Budorcas taxicolor (takin): 128063697 Help Entry 128063697         CDS       T08909                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism btax  Budorcas taxicolor (takin) Pathway btax04020   Calcium signaling pathway btax04371   Apelin signaling pathway btax04713   Circadian entrainment btax04730   Long-term depression btax04921   Oxytocin signaling pathway btax05017   Spinocerebellar ataxia btax05020   Prion disease btax05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:btax00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128063697 (RYR1)    04020 Calcium signaling pathway     128063697 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     128063697 (RYR1)   09156 Nervous system    04730 Long-term depression     128063697 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     128063697 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     128063697 (RYR1)    05020 Prion disease     128063697 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     128063697 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:btax01009]     128063697 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:btax04147]     128063697 (RYR1)    04040 Ion channels [BR:btax04040]     128063697 (RYR1) Protein phosphatases and associated proteins [BR:btax01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      128063697 (RYR1) Exosome [BR:btax04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    128063697 (RYR1) Ion channels [BR:btax04040]  Voltage-gated cation channels   Ryanodine receptor    128063697 (RYR1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 CDC45 Motif Other DBs NCBI-GeneID:  128063697 NCBI-ProteinID:  XP_052512469 LinkDB All DBs Position 18:49526686..49653306 Genome browser AA seq 5041 aa AA seqDB search MGDGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPP DLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSGMYLSC LTTSRSMTDKLAFDVGLQEDAIGEACWWTTHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLFHGHMDECLTISPADSED QRRLVYYEGGSVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALVEDQGLV VVDASKAHTKATSFCFRISKEKLDTAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYA APDPKALRLGVLKKKAILHQEGHMDDALSLTRCQHEESQAARMIYSTAGLYNHFIKGLDS FSGKPRGSGSPVGTALPLEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQE EGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYEILASLIRGNRANCALF SNNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYL KWYFEVMVDEVVPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLH LWTGHVPRLVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPV VSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLV GPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDN KRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYM MSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPR LVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVESQSRWDRVRIFRAEKS YVVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADDLSYVFNGHRGQRWHLGSEPFG RPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFRDIEIGDGFLPVCSLGPGQVG HLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEAVPPEHPHYEVTRV DGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAE DEARAAEPDPDYENLRRSAGHWAEAEGNKEGTAKEGTPGGPAQAGMEAQPARVENEKDAT