KEGG ORTHOLOGY: K10605

ORTHOLOGY: K10605

Entry

K10605                      KO

Symbol

BRCA1

Name

breast cancer type 1 susceptibility protein [EC:2.3.2.27]

Pathway

map01524

Platinum drug resistance

map03440

Homologous recombination

map03460

Fanconi anemia pathway

map04120

Ubiquitin mediated proteolysis

map04151

PI3K-Akt signaling pathway

map05206

MicroRNAs in cancer

map05224

Breast cancer

Disease

H00019

Pancreatic cancer

H00027

Ovarian cancer

H00031

Breast cancer

H00238

Fanconi anemia

H01554

Fallopian tube cancer

H01665

Primary peritoneal carcinoma

H02531

Familial breast-ovarian cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  09124 Replication and repair
   03440 Homologous recombination
    K10605  BRCA1; breast cancer type 1 susceptibility protein
   03460 Fanconi anemia pathway
    K10605  BRCA1; breast cancer type 1 susceptibility protein
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K10605  BRCA1; breast cancer type 1 susceptibility protein
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  09162 Cancer: specific types
   05224 Breast cancer
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K10605  BRCA1; breast cancer type 1 susceptibility protein
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10605  BRCA1; breast cancer type 1 susceptibility protein
   03036 Chromosome and associated proteins
    K10605  BRCA1; breast cancer type 1 susceptibility protein
   03400 DNA repair and recombination proteins
    K10605  BRCA1; breast cancer type 1 susceptibility protein
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10605  BRCA1; breast cancer type 1 susceptibility protein
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K10605  BRCA1; breast cancer type 1 susceptibility protein
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  Multi subunit Ring-finger type E3
   BRCC complex
    K10605  BRCA1; breast cancer type 1 susceptibility protein
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     K10605  BRCA1; breast cancer type 1 susceptibility protein
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     K10605  BRCA1; breast cancer type 1 susceptibility protein
    BRCA1-A complex
     K10605  BRCA1; breast cancer type 1 susceptibility protein
    BRCA1-B complex
     K10605  BRCA1; breast cancer type 1 susceptibility protein
    BRCA1-C complex
     K10605  BRCA1; breast cancer type 1 susceptibility protein
    BRCA complex
     K10605  BRCA1; breast cancer type 1 susceptibility protein
   FA (Fanconi anemia) pathway
    Downstream FA components
     K10605  BRCA1; breast cancer type 1 susceptibility protein

Genes

HSA:	672(BRCA1)

PTR:	449497(BRCA1)

PPS:	100986197(BRCA1)

GGO:	101138567(BRCA1)

PON:	100439533(BRCA1)

PPYG:

129017314(BRCA1)

NLE:	100580360(BRCA1)

HMH:	116474903(BRCA1)

SSYN:

129469801(BRCA1)

MCC:	712634(BRCA1)

MCF:	102121313(BRCA1)

MTHB:

126938407

MNI:	105472075(BRCA1)

CSAB:

103243855(BRCA1)

CATY:

105579705(BRCA1)

PANU:

101022062(BRCA1)

TGE:	112610045(BRCA1)

MLEU:

105553071(BRCA1)

RRO:	104673233(BRCA1)

RBB:	108526765(BRCA1)

TFN:	117066917(BRCA1) 117089756

PTEH:

111537329(BRCA1)

CANG:

105503134(BRCA1)

CJC:	100388186(BRCA1)

SBQ:	101046814(BRCA1)

CIMI:

108289781(BRCA1)

ANAN:

105711233(BRCA1)

CSYR:

103267879(BRCA1)

MMUR:

105859393(BRCA1)

LCAT:

123620994(BRCA1)

OGA:	100952916(BRCA1)

MMU:	12189(Brca1)

MCAL:

110304614(Brca1)

MPAH:

110331180(Brca1)

RNO:	497672(Brca1)

MCOC:

116078743(Brca1)

ANU:	117711765(Brca1)

MUN:	110550902(Brca1)

CGE:	100770724(Brca1)

MAUA:

101840909(Brca1)

PROB:

127216728(Brca1)

PLEU:

114682837(Brca1)

MORG:

