KEGG   Bos taurus (cow): 535298
Entry
535298            CDS       T01008                                 
Symbol
GRB2
Name
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
bta  Bos taurus (cow)
Pathway
bta01521  EGFR tyrosine kinase inhibitor resistance
bta01522  Endocrine resistance
bta04010  MAPK signaling pathway
bta04012  ErbB signaling pathway
bta04014  Ras signaling pathway
bta04062  Chemokine signaling pathway
bta04068  FoxO signaling pathway
bta04072  Phospholipase D signaling pathway
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04380  Osteoclast differentiation
bta04510  Focal adhesion
bta04517  IgSF CAM signaling
bta04540  Gap junction
bta04550  Signaling pathways regulating pluripotency of stem cells
bta04630  JAK-STAT signaling pathway
bta04650  Natural killer cell mediated cytotoxicity
bta04660  T cell receptor signaling pathway
bta04662  B cell receptor signaling pathway
bta04664  Fc epsilon RI signaling pathway
bta04714  Thermogenesis
bta04722  Neurotrophin signaling pathway
bta04910  Insulin signaling pathway
bta04912  GnRH signaling pathway
bta04915  Estrogen signaling pathway
bta04917  Prolactin signaling pathway
bta04926  Relaxin signaling pathway
bta04935  Growth hormone synthesis, secretion and action
bta05034  Alcoholism
bta05160  Hepatitis C
bta05161  Hepatitis B
bta05163  Human cytomegalovirus infection
bta05165  Human papillomavirus infection
bta05200  Pathways in cancer
bta05203  Viral carcinogenesis
bta05205  Proteoglycans in cancer
bta05206  MicroRNAs in cancer
bta05207  Chemical carcinogenesis - receptor activation
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05210  Colorectal cancer
bta05211  Renal cell carcinoma
bta05213  Endometrial cancer
bta05214  Glioma
bta05215  Prostate cancer
bta05220  Chronic myeloid leukemia
bta05221  Acute myeloid leukemia
bta05223  Non-small cell lung cancer
bta05224  Breast cancer
bta05225  Hepatocellular carcinoma
bta05226  Gastric cancer
bta05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    535298 (GRB2)
   04012 ErbB signaling pathway
    535298 (GRB2)
   04014 Ras signaling pathway
    535298 (GRB2)
   04630 JAK-STAT signaling pathway
    535298 (GRB2)
   04068 FoxO signaling pathway
    535298 (GRB2)
   04072 Phospholipase D signaling pathway
    535298 (GRB2)
   04151 PI3K-Akt signaling pathway
    535298 (GRB2)
   04150 mTOR signaling pathway
    535298 (GRB2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    535298 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    535298 (GRB2)
   04540 Gap junction
    535298 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    535298 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    535298 (GRB2)
   04660 T cell receptor signaling pathway
    535298 (GRB2)
   04662 B cell receptor signaling pathway
    535298 (GRB2)
   04664 Fc epsilon RI signaling pathway
    535298 (GRB2)
   04062 Chemokine signaling pathway
    535298 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    535298 (GRB2)
   04912 GnRH signaling pathway
    535298 (GRB2)
   04915 Estrogen signaling pathway
    535298 (GRB2)
   04917 Prolactin signaling pathway
    535298 (GRB2)
   04926 Relaxin signaling pathway
    535298 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    535298 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    535298 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    535298 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    535298 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    535298 (GRB2)
   05206 MicroRNAs in cancer
    535298 (GRB2)
   05205 Proteoglycans in cancer
    535298 (GRB2)
   05207 Chemical carcinogenesis - receptor activation
    535298 (GRB2)
   05208 Chemical carcinogenesis - reactive oxygen species
    535298 (GRB2)
   05203 Viral carcinogenesis
    535298 (GRB2)
   05231 Choline metabolism in cancer
    535298 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    535298 (GRB2)
   05225 Hepatocellular carcinoma
    535298 (GRB2)
   05226 Gastric cancer
    535298 (GRB2)
   05214 Glioma
    535298 (GRB2)
   05221 Acute myeloid leukemia
    535298 (GRB2)
   05220 Chronic myeloid leukemia
    535298 (GRB2)
   05211 Renal cell carcinoma
    535298 (GRB2)
   05215 Prostate cancer
    535298 (GRB2)
   05213 Endometrial cancer
    535298 (GRB2)
   05224 Breast cancer
    535298 (GRB2)
   05223 Non-small cell lung cancer
    535298 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    535298 (GRB2)
   05160 Hepatitis C
    535298 (GRB2)
   05163 Human cytomegalovirus infection
    535298 (GRB2)
   05165 Human papillomavirus infection
    535298 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    535298 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    535298 (GRB2)
   01522 Endocrine resistance
    535298 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bta04131]
    535298 (GRB2)
Membrane trafficking [BR:bta04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    535298 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH3_3 SH2_2 DUF5093 DUF7145 hSH3 SH3_4
Other DBs
NCBI-GeneID: 535298
NCBI-ProteinID: NP_001029802
BGD-bta: BT17792
Ensembl: ENSBTAG00000004736
VGNC: 29631
UniProt: Q3T0F9
LinkDB
Position
19:56117213..56183327
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagccaccgcagacgacgagctgagcttcaaa
agaggggacatcctcaaggttttgaatgaggaatgtgatcagaactggtacaaggcagag
ctcaatgggaaagacggcttcatccccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgctcagcaaacagcggcatgac
ggggcctttcttatccgagagagcgagagtgctcctggggatttctccctctccgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggggctggaaagtatttcctc
tgggtggtcaagttcaactctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatatttctccgggacatagagcaggtgccacagcagccaacatac
gtccaagccctctttgactttgacccccaagaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcttgccacggg
cagaccggcatgttcccacgcaattacgtcacccccgtgaaccggaacgtctaa

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