KEGG   Cervus canadensis (wapiti): 122441015
Entry
122441015         CDS       T07554                                 
Symbol
BRCA1
Name
(RefSeq) breast cancer type 1 susceptibility protein isoform X1
  KO
K10605  breast cancer type 1 susceptibility protein [EC:2.3.2.27]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad01524  Platinum drug resistance
ccad03440  Homologous recombination
ccad03460  Fanconi anemia pathway
ccad04120  Ubiquitin mediated proteolysis
ccad04151  PI3K-Akt signaling pathway
ccad05206  MicroRNAs in cancer
ccad05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    122441015 (BRCA1)
  09124 Replication and repair
   03440 Homologous recombination
    122441015 (BRCA1)
   03460 Fanconi anemia pathway
    122441015 (BRCA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    122441015 (BRCA1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    122441015 (BRCA1)
  09162 Cancer: specific types
   05224 Breast cancer
    122441015 (BRCA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    122441015 (BRCA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:ccad01009]
    122441015 (BRCA1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:ccad04121]
    122441015 (BRCA1)
   03036 Chromosome and associated proteins [BR:ccad03036]
    122441015 (BRCA1)
   03400 DNA repair and recombination proteins [BR:ccad03400]
    122441015 (BRCA1)
Enzymes [BR:ccad01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     122441015 (BRCA1)
Protein phosphatases and associated proteins [BR:ccad01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     122441015 (BRCA1)
Ubiquitin system [BR:ccad04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    122441015 (BRCA1)
  Multi subunit type E3
   BRCC complex
    122441015 (BRCA1)
Chromosome and associated proteins [BR:ccad03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     122441015 (BRCA1)
DNA repair and recombination proteins [BR:ccad03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     122441015 (BRCA1)
    BRCA1-A complex
     122441015 (BRCA1)
    BRCA1-B complex
     122441015 (BRCA1)
    BRCA1-C complex
     122441015 (BRCA1)
    BRCA complex
     122441015 (BRCA1)
   FA (Fanconi anemia) pathway
    Downstream FA components
     122441015 (BRCA1)
SSDB
Motif
Pfam: BRCT_assoc BRCT zf-C3HC4 zf-C3HC4_2 zf-RING_UBOX zf-C3HC4_3 zf-RING_2 zf-C3HC4_4 zf-RING_5 RING_XB3-XBAT31 zf-RING_6 BRCT_2 zf-ANAPC11 zf-Nse zf-RING_10 zf-rbx1 RTT107_BRCT_5 Prok-RING_4 Baculo_IE-1
Other DBs
NCBI-GeneID: 122441015
NCBI-ProteinID: XP_043323582
LinkDB
Position
