KEGG   Castor canadensis (American beaver): 109682554
Entry
109682554         CDS       T04791                                 
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ccan  Castor canadensis (American beaver)
Pathway
ccan01521  EGFR tyrosine kinase inhibitor resistance
ccan01522  Endocrine resistance
ccan01524  Platinum drug resistance
ccan04012  ErbB signaling pathway
ccan04014  Ras signaling pathway
ccan04015  Rap1 signaling pathway
ccan04024  cAMP signaling pathway
ccan04062  Chemokine signaling pathway
ccan04066  HIF-1 signaling pathway
ccan04068  FoxO signaling pathway
ccan04070  Phosphatidylinositol signaling system
ccan04071  Sphingolipid signaling pathway
ccan04072  Phospholipase D signaling pathway
ccan04081  Hormone signaling
ccan04140  Autophagy - animal
ccan04145  Phagocytosis
ccan04150  mTOR signaling pathway
ccan04151  PI3K-Akt signaling pathway
ccan04152  AMPK signaling pathway
ccan04210  Apoptosis
ccan04211  Longevity regulating pathway
ccan04213  Longevity regulating pathway - multiple species
ccan04218  Cellular senescence
ccan04360  Axon guidance
ccan04370  VEGF signaling pathway
ccan04380  Osteoclast differentiation
ccan04510  Focal adhesion
ccan04517  IgSF CAM signaling
ccan04518  Integrin signaling
ccan04550  Signaling pathways regulating pluripotency of stem cells
ccan04611  Platelet activation
ccan04613  Neutrophil extracellular trap formation
ccan04620  Toll-like receptor signaling pathway
ccan04625  C-type lectin receptor signaling pathway
ccan04630  JAK-STAT signaling pathway
ccan04650  Natural killer cell mediated cytotoxicity
ccan04660  T cell receptor signaling pathway
ccan04662  B cell receptor signaling pathway
ccan04664  Fc epsilon RI signaling pathway
ccan04666  Fc gamma R-mediated phagosome formation
ccan04668  TNF signaling pathway
ccan04670  Leukocyte transendothelial migration
ccan04722  Neurotrophin signaling pathway
ccan04725  Cholinergic synapse
ccan04750  Inflammatory mediator regulation of TRP channels
ccan04810  Regulation of actin cytoskeleton
ccan04910  Insulin signaling pathway
ccan04914  Progesterone-mediated oocyte maturation
ccan04915  Estrogen signaling pathway
ccan04917  Prolactin signaling pathway
ccan04919  Thyroid hormone signaling pathway
ccan04923  Regulation of lipolysis in adipocytes
ccan04926  Relaxin signaling pathway
ccan04929  GnRH secretion
ccan04930  Type II diabetes mellitus
ccan04931  Insulin resistance
ccan04932  Non-alcoholic fatty liver disease
ccan04933  AGE-RAGE signaling pathway in diabetic complications
ccan04935  Growth hormone synthesis, secretion and action
ccan04960  Aldosterone-regulated sodium reabsorption
ccan04973  Carbohydrate digestion and absorption
ccan05010  Alzheimer disease
ccan05017  Spinocerebellar ataxia
ccan05020  Prion disease
ccan05100  Bacterial invasion of epithelial cells
ccan05135  Yersinia infection
ccan05142  Chagas disease
ccan05146  Amoebiasis
ccan05160  Hepatitis C
ccan05161  Hepatitis B
ccan05162  Measles
ccan05163  Human cytomegalovirus infection
ccan05164  Influenza A
ccan05165  Human papillomavirus infection
ccan05166  Human T-cell leukemia virus 1 infection
ccan05167  Kaposi sarcoma-associated herpesvirus infection
ccan05168  Herpes simplex virus 1 infection
ccan05169  Epstein-Barr virus infection
ccan05170  Human immunodeficiency virus 1 infection
ccan05171  Coronavirus disease
ccan05200  Pathways in cancer
ccan05203  Viral carcinogenesis
ccan05205  Proteoglycans in cancer
ccan05206  MicroRNAs in cancer
ccan05207  Chemical carcinogenesis - receptor activation
ccan05208  Chemical carcinogenesis - reactive oxygen species
ccan05210  Colorectal cancer
ccan05211  Renal cell carcinoma
ccan05212  Pancreatic cancer
ccan05213  Endometrial cancer
ccan05214  Glioma
ccan05215  Prostate cancer
ccan05218  Melanoma
ccan05220  Chronic myeloid leukemia
ccan05221  Acute myeloid leukemia
ccan05222  Small cell lung cancer
ccan05223  Non-small cell lung cancer
ccan05224  Breast cancer
ccan05225  Hepatocellular carcinoma
ccan05226  Gastric cancer
ccan05230  Central carbon metabolism in cancer
ccan05231  Choline metabolism in cancer
ccan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccan05415  Diabetic cardiomyopathy
ccan05417  Lipid and atherosclerosis
ccan05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccan00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    109682554
   04014 Ras signaling pathway
    109682554
   04015 Rap1 signaling pathway
    109682554
   04370 VEGF signaling pathway
