KEGG   Cercocebus atys (sooty mangabey): 105588401
Entry
105588401         CDS       T07242                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
caty  Cercocebus atys (sooty mangabey)
Pathway
caty00562  Inositol phosphate metabolism
caty01100  Metabolic pathways
caty01521  EGFR tyrosine kinase inhibitor resistance
caty04012  ErbB signaling pathway
caty04014  Ras signaling pathway
caty04015  Rap1 signaling pathway
caty04020  Calcium signaling pathway
caty04062  Chemokine signaling pathway
caty04064  NF-kappa B signaling pathway
caty04066  HIF-1 signaling pathway
caty04070  Phosphatidylinositol signaling system
caty04072  Phospholipase D signaling pathway
caty04360  Axon guidance
caty04370  VEGF signaling pathway
caty04613  Neutrophil extracellular trap formation
caty04650  Natural killer cell mediated cytotoxicity
caty04658  Th1 and Th2 cell differentiation
caty04659  Th17 cell differentiation
caty04660  T cell receptor signaling pathway
caty04664  Fc epsilon RI signaling pathway
caty04666  Fc gamma R-mediated phagocytosis
caty04670  Leukocyte transendothelial migration
caty04722  Neurotrophin signaling pathway
caty04750  Inflammatory mediator regulation of TRP channels
caty04919  Thyroid hormone signaling pathway
caty04933  AGE-RAGE signaling pathway in diabetic complications
caty04935  Growth hormone synthesis, secretion and action
caty05012  Parkinson disease
caty05022  Pathways of neurodegeneration - multiple diseases
caty05135  Yersinia infection
caty05167  Kaposi sarcoma-associated herpesvirus infection
caty05170  Human immunodeficiency virus 1 infection
caty05171  Coronavirus disease - COVID-19
caty05200  Pathways in cancer
caty05205  Proteoglycans in cancer
caty05206  MicroRNAs in cancer
caty05214  Glioma
caty05223  Non-small cell lung cancer
caty05225  Hepatocellular carcinoma
caty05231  Choline metabolism in cancer
caty05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
caty05417  Lipid and atherosclerosis
Module
caty_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:caty00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105588401 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105588401 (PLCG1)
   04014 Ras signaling pathway
    105588401 (PLCG1)
   04015 Rap1 signaling pathway
    105588401 (PLCG1)
   04370 VEGF signaling pathway
    105588401 (PLCG1)
   04064 NF-kappa B signaling pathway
    105588401 (PLCG1)
   04066 HIF-1 signaling pathway
    105588401 (PLCG1)
   04020 Calcium signaling pathway
    105588401 (PLCG1)
   04070 Phosphatidylinositol signaling system
    105588401 (PLCG1)
   04072 Phospholipase D signaling pathway
    105588401 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    105588401 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    105588401 (PLCG1)
   04660 T cell receptor signaling pathway
    105588401 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    105588401 (PLCG1)
   04659 Th17 cell differentiation
    105588401 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    105588401 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    105588401 (PLCG1)
   04670 Leukocyte transendothelial migration
    105588401 (PLCG1)
   04062 Chemokine signaling pathway
    105588401 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    105588401 (PLCG1)
   04919 Thyroid hormone signaling pathway
    105588401 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    105588401 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105588401 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    105588401 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105588401 (PLCG1)
   05206 MicroRNAs in cancer
    105588401 (PLCG1)
   05205 Proteoglycans in cancer
    105588401 (PLCG1)
   05231 Choline metabolism in cancer
    105588401 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105588401 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    105588401 (PLCG1)
   05214 Glioma
    105588401 (PLCG1)
   05223 Non-small cell lung cancer
    105588401 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    105588401 (PLCG1)
   05171 Coronavirus disease - COVID-19
    105588401 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105588401 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105588401 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    105588401 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    105588401 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105588401 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105588401 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105588401 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:caty04131]