TEKNKKRGFLFKAKKAAMMTQPPATPTLPRLPHEVVPADDRDDPEIILNTTTYYYSVRVF AGQEPSCVWVGWVTPDYHQHDMNFDLSKVRAVTVTMGDEQGNIHSSLKCSNCYMVWGGDF LSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQN VIQFELGKQKNIMPLSAAMFLSERKNPTPQCPPRLEVQMLMPVSWSRMPNHFLQVETRRA GERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNR VAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTP ETRAITLFPPGKRADNGPRRHGLPGVGVTTSLRPPHHFSAPCFVAALPAARAAEAPARLS PSIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDV KQILKMIEPEVFTEEEEEEEEDEEEGEEEEEDEEEKEEDEEEEAREKEDEEKEEEETAEG EKEDLEEGLLQMKLPESVKLQMCNLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRY AILMKAFTMTAAETARRTREFRSPPQEQINMLLHFKTAEDEEECPLPEEVRQDLLEFHQD LLTHCGIQLAGEEEEPEEEATLGSRLMSLLEKVRLVKKKEEKSEEESPAEERKPQSLQEL VSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLE CLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGG GESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAA ASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRF AVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLATIEEAIRISEDPARDGPGV RRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAIL RSLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDF LLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAI MVDSMLHTVYRLSRGRSLTKAQRDVIEECLMALCRYIRPSMLQHLLRRLVFDVPILNEFA KMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYR MAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINK FAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMI AWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDAREGYNPQPPDLSGVTLSRELQAMAEQ LAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAV TRGLKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKF FAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLF GTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQ ARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGT TRNPYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVE EMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALP AGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEATWMKRLAVFAQPIVSRARPELLHSH FIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVD NNRAHWLTEPNPSAEELFRMVGEIFIYWSKSHHFKREEQNFVVQNEINNMSFLTADNKSK MAKAGDVQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQELITLAK TRYALKDTDEEVREYLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQ EVSAVLYHLEQIEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESY KAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLD EDYLYIAYADIMAKSCHLEEGGENGEAEEEEVEVSFEEKEMEKQRLLYQQARLHTRGAAE MVLQMISACKGETGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQSIQALMQ TCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNN DFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSV AKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELL DLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAF QDYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMIDCEEFANRFQEPAR DIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEI SETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEMQIAAQISEPEGE PEEDEDEGAGAAEAGAESAEEAAAGPEGAAATAAAGATARLAAAANRAMRGLSYRSLRRR ARRLRRLTAREAATAVAALLWAVLARAGSAGAGAAAGALRLLWGSLFGGGLVEGAKKVTV TELLAGMPDPTSDEVHGEQPAGSGGDADGEGAGDGAGDAAEGAGDEEVADQEGPGVADGT