    109682554
   04630 JAK-STAT signaling pathway
    109682554
   04668 TNF signaling pathway
    109682554
   04066 HIF-1 signaling pathway
    109682554
   04068 FoxO signaling pathway
    109682554
   04070 Phosphatidylinositol signaling system
    109682554
   04072 Phospholipase D signaling pathway
    109682554
   04071 Sphingolipid signaling pathway
    109682554
   04024 cAMP signaling pathway
    109682554
   04151 PI3K-Akt signaling pathway
    109682554
   04152 AMPK signaling pathway
    109682554
   04150 mTOR signaling pathway
    109682554
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    109682554
   04517 IgSF CAM signaling
    109682554
   04518 Integrin signaling
    109682554
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    109682554
   04140 Autophagy - animal
    109682554
  09143 Cell growth and death
   04210 Apoptosis
    109682554
   04218 Cellular senescence
    109682554
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109682554
   04550 Signaling pathways regulating pluripotency of stem cells
    109682554
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109682554
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109682554
   04613 Neutrophil extracellular trap formation
    109682554
   04620 Toll-like receptor signaling pathway
    109682554
   04625 C-type lectin receptor signaling pathway
    109682554
   04650 Natural killer cell mediated cytotoxicity
    109682554
   04660 T cell receptor signaling pathway
    109682554
   04662 B cell receptor signaling pathway
    109682554
   04664 Fc epsilon RI signaling pathway
    109682554
   04666 Fc gamma R-mediated phagosome formation
    109682554
   04670 Leukocyte transendothelial migration
    109682554
   04062 Chemokine signaling pathway
    109682554
  09152 Endocrine system
   04910 Insulin signaling pathway
    109682554
   04923 Regulation of lipolysis in adipocytes
    109682554
   04929 GnRH secretion
    109682554
   04915 Estrogen signaling pathway
    109682554
   04914 Progesterone-mediated oocyte maturation
    109682554
   04917 Prolactin signaling pathway
    109682554
   04926 Relaxin signaling pathway
    109682554
   04935 Growth hormone synthesis, secretion and action
    109682554
   04919 Thyroid hormone signaling pathway
    109682554
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    109682554
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109682554
  09156 Nervous system
   04725 Cholinergic synapse
    109682554
   04722 Neurotrophin signaling pathway
    109682554
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109682554
  09158 Development and regeneration
   04360 Axon guidance
    109682554
   04380 Osteoclast differentiation
    109682554
  09149 Aging
   04211 Longevity regulating pathway
    109682554
   04213 Longevity regulating pathway - multiple species
    109682554
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109682554
   05206 MicroRNAs in cancer
    109682554
   05205 Proteoglycans in cancer
    109682554
   05207 Chemical carcinogenesis - receptor activation
    109682554
   05208 Chemical carcinogenesis - reactive oxygen species
    109682554
   05203 Viral carcinogenesis
    109682554
   05230 Central carbon metabolism in cancer
    109682554
   05231 Choline metabolism in cancer
    109682554
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109682554
  09162 Cancer: specific types
   05210 Colorectal cancer
    109682554
   05212 Pancreatic cancer
    109682554
   05225 Hepatocellular carcinoma
    109682554
   05226 Gastric cancer
    109682554
   05214 Glioma
    109682554
   05221 Acute myeloid leukemia
    109682554
   05220 Chronic myeloid leukemia
    109682554
   05218 Melanoma
    109682554
   05211 Renal cell carcinoma
    109682554
   05215 Prostate cancer
    109682554
   05213 Endometrial cancer
    109682554
   05224 Breast cancer
    109682554
   05222 Small cell lung cancer
    109682554
   05223 Non-small cell lung cancer
    109682554
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109682554
   05170 Human immunodeficiency virus 1 infection
    109682554
   05161 Hepatitis B
    109682554
   05160 Hepatitis C
    109682554
   05171 Coronavirus disease
    109682554
   05164 Influenza A
    109682554
   05162 Measles
    109682554
   05168 Herpes simplex virus 1 infection
    109682554
   05163 Human cytomegalovirus infection
    109682554
   05167 Kaposi sarcoma-associated herpesvirus infection
    109682554
