Cervus canadensis (wapiti): 122448821
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Entry
122448821 CDS
T07554
Symbol
ITCH
Name
(RefSeq) E3 ubiquitin-protein ligase Itchy homolog isoform X1
KO
K05632
E3 ubiquitin-protein ligase Itchy [EC:
2.3.2.26
]
Organism
ccad
Cervus canadensis (wapiti)
Pathway
ccad04120
Ubiquitin mediated proteolysis
ccad04144
Endocytosis
ccad04330
Notch signaling pathway
ccad04668
TNF signaling pathway
ccad04932
Non-alcoholic fatty liver disease
Brite
KEGG Orthology (KO) [BR:
ccad00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
122448821 (ITCH)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
122448821 (ITCH)
04668 TNF signaling pathway
122448821 (ITCH)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
122448821 (ITCH)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
122448821 (ITCH)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ccad04131
]
122448821 (ITCH)
04121 Ubiquitin system [BR:
ccad04121
]
122448821 (ITCH)
Enzymes [BR:
ccad01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
122448821 (ITCH)
Membrane trafficking [BR:
ccad04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
122448821 (ITCH)
Ubiquitin system [BR:
ccad04121
]
Ubiquitin ligases (E3)
HECT type E3
122448821 (ITCH)
BRITE hierarchy
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HECT
WW
C2
Motif
Other DBs
NCBI-GeneID:
122448821
NCBI-ProteinID:
XP_043336381
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All DBs
Position
10:62638859..62735774
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AA seq
862 aa
AA seq
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MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVVTL
QLVGDKEPTETIGDLSVCLDGLQLESEVVANGETACSESASQNDDGSRPRDETRANASGS
DDPEDAGSGENRRINGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSTTSESD
GSSTGSLPPTNTNSSTSEGATSGLIIPLTISGGAGPRPLNPIPQAPLPPGWEQRVDQHGR
VYYVDHIEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
LQRSQLQGAMQQFNQRFIYGNQDLFATSQNKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
RITQWEDPRNQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ
IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF
PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGL
EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDN
EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
SYEQLKEKLLFAIEETEGFGQE
NT seq
2589 nt
NT seq
+upstream
nt +downstream
nt
atgtctgacagtggatcacagcttggttcaatgggtagtttgaccatgaaatcacaactt
cagattactgtcatttcagcaaagcttaaagaaaataaaaagaattggtttgggccaagt
ccttatgtggaagtcacagtagatggacagtcaaagaagacagaaaaatgcaacaatacg
aacagtcccaagtggaagcagcctcttacagttattgtcacccctgtgagtaaattacat
tttcgtgtgtggagtcaccagacactgaaatctgatgttttgttgggaactgctggattg
gatatctatgaaacattaaagtcaaacaatatgaaacttgaggaagtagttgtgacttta
cagcttgtaggtgacaaagaaccaacggagacaataggagatttgtcagtctgtcttgat
gggctgcaactagagtctgaggttgttgccaatggtgaaactgcatgttcagaaagtgct
tcacagaatgatgatggctccagacccagggatgaaacaagagcgaacgcaagtggatca
gatgaccctgaggatgcagggtctggtgaaaataggaggatcaatgggaataattctcca
tcactctcaaatggcggttttaaaccttctaggcctccaagaccttcacgaccacctcca
cctaccccacgtagaccagcgtctgtcaatggctcaccatctaccacttctgaaagtgat
ggctctagtacaggctctctgccaccaacaaatacaaattcaagtacatctgaaggagca
acatctggattaataattcctcttactatatctggaggtgcaggccctagaccattaaat
cctatacctcaagctcccctcccacctggttgggagcagagagtggaccagcatgggcga
gtttactatgtagatcatattgaaaaaagaacaacgtgggatagaccagaacctctacct
cctggctgggaacggcgggttgacaacatgggacgtatttattatgttgaccatttcaca
agaacaacaacgtggcagaggccaacattggaatccgtccggaactatgaacaatggcag
ctccagcgtagtcaacttcagggagctatgcagcaatttaaccagaggttcatttacggg
aatcaagatttgtttgctacatcacaaaataaagaatttgatcccctgggtcccctgcca
cctggatgggagaagagaacggacagcaacggtagagtatattttgtcaaccacaacact
cgtattacacaatgggaagaccccagaaatcaaggtcaattaaatgaaaagcccttacct
gaaggctgggaaatgagattcacggtagatggaattccgtattttgtggaccacaataga
agaacaaccacctatatagatccccgcaccggaaaatctgccttagacaatggaccccag
atagcctatgtacgggacttcaaggcaaaggttcagtatttccgtttctggtgtcagcaa
ctggccatgccacagcacataaagattacagtgacaagaaaaacattgtttgaggattcc
tttcagcagataatgagcttcagtcctcaagatctgcgaagacgtttgtgggtgattttt
ccaggagaagaaggtttagattatggaggtgtagcaagagaatggttctttcttttgtca
catgaggtgttgaacccaatgtattgcctgtttgaatatgcagggaaggataactactgc
ttgcagataaaccccgcttcttacatcaatccagatcacctgaaatattttcgttttatt
ggcaggtttattgctatggctctgttccatgggaaattcatagacacaggtttttctttg
ccattctataagcgtatcttgaataaaccagttggactgaaggatttagaatcgattgat
ccagaattttacaattctctcatctgggttaaagaaaacaatattgaggagtgtggtttg
gaaatgtatttctccgttgataaagaaattttaggtgaaatcaagagtcatgatttgaaa
cccaatggtggcaatattcttgtaacagaagaaaataaagaggaatatatcagaatggta
gctgaatggagattgtctcgtggtgttgaagaacagacgcaagctttctttgagggcttt
aatgaaattcttccccagcagtatttacagtactttgatgcaaaggaattagaggttctt
ttatgtgggatgcaagagattgatttgaatgattggcaaagacatgccatctaccgtcat
tatactaggacaagtaaacagatcatgtggttttggcagtttgttaaagaaatcgataat
gagaagagaatgcgacttttgcagtttgttactgggacctgccgactgccagttggagga
tttgctgacctaatggggagcaatgggccacagaagttctgcattgaaaaagtcgggaaa
gaaaattggttgcctagaagtcatacctgttttaaccgcctggacctgccgccctacaag
agctatgagcaactgaaggaaaagctgttatttgctattgaagaaacagaaggctttgga
caagagtga
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