VAVADGGPFRPEGAGLGDMGDTTPAEPPTPEGSPIIKRKLGVAGEEEELPPEPEPEPEPE PEKADAENGEKEEVPETPPEPPKKAAPPPPPPKKEGAGGAGLEFWGELEVQRVKFLNYLS RNFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGGLSGAGSGGGSGWGSGAG EEAEGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKE LARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRER IAELLGMDLATLEITAHNERKPEPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYM VMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAF NFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVF DITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFE THTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL S NT seq 15126 nt NT seq  +upstreamnt  +downstreamnt atgggtgacggaggagagggcgaggatgaggtccagtttctgcggacggacgacgaggtg gtcctgcagtgcagcgccacggtgctcaaggagcagctcaagctctgcctggccgccgag ggcttcggcaaccgcctctgcttcctggagcccaccagcaacgcccagaatgtacccccc gacctggccatctgttgcttcgtcctggagcagtccctgtctgtccgagccctacaggag atgctggccaacactgtggaggccggcgtggagtcgtcccagggtgggggacacaggaca ctcctgtatggccatgccatcctgctccggcatgcacacagcggcatgtacctgagctgc ctcaccacctcccgctccatgactgacaagctggccttcgacgtgggacttcaggaggat gcaataggagaggcctgttggtggacgacgcacccagcctccaagcagaggtcagaagga gagaaggtccgagttggcgatgacctcattcttgtcagtgtctcctccgagcgctacctg cacctgtcgacagccagtggggagctccaggttgatgcctccttcatgcagacactgtgg aacatgaaccccatctgctctggctgtgaagagggctatgtgactggtggccacgtcctc cgcctcttccatggacacatggatgaatgtctgaccatttcccctgctgacagtgaggac cagcgcagacttgtctactatgaggggggatctgtgtgtacccacgcccgctccctctgg agactggaaccactgagaatcagctggagtgggagccacctgcggtggggccagccactc cgcatccggcatgtcaccactgggcggtacctggcactcgtggaggaccagggcctcgtg gtggttgacgccagcaaggcccacaccaaggccacctccttctgcttccgcatctccaag gagaaattggatacggctcccaagcgggacgtggagggcatgggccccccggaaatcaag tatggggagtcactgtgcttcgtgcagcacgtggcctcaggcctgtggctcacctatgct gccccagaccccaaggccctgcgactcggtgtgctcaagaaaaaggccattctgcaccag gaaggccacatggacgatgcactgtcactgacccgctgtcagcacgaggagtctcaggct gcccgcatgatctacagcactgccggcctctacaaccacttcatcaagggcctggacagc ttcagcggaaagccgaggggctcggggtccccggtgggcacagcgctgcctctcgagggc gtcatcttgagcctgcaggacctcatcggctactttgagccgccctccgaggagctacag cacgaagagaagcagagcaagctgcgtagcctgcgcaaccgccagagcctcttccaggag gaggggatgctctccttggtcctgaattgcattgaccgcctaaatgtctataccactgct gcccacttcgctgaatttgcaggggaggaggcagccgaatcctggaaagagattgtgaac ctgctgtatgaaatcctggcctctctgatccgtggcaatcgtgccaactgtgccctcttc tctaacaacttggattggctggtcagcaagctggatcggctagaggcctcctcggggatc ctggaggtgctgtactgtgtcctgattgagagtccggaagtcctgaacatcatccaagag aaccacatcaagtccatcatctccctcctggacaagcatgggaggaaccacaaggtgctg gatgtgctatgttccctgtgtgtgtgcaatggtgtggccgtgcgctccaaccaagacctc atcactgagaacttgctccctggccgcgagcttctgctgcagacaaacctcatcaactac gtcaccagcatccgccccaacatctttgtgggccgagcagagggcaccacgcagtacctc aaatggtactttgaggtgatggtggacgaggtggttccattcctgacggctcaggccacc cacctgagggtgggctgggccctcactgagggctacagcccctaccccgggggcggcgag ggctggggcggcaacggggtcggcgatgacctctattcctacggctttgacgggctgcac ctctggacaggacacgtgccacgcctggtcacttcccccgggcagcacctcctggccccc gaggacgtggtcagctgctgcctggacctcagtgtgccgtccatctctttccgcatcaat ggctgtcccgtgcagggggtcttcgaggccttcaaccttgatgggctcttcttccctgtt gtcagcttttcggctggtgtcaaagtgcggttcctccttggtggtcgccatggagaattc aagttcctccctcctcctggctacgccccttgccacgaggctgtgctcccacgagagcga ctccatctggaacccatcaaggagtatcggcgggaagggccacgggggccccacctggtg