121442452(Brca1)

MFOT:

126510109

AAMP:

119813231(Brca1)

NGI:	103751919(Brca1)

HGL:	101705460(Brca1)

CPOC:

100722339(Brca1)

CCAN:

109687320(Brca1)

DORD:

105997512(Brca1)

DSP:	122103440(Brca1)

PLOP:

125366407(Brca1)

NCAR:

124979164

MMMA:

107150537(Brca1)

OCU:

100347269

OPI:	101523476(BRCA1)

TUP:	102494934(BRCA1)

GVR:	103589870(BRCA1)

CFA:	403437(BRCA1)

CLUD:

112655359(BRCA1)

VVP:	112910801(BRCA1)

VLG:	121472899(BRCA1)

NPO:	129508022(BRCA1)

AML:	100480891(BRCA1)

UMR:	103672599(BRCA1)

UAH:	113265384(BRCA1)

UAR:	123781964(BRCA1)

ELK:

111151634

LLV:

125086735

MPUF:

101671098(BRCA1)

MNP:	132003500(BRCA1)

MLK:	131816810(BRCA1)

NVS:	122906161(BRCA1)

ORO:	101362868(BRCA1)

EJU:	114201332(BRCA1)

ZCA:	113939007(BRCA1)

MLX:	118024950(BRCA1)

NSU:	110573207(BRCA1)

FCA:	101081937(BRCA1)

PYU:	121045059(BRCA1)

PCOO:

112854200(BRCA1)

PBG:	122485639(BRCA1)

PVIV:

125158583(BRCA1)

LRUF:

124522205

PTG:	102966376(BRCA1)

PPAD:

109258507(BRCA1)

PUC:

125926591

AJU:

106972629

HHV:	120226086(BRCA1)

BTA:	353120(BRCA1)

BOM:	102266344(BRCA1)

BIU:	109573698(BRCA1)

BBUB:

102399547(BRCA1)

BBIS:

104990403(BRCA1)

CHX:	102173121(BRCA1)

OAS:	101108584(BRCA1)

BTAX:

128065278(BRCA1)

CSUM:

138082685(BRCA1)

ODA:	120867062(BRCA1)

CCAD:

122441015(BRCA1)

MREE:

136148989(BRCA1)

MBEZ:

129544459(BRCA1)

SSC:	100049662(BRCA1)

CFR:	102512160(BRCA1)

CBAI:

105080080(BRCA1)

CDK:	105090493(BRCA1)

VPC:	102532151(BRCA1)

BACU:

103005164 103008156

BMUS:

118887242(BRCA1)

LVE:	103073470 103081109(BRCA1)

OOR:	101269506(BRCA1)

DLE:	111166258(BRCA1)

PCAD:

102986597(BRCA1)

PSIU:

116745065(BRCA1)

NASI:

112397998(BRCA1)

ECB:	100051990(BRCA1)

EPZ:	103566867(BRCA1)

EAI:	106826352(BRCA1)

MYB:	102250563(BRCA1)

MYD:	102761726(BRCA1)

MMYO:

118671456(BRCA1)

MLF:	102434930(BRCA1)

MDT:	132218694(BRCA1)

PKL:	118726420(BRCA1)

EFUS:

103293060(BRCA1)

MNA:	107528909(BRCA1)

DRO:	112298867(BRCA1)

SHON:

118978170(BRCA1)

AJM:	119051686(BRCA1)

PDIC:

114502888(BRCA1)

PHAS:

123817357(BRCA1)

MMF:	118634791(BRCA1)

PPAM:

129086900(BRCA1)

HAI:	109395752(BRCA1)

RFQ:	117013957(BRCA1)

PALE:

102895982(BRCA1)

PGIG:

120611051(BRCA1)

PVP:	105306256(BRCA1)

RAY:	107513858(BRCA1)

MJV:	108394617(BRCA1)

TOD:	119230413(BRCA1)

SARA:

101538721(BRCA1)

SETR:

126000905(BRCA1)

LAV:	100653763(BRCA1)

TMU:

101356605

ETF:	101639869(BRCA1)

DNM:	101429125(BRCA1)

MDO:	554178(BRCA1)

