Cercocebus atys (sooty mangabey): 105594519 Help Entry 105594519         CDS       T07242                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism caty  Cercocebus atys (sooty mangabey) Pathway caty04020   Calcium signaling pathway caty04371   Apelin signaling pathway caty04713   Circadian entrainment caty04730   Long-term depression caty04921   Oxytocin signaling pathway caty05017   Spinocerebellar ataxia caty05020   Prion disease caty05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:caty00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105594519 (RYR1)    04020 Calcium signaling pathway     105594519 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     105594519 (RYR1)   09156 Nervous system    04730 Long-term depression     105594519 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     105594519 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     105594519 (RYR1)    05020 Prion disease     105594519 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     105594519 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:caty01009]     105594519 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:caty04147]     105594519 (RYR1)    04040 Ion channels [BR:caty04040]     105594519 (RYR1) Protein phosphatases and associated proteins [BR:caty01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      105594519 (RYR1) Exosome [BR:caty04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    105594519 (RYR1) Ion channels [BR:caty04040]  Voltage-gated cation channels   Ryanodine receptor    105594519 (RYR1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  105594519 NCBI-ProteinID:  XP_011934098 Ensembl:  ENSCATG00000040511 UniProt:  A0A2K5NDB8 LinkDB All DBs Position Unknown AA seq 5036 aa AA seqDB search MADAEGEDDVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL TTSRSMTDKLAFDVGLQEDAIGEACWWTTHPASKQRSEGEKVRVGDDIILVSVSSERYLH LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGRYLALSEDQGLVV VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE GMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK WYFEVMVDEVTPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHL WTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRWDRVRIFRAEKSY AVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPLEHPHYEVARVD GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED EARAAEPDPDYENLRRSAGGWGEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA GQEPSCVWVGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNIHSSLKCSNCYMVWGGDFV SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG ERLGWAVQCREPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE TRAITLFPPGRSTENGHSRHGLPGVGVSTSLRPPHHFSAPCFVAALPAAGAAEAPARLSP AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK QILKMIEPEVFTEEEEEEEEEEEEEEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE EGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGL LMKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLL AHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERPAEESKPRSLQELVS HMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECL GQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGG ESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAA SVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFA VFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIR RDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQACKGEALRIRAILR SLVPLEDLVGIISLPLQMPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFL LHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIM VDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAK MPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRM AMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKF AEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIA WEWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQL AENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVT RGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFF AKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFG TDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQA RTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTT KNIYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEE MCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPA GAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHF IPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDN NRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKM AKAGDTQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKT RYALKDTDEEVREFLNNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQE VSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYK AAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDE DYLYMAYADIMAKSCHLEEGGENGEGEEEVEVSFEEKEMEKQRLLYQQARLHTRGAAEMV LQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTC SVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDF QNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAK QVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDL QKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQD YVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDI GFNVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISE TNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPE TDEDEGAAEAGVEGAEESAAGPEGTAATAAAGATARVAAAMGRALRGLSYRSLRRRVRRL RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVDEAGAGGADGAVAV TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPELEPE KADAENGEKEEVPEPPPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYT LRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGGSGWGLGAGEEAEG DEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKL EFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELL GMDLATLEITAHNERKPDPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLL GHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRK FYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFF FFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLE EHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15111 nt NT seq  +upstreamnt  +downstreamnt atggctgacgcagaaggcgaggacgacgtccagttcctgcggacggatgatgaggtggtc ctgcagtgcagcgccaccgtgctcaaggagcagctcaagctctgcctggccgccgagggt