ggccccagccgctgcctctcacacactgactttgtgccctgccctgtggacactgtccag attgtccttcctccccatctggagcgtattcgggagaagctggccgagaacatccatgaa ctctgggcactgactcgcatcgagcagggctggacctatggcccggttcgggatgacaat aagagactgcacccctgcctcgtggattttcacagcctaccggagcctgagaggaactac aacctgcagatgtcaggggagacgctcaagactctactggcgctgggctgccacgtgggc atggcggacgagaaggcggaggacaacctgaaaaagacgaagctccccaagacgtacatg atgagcaacgggtacaagccagcgccgctggacctgagccacgtgaggctgacgcccgcg cagaccacactggtggaccggctggcggagaacgggcacaacgtgtgggcccgagaccga gtggcccaaggctggagctacagtgccgtgcaggacatccctgcccgccggaaccctcgc ctcgtgccctaccgcctgctggatgaggccaccaagcgcagcaaccgcgacagcctctgc caggccgtgcgcaccctgctgggctacggctacaacatcgagccgcccgaccaggagccc agtcaggtggagagccagtctcgctgggaccgggtgcgcatcttccgggcagagaaatcc tatgtggtgcagagtggccgctggtacttcgagttcgaggcggtcaccaccggcgagatg cgagtgggctgggcgaggcccgagctgcgcccagacgtggagctgggagcggatgacctg tcctatgtcttcaacgggcaccgcggtcagcgctggcacctgggcagtgaaccgtttggg cgtccctggcagtcgggagacgtcgtgggctgcatgatcgacctcacggagaacaccatc atcttcaccctcaacggcgaggtcctcatgtccgattccggctcagaaacagccttccgc gatatcgagattggggatggcttcctgcctgtgtgcagcttgggacctggccaggtgggt cacctgaacctgggccaggacgtgagctccctgcggttctttgccatctgtggcctccag gaaggttttgagccatttgccatcaacatgcagcggccggtcactacctggttcagcaaa ggccttcctcaatttgaggccgtgcctcctgagcacccgcactatgaggtgactcgtgtg gacggcaccgtggatacgcccccctgcctgcgcctgacccaccgcacctggggctcccag aacagtctggtggagatgctgtttctccggctgagccttccggtccagttccaccagcac ttccggtgcaccgcaggggccaccccactggcaccccctggcctgcagcctcctgcagag gatgaggcccgggcagcggaacctgatcccgactatgaaaacctgcgccgctcagcgggg cactgggccgaggctgaggggaacaaggaaggaactgccaaggaggggacacccgggggt cctgcccaggctgggatggaggcccagcctgccagggtggagaatgagaaggatgctacc acagagaagaacaagaagagagggttcttgttcaaggccaagaaggccgccatgatgacc cagccaccagccacacccactctgccccgactccctcatgaggtggtgcctgctgacgac cgtgatgaccccgagatcatcctcaataccaccacgtactattactctgtgagggtcttt gccggccaggagcccagctgcgtgtgggtgggctgggtcacccctgactaccaccagcac gacatgaacttcgacctcagcaaggtccgggcagtgacagtgaccatgggagacgagcaa ggcaacatccacagcagcctcaagtgcagtaactgctacatggtgtggggtggagacttc ctgagccctgggcagcagggccggatcagccacacagaccttgtcattggctgcttggtg gacttggccactggcctaatgacctttactgccaacggcaaagagagcaacacctttttc caggtggaacccaacacaaagctgttccctgccgtctttgtcctccccacgcaccagaac gtgatccagtttgagttggggaaacagaagaacatcatgccgctgtcagccgccatgttt ttgagcgagcgcaagaaccccacgccgcagtgcccgccgcggctggaggtgcagatgctg atgcccgtgtcttggagccgcatgcccaaccacttcctgcaggtggagacgcggcgggcg ggcgagcggctcggctgggcagtgcagtgccaggagccgctcaccatgatggcgctgcac atccccgaggagaaccgatgcatggacatcctggagttgtctgagcgcttggacctgcag cggttccattcacacaccctccgcctctaccgcgctgtgtgcgccctgggcaacaaccgc gtggcgcatgctctgtgcagccatgtggaccaggcgcagctgctgcacgccctggaggac gcgcacctgcccggccctctgcgtgcaggctactacgacctcctcatcagcatccacctc gaaagtgcctgccgcagccgccgctccatgctgtctgagtacatcgtgcccctcacgcct gagacccgcgccatcactctcttcccacccggaaagagagcagataacggtccccgccgc cacgggcttcctggcgtcggcgttaccacctcgctgcggcctccacaccatttctcagcc ccgtgtttcgtggctgccctgccagctgctcgagcggcagaagccccagcccgcctcagc cccagcatccctctggaagctcttcgggacaaagcacttagaatgctgggggaggctgtg cgagatggtgggcagcacgctcgtgacccagtcgggggctctgtggagttccagtttgtg ccggtgctcaagctggtgtccaccctgctggtgatgggcatctttggcgatgaggatgtg aaacagatcttgaagatgattgagcctgaagtattcactgaggaagaagaggaagaggag gaggacgaggaggaaggggaggaggaagaggaggatgaggaggagaaggaggaggacgag