1:19330322..19399109
AA seq 1860 aa
MDLSVDHVEEVQNVLNAMQKILECPICLELIREPVSTKCDHIFCKFCMLKLLNQKKGPSQ
CPLCKNDITKRSLQESTRFSQLVEELLKIIHAFELDTGLQFANSYNFSRKKNKSPEHLKE
EVSIIQSMGYRNRAKRLWQSEPENPTLQETGLTVELSNLGIVRSLRTKQQIQSQNKSVYI
ELGSDSSEDTVNKASYFSVGEHELLEITPQGAKAETNLNPAKKAACEFSEKDITNTEHHQ
FSIKDLITTHKHATETHPENYQGISVSNFHVEPCGTDTHASSLQHENSSLLLTENRLNVE
KAEFCNESKQPVLGKSQQSRWAESKGTCKDRQIPSTGKKIVLNADPLYRRKELHKQKPAC
PNSPGDSQDVPWVTLNNSIQKVNEWFSRSDEILTSDDSCDGGSESNNEVAGAVEIPNKVD
GYSGSSEKIDLMASDPHGALIHERVHSKPVESNIEDKIFGKTYRRKSSFPNFSHVAEDLI
IGAFTVEPQITQEQPLTNKLKCKRRGTSGLQPEDFIKKVDLTIVPKTPEKMIEGTDQTEQ
KGHGINITSDGHENKTKRDYVQKEQNANPTESLGKESVFRTKAEPISVSVSNMELELNIH
GSKAPKNRLKRKSSTRKIPELELVVSRNPSPPNHTELPIDSCSSSEEMKKKHSSQMPVRQ
GQKLQLMGDKEPIAGAKKSNKAYEQINKRLGSDAFPEINLANTPGYFTNCSSSNKLEEFV
HPSVQREENLGTIQVSNSTKDPKDLILRGGKALQIERSVESTNISLVPDTDYSTQDSISL
LEANTPEKAKTAPNPCVSLCAAIENPKELIHGDFKGTKNDTEGFQDLLGHDVNCVIQETS
GEMEDSELDTQYLQNTFKVSKRQTFALFSNPGNPQKECTTVFAHSGSLRDQSPRDPLKCR
QKEDSRGKNESKSQHVQAICTTVHFPVAGQKDRTLGDDAKCSGKEVTRLCQSSQLRGHKT
ELVFANKHGISEKTFLIPSLSPIKSSVKTVCKKSPSEKFEEPVMSPERTRGSESIIQSAV
STVSQNNIQESTFKEVSSSSVNEVGSSTNEVGSSINEVGSSGENIQAEPGRNREPKLRAL
LKLGLMQPEVYKQSLPVSNCHHPEIKRQGENEDMLQAVKADFSPCLISDNLEQPMGSCHA
SQVCSETPDNLLNDDEIKENSHFAESDIKERSAVFSESIQKGEFRGSPDPFTHTHLAQDH
QRGAGKLESEEIVSSEDEELPCFQQLLFGKVTNTLSPSTGRNTVASEGLSKETEENLESL
KSGLNDCSGQVTSAKASQEHHLNEEARCSSSLFSSQCSAVEDLTTNTNTQDPFLMFEHPS
KQVYQSESEEFLSDKELVSDDEERETGLEEDSCQEEQSVDSDLGEAASNHVSETSLSEDS
VGLSSQSDILTTQQRDTMQDNLLKLQQEMAELEAVLERHGSQPSHSSASLTADSRGPEHL
LNPEQNTSERAILTSEKSRDYSRSQNPESLSADKFPVSLDSSTNKNKEPGMEGSSPSKFQ
LSDNRWYVHSHSRSLQDRNCPSQKVPINVADMEEQQLAKYEAQDLMGSYLPRQDQEGTPY
LKSGISLFSHDLESDPSEDRAPEPAHVHCMPPSASAPKLSQFRVEESTKNPAAAHITNTT
GCNLREESVSKEKPEVISSTERSNKRLSMVASGLTPKELMLVQKFARKHHITLTNLITEE
TTHIIMKTDPEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLDEHDFEVRGDVVNG
RNHQGPKRARESQDKKIFKGLEICCYGPFTNMPTDQLEWMVQLCGASVVKEPSSFTPGQG
THPVVVVQPDAWTEDAGFRVIGQMCEAPVVTREWVLDSVALYHCQELDTYLVPQVAQSCC
NT seq 5583 nt   +upstreamnt  +downstreamnt
atggatttatctgtggatcatgttgaggaagtacaaaatgtccttaatgctatgcagaaa
atcttagagtgtccaatatgtctggagttgatcagagagcctgtctctacaaagtgtgac
cacatattttgcaaattttgtatgctgaaacttctcaaccagaagaaagggccttcacaa
tgtcctttgtgtaagaatgatataaccaaaagaagcctacaagaaagtacaagatttagt
caacttgttgaagagctgttgaagatcattcatgcttttgagcttgacacaggattgcag
tttgcaaacagctataacttttcgagaaagaaaaataagtctcctgagcatctgaaggag
gaagtttctatcatccaaagtatgggctaccggaaccgggccaaaagactttggcagagt
gaacctgaaaatcctaccttgcaggaaactggtcttactgtcgaactctctaaccttgga
attgtgagatctctgaggacaaagcagcagatacaatctcagaataagtccgtctacatt
gaattgggatctgattcttctgaagacacagttaataaggccagttacttcagtgtggga