   05169 Epstein-Barr virus infection
    109682554
   05165 Human papillomavirus infection
    109682554
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    109682554
   05100 Bacterial invasion of epithelial cells
    109682554
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109682554
   05142 Chagas disease
    109682554
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109682554
   05017 Spinocerebellar ataxia
    109682554
   05020 Prion disease
    109682554
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109682554
   05418 Fluid shear stress and atherosclerosis
    109682554
   05415 Diabetic cardiomyopathy
    109682554
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109682554
   04932 Non-alcoholic fatty liver disease
    109682554
   04931 Insulin resistance
    109682554
   04933 AGE-RAGE signaling pathway in diabetic complications
    109682554
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109682554
   01524 Platinum drug resistance
    109682554
   01522 Endocrine resistance
    109682554
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ccan04131]
    109682554
Membrane trafficking [BR:ccan04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    109682554
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 ODF2_C SH2_1 SH3_9 ATG11
Other DBs
NCBI-GeneID: 109682554
NCBI-ProteinID: XP_020013435
UniProt: A0A250Y4J7 A0AC58KXH9
LinkDB
Position
Unknown
AA seq 719 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDMLVVSRAALQALGVSEGGERCPQSVGWMPGF
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPHDGAPEPGLTLPDLPEQFSP
PDVAPPILVRLVEAMEQTGLDGDALCRPELPAARTDWALGDVDQWDTAALSDGIKAFLRA
LPAALLTPEAAAEAHRALREAAGPVGPVLEPPTLPLHRALTLRFLLQHLARVARRAPAPG
PAVRALAAAFGPLLLPTAPPGGAPDGSEPSPDFPALLVEKLLRELLEEREVAPPALPPKP
SRAKPGPANGGSAPALQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTL
RKGGNNKLIKVFHRDGHYGFSEPLTFGSVVDLITHYRHESLAQYNAKLDTRLLYPVSKHQ
QDQVVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIK
IFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRAKLEQDLRAQ
ASDNREIDKRMNSLKPDLLRLRKTRDQYLLWLTQKGARQKNINEWLGIRNEAEDQYALME
DEDDLPHHEERTWYVGKINRTQAEEMLSGRRDGTFLIRESSQRGCYACSVVVDGDTKHCV
IYRTATGFGFAEPYNLYGSLKELVLHYQHASLMQHNDALAVTLAHPVRAPGPGPPPTAR
NT seq 2160 nt   +upstreamnt  +downstreamnt
atggccggcgccgagggcttccagtaccgcgcgctgtacccgttccgccgggagcggcct
gaggacctggagctgctgcccggcgacatgctggtggtcagcagggcggccctgcaggcg
ctgggcgtgagcgagggcggcgagcgctgcccgcagagcgtgggctggatgcccgggttt
aacgagcgcacacggcagcgcggtgacttccccggcacctacgtggagttcctggggccc
gtggccctggcccggcctggccctcgtccgcgaggcccccgcccgctgcccgccaggccc
cacgacggagcccctgagccaggcctcacgctccccgacctgcccgagcagttctccccg
cccgacgtggcgccccccatcctggtgaggctggtggaagccatggagcagacagggctg
gacggcgacgctctctgcaggcccgagttgccggccgccaggacagactgggccctgggg
gacgtggaccagtgggacaccgccgccctgtccgacggcatcaaggccttcctgcgggcc
ctgcctgcagccctgctgacccccgaggccgcggccgaggcgcaccgggccctgcgggag
gccgcggggcccgtggggccggtgctggagcccccgacgctgccgctgcaccgcgcgctc
acgctgcgcttcctgctccagcacctggcgcgcgtggcccgccgcgcgcccgcccccggc
cccgccgtccgcgcgctggccgccgccttcgggccgctgctgctgcccaccgcgccgcca
gggggcgcgcctgacgggagcgagccgagccccgacttccccgcgctgctggtggagaag
ctgctgcgtgagctcctggaggagcgggaggttgcgcccccagccctgccgcccaagccg
tccagggccaagccgggcccggccaacgggggcagcgcgccggccctgcaggacgccgag
tggtactggggggacatctccagggaggaggtgaacgagaagctgcgggacacgcccgac
ggcaccttcctcgtgcgggacgcgtccagcaagatccagggcgagtacacgctgacgctc
aggaagggcgggaacaacaagctgatcaaggtcttccaccgcgacggccactacggcttc
tcggagccgctgaccttcggctccgtggtggacctcatcacgcactaccgccacgagtca
ctggcccagtacaacgccaagctggacacgcggctgctctaccccgtgtccaagcaccag
caggaccaggtcgtcaaggaggacagcgtggaggccgtgggcgcccagctcaaggtctac
caccagcagtaccaggacaagagccgcgagtacgaccagctgtacgaggagtacacgcgg
acctcacaggagctgcagatgaagcgcacagccatcgaggcgttcaacgagaccatcaag
atcttcgaggagcaaggccagacgcaggagaagtgcagcaaggagtacctggagcgcttc
cggcgggagggcaacgagaaggagatgcagaggatcctgctgaactcggagcggctcaag
tcccgcatcgccgagatccacgagagccgcgccaagctggagcaggacctgcgggcgcag
gcgtcggacaaccgcgagatcgacaagcgcatgaacagcctgaagcccgacctgctgcgc
ctgcgcaagacgcgggaccagtacctgctgtggctcacccagaaaggcgcccggcagaag
aacatcaacgagtggctggggatcagaaatgaggctgaggaccagtacgcgctgatggag
gacgaggacgacctgccgcaccacgaggagcgcacctggtacgtgggcaaaatcaaccgg
acgcaggcggaagagatgctgagcggccggcgggacgggacgttcctcatccgggagagc
agccagcggggctgctacgcctgctccgtcgtggtggacggggacaccaagcactgcgtc
atctaccgcacggccaccggcttcggcttcgcggagccctacaacctgtacggctcgctg
aaggagctggtgctccattaccagcatgcatccctcatgcagcacaacgacgcgctggcc
gtcaccctcgcccaccccgtgcgcgccccgggcccggggccgccgcccaccgcgcgctga

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