ttcggtaaccgcctgtgcttcctggagcccaccagcaacgcccagaatgtgccccctgat ctggccatctgttgcttcgtcctggagcagtccctgtccgtgcgagccctgcaggagatg ctggccaacacggtggaggccggcgtggagtcatcccagggcgggggacacaggacgctc ctgtacggccatgccatcttactccggcacgcacacagccgcatgtatctgagctgcctc accacctcccgctccatgactgacaagctggccttcgatgtgggactgcaggaggatgca ataggagaggcttgctggtggaccacgcacccagcctccaagcagaggtctgaaggagaa aaggtccgtgttggggatgacatcatccttgtcagtgtctcttctgaacgctacctgcac ctgtcgactgccagcggggagctccaggttgacgcttccttcatgcagacgctgtggaac atgaaccccatctgctcccgctgcgaagagggcttcgtgacaggaggtcacgtcctccgc ctctttcatggacatatggatgagtgtctgaccatttcccctgctgacagtgacgaccag cgcagacttgtctactatgaggggggagctgtgtgcacccacgcccgctccctctggagg ctggagcccctgagaatcagctggagtgggagccacctacgctggggccagccactccga gtccggcatgtcaccaccgggcggtacctggcactctccgaggaccagggcctggtggtg gttgatgccagcaaggcccataccaaggctacgtccttctgcttccgcatctccaaggag aagctggatgtggcccccaagcgggatgtggaaggcatgggcccccctgagatcaagtac ggggagtcactgtgctttgtgcagcatgtggcctcaggactgtggctcacctatgccgct ccagaccccaaggccctgaggctcggcgtgctcaagaagaaggccatgctgcaccaggaa ggccacatggacgacgcactgtcactgacccgctgccagcaggaggagtcccaggctgcc cgcatgatccacagcaccaatggcctgtacaaccagttcatcaagagcctggacagcttc agcgggaagccacggggctcggggccgccggctggcacggcgctgcccatcgagggcgtt atcctgagcctgcaggacctcatcatctacttcgagccgccctccgaggacttgcagcat gaggagaagcagagcaagctgcgaagcctgcgcaaccgccagagtctcttccaggaggag gggatgctctccctggtcctgaattgcattgaccgcctaaatgtctacaccaccgctgcc cactttgccgagtttgcaggggaggaggcagccgagtcctggaaagagattgtgaatctt ctttatgaactcctggcttctctgatccgtggcaatcgtagcaactgtgccctcttctcc acaaacttggactggctggtcagcaagctggatcggctggaggcctcatctggcatcctg gaggtcctgtactgtgtcctcattgagagtccagaggttctgaacatcatccaggagaat cacatcaagtccatcatctccctcctggacaagcatgggaggaaccacaaggtcctggac gtgctgtgctccctgtgtgtgtgtaatggtgtggctgtacgctccaaccaagatcttatt actgagaacttgctgcctggccgtgagcttctgctgcagacaaacctcatcaactatgtc accagcatccggcccaacatcttcgtgggccgagcggagggcaccacgcagtacagcaaa tggtactttgaggtgatggtggacgaggtgactccatttctgacagctcaggccacccac ttgcgggtgggctgggccctcaccgagggctacagcccctaccctgggggcggcgagggc tggggcggcaacggggtcggcgatgacctctattcctacggctttgatggactgcatctc tggacaggacacgtggcacgcccagtgacttccccagggcagcacctcctggcccctgaa gacgtagtcagctgctgtctggacctcagcgtgccgtccatctccttccgcatcaatggc tgccctgtgcagggcgtctttgagtccttcaacctggacgggcttttcttccctgttgtc agcttctcggctggtgtcaaggtgcggttcctccttggtggccgccatggcgaattcaag ttcctgcccccacctggctatgccccatgccatgaggctgtgctccctcgagagcgactc catcttgaacccatcaaggagtatcgacgggaggggccccgggggcctcacctggtgggc cccagtcgctgcctctcacacactgactttgtgccctgccctgtggacaccgttcagatc gtcctgccaccccatctggagcgcattcgggagaagctggcggagaacatccacgagctc tgggcactgacccgcattgagcaaggctggacctacggcccggttcgggatgacaacaag aggctgcacccgtgtcttgtggacttccacagccttccagagcccgagaggaactacaac ctgcagatgtcgggggagacgctcaagactctgctggctctgggctgccacgtgggtatg gcggatgagaaggcggaggacaacctgaagaagacaaaactccccaagacgtatatgatg agcaatgggtacaagccggctccgctggacctgagccacgtgcggctgacgccggcgcag acgacactggtggaccgtctggcagaaaatgggcacaacgtgtgggcccgagaccgtgtg ggccagggctggagctacagtgcggtgcaggacatccctgcgcgccgaaacccacggctc gtgccctaccgcctcctggacgaggccaccaagcgcagcaaccgggacagcctctgccag