KEGG   ORTHOLOGY: K05632
Entry
K05632                      KO                                     
Symbol
ITCH, AIP4
Name
E3 ubiquitin-protein ligase Itchy [EC:2.3.2.26]
Pathway
map04120  Ubiquitin mediated proteolysis
map04144  Endocytosis
map04668  TNF signaling pathway
map04932  Non-alcoholic fatty liver disease
Disease
H01232  Syndromic multisystem autoimmune disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
   04121 Ubiquitin system
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  HECT type E3
   K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Genes
HSA: 83737(ITCH)
PTR: 458191(ITCH)
PPS: 100975428(ITCH)
GGO: 101129438(ITCH)
PON: 100442751(ITCH)
NLE: 100599625(ITCH)
MCC: 707640(ITCH)
MCF: 101925768(ITCH)
MTHB: 126964180
CSAB: 103248756(ITCH)
CATY: 105582292(ITCH)
PANU: 101020727(ITCH)
TGE: 112633058(ITCH)
RRO: 104680506(ITCH)
RBB: 108533724(ITCH)
TFN: 117068672(ITCH)
PTEH: 111548161(ITCH)
CJC: 100400273(ITCH)
SBQ: 101050449(ITCH)
CSYR: 103270082(ITCH)
MMUR: 105865825(ITCH)
LCAT: 123622421(ITCH)
MMU: 16396(Itch)
MCAL: 110309477(Itch)
MPAH: 110317579(Itch)
RNO: 311567(Itch)
MCOC: 116091228(Itch)
MUN: 110550572(Itch)
CGE: 100751263(Itch)
MAUA: 101830914(Itch)
PLEU: 114706546(Itch)
MORG: 121460097(Itch)
MFOT: 126506974
AAMP: 119814200(Itch)
HGL: 101711522(Itch)
CPOC: 100724288(Itch)
CCAN: 109685893(Itch) 109695579
DORD: 105981497(Itch)
DSP: 122120175(Itch)
NCAR: 124976070
OCU: 100356696
OPI: 101525667(ITCH)
TUP: 102490973(ITCH)
GVR: 103589303(ITCH)
CFA: 477199(ITCH)
CLUD: 112673839(ITCH)
VVP: 112928234(ITCH)
VLG: 121477743(ITCH)
AML: 100480824(ITCH)
UMR: 103669818(ITCH)
UAH: 113258514(ITCH)
UAR: 123798221(ITCH)
ELK: 111141415
LLV: 125108541
MPUF: 101677061(ITCH)
ORO: 101370748(ITCH)
EJU: 114220667(ITCH)
ZCA: 113937583(ITCH)
MLX: 118011397(ITCH)
NSU: 110579401(ITCH)
LWW: 102729580(ITCH)
FCA: 101086133(ITCH)
PYU: 121012287(ITCH)
PBG: 122497546(ITCH)
LRUF: 124504064
PTG: 102963505(ITCH)
PPAD: 109272538(ITCH)
AJU: 106989132(ITCH)
HHV: 120242777(ITCH)
BTA: 508431(ITCH)
BOM: 102266581(ITCH)
BIU: 109567383(ITCH)
BBUB: 102390921(ITCH)
BBIS: 104999328(ITCH)
CHX: 102191813(ITCH)
OAS: 101118041(ITCH)
ODA: 120868691(ITCH)
CCAD: 122448821(ITCH)
CFR: 102524299(ITCH)
CBAI: 105073541(ITCH)
CDK: 105084946(ITCH)
VPC: 102527039(ITCH)
BACU: 103003555(ITCH)
LVE: 103090259(ITCH)
OOR: 101278816(ITCH)
DLE: 111184253(ITCH)
PCAD: 102982983(ITCH)
PSIU: 116740798(ITCH)
ECB: 100069340(ITCH)
EPZ: 103553776(ITCH)
EAI: 106824941(ITCH)
MYB: 102245579(ITCH)
MYD: 102766823(ITCH)
MMYO: 118663358(ITCH)
MLF: 102427630(ITCH)
MNA: 107537192(ITCH)
PKL: 118708400(ITCH)
HAI: 109389600(ITCH)
DRO: 112304130(ITCH)
SHON: 118985391(ITCH)
AJM: 119063357(ITCH)
PDIC: 114506905(ITCH)
PHAS: 123814815(ITCH)
MMF: 118619138(ITCH)
RFQ: 117016192(ITCH)
PALE: 102897965(ITCH)
PGIG: 120603562(ITCH)
PVP: 105304290(ITCH)
RAY: 107519483(ITCH)
MJV: 108391264(ITCH)
TOD: 119233908(ITCH)
SARA: 101549202(ITCH)
LAV: 100665515(ITCH)
TMU: 101356519
ETF: 101654665(ITCH)
DNM: 101430618(ITCH)
MDO: 100032356(ITCH)
GAS: 123237451(ITCH)
SHR: 100926872(ITCH)
PCW: 110216682(ITCH)
OAA: 100089108(ITCH)
GGA: 419145(ITCH)
PCOC: 116236849(ITCH)
MGP: 100541785(ITCH)
CJO: 107322843(ITCH)
NMEL: 110408063(ITCH)
APLA: 101795643(ITCH)
ACYG: 106045424(ITCH)
AFUL: 116495622(ITCH)
TGU: 100232505(ITCH)
LSR: 110479210(ITCH)
SCAN: 103818584(ITCH)
PMOA: 120503695(ITCH)
OTC: 121335924(ITCH)
PRUF: 121357312(ITCH)
GFR: 102043996(ITCH)
FAB: 101813986(ITCH)
PHI: 102099918(ITCH)
PMAJ: 107213310(ITCH)
CCAE: 111938382(ITCH)
CCW: 104683779(ITCH)
CBRC: 103619005(ITCH)
ETL: 114070955(ITCH)
ZAB: 102071203(ITCH)
ACHL: 103807940(ITCH)
FPG: 101923443(ITCH)