gaacatgaattgttagagatcacccctcaaggagccaaggcagagaccaatttgaatcct
gcaaaaaaggctgcttgtgagttttctgagaaggacataacaaatactgaacatcatcag
ttcagtattaaagatctgatcaccacccataagcatgcaactgagacgcatccagaaaac
tatcagggtatttctgtttcaaactttcacgtggagccatgtggcacagatactcatgcc
agctcattacagcatgagaacagcagtttattgctcactgaaaacagactgaatgtagaa
aaggctgaattctgtaatgaaagcaaacagcctgtcttaggaaagagccaacagagcaga
tgggctgaaagtaagggcacatgtaaggataggcagattcccagcactgggaaaaagata
gttctgaatgctgatcccctgtacagaagaaaagaactgcataagcagaaacctgcatgc
cctaacagtcctggagattcccaagatgttccttgggtaaccctgaataatagcatacag
aaagttaatgaatggttttccagaagtgatgaaatattaacttctgatgactcatgcgat
ggtgggtctgaatcaaataatgaagtagctggtgcagtggaaattccaaataaagttgat
ggatattcaggttcttcagagaaaatcgacttaatggccagtgatcctcatggtgcttta
atacatgaaagagtccactccaaaccagtagagagtaatattgaagataaaatatttggg
aaaacctatcggaggaagtcaagtttccctaacttcagccacgtagctgaagatctaatt
ataggcgcatttactgtagaacctcagataacacaagagcagcccctcacaaataaacta
aagtgtaaaaggagaggtacatcaggccttcagcctgaggattttatcaagaaagtcgat
ttgacaattgttccaaagactcctgaaaagatgattgagggaactgatcaaacagagcag
aaaggtcatgggataaatattactagtgatggtcatgagaataaaacaaaacgtgattat
gttcagaaagagcaaaacgctaacccaacagaatcattgggaaaagaatctgttttcaga
actaaggctgaacctataagcgtcagtgtaagcaatatggaactagaattgaatatccac
ggttcaaaagcaccgaagaataggctgaagaggaagtcctctaccaggaaaattcctgaa
cttgaactagtagtcagtagaaacccaagtccacctaatcatactgagctaccaattgat
agctgttctagcagtgaagagatgaagaaaaaacattctagccaaatgccagtcaggcag
ggccaaaagcttcaactcatgggagataaagaacctatagctggagccaagaagagtaac
aaagcatatgaacaaataaataaaagacttggtagtgatgcctttccagaaataaattta
gcaaacacacctggttattttactaactgttctagttctaataaacttgaagagtttgtt
catcctagcgttcaaagagaggagaatctaggaacaattcaagtgtcaaatagtaccaaa
gaccccaaagatctgatattaagaggaggaaaagctttgcaaattgaaagatctgtagag
agtaccaatatttccttggttcctgatactgattatagcactcaggatagtatctcatta
ctggaagctaacaccccagagaaggcaaagactgcaccaaatccttgtgtgagtctgtgt
gcagcaatcgaaaaccccaaggaacttatccatggggattttaaaggtaccaaaaacgac
acagagggctttcaggatctactgggacatgacgttaactgcgtcattcaggagacaagc
ggagaaatggaagacagtgaacttgatacacagtatttgcagaatacgttcaaggtttca
aagcgtcagacatttgctctgttttcaaatccaggaaatccacaaaaggaatgtaccaca
gtctttgcccactcggggtccttaagggatcaaagtccaagagaccccctcaaatgcagg
caaaaagaagacagtcggggaaagaatgagtctaaaagccagcatgtgcaggccatttgt
acaacagtgcactttcctgtggctggtcagaaagataggacgctgggtgacgatgccaaa
tgtagtggaaaagaagtaactaggctttgtcagtcatcacagttgagaggccacaaaact
gaacttgtttttgcaaataaacatgggatttcagaaaaaacatttcttataccatcactt
tctcccatcaagtcatctgttaaaaccgtatgtaagaaaagcccatcagagaagtttgag
gaacctgtaatgtcacctgaaagaacgcggggaagtgagagcatcattcaaagtgcagtg
agcacagtcagtcaaaataacattcaagaaagcacttttaaagaagtcagctcaagcagt
gttaatgaagtaggttccagtactaatgaagtaggctctagtattaatgaagtaggttcc
agtggtgaaaacattcaagcagaaccaggtagaaacagagaacctaaattaagagcttta
ctcaaattaggtcttatgcaacctgaagtctataagcaaagtcttcctgtaagtaactgt
caccatcctgaaataaaaaggcaaggagaaaatgaggacatgcttcaggctgttaaggca
gatttctccccatgtctaatttcagataatctcgaacaacctatgggaagctgtcatgct
tctcaggtttgttctgagacacctgacaacttgttgaatgatgatgaaataaaagaaaat
agccactttgctgaaagtgacattaaggaaagatctgctgtttttagtgaaagtatccaa
aaaggagaattcagagggagccctgaccctttcacccatacacatttggctcaggatcac
caaagaggggctggaaaactggagtcagaagagattgtgtctagtgaggatgaagagctt
ccctgcttccaacaattattgtttggtaaagtaaccaatacactgtctccatctaccgga
cgtaacactgttgccagtgagggtctgtctaaggaaacagaggagaacctagaatcattg
aagagtggcttaaatgactgcagtggccaggtaacatcagccaaggcgtcccaggaacat
caccttaatgaggaagcgagatgttctagtagcttattttcctcacagtgcagtgcagtg
gaagacttgaccactaatacaaacacccaggatcctttcttgatgtttgagcatccttcc
aaacaagtgtatcagtctgaaagcgaggaatttctgagtgacaaggaattggtttcagat
gatgaagaaagggaaaccggcttggaagaagatagttgccaagaagagcagagtgtggat
tcagacttaggtgaagcagcatccaaccatgtgagtgaaacaagcctctctgaagactct
gtggggctgtcttctcagagtgatatcttaaccactcagcagagggataccatgcaagat
aacctactaaagctccagcaggaaatggccgagctggaagctgtgttagagcggcacggg
agccagccttcccacagctctgcttccctcacagctgattctcgtggcccagagcacctg
ctaaatccagagcaaaacacatcagaaagagcaatattaacttcagagaaaagtagagac
tattctagaagccagaatcctgaaagcctctctgctgacaagtttccagtatctctggat
agttctaccaataaaaataaagaaccaggaatggaagggtcttccccttctaaattccag
ttgtcggataataggtggtatgtgcacagccactcaaggagtcttcaggacagaaactgc
ccatctcaaaaggtgcccattaatgttgctgacatggaggagcaacagctggctaagtat
gaggcccaagatttaatggggtcttatttgccaagacaagatcaagaaggaaccccttac
ctgaaatctggaatcagcctcttctctcatgacctcgagtctgatccctctgaagacaga
gccccagagccagctcatgttcactgcatgccaccctctgcctctgcaccgaaattatcc
caatttcgagtagaagaatctaccaagaatccagctgctgctcacattactaatactaca
gggtgtaacctgagggaagaaagtgtgagcaaagagaagccagaagtgatatcttcaaca
gaaagaagcaacaaaagactttctatggtggcatcaggcttgaccccaaaagaactcatg
cttgtgcagaaatttgccagaaaacatcacatcactttaactaatctaattactgaagag
actactcatatcattatgaaaacagatcctgagtttgtgtgtgaacggacactgaaatat
tttctgggaattgcaggaggaaaatgggtagttagctatttttgggtcacccagtctatt
aaagaaagaaagatgctggatgagcatgattttgaagtcagaggagatgttgtcaatgga
agaaaccatcaaggcccaaagcgagcaagagaatcccaagacaagaagatcttcaaaggc
ctagagatctgttgctatggaccttttaccaatatgcccacagatcaactagagtggatg
gtgcagctgtgtggggcttctgtggtgaaggagccctcgtcattcaccccaggccagggt
actcacccagttgtggtcgtgcagccggatgcctggacagaggatgctggcttccgtgtg
atcgggcagatgtgtgaagcacctgtggtaacccgagagtgggtactggacagtgtggcc
ctctaccattgccaggagctggacacctacctggtcccccaggtcgcccagagctgctgc
tga

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