KEGG   Budorcas taxicolor (takin): 128045498
Entry
128045498         CDS       T08909                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
btax  Budorcas taxicolor (takin)
Pathway
btax00140  Steroid hormone biosynthesis
btax01100  Metabolic pathways
btax04913  Ovarian steroidogenesis
btax04925  Aldosterone synthesis and secretion
btax04927  Cortisol synthesis and secretion
btax04934  Cushing syndrome
Module
btax_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
btax_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
btax_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
btax_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:btax00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    128045498
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    128045498
   04925 Aldosterone synthesis and secretion
    128045498
   04927 Cortisol synthesis and secretion
    128045498
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    128045498
Enzymes [BR:btax01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     128045498
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     128045498
SSDB
Motif
Pfam: 3Beta_HSD Epimerase GDP_Man_Dehyd NAD_binding_4 Polysacc_synt_2 NAD_binding_10 RmlD_sub_bind NmrA KR
Other DBs
NCBI-GeneID: 128045498
NCBI-ProteinID: XP_052493956
LinkDB
Position
3:complement(24125430..24134595)
AA seq 373 aa
MAGWSCLVTGGGGFLGQRIICLLVEEKDLQEIRVLDKVFRPEVREEFSKLQSKIKLTLLE
GDILDEQCLKRAFQGISVVIHTASVIDVRNAVPRETIMNVNVKGTQLLLEACVQASVPVF
IHTSTIEVAGPNSYREIIQDGHEEEHHESAWFSPYPYSKKLAEKAVLEANGWALKNGGTL
YTCALRPMYIYGEGSPFLSAYMHGALKNNGVLTNHCKFSRVNPVYVGNVAWAHILALRAL
RDPKKVPNIQGQFYYISDDTPHQSYDDLNYALSKEWGFCLDSRMSLPISLQYWLAFLLEM
VSFLLSPIYKYHPCFNRHLVTLCNSVFTFSYKKAQRDLGYEPLYTWEEAKQKTKEWIGSL
VKQHKETLKTKIH
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggcagggtggagctgcctcgtgaccggaggaggaggatttctgggccagaggatcatc
tgcctgttggtggaggagaaggatctgcaggaaatccgggtgctagacaaagtcttcaga
ccagaagttcgggaggaattttctaagctccagagcaagatcaagctgaccctgctggaa
ggagacattctggatgagcagtgcctgaagagggccttccaaggcatctcggtggtcatc
cacaccgcttctgtcatcgacgtcaggaatgctgtcccgcgagagaccatcatgaacgtc
aatgtgaaaggtacccagctgctgctggaggcctgtgtccaggctagtgtgccagtcttt
atccacaccagcaccatagaggtggctgggcccaactcctacagggagatcatccaagac
ggccatgaagaagagcatcatgaatcggcatggttctctccatacccatacagcaagaag
cttgccgagaaggctgtgctggaagctaatgggtgggctctgaagaatggcggcaccttg
tacacttgtgccttgaggcccatgtacatctacggggaggggagcccattcctttctgcc
tacatgcatggagccttgaagaacaacggcgtcctgaccaatcactgcaagttctccaga
gtcaacccagtctatgttggcaatgtggcctgggcccacattctggccttgagggccctg
cgggaccccaaaaaggtcccaaacatccaaggacagttctactacatctcagacgacaca
ccacaccaaagctacgatgacctcaattacgctttgagcaaagaatggggcttctgcttg
gattcccggatgagccttcctatttctctgcagtactggcttgccttcctgctggaaatg
gtgagcttcctgctcagtccaatttacaaatatcacccctgcttcaaccgccacctagtg
actctttgcaacagcgtgttcaccttctcctataagaaagctcagcgagatctggggtat
gagcccctctacacttgggaggaagccaagcagaaaaccaaggaatggattggctccctg
gtgaaacaacacaaagagaccctgaaaacaaagattcactga

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