gccgtgcgcaccctcctaggttacggctacaacatcgagcctcctgaccaggagcccagt caggtggagaaccagtctcgttgggaccgggtgcgcatcttccgggcagagaaatcctat gcagtgcagagcggccgctggtacttcgagtttgaagcagtcaccacaggcgagatgcga gtgggctgggcgaggcccgagctgaggcctgatgtagagctgggagctgatgagctggcc tatgtcttcaatgggcaccgcggccagcgctggcacttgggtagtgaaccatttgggcgc ccctggcagccgggcgatgtcgttggctgtatgatcgacctcacagagaacaccattatc ttcaccctcaatggcgaggtcctcatgtctgactcgggctccgaaacagccttccgggag attgagattggggacggcttcctgcccgtctgcagcttgggacctggccaggtgggtcac ctgaacctgggccaggacgtgagctccctgcggttctttgccatctgtggcctccaggaa ggcttcgagccatttgccatcaacatgcagcgcccagtcaccacctggttcagcaaaagc ctgccccagtttgagccagtgccccttgaacaccctcactatgaggtagcccgagtggac ggcactgtggacacgcccccgtgtctgcgtctgactcaccgcacctggggctcccagaac agcctggtggagatgctcttcctgcgactgagcctcccagtccagttccaccagcacttc cgctgcaccgcaggggccaccccgctggcaccccccggcctgcagccccccgccgaggac gaggcccgggcggcggaacccgaccctgactacgaaaacctgcgccgctcagctgggggc tggggcgaggccgagaacggcaaagaagggactgcgaaggagggcgcccccgggggcacc ccgcaggcggggggagaggcacagcccgccagggctgagaatgagaaggacgccaccacc gagaagaacaagaagagaggcttcttattcaaggccaagaaggtcgccatgatgacccaa ccaccggccacccccacgctgcctcggctccctcacgatgtggtgcctgcagacaaccgc gatgaccctgagatcatcctcaacaccaccacgtactattactccgtgagggtctttgcc ggacaggagcccagctgcgtgtgggtgggctgggtcactcctgactaccatcagcacgac atgagcttcgacctcagcaaggtccgggttgtgacagtgaccatgggggatgaacaaggc aacatccacagcagcctcaagtgcagcaattgctacatggtgtggggtggggactttgtg agtcccgggcagcagggccggatcagccacacggatcttgtcattgggtgcctggtggac ttggccactggcttaatgacctttacagccaatggcaaagagagcaacacctttttccag gtggaacccaacacaaagctatttcctgctgtcttcgtcctgcccacccaccagaacgtc atccagtttgagctggggaagcagaagaacatcatgccgttgtcagctgccatgttccag agcgagcgcaagaacccggccccgcagtgcccgccgcggctggagatgcagatgctgatg ccagtgtcctggagccgcatgcccaaccacttcctgcaggtggagacgaggcgcgccggc gagcggctgggctgggccgtgcagtgccgggagccgctgaccatgatggcgctgcacatc cccgaggagaaccgatgcatggacatcctggagctgtcggagcgcctggacctgcagcgc ttccactcgcacaccctgcgcctctaccgcgctgtgtgcgccctgggcaacaatcgcgtg gcgcacgctctgtgcagccacgtggaccaggctcagctgctgcacgccctggaggacgcg cacctgccaggtccactgcgtgcaggctactacgacctcctcatcagcatccatctcgaa agtgcctgtcgcagccgccgctccatgctctctgaatacatcgtgcccctcacgcctgag acccgcgccatcacgctcttccctcctggaaggagcacagaaaatggtcactcccggcac ggcctgccgggagttggagtcagcacttcgctgcggcccccgcatcatttctcggccccc tgtttcgtggcggctctgccagctgctggggcagcagaggctccggcccgcctcagcccc gccatcccgttggaggccctacgggacaaggcactgaggatgctgggggaggcggtgcgc gacggtgggcagcacgctcgcgaccccgtcgggggctccgtggagttccagtttgtgcct gtgctcaagcttgtgtccaccctgctggtgatgggcatctttggcgatgaggatgtgaaa cagatcttgaagatgattgagcctgaagtcttcactgaggaagaagaggaggaggaggag gaggaagaagaggaggaagaggaagatgaggaggagaaggaggaggatgaggaggaaaca gcacaggaaaaggaagatgaagaaaaagaggaagaggaggcagcagaaggagagaaggaa gaaggcttggaggaggggctgctccagatgaagttgccagagtctgtgaagttacagatg tgccacctgctggaatatttctgtgaccaagagttgcagcaccgtgtggagtccctggca gcctttgcggagcgctatgtggacaagctccaggccaaccagcggagccgctatggcctc ctcatgaaagccttcagcatgaccgcagcggagactgcaagacgtacccgcgagttccgc tccccaccccaggagcagatcaatatgctattgcaattcaaagatggtacagatgaggaa gactgtcctctccctgaagagatacgacaggatttgcttgactttcatcaagacctgctg gcacactgtggaattcagctggatggagaggaggaggaaccggaggaagagaccaccctg ggcagccgcctcatgagccttttggagaaagtgcggctggtgaagaagaaggaggagaaa cctgaggaggagcggccagcagaggagagcaaaccccggtccctgcaggaactggtgtcc catatggtggtgcgctgggcccaagaggacttcgtgcagagccccgagctggtgcgggcc atgttcagcctcctgcaccggcagtacgacgggctgggtgagctgctgcgtgccctgcca cgggcgtacaccatctcaccgtcctcggtggaagacaccatgagcctgcttgagtgcctc ggccagatccgctccctgctcatcgtgcagatgggccctcaggaggagaacctcatgatc cagagcatcgggaacatcatgaacaacaaagtcttctaccaacacccgaacctgatgagg gcgctgggcatgcacgagacggtcatggaggtcatggtcaacgtcctcgggggcggcggc gagtccaaggagatccgcttccccaagatggtgacaagctgctgccgcttcctctgctat ttctgccgcatcagccggcagaaccagcgctccatgtttgaccacctgagctacctgctg gagaacagcggcatcggcctgggcatgcagggctccacgcccctggacgtggctgctgcc tctgtcattgacaacaatgagctggccttggcgttgcaggagcaggacctggaaaaggtc gtgtcctacctggcaggctgtggcctccaaagctgccccatgcttgtggccaagggatac ccagatattggctggaacccctgcggtggagagcgctacctggacttcctgcgcttcgct gtcttcgtaaacggcgagagcgtggaggagaacgccaacgtggtggtgcggctgctcatc cggaagcctgagtgcttcggacccgccctgcggggtgagggtggctcagggctgctggct gccatcgaagaggccatccgcatctccgaggaccctgcgagggatggcccaggcatccgc agggaccggcggcgcgagcacttcggtgaggaaccacctgaagaaaaccgggtgcacctg ggacacgccatcatgtccttctatgctgccttgatcgacctgcttggacgctgtgcgcca gagatgcatctaatccaagcctgcaagggtgaggccctgcgcatccgtgccatcctccgc tcccttgtgcccttggaggacctcgtgggcatcatcagcctcccactgcagatgcccacc ctgggcaaagacggggctctggtgcagccaaagatgtcagcatccttcgtgccggaccac aaggcgtccatggtgctcttcctggaccgtgtgtacggcattgagaaccaggacttcttg ctgcacgtgctggacgtgggattcctgcccgacatgagggcagccgcctcgctggacacg gccactttcagcaccaccgagatggcactggcgctgaaccgctacctgtgcctggccgtg ctgcctctcatcaccaagtgtgcgccgctctttgcgggcacggaacaccgcgccatcatg gtggactccatgctgcacacggtgtaccgcctgtcccggggtcgctcgctcaccaaggcg cagcgcgacgtcatcgaggactgcctcatggctctctgcaggtacatccgcccgtcgatg ctgcagcacctgctgcggcgtctggtgttcgacgtgcccatcttaaacgagtttgccaag atgccactcaagctcctcaccaaccactatgagcgttgttggaagtactactgcctaccc acaggctgggccaacttcggggtcacctcggaggaggagctgcacctcacgcggaaactc ttctggggcatctttgactccctggcccataagaaatacgacccggagctttaccgaatg gccatgccttgtctgtgtgccattgctggggctctgccccccgactacgtggacgcctca tactcatctaaggcggagaaaaaggccacagtggatgctgaaggcaactttgatccccgg cctgtggaaaccctcaatgtgatcatcccggagaagctggactccttcattaacaagttt gcggagtatacacatgagaagtgggccttcgacaagatccagaacaactggtcctatgga gagaacatagatgaggagttgaagacccaccccatgctgaggccctacaagaccttttca gagaaggacaaggagatttaccgctggcccatcaaggagtccctgaaggccatgattgcc tgggaatggaccatagagaaggccagggagggtgaggaggagaagacggaaaagaaaaaa acgcggaagatatcacaaagtgcccagacctacgatcctcgagaaggctacaacccccag ccccccgaccttagcgcagttaccctgtcccgggagctgcaggccatggcagaacaactg gcggaaaattaccacaacacgtggggaaggaagaagaagcaggagctggaagccaaaggc ggtgggacccaccccctgctggtcccctacgacacgctaacagccaaggagaaggcacga gatcgagagaaggcccaggagctgctgaaattcctgcagatgaatggctacgcggttaca agaggccttaaggacatggaactggactcatcttccattgaaaagcggtttgcctttggc ttcctgcagcagctgctgcgctggatggacatttctcaggagttcattgcccacctggag gctgtggtcagcagtgggcgagtggaaaagtccccacatgaacaggagattaaattcttt gccaagatcctgctccctttgatcaaccagtacttcaccaaccactgcctctatttcttg tccactcctgctaaagtgctgggcagtggtggccacgcctccaacaaggagaaggaaatg atcaccagcctcttctgcaaacttgctgctcttgtccgccaccgagtctctctctttggg acggatgccccggctgtggttaactgtcttcacatcctggcccgctccctggatgccagg acggtgatgaagtcaggccctgagatcgtgaaggctggcctccgctccttcttcgagagt gcctcggaggacattgagaagatggtggagaacctgcggctgggcaaggtgtcacaggcg cgcacccaggtgaagggcgtgggccagaacctcacctacaccaccgtggcgctgctgccg gtcctcaccaccctcttccagcacatcgcccagcaccagttcggagatgacgtcatcctg gacgacgtccaggtctcttgctaccgaacgctgtgcagtatctactccctgggaaccacc aagaacatttacgtggaaaagcttcggccagcccttggggagtgcctggcccgtctggca gcagccatgccggtggcattcctggagccccagctgaacgagtacaacgcctgctccgtg tacaccaccaagtctccccgagagcgggccatcctggggctccccaacagtgtggaggag atgtgtcctgacatcccggtgctggagcggctcatggcagacatcggggggctggccgag tcaggggcccgctacacagagatgccgcacgtcattgagatcacgctgcccatgctatgc agctacctgccccgatggtgggagcgcgggcccgaggcaccccctcctgccctgcccgcc ggcgcccccccaccctgcacagctgtcacctctgaccacctcaactccctgctggggaat atcctgagaatcatcgtcaacaacctgggcattgacgaggcctcctggatgaagcggctg gctgtgttcgcacagcccatcgtgagccgtgcgcggccggagctcctgcagtcccacttc atccccaccatcgggcggctgcgcaagagggcggggaaggtggtgtccgaggaggagcag ctgcggctggaggccaaggccgaggcccaggagggcgagctgctggtgcgagacgagttc tccgtgctctgccgggacctgtacgccctgtatccgctgctcatccgctatgtggacaac aacagggcgcagtggctgacagagccgaatcccagtgcggaggagctgttcaggatggtg ggcgagatcttcatctactggtccaagtcccacaacttcaagcgcgaggagcagaacttc gtggtccagaacgagatcaacaacatgtccttcctgactgcggacaacaagagcaaaatg gctaaggcgggagatacacagtccggtggctcggaccaggaacgcaccaagaagaagcgc cgcggggaccggtactccgtgcagacgtcgctgatcgtggccacgctgaagaagatgctg cccatcggcctgaacatgtgcgcgcccaccgaccaggacctcatcacgctggccaagacc cgctatgccctgaaagacacagatgaggaggtccgggaatttctgaacaacaaccttcac cttcagggaaaggtcgaaggctccccgtctctgcgctggcagatggccctgtaccggggc gtcccaggtcgtgaggaggacgccgacgaccccgagaaaatcgtgcgcagagtccaggaa gtgtcagccgtgctctactacctggaccagaccgagcacccttacaagtctaagaaggcc gtgtggcacaagcttttgtccaagcagcgccggcgggcagtcgtggcctgtttccgtatg acgcccctgtacaacctgcccacgcaccgggcatgtaacatgttcctggagagctacaag gctgcatggatcctgaccgaagaccacagttttgaggaccgcatgatagatgacctttca aaagctggggagcaggaggaggaagaggaagaggtggaagaaaagaagccagaccccctg caccagttggtcctacacttcagccgcactgccctgacggaaaagagcaaactggacgag gattacctgtacatggcctatgctgatatcatggcaaagagctgccacctggaggaggga ggggagaacggcgaaggtgaagaggaggttgaggtctcctttgaggagaaagagatggag aagcagcggcttctataccagcaagcacggctgcacacccggggggcagccgagatggtg ctgcagatgatcagtgcctgcaaaggagagacaggtgccatggtgtcctccaccctgaag ctgggcatctctatcctcaatggaggcaatgctgaggtccagcagaaaatgctggattat cttaaggacaagaaggaagttggcttcttccagagtatccaggcactgatgcaaacatgc agcgtactggatctcaatgcctttgagagacagaacaaggccgaggggctgggcatggtg aacgaggatggcactgtcatcaatcgccagaacggagagaaggtcatggcggatgatgaa ttcacacaagacctgtttcgattcctacaattgctctgtgaggggcacaataatgatttc cagaactacctacggacacagacagggaacacgaccactattaacatcatcatctgcacg gtggactacctcctgcggctgcaggaatccatcagcgacttctactggtactactcaggc aaggatgtcattgaagagcagggcaagaggaacttctccaaagccatgtcggtggctaag caggtgttcaacagcctcactgagtacatccagggcccctgcaccgggaaccagcagagc ctggcgcacagccgcctttgggacgcagtggtgggattcctgcacgtgttcgcccacatg atgatgaagctcgctcaggactcaagccagatcgagctgctgaaggagctgctggatctg cagaaggacatggtggtgatgttgctgtcgctactagaagggaacgtggtaaacggcacg atcgcccggcagatggtggacatgctagtggaatcctcgtccaatgtggagatgatcctc aagttcttcgacatgttcctgaaactcaaggacattgtgggctctgaagccttccaggac tacgtaacggatccccgtggcctcatctccaagaaggacttccagaaggccatggacagc cagaagcagttcagcggtccagaaatccagttcctgctttcgtgctccgaagcggatgag aacgagatgatcaactgcgaggagttcgccaaccgcttccaggagccagctcgcgacatc ggcttcaacgtggcggtgctgctgaccaacctgtcggagcatgtgccgcatgacccgcgc ctgcacaacttcctggagctggccgagagcatcctcgagtacttccgcccctacctgggc cgcatcgagatcatgggcgcctcgcgccgcatcgagcgcatctacttcgagatctcggag accaaccgcgcccagtgggagatgccccaggtgaaggagtccaagcgccagttcatcttc gacgtggtgaacgagggcggcgaggccgagaagatggagctcttcgtgagtttctgcgag gacaccatcttcgagatgcagattgccgcgcagatctcggagcccgagggcgagccggag accgacgaggacgagggcgcggcggaggcgggcgtggagggcgcggaggagagcgcggcg ggccccgagggcacggcggccacggcggcggcaggggcgacagcgcgggtggcggcggcc atgggccgggccctgcgcggcctcagctaccgcagcctgcggcggcgcgtgcggcggctg cggcggctcacggcccgcgaggcggccaccgcggtggcggcgctgctctgggcagccgtg acgcgcgcgggggccgctggcgcgggggcggcggcgggcgcgctgggcctgctctggggc tcgctgttcggcggcggcctggtggagggcgccaagaaggtgacggtgaccgagctcctg gcgggcatgcccgaccccaccagcgacgaggtgcacggcgagcagccggccgggcccggc ggagacgcagacggcgaaggtgccagcgaaggcgcaggggacgccgcggagggcgctgga gacgaggaggaggcggtggacgaggccggggcgggcggcgccgacggggcggtggccgtg acggatgggggccccttccggcccgaaggggctggcggtctcggggacatgggggacacg acgcctgcggaaccgcccacgcccgagggctctcccattctcaagaggaagctgggggtg gatggagtggaggaggagctcccgccagagccggagccggaaccagaactggagccggag aaagcagatgccgagaatggggagaaagaagaagttcccgaacccccaccagagcccccc aagaagcaagcacctccctcaccccctccaaagaaggaagaagctgggggtgaattctgg ggagaactggaggtgcagagggtgaagttcctgaactacctgtcccggaacttttacacc ctgaggttccttgccctcttcttggcatttgccatcaacttcatcttgctgttttataag gtctcagactctccaccaggggaagacgacatggaaggctcagctgctggggacgtgtca ggtgcaggctctggtggcggctctggctggggcttgggggccggagaggaggcagagggc gatgaggatgagaacatggtgtactacttcctggaggagagcacaggctacatggagcct gccctgcggtgtctgagcctcctgcatacactggtggcctttctctgcatcattggctat aactgtctcaaggtgcccctggtaatctttaagcgggagaaggagctggcccggaagctg gagtttgacggcctatacatcacagagcagcccgaggacgatgacgtgaaggggcagtgg gaccgactggtgctcaacacaccgtctttccccagcaactactgggacaagtttgtcaag cgcaaggtcctggacaaacatggggacatctacgggcgggagcggattgctgagctactg ggcatggacctggccacgctagagatcactgcccacaatgagcgcaagcccgacccgcca ccagggctgctgacctggctcatgtccatcgatgtcaagtaccagatctggaagttcggg gtcatcttcacagacaactccttcctgtacctgggctggtatatggtgatgtccctcttg gggcactacaacaacttcttcttcgctgcccatctcctggacatcgccatgggggtcaag acgctgcgcaccatcctctcctccgtcacccacaatgggaaacagctggtgatgaccgtg ggccttctggcggtggtcgtctacctgtacaccgtagtggccttcaacttcttccgcaag ttctacaacaagagcgaggatgaggatgagcctgacatgaaatgtgacgacatgatgacg tgttacctgtttcacatgtacgtgggtgtccgggctggcggaggcattggggacgagatc gaggaccccgcgggtgacgaatacgagctctacagggtggtcttcgacatcaccttcttc ttctttgtcatcgtcatcctgttggccatcatccagggtctgatcatcgacgcttttggt gagctccgagaccaacaagagcaagtgaaggaggatatggagaccaagtgcttcatctgt ggaatcggcagcgactactttgatacgacaccgcatggcttcgagactcacacgctggag gagcacaacctggccaattacatgtttttcctgatgtatttgataaacaaggatgagaca gaacacacaggtcaggagtcttatgtctggaagatgtaccaagagagatgttgggatttc ttcccggctggcgattgtttccgcaagcagtatgaggaccagcttagctga

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