    105588401 (PLCG1)
Enzymes [BR:caty01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105588401 (PLCG1)
Membrane trafficking [BR:caty04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105588401 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105588401 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 105588401
NCBI-ProteinID: XP_011921034
Ensembl: ENSCATG00000034738
UniProt: A0A2K5MB06
LinkDB
Position
Unknown
AA seq 1291 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLQTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAISVEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcatccccctgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgacccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccggggcgccgacaagatagagggggccattgatattcgagaaatcaaggag
attcgcccagggaagacctcacgagactttgatcgctatcaagaggaccccgctttccgg
ccggaccagtcacactgctttgtcattctctatggaatggaattccgtctgaagactctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacattgcaggcacccacacccctgcagattgagaggtggctccggaagcag
ttttactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctaaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcagcggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtactctgagggct
ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttccttcttgac
taccagggggagctgtgggctgttgatcgcctccaggtgcaggagttcatgcttagcttc
ctccgagaccccttgcgagagatcgaggagccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaatagtgtgtggaactcacagctggatgcagtatgcccggac
accatgaacaaccccctttcccactattggatctcctcttcacacaacacgtacctgacc
ggggaccagttctctagtgagtcctccttggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccagatgggatgccagttatttaccat
gggcacacccttaccaccaagatcaagttctcagatgtcctgcaaaccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagcacttcaagaaggtgctaggggacacactcctcaccaag
cccgtggagatctccgccgatgggctcccctcacccaaccagcttaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcctacatccatgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccacgaatggtatccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcagc
agcacagagctgcactccaatgagaagtggttccatgggaagctaggggcagggcgtgac
gggcggcacatcgctgagcgcctgctcactgagtactgcatcgagaccggggcccctgac
ggctccttcctcgtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg
cggaacgggaaagtccagcactgccgtatccactcacggcaagatgctgggacccccaag
ttcttcttgacagacaacctcgtctttgactccctctatgacctcatcacacactaccag
caggtgcccctgcgctgcaatgagtttgagatgcgactttcagagcctgtcccacagacc
aatgcccatgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac
atgctgatgcgtgtccctcgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcatatgccatctctttccgggctgaaggcaagatcaagcattgccgtgtccagcaagag
ggccagactgtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac
tatgagaagcacccgctataccgcaagatgaagctgcgctatccaatcaatgaggaggcg
ctggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct
ggcttctatgtagaggcaaaccctatgccaactttcaagtgtgcagtcaaagccctcttt
gactacaaggcccagagggaggatgagctgaccttcaccaagagcgccatcatccagaat
gtggagaagcaagagggaggctggtggcgaggggactatggagggaagaagcagctgtgg
ttcccatcaaactacgtggaagagatggtcaaccccgtggccctggagccagagagggag
cacttggacgagaacagccccctaggggacttgctgcggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcgtcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaaggg
aagataatggaacggaggaagaagatcgccctggagctctctgaacttgttgtctactgc
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg
tcatccttcccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
cttcagtacaatcgactgcagctctcccgcatctaccccaagggccagcgactggattcc
tccaactacgatcctttgcccatgtggatctgtggcagtcagctggtggccctcaacttc
cagacccctgacaagcctatgcagatgaaccaggctctcttcatgacgggcaggcactgt
ggctacgtgctgcagccaagcaccatgcgggatgaggccttcgacccctttgacaagagc
agcctccgcgggctggagccatgtgccatctctgttgaggtgctgggtgcccgacatttg
ccaaagaatggccgaggcattgtgtgcccttttgtggagattgaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtggtggacaacggactcaaccctgtatgg
ccggccaagcccttccacttccagatcagtaaccctgaatttgcctttctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaatttcctggctcaggctactttcccggta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaggaccta
gagttggcctccctgctgatcaagattgacattttccctgccaagcaggagaatggtgac
ctcagtcccttcagtggtacgtccctgcgggagcggggctcagatgcctcaggccagctg
tttcacggccgagcccgggaaggctcctttgaatcccgctaccagcagccatttgaggac
ttccgcatatcccaggagcatcttgcagaccattttgacagtcgagaacgaagggcccca
agaaggactcgggtcaatggagacaaccgcctctag

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