Castor canadensis (American beaver): 109689613 Help Entry 109689613         CDS       T04791                                  Symbol Casp8 Name (RefSeq) caspase-8   KO K04398   caspase 8 [EC:3.4.22.61] Organism ccan  Castor canadensis (American beaver) Pathway ccan01524   Platinum drug resistance ccan04115   p53 signaling pathway ccan04210   Apoptosis ccan04215   Apoptosis - multiple species ccan04217   Necroptosis ccan04620   Toll-like receptor signaling pathway ccan04621   NOD-like receptor signaling pathway ccan04622   RIG-I-like receptor signaling pathway ccan04623   Cytosolic DNA-sensing pathway ccan04625   C-type lectin receptor signaling pathway ccan04657   IL-17 signaling pathway ccan04668   TNF signaling pathway ccan04932   Non-alcoholic fatty liver disease ccan04936   Alcoholic liver disease ccan05010   Alzheimer disease ccan05016   Huntington disease ccan05022   Pathways of neurodegeneration - multiple diseases ccan05132   Salmonella infection ccan05134   Legionellosis ccan05142   Chagas disease ccan05145   Toxoplasmosis ccan05152   Tuberculosis ccan05160   Hepatitis C ccan05161   Hepatitis B ccan05162   Measles ccan05163   Human cytomegalovirus infection ccan05164   Influenza A ccan05165   Human papillomavirus infection ccan05167   Kaposi sarcoma-associated herpesvirus infection ccan05168   Herpes simplex virus 1 infection ccan05169   Epstein-Barr virus infection ccan05170   Human immunodeficiency virus 1 infection ccan05200   Pathways in cancer ccan05203   Viral carcinogenesis ccan05416   Viral myocarditis ccan05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:ccan00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     109689613 (Casp8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     109689613 (Casp8)    04215 Apoptosis - multiple species     109689613 (Casp8)    04217 Necroptosis     109689613 (Casp8)    04115 p53 signaling pathway     109689613 (Casp8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     109689613 (Casp8)    04621 NOD-like receptor signaling pathway     109689613 (Casp8)    04622 RIG-I-like receptor signaling pathway     109689613 (Casp8)    04623 Cytosolic DNA-sensing pathway     109689613 (Casp8)    04625 C-type lectin receptor signaling pathway     109689613 (Casp8)    04657 IL-17 signaling pathway     109689613 (Casp8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     109689613 (Casp8)    05203 Viral carcinogenesis     109689613 (Casp8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     109689613 (Casp8)    05161 Hepatitis B     109689613 (Casp8)    05160 Hepatitis C     109689613 (Casp8)    05164 Influenza A     109689613 (Casp8)    05162 Measles     109689613 (Casp8)    05168 Herpes simplex virus 1 infection     109689613 (Casp8)    05163 Human cytomegalovirus infection     109689613 (Casp8)    05167 Kaposi sarcoma-associated herpesvirus infection     109689613 (Casp8)    05169 Epstein-Barr virus infection     109689613 (Casp8)    05165 Human papillomavirus infection     109689613 (Casp8)   09171 Infectious disease: bacterial    05132 Salmonella infection     109689613 (Casp8)    05134 Legionellosis     109689613 (Casp8)    05152 Tuberculosis     109689613 (Casp8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     109689613 (Casp8)    05142 Chagas disease     109689613 (Casp8)   09164 Neurodegenerative disease    05010 Alzheimer disease     109689613 (Casp8)    05016 Huntington disease     109689613 (Casp8)    05022 Pathways of neurodegeneration - multiple diseases     109689613 (Casp8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     109689613 (Casp8)    05416 Viral myocarditis     109689613 (Casp8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     109689613 (Casp8)    04932 Non-alcoholic fatty liver disease     109689613 (Casp8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     109689613 (Casp8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:ccan01002]     109689613 (Casp8) Enzymes [BR:ccan01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      109689613 (Casp8) Peptidases and inhibitors [BR:ccan01002]  Cysteine peptidases   Family C14: caspase family    109689613 (Casp8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Peptidase_C14 DED PYRIN DCX2_DCDC1 Motif Other DBs NCBI-GeneID:  109689613 NCBI-ProteinID:  XP_020024141 UniProt:  A0A8B7UWT7 LinkDB All DBs Position Unknown AA seq 483 aa AA seqDB search MDFSECLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDTLMLFQRLQEKGMLEEGNLS FLKELLFRINRLDLLQTFLATTKEEMEKELQILGRAQISAYRVMLFQVSEDVDKQELKSF KFFLNKEISKCKLDNDMSLLDIFTEMEKRVLLGETNLDILKRICEQINKSLLGKINDYEL RRCSDNLTERRMSIEGCSDSFLNGEGSLGALAMSDSPREQDSESQTSDKAYQMKNKPRGY CLIFNNYDFSVARKSVPKLHNIKDRKGTDLDEETLRQTFKMLHFEIILYKNATAKEIYEV LQSYQTMDHNNKDCFVCCILSHGDKGIVYGTDGKQASIYELTSYFTGSKCPSLAGKPKVF FIQACQGENYHQAIPIDTDSEQDTYLEMDSSSQKRYIPDEADFLLGMATVTNCVSYRDPL RGTWFIQSLCRSLKERCPLGDDILTILTEVNYEVSNKDDWKNMGKQMPQPTFTLRKKLFF PLK NT