY8)    04914 Progesterone-mediated oocyte maturation     535017 (ADCY8)    04921 Oxytocin signaling pathway     535017 (ADCY8)    04926 Relaxin signaling pathway     535017 (ADCY8)    04935 Growth hormone synthesis, secretion and action     535017 (ADCY8)    04918 Thyroid hormone synthesis     535017 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     535017 (ADCY8)    04916 Melanogenesis     535017 (ADCY8)    04925 Aldosterone synthesis and secretion     535017 (ADCY8)    04927 Cortisol synthesis and secretion     535017 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     535017 (ADCY8)    04270 Vascular smooth muscle contraction     535017 (ADCY8)   09154 Digestive system    04970 Salivary secretion     535017 (ADCY8)    04971 Gastric acid secretion     535017 (ADCY8)    04972 Pancreatic secretion     535017 (ADCY8)    04976 Bile secretion     535017 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     535017 (ADCY8)    04727 GABAergic synapse     535017 (ADCY8)    04725 Cholinergic synapse     535017 (ADCY8)    04720 Long-term potentiation     535017 (ADCY8)    04723 Retrograde endocannabinoid signaling     535017 (ADCY8)   09157 Sensory system    04742 Taste transduction     535017 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     535017 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     535017 (ADCY8)    04213 Longevity regulating pathway - multiple species     535017 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     535017 (ADCY8)    04714 Thermogenesis     535017 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     535017 (ADCY8)    05207 Chemical carcinogenesis - receptor activation     535017 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     535017 (ADCY8)    05163 Human cytomegalovirus infection     535017 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     535017 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     535017 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     535017 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     535017 (ADCY8) Enzymes [BR:bta01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      535017 (ADCY8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD Motif Other DBs NCBI-GeneID:  535017 NCBI-ProteinID:  NP_001179770 BGD-bta:  BT15209 Ensembl:  ENSBTAG00000014600 VGNC:  25649 UniProt:  E1BQ12 Structure PDBPDBj LinkDB All DBs Position 14:9754131..9979386 Genome browser AA seq 1253 aa AA seqDB search MELSDVRCLSGSEELYTIHPTPPAGDSGSGSRPQRLLWQTAVRHITEQRFIHGHRGGGGG GGNGSSSKASDPGGGGPNHHHASQLSGDSALPLYALGPGERAHGTGGPKVFPERSGSGSA SGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQR RKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTS HTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLG TSLMQVVLQAVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVE ARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFA DVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDH AHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIAN KLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLP EDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQAL HVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVC AFIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWI NETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVF TGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTK EASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSH VARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADF DELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEIN KHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYL ILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLG LVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLTPSGPEPGAPAEGADKPELP NT seq 3762 nt NT seq  +upstreamnt  +downstreamnt atggagctctccgatgtgcgctgcctgagcggcagcgaggaactctacaccatccacccg