FCH: 102049631(ITCH)
CLV: 102095059(ITCH)
EGZ: 104124972(ITCH)
NNI: 104019915(ITCH)
PLET: 104622564(ITCH)
PCRI: 104031435(ITCH)
PCAO: 104053851(ITCH)
ACUN: 113487429(ITCH)
TALA: 104365868(ITCH)
PADL: 103912391(ITCH)
AFOR: 103902895(ITCH)
ACHC: 115339215(ITCH)
HALD: 104311958
HLE: 104841988(ITCH)
AGEN: 126045894
GCL: 127023130
CCRI: 104155367(ITCH)
CSTI: 104550361(ITCH)
EHS: 104505890(ITCH)
CMAC: 104475811(ITCH)
MUI: 104540498
FGA: 104073007(ITCH)
GSTE: 104255736(ITCH)
LDI: 104353859(ITCH)
MNB: 103775855(ITCH)
OHA: 104334560(ITCH)
NNT: 104408066(ITCH)
DPUB: 104303859(ITCH)
PGUU: 104469927(ITCH)
ACAR: 104531754
CPEA: 104390256(ITCH)
AVIT: 104275682
CVF: 104292686(ITCH)
CUCA: 104063217(ITCH)
TEO: 104371696(ITCH)
BRHI: 104491866(ITCH)
AAM: 106486232(ITCH)
AROW: 112974641(ITCH)
NPD: 112950027(ITCH)
TGT: 104579841(ITCH)
DNE: 112992572(ITCH)
SCAM: 104147954(ITCH)
ASN: 102377307(ITCH)
AMJ: 102571523(ITCH)
CPOO: 109313242(ITCH)
GGN: 109294632(ITCH)
PSS: 102444318(ITCH)
CMY: 102942150(ITCH)
CPIC: 101949925(ITCH)
TST: 117885823(ITCH)
CABI: 116825145(ITCH)
MRV: 120380596(ITCH)
ACS: 100567001(itch)
PVT: 110085919(ITCH)
SUND: 121929870(ITCH)
PBI: 103052699
PMUR: 107288388(ITCH)
CTIG: 120299187(ITCH)
TSR: 106538618(ITCH)
PGUT: 117663675(ITCH)
VKO: 123032035(ITCH)
PMUA: 114599512(ITCH)
ZVI: 118088471(ITCH)
GJA: 107112263(ITCH)
STOW: 125433778(ITCH)
XTR: 780194(itch)
NPR: 108786814(ITCH)
RTEM: 120918693(ITCH)
BBUF: 121005854(ITCH)
BGAR: 122940241(ITCH)
DRE: 100330031(itchb) 100331274(itcha)
PPRM: 120481003(itchb) 120493851(itcha)
MAMB: 125259522(itchb) 125273364(itcha)
IPU: 108271999(itcha) 108276113
SMEO: 124387127(itcha) 124398908(itchb)
TFD: 113643040(itcha) 113655279(itchb)
ELY: 117257099(itcha) 117258181(itchb)
EFO: 125890276(itcha) 125891210(itchb)
PLEP: 121947014(itchb) 121956818(itcha)
SLUC: 116040739(itchb) 116051414(itcha)
ECRA: 117943460(itcha) 117947062(itchb)
GAT: 120828797(itchb) 120834580(itcha)
PPUG: 119222797(itchb) 119229686
MSAM: 119886410(itcha) 119905958(itchb)
CUD: 121506844(itcha) 121517310(itchb)
ALAT: 119021293(itcha) 119022197(itchb)
OAU: 116311216(itchb) 116326846(itcha)
OML: 112144968(itcha) 112158896(itchb)
XCO: 114134640(itch) 114135506
PRET: 103464828 103467052(itch)
PFOR: 103150133(itch) 103156105
PMEI: 106923330(itch)
GAF: 122823917(itchb) 122834214(itcha)
GMU: 124856772(itcha) 124868273(itchb)
NFU: 107385376(itch) 107391319
KMR: 108231686(itcha) 108233117(itchb)
ALIM: 106517648(itch) 106522383
NWH: 119411866(itcha) 119417732(itchb)
AOCE: 111574438 111576049(itch)
MCEP: 125006506(itcha) 125022491(itchb)
CSEM: 103384749(itch) 103386711
SSEN: 122768379(itcha) 122776851(itchb)
HHIP: 117761475 117765289(itchb)
HSP: 118104948(itcha) 118110539(itchb)
LCF: 108882654(itchb) 108902110(itcha)
XGL: 120783007(itcha) 120804468(itchb)
BPEC: 110158088 110173739(itch)
BSPL: 114855782(itcha) 114858841(itchb)
SFM: 108918588 108939341(itch)
PKI: 111842301(itch) 111856426
AANG: 118208005(itchb) 118211380
LOC: 102682803(itch)
PSEX: 120538006(itcha)
LCM: 102365782(ITCH)
CMK: 103188616
RTP: 109914922
HMG: 100204448
 » show all
Reference
  Authors
Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL
  Title
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4.
  Journal
Dev Cell 5:709-22 (2003)
DOI:10.1016/S1534-5807(03)00321-6
  Sequence
[hsa:83737]
Reference
  Authors
Zhang P, Wang C, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L
  Title
The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation.
  Journal
J Biol Chem 285:8869-79 (2010)
DOI:10.1074/jbc.M109.063321
  Sequence
[hsa:83737]
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