gaggaagaggcacgggagaaggaagatgaggaaaaagaggaggaggagacagcagagggg gaaaaagaggacttggaggaggggctgctccagatgaagttgcccgagtctgtgaagtta cagatgtgtaacctgctggagtatttctgtgaccaagagctacagcaccgtgtggaatct ctggcagcctttgcagagcgctatgtggacaagctccaggccaaccagagggaccgctac gccatcctcatgaaagccttcaccatgactgcagctgagacagcccgacgcactcgcgag ttccgctccccaccccaggagcagatcaacatgctattgcacttcaaaactgctgaggat gaggaagaatgtcctctccctgaagaggtccgacaggatttgctcgaatttcatcaagac ctgctgacacactgtggaattcaactggcgggggaagaggaggaaccagaggaagaagcc accctgggcagtcgcctgatgagcctgttggagaaggtgcggctggtgaagaagaaggag gagaaatcggaggaggaatcacctgccgaggagcgcaaaccccagtcgctgcaagagctg gtgtcccacacggtggtgcgttgggcccaagaggacttcgtgcagagccctgagctggtc cgcgccatgttcagcctcctgcaccggcagtacgatgggctcggggagctgctgcgcgcc ctgccccgggcctacaccatctccccctcctccgtggaggacaccatgagcctgctcgag tgcctcggccagatccgctcactgctcatcgtgcagatgggcccccaggaggagaacctc atgatccagagcatcgggaacatcatgaacaacaaagtcttctaccaacacccgaacctg atgagggcactgggcatgcatgagacagtcatggaggtcatggtgaacgtccttgggggc ggtgaatccaaggagatccgcttccccaagatggtgacgagctgctgccgcttcctctgc tacttctgccgcatcagccggcagaaccagcgctccatgttcgaccacctgagctacctg ctggagaacagtggcatcggcctgggcatgcagggctccactcccctggacgtggcagct gcctctgtcatcgacaacaacgagctggccttggcgttgcaggagcaggatctggagaag gtggtgtcctacctggctggctgtggcctccaaagctgccccatgctcctggccaaaggg tacccagacatcggctggaacccctgtggtggcgagcgctacctggacttcctgcgcttc gctgtcttcgtcaatggcgagagcgtggaggagaacgccaatgtggtggtgcggctgctg atccgcaagcccgagtgctttgggcctgccctgcggggtgagggcggctcggggctgctg gccaccatcgaagaggccatccgcatctccgaggaccctgcgcgggatggcccaggcgtc cgtagggaccggcggcgcgagcactttggggaggagccccccgaagaaaaccgggtgcac ctgggacacgccatcatgtccttctacgctgccttgattgacctgctgggacgctgcgcg ccagagatgcatctaattcaagccggcaagggtgaggccctgcggatccgcgccatcctg cgctcccttgtgcccctggacgacctcgtgggcatcatcagcctcccgctgcagatcccc accctgggcaaagatggggctctggtgcaaccaaagatgtcagcatcctttgtgcccgac cacaaggcgtctatggtgctcttcctggaccgagtatatggcattgagaaccaggacttc ctactgcatgtgctggacgtggggttcctgcccgacatgcgggcggctgcctcgctggac acggccactttcagcacgacggagatggcgctggcgctgaaccgctacctgtgcctggcg gtgctgccgctcatcaccaagtgtgcgcccctgtttgcgggaacggagcatcgcgccatc atggtggactccatgcttcacacggtgtaccgcctgtcacgcggccgctcgctcaccaag gcacagcgcgacgtcatcgaggaatgcttgatggcgctctgcaggtacatccgcccgtcc atgctgcagcacctgctgcggcgcctggtgttcgacgtgcccatccttaacgagttcgcc aagatgccgctcaagctcctcaccaaccactatgagcgctgttggaagtactactgcctc cccacaggttgggccaactttggggtcacctcggaggaagagctgcacctcactcgtaaa ctcttctggggcatctttgactcgctggcccataagaaatatgatcaagagttgtaccgc atggctatgccctgcctgtgtgccatcgcaggagccctgcccccagactacgtggatgcc tcatactcatccaaggctgagaaaaaggccacggtggatgctgaaggcaactttgatcct cggcctgtggagaccctcaatgtgatcatcccagagaagctggactccttcattaacaag ttcgccgagtacacacacgagaagtgggccttcgacaagatccagaacaactggtcctat ggggagaacatagatgaggaactcaagacccatcccatgctgaggccctacaagaccttt tcagagaaggacaaagagatttaccgctggcccataaaggagtccttgaaggccatgatt gcctgggaatggacgatagagaaggccagggagggtgaggaggagaagacggagaagaag aaaacccggaagatatcccaaagcgcccagacctatgatgcaagagaaggctacaaccca caaccccccgatctcagtggagttaccctgtctcgggagctgcaagccatggcggaacaa ctggcggaaaattaccacaacacatggggacgcaaaaagaagcaggagctggaagccaag ggcggtgggacccatcccctgctggttccctacgacacgctcacggccaaggagaaggca cgagatcgggagaaggcccaggagctgttgaagttcctgcagatgaacggctacgcggtc