acgcccccggccggcgacagcgggagcggctcccggccgcagcggctgctgtggcagacg gcggtgcggcacatcaccgagcagcgcttcatccatgggcaccgcggcggcggcggcggt ggcgggaacggaagctccagcaaagcctcggaccccggaggcggcggacccaaccaccac cacgcgtcgcagctgtccggcgactcggcgctgcccctctacgcgctgggccctggggag cgagcgcacggcaccggcggccccaaagtcttcccggaacgcagcgggagcggcagcgcc agcggcagcggcggcgggggagacctgggcttcctgcacctcgactgcgccccgagcaac tcggatttcttcctcaatgggggctacagctaccgaggggtcattttccccaccctgcgc aactccttcaagtcccgggatctggagcgcctctaccagcgctatttcctgggccagagg cgcaaatcggaggtggtgatgaacgtgctggacgtgctgaccaaactcaccctcctggtt ctccacttgagcctggcctcggcccccatggacccgctcaagggcatcctgctgggcttc ttcaccggcatagaggtggtgatctgcgccctggtggtggtcagaaaggacaccacctcg cacacatacctgcagtacagcggtgtggtcacttgggtggccatgaccacccagatctta gcagcagggctcggctatgggctcctgggagacggcatcggctacgtgctcttcaccctt tttgccacctacagcatgctgccgctgccgctcacctgggccatcctggccggcctaggc acctctttgatgcaggtggtcctccaagcggtcatccccaggctggcggtcatttccatc aatcaggttgtggcccaggcagtgttattcatgtgtatgaacacagctggaatcttcatc agttacctgtcagaccgggcccagcgccaggccttcctggagacacggaggtgtgtggag gccaggctgcgcctggagacggaaaaccaaagacaggagcgacttgtgctgtccgtgctt cctcgttttgttgtcctggagatgatcaatgacatgaccaacgtggaagacgagcaccta cagcatcagttccaccggatctacatccatcgctacgagaatgtcagtattctttttgca gatgttaaaggatttaccaacctctccacgaccttgtctgctcaggagctggtcaggatg ctcaacgagctctttgccagatttgatcgactggcccatgagcatcactgccttcgtatt aaaatcctgggggactgctactactgcgtttcaggacttcctgagccccgccaggaccac gcccactgctgtgttgaaatgggcctcagcatgatcaaaactatcaggtatgtgcgatca aggacaaagcacgatgttgacatgcggattggaatccactcgggctcggtgctgtgcggt gtgttgggtcttcggaagtggcagtttgatgtctggtcttgggatgtggacatcgcgaac aaacttgaatctggaggaatccccgggcggattcacatttccaaggccacgctggactgc ctcaacggtgactataatgtggaagagggtcacggtaaagagaggaatgaattcttgagg aagcataatatagagacctatttaattaagcagcctgaggagagtctgctgtctttgccc gaagacatcgtcaaggagtctgtgagctcctcagacaggagaaacagcggggcgacgttc acagagggatcttggagccccgaactgcccttcgataacatagtggggaaacagaacact ctggctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttg catgtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcgg agtggtgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactcc agcctggagcacaagtattctcaaatgagggatgaagtattcaaatcaaacttggtctgt gcgtttatcgttcttctatttatcacggcaatacaaagcttgcttccttcttcaagggtg atgcccatggccatccagttttccatcctgatcatgctgcactcagctctggtcctcatc actacggcagaggattacaagtgtttgcccctggtcctccggaaaacctgctgttggatt aacgagacctatttggccaggaacgtcatcatctttgcatccatcttgattaatttcctg ggcgccatcctaaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctg actttcaattcctcagctgtgtttacagatatctgctcctacccagagtactttgtcttc acgggggtgctggccatggtgacctgtgcggttttcctccgactcaactctgtccttaag ctggctgtgctcctgatcatgattgccatctacgccctgctgaccgagaccatctatgca ggcctcttcctgcgctacgacaacctgaaccacagcggagaagatttcctggggaccaag gaagcgtcactgctgctaatggccatgtttcttcttgccgttttctaccatggacagcag ctggagtacacagcccgcctggacttcctgtggcgagtccaggccaaagaggagatcaac gagatgaaggagctgagggagcacaatgagaacatgctgcggaacatcctgcccagccac gtggcccgccacttcctggagaaggaccgggacaatgaggagctgtattctcaatcctat gacgccgtcggggtgatgtttgcctccatcccggggtttgcagacttttactctcagacc gaaatgaacaaccaaggagtggagtgcctccgcctactgaatgagatcattgctgacttc gatgagctgctcggtgaagaccggtttcaagacattgaaaagattaagaccattggtagt acctacatggccgtgtcaggcctgtcacctgaaaagcagcaatgcgaggataagtggggg catttgtgcgccctggccgacttctccctcgccctgactgaaagcatccaggagatcaac aagcattccttcaacaatttcgagctccggattggcatcagccacggctcagtggtagcc ggtgtcatcggcgctaagaaaccacagtacgacatttggggcaaaaccgtgaacctggcg agtcggatggacagcacaggggtcagcggcaggatccaggtcccggaggagacctacctc atcctgaaggaccagggctttgcctttgactaccgaggggagatctatgtgaagggcatc agcgaacaggaagggaaaatcaaaacgtactttctcctgggaagagtccagcccaacccc ttcatcctgccccccaggagactgcccgggcagtactccttggccgcggtcgtcctgggc ctcgtccagtccctcaacaggcagaggcagaagcagctgctgaacgagaacaacaacacg ggcattatcaagggccactataaccggcggactttgctgacgcccagcgggcccgagccg ggagccccagccgaaggcgccgacaagcccgagttgccataa

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