GAS:	123245322(BRCA1)

SHR:	100914310(BRCA1)

AFZ:

127560081

PCW:	110198384(BRCA1)

TVP:	118848966(BRCA1)

PBRV:

138145918(BRCA1)

OAA:	103167900(BRCA1)

GGA:	373983(BRCA1)

PCOC:

116233569(BRCA1)

MGP:

100548521

CJO:	107325322(BRCA1)

TPAI:

128089158(BRCA1)

LMUT:

125684604(BRCA1)

NMEL:

110388719(BRCA1)

APLA:

101789679(BRCA1)

ACYG:

106048796(BRCA1)

CATA:

118259098(BRCA1)

AFUL:

116498528(BRCA1)

TGU:	100224649(BRCA1)

LSR:	110471836(BRCA1)

SCAN:

103821581(BRCA1)

PMOA:

120496693(BRCA1)

OTC:	121347721(BRCA1)

PRUF:

121351138(BRCA1)

GFR:	102034543(BRCA1)

FAB:	101814437(BRCA1)

OMA:	130264186(BRCA1)

PHI:	102105698(BRCA1)

PMAJ:

107215173(BRCA1)

CCAE:

111940108(BRCA1)

CCW:	104697774(BRCA1)

ACOE:

138099161(BRCA1)

ETL:	114063608(BRCA1)

ZAB:	102063385(BRCA1)

ZLE:	135458534(BRCA1)

ACHL:

103809371(BRCA1)

SVG:	106858689(BRCA1)

MMEA:

130581425(BRCA1)

HRT:	120763879(BRCA1)

SATI:

136372275(BRCA1)

FPG:	106112589(BRCA1)

FCH:	102051878(BRCA1)

CCRI:

104161284(BRCA1)

NNT:	104401552(BRCA1)

SHAB:

115617619(BRCA1)

ACUN:

113489164(BRCA1)

TALA:

104358725(BRCA1)

ACHC:

115344989(BRCA1)

HALD:

104325729

HLE:	104842963(BRCA1)

AGEN:

126038513

HHAR:

128141042(BRCA1)

GCL:

127026385

CSTI:

104555031(BRCA1)

MNB:	103774230(BRCA1)

DPUB:

104300566(BRCA1)

PPUS:

135191614(BRCA1)

AVIT:

104279026(BRCA1)

BRHI:

104499403(BRCA1)

EGZ:	104134710(BRCA1)

NNI:	104009881(BRCA1)

PCRI:

104037885(BRCA1)

PCAO:

104049732(BRCA1)

PADL:

103919153(BRCA1)

AFOR:

103902465(BRCA1)

FGA:	104083261(BRCA1)

GSTE:

104256017(BRCA1)

CLV:	102087906(BRCA1)

MUI:	104537348(BRCA1)

PGUU:

104467299(BRCA1)

PLET:

104625332(BRCA1)

EHS:	104513407(BRCA1)

CMAC:

104480680(BRCA1)

TEO:	104373669(BRCA1)

BREG:

104643551(BRCA1)

OHA:	104338704(BRCA1)

ACAR:

104520963(BRCA1)

CPEA:

104385645(BRCA1)

CVF:	104294439(BRCA1)

RTD:	128919175(BRCA1)

AAM:	106491786(BRCA1)

AROW:

112968743(BRCA1)

NPD:	112960276(BRCA1)

TGT:	104576611(BRCA1)

DNE:	112991230(BRCA1)

SCAM:

104141229(BRCA1)

ASN:	102369036(BRCA1)

AMJ:	102573178(BRCA1)

CPOO:

109320418(BRCA1)

GGN:	109289366(BRCA1)

PSS:	102444617(BRCA1)

CMY:	102936790(BRCA1)

CCAY:

125626664(BRCA1)

DCC:	119848890(BRCA1)

CPIC:

101942702(BRCA1)

TST:	117869319(BRCA1)

CABI:

116820339(BRCA1)

MRV:	120392042(BRCA1)

ACS:	100553919(brca1)

ASAO:

132778368(BRCA1)

PVT:	110080303(BRCA1)

SUND:

121934862(BRCA1)

