Cervus canadensis (wapiti): 122426865 Help Entry 122426865         CDS       T07554                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism ccad  Cervus canadensis (wapiti) Pathway ccad04022   cGMP-PKG signaling pathway ccad04068   FoxO signaling pathway ccad04081   Hormone signaling ccad04140   Autophagy - animal ccad04150   mTOR signaling pathway ccad04151   PI3K-Akt signaling pathway ccad04152   AMPK signaling pathway ccad04211   Longevity regulating pathway ccad04213   Longevity regulating pathway - multiple species ccad04722   Neurotrophin signaling pathway ccad04910   Insulin signaling pathway ccad04920   Adipocytokine signaling pathway ccad04923   Regulation of lipolysis in adipocytes ccad04930   Type II diabetes mellitus ccad04931   Insulin resistance ccad04932   Non-alcoholic fatty liver disease ccad04935   Growth hormone synthesis, secretion and action ccad04960   Aldosterone-regulated sodium reabsorption ccad05010   Alzheimer disease ccad05206   MicroRNAs in cancer ccad05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ccad00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     122426865 (IRS1)    04022 cGMP-PKG signaling pathway     122426865 (IRS1)    04151 PI3K-Akt signaling pathway     122426865 (IRS1)    04152 AMPK signaling pathway     122426865 (IRS1)    04150 mTOR signaling pathway     122426865 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     122426865 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     122426865 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     122426865 (IRS1)    04923 Regulation of lipolysis in adipocytes     122426865 (IRS1)    04920 Adipocytokine signaling pathway     122426865 (IRS1)    04935 Growth hormone synthesis, secretion and action     122426865 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     122426865 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     122426865 (IRS1)   09149 Aging    04211 Longevity regulating pathway     122426865 (IRS1)    04213 Longevity regulating pathway - multiple species     122426865 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     122426865 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     122426865 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     122426865 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     122426865 (IRS1)    04932 Non-alcoholic fatty liver disease     122426865 (IRS1)    04931 Insulin resistance     122426865 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  122426865 NCBI-ProteinID:  XP_043302030 LinkDB All DBs Position 24:20207874..20271566 Genome browser AA seq 1236 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN GHYILPRGGNGHRYVPAAGLGTSPALPGEEGAGVADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPTYPPGGGSGGRVPSYRHSAFVPTHSYPEEGLEMHPLERRGGHHR PDTSSLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPSSGGSSSGAAPSGSSYGKLWANGVGGHHSHALPHPKLPVES GSGKLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEL EEPRHHQHLRLSSSSGRLLYTAAAEDSSSSTSSDSLGGGYCGARPEPGLPHLHHQVLQAH LPRKVDTAAQTNNRLARPTRLSLGDPKASTLPRAREQQPPPPLLLPPEPKSPGEYVNIEF GSDQPGYLSGPVASHSSPSIRCPSQLQPAPREEETGTEEYMNMDLGPGRRATWQESVGVQ PGRVGPAPPGAASVCRPTRAVPSSRGDYMTMQMGGPRQNYVDTSPVAPISYADMRTGVVV EEASLPRATAAAPSSSSTASVSSTAPPGTGELAARSALLGGPSAFTRVNLSPNRNQSAKV IRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGSAGGSSSSAEDVKRHSSASF ENVWLRPGELGGVPKELAQVCGATGGLENGLNYIDLDLVKDFKQRPQECPPQPQPPPLPA PHQPLGSSQSGPTSRSSEDLSAYASITFQKQPEDLQ NT seq 3711 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagacggacggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaagcgattcttcgtgctgcgggcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggcggactccaagaac aagcacctggtggccctctacacccgggacgagcactttgccatcgcggcagacagcgag gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac cacgacggggccgcggcgcctggggccggaggcggcgggggcagctgcagtggcagctct ggcctcggagaggccggggaggacttgagctacggggatgtgcccccagggcccgccttc aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcggcggccgtggtgctgcagctgatgaacatcaggcgctgcggccactcagagaacttc ttcttcatcgaagtgggccgttccgcagtgacgggccccggggagttctggatgcaggtg gacgactccgtggtggcccagaacatgcacgagacaatcttggaggccatgcgggccatg agcgatgagttccgccctcgaagcaagagtcagtcttcctccaactgctccaaccccatc agtgtgccgctgcggaggcatcacctcaacaaccctccacccagccaggtggggctgacc cgccgctcgcgcaccgagagcatcacggccacctccccggccagcttggtgggcgggaag cagggctccttccgcgtacgtgcctccagtgatggcgaaggcaccatgtctcggcccgcc tctgtggacggcagtcctgtgagtcctagcaccaacaggacccacgcccaccgccatcga ggcagctcccggctgcacccgcctctcaaccacagccgctccatccccatgccttcttct cgctgctcgccttccgccaccagcccggtcagcctgtcctccagcagcactagtggccac ggctccacctcagactgcctcttcccgcggcggtctagtgcttctgtgtctggctccccc agtgatggcggcttcatctcctccgatgagtatggctccagtccctgcgatttccgaagt tctttccgcagcgtcaccccagattccctgggccacaccccgcctgcccggggtgaggag gagctaagcaactacatctgcatgggaggcaagggggcctccaccctcactgcccccaat ggtcactacattttgcctcggggtggcaatggtcaccgctacgtgccagctgccggcttg ggcacaagcccagccctgccaggagaagaaggagccggtgtggcagatctggataatcgg ttccgaaagcggactcactctgcaggcacctcgcctaccatttcccaccagaaaaccccg tctcagtcctctgtggcttccattgaggaatataccgaaatgatgcccacctacccacca ggaggtggcagtggaggccgagtacccagctaccggcactctgccttcgtgcccacccac tcctacccagaggagggtctggaaatgcaccccttggagcggcgtgggggccaccaccgc ccagacacctccagccttcacaccgatgatggctacatgcccatgtccccaggggtggcc ccggtgcccggcagccggaaaggcagtggggactacatgcccatgagccccaagagcgtg tctgccccgcagcagatcatcaaccccatcagacgccatccccagagagtggaccccaac ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggtgggcccagc agcggcggcagcagcagcggcgccgccccttctgggagcagctatggcaaactctgggca aacggcgtagggggccaccactctcacgccctgccacaccccaaactcccggtggagagc ggtagtggcaaactcttgtcttgtacaggtgactacatgaacatgtcgcccgtcggggac tccaacaccagcagcccctccgactgctactatggccccgaggacccccagcacaagcca gtcctctcctactactcattgccaaggtcctttaagcacacccagcgccctggggagctg gaggagcctcggcatcaccagcacctccgcctttcctccagttccggtcgactcctctac actgcggccgcagaagattcctcgtcgtccaccagcagcgacagcctgggcgggggatac tgtggggctcggcccgagcccggcctcccgcatctccatcatcaggtcctgcaggcccat ctgcctcgaaaggtggacacagctgcccagaccaacaaccgcctggctcggcccacgagg ctgtctctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagccgccg ccccccttgctgctccctccggagcccaagagcccaggggagtatgtgaatattgaattt gggagcgatcagcctggctacttatcgggcccggtggcgtcccacagctcgccttccatc aggtgtccatcccagctccagccagctcccagagaggaggagacgggcacagaagagtat atgaacatggacctggggccgggccggagggccacctggcaagagagcgtgggggttcag ccgggcagggtgggcccggcgcctcctggagctgctagcgtgtgcaggccgaccagggcg gtgcccagcagccgcggcgactacatgaccatgcagatgggcggtccccggcagaactac gtggacacctcacccgtcgcgcccatcagctacgccgacatgcggacgggcgtcgttgtg gaggaagccagcctgcccagggccaccgcggccgctccctcctcatcctcgacggcctct gtttcctccactgctcctccaggaacaggggagctggcggcccgctcggccctgctgggg ggcccgagcgccttcacgcgggtgaacctcagtcccaaccgcaaccagagtgccaaagtg atccgtgccgacccgcaagggtgcaggaggcggcacagctccgagaccttctcctcgacg cccagtgccacccgggtgggcaacacggtgcccttcggagccggggctgccgtcgggggc agtgctggtggcagcagcagcagcgccgaggatgtcaaacgccacagctctgcttccttc gagaacgtgtggctgaggcctggggagctcgggggagtccccaaggagctggcccaagtg tgcggggccactgggggtttggagaatggtcttaactacatagacctggatttggtcaag gacttcaaacagcgccctcaagagtgcccacctcaaccgcagcctcctccactcccggcc cctcatcagcctctgggcagtagtcagagcggccccaccagccgctccagcgaggatcta agcgcctatgccagcatcactttccagaagcagccagaggacctccagtag

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