accagaggtcttaaggacatggaactggacacgtcttccattgagaaacggttcgccttc ggcttcctgcagcagttgctgcgctggatggacatatctcaggagtttatcgcccacctg gaggccgtggtcagcagtggacgagtggaaaagtcccctcacgaacaggagattaaattc tttgccaagatcctgctccctttgatcaaccagtacttcaccaaccactgcctctatttc ctgtccaccccagccaaagtgctgggcagcggcggccacgcctccaacaaggagaaggaa atgatcaccagcctcttctgcaagcttgcggctcttgtccgtcaccgagtctctctcttt ggcacggatgccccagctgtggtcaactgtcttcacatcctggcacgctccctggatgcc aggaccgtgatgaagtctggccctgagatcgtgaaggctggcctccgttccttctttgag agtgcctcggaggacattgagaagatggtggagaacctgcggctcggcaaggtgtcgcag gcgcgcacgcaggtgaagggcgtgggccagaacctcacctacaccaccgtggccctgctg ccggtcctcaccaccctcttccagcacatcgcccagcatcagttcggagacgatgttatc ctggatgacgtccaggtctcttgctaccgaacactgtgcagtatctactctctggggacc accaggaacccttacgtggaaaaattgcggccagccctgggagagtgcctggcccgcctg gcagcagccatgccagtggcgttcctggagccacagctgaatgaatacaacgcctgctca gtgtacaccaccaagtctccccgggagcgggccatcctggggctccccaacagtgtggag gagatgtgtcccgacatcccagtgctggagcggctcatggctgacatcggggggctggct gagtcgggcgcccgctacacggagatgccgcacgtcatcgagatcacgctgcccatgctg tgcagctacctgccccgctggtgggagcgtgggcccgaggcacccccacccgccctacct gccggggcccctccaccctgcacggccgtcacctccgaccacctcaactcgctgctgggg aacatcctaagaatcatcgtcaacaacctgggcattgacgaggccacctggatgaagcgg ctggctgtgtttgcccagcccatcgtgagccgggcccggccggagctcctgcactctcac ttcatccccaccatcgggcggctgcgcaaacgggcgggaaaggtggtggctgaggaggag cagctgcgcctggaggccaaggcggaggccgaggagggcgagctcctggtgcgggatgag ttctctgtgctctgccgggatctgtacgccctctacccgctgctcatccgctacgtggac aacaacagggcacactggctgaccgagcccaaccccagcgcggaggagctgttcaggatg gtgggcgagatcttcatctactggtccaagtcccaccactttaagcgcgaggagcagaac tttgtggtccagaatgagatcaacaacatgtcatttctgacggccgacaacaagagcaaa atggccaaggcgggagatgtacagtcgggtggctcggaccaggaacgcaccaagaagaag cgccggggtgaccggtactccgtgcagacatcgctgattgtggccacgctcaagaagatg ctgcccatcggcctgaacatgtgtgcccccactgaccaggagctcatcacactggccaag acccgctatgccctgaaagacacagatgaggaggtccgggaatatctgcaaaacaacctt caccttcagggaaaggtcgaaggctccccttctctgcgctggcagatggccctgtaccgg ggcctcccgggccgcgaggaggacgctgacgatccggagaaaatcgtgcgcagagtccag gaagtgtccgctgtgctctaccatttggagcagatcgagcacccttacaagtccaagaag gccgtgtggcacaagctcttgtcgaagcagcgccggagggcagtcgtcgcctgtttccgc atgacccccctgtacaatctgcccacgcaccgggcctgtaatatgtttttggagagctac aaggcggcgtggatcctgacggaagaccacagttttgaggaccgcatgatagatgacctt tcaaaagctggggagcaggaggaggaggaggaggaagtggaggagaagaagccagacccc ctgcaccagctggtcctgcacttcagccgcaccgccctgactgaaaagagcaaactggat gaagattacttgtatatagcgtacgctgatatcatggctaagagctgccacctggaggaa ggaggggagaatggtgaagctgaagaagaggaggttgaggtttccttcgaggaaaaagag atggagaagcagcgtctcctgtaccagcaggcgcggctgcacacccggggggctgcagag atggtgctgcagatgatcagcgcctgcaaaggagagacaggcgccatggtgtcctccact ctgaagctgggcatctcgatcctaaacggaggcaatgctgatgtgcagcagaaaatgctg gattacctgaaggacaagaaggaagttggcttcttccagagtatccaggcactgatgcaa acctgcagtgtcctggatctcaatgccttcgagagacagaacaaggcagaggggctgggc atggtgaatgaggatggaactgtcatcaaccgccagaacggagagaaggtcatggcagat gatgaattcacccaggacctgttccgattcctgcagttgctctgcgagggtcacaataat gatttccaaaattacctacggacacagacagggaatacaaccactattaacatcatcatc tgtaccgtggactacctcctgcggctgcaggagtccatcagcgacttctactggtactac tccggcaaggatgtcattgaggagcaaggcaagaggaacttttccaaggcaatgtcggtg gctaaacaggtgttcaacagcctcaccgagtacatccagggcccctgcactgggaaccag cagagtctagcgcacagccgcctctgggacgccgtggtgggattcctgcacgtgtttgcg cacatgatgatgaagctcgcgcaggactcaagccagatcgagctgttgaaggagctgctg gatctgcagaaggacatggtggtgatgttgctgtcactactggaagggaacgtggtgaac ggcatgattgcccggcagatggtggacatgcttgtggaatcctcatccaacgtggagatg atcctcaagttctttgacatgttcctgaaactcaaggacatcgtgggctctgaggccttc caggactatgtcactgatccccgtggtctcatctccaagaaggacttccagaaggccatg gacagtcagaagcagttcactggtccggaaatccagttcctgctttcgtgctccgaagcg gatgagaacgagatgatcgactgtgaggagttcgccaaccgcttccaggagccagcccgc gacatcggctttaacgtggcggtgctgctgaccaacctgtcagagcacgtgccgcacgac ccgcgcctgcgcaacttcctcgagctcgcggagagcatcctcgagtacttccggccctac ctgggccgcatcgagatcatgggggcttcccgccgcatcgagcgtatctacttcgagatc tcggagaccaaccgcgcccagtgggagatgccccaggtgaaggagtcgaagcgtcagttc atcttcgacgtggtgaacgagggcggcgagtcggagaagatggagctcttcgtgagcttc tgcgaggacaccatcttcgagatgcagatcgccgcgcagatctcggagcccgagggcgag ccggaggaggacgaggacgagggcgccggcgcggcggaggcgggcgccgagagcgcggag gaggccgccgcggggcccgagggcgcggcggccacggcggcggcgggcgccacggcgcgg ctggcggcggccgcgaaccgggccatgcggggcctcagctaccgcagcctgcggcggcgc gcgcggcggctgcggcggctcacggcgcgcgaggcggcgaccgcggtggccgcactcctc tgggcggtgctggcgcgcgcgggctcggcgggcgcaggggccgcggcgggcgcgctgcgc ctgctctggggctcgctcttcggcggcggcctggtggagggcgccaagaaggtgacggtg accgagctcctggcgggcatgcccgaccccacgagcgacgaggtgcacggagagcagccg gccgggtccgggggcgacgcggacggcgagggcgcgggcgacggcgcgggcgatgccgcc gagggtgcgggcgacgaggaggtggcggaccaggagggcccgggagtcgccgatgggacg gtggctgtggccgatgggggccccttccgacccgaaggggccggcctcggggacatgggt gacacgacgccggcggagccgcccacgcccgagggctcgcccatcatcaagaggaagctg ggggtggctggagaggaagaagagctgcctccagagccagagccagagccagaacccgag ccggagaaagctgacgctgagaatggggagaaggaagaagtccccgagaccccaccagaa ccccccaagaaggcagctcctcctccaccccctccaaagaaggagggagctggcggtgca ggcctggaattctggggagaactggaagtacagcgggtgaagttcttgaactacctctca aggaatttttacaccctgcgattccttgccctcttcttggcatttgccatcaacttcatc ctgctgttttataaggtctctgactctccacctggggaggatgacatggaggggtcagca gctgggggcctgtcaggagcagggtctggtggcggctccggctggggctcgggggctgga gaggaagcagagggcgacgaggatgagaacatggtgtactacttcctggaggagagcacg ggctacatggagcctgccttgcggtgcttgagccttctgcatacgctggtggcctttctc tgtatcattggctacaactgcctcaaggtgcccctggtgatctttaagcgggagaaggaa ctggcccggaagctggagtttgacggcctctatatcacggagcagcctgaggatgatgac gtgaaaggccagtgggacagactggtgctcaacactccgtctttccccagcaactactgg gacaagtttgtcaagcggaaggtcttggacaagcacggggacatctatgggcgggagcgg atcgccgagctgctgggcatggatctggccacgctggagatcacagcccacaacgagcgc aagcctgaaccaccgccggggctgctcacctggcttatgtccatcgatgtgaagtaccag atctggaagttcggggtcatcttcacagacaattctttcctgtatctgggctggtacatg gtgatgtccctccttggacactacaacaacttcttctttgccgcccacctcctggacatc gccatgggggtcaagacgctgcgcaccatcctctcctctgtcacccacaatgggaagcag ctggtgatgacggtgggcctcctggcggtggtggtctacctgtacaccgtggtggccttc aacttcttccgcaagttctacaacaagagcgaggatgaggacgaacctgacatgaagtgt gacgacatgatgacatgttacctcttccacatgtacgtgggtgtccgagctggtgggggc attggggacgagatagaggacccagcaggcgatgaatacgagctgtaccgagtggtcttc gacatcaccttctttttcttcgtcatcgtcatcctcttggccatcatccagggtctgatc attgacgcttttggcgagctccgagaccaacaagagcaagtgaaggaagatatggagacc aagtgcttcatctgcggtattggcagtgattactttgatacgacaccgcatgggttcgag actcacacactggaggaacacaacctggccaattacatgtttttcctgatgtatctgata aacaaggacgagacagaacacacaggccaggagtcttacgtctggaagatgtaccaagag agatgctgggatttcttcccagctggcgattgtttccgcaagcagtatgaggaccagctt agctga

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