PBI:	103057262(BRCA1)

PMUR:

107285925(BRCA1)

CTIG:

120297989(BRCA1)

PGUT:

117664858(BRCA1)

VKO:	123017394(BRCA1)

PMUA:

114581534(BRCA1)

PRAF:

128399995(BRCA1)

ZVI:	118095327(BRCA1)

HCG:	128329255(BRCA1)

STOW:

125444850(BRCA1)

EMC:	129339088(BRCA1)

XLA:	399391(brca1.L)

XTR:	733513(brca1)

RTEM:

120919189(BRCA1)

BBUF:

121004624(BRCA1)

BGAR:

122942380(BRCA1)

MUO:	115481752(BRCA1)

GSH:	117347289(BRCA1)

IPU:

108273781

IFU:

128617523

PHYP:

113535268(brca1)

SMEO:

TFD:

TRN:

AMEX:

EEE:

TRU:	101064828(brca1)

TFS:

130531204

LCO:	104930986(brca1)

NCC:	104967610(brca1)

TBEN:

117474119

CGOB:

115025041(brca1)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116670727(brca1)

PFLV:

114548467(brca1)

GAT:

PPUG:

AFB:

CLUM:

CANA:

MSAM:

SCHU:

CUD:

ALAT:

ASTR:

MZE:	101470273(brca1)

ONL:	100708332(brca1)

OAU:

116329847

OLA:	101160694(brca1)

OML:

112154310

CSAI:

133419513

XMA:	102225738(brca1)

XCO:	114151962(brca1)

XHE:	116726713(brca1)

PRET:

103481274(brca1)

PFOR:

103153387(brca1)

PLAI:

106948321(brca1)

PMEI:

106907616(brca1)

GAF:

122822877

PPRL:

129368344

CVG:	107094717(brca1)

CTUL:

119792213

GMU:

124875033

NFU:	107387869(brca1)

KMR:

108246763

ALIM:

106516970(brca1)

AOCE:

111567306(brca1)

EJA:

138201932

MCEP:

125023060

CSEM:

103381460(brca1)

POV:	109626726(brca1)

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111219611(brca1)

SLAL:

111657129(brca1)

XGL:

120794600

HCQ:	109523943(brca1)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110154390(brca1)

MALB:

109963046(brca1)

BSPL:

114845371

SJO:

128381104

SASA:

106579155(brca1)

STRU:

115160697 115163383 115184009

OTW:

112223766

OMY:

110491673

OGO:

124048417

ONE:	115106633(brca1)

OKI:	109876862(brca1)

OKE:

118364750

SALP:

111977731(brca1)

SNH:

120046291

CCLU:

121557107

ELS:	105030602(brca1)

SFM:	108918991(brca1)

PKI:	111856111(brca1)

AANG:

118220721

LOC:	102698102(brca1)

PSPA:

121302017

ARUT:

117433289

LCM:	102353765(BRCA1)

CMK:

BFO:

BBEL:

CIN:

SPU:	105438132 755086

AME:

ACER:

ALAB:

ADR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

VPS:

NVI:

CSOL:

TPRE:

CCIN:

DPA:

AGB:

BMOR:

BMAN:

MSEX:

DPL:	KGM_205798

BANY:

PPOT:

PXU:

BPHI:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

LGLY:

CSTB:

CLEC:

TPAL:

CSEC:

DMK:	116920843 123470965

PVM:

PJA:

PCHN:

HAME:

HAZT:

EAF:

DSV:	119441871 119441873

RMP:

MYI:

PMAX:

OBI:

OSN:

SMM:	Smp_132510

SHX:	MS3_00005494(BRCA1)

OVI:	T265_02041

NVE:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_54061

» show all

Reference

PMID:8938427

Authors

Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC

Title

Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.

Journal

Genome Res 6:1029-49 (1996)
DOI:10.1101/gr.6.11.1029

Sequence

[hsa:672]

Reference

PMID:14976165

Authors

Morris JR, Solomon E

Title

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.

Journal

Hum Mol Genet 13:807-17 (2004)
DOI:10.1093/hmg/ddh095

Sequence

[hsa:672]

LinkDB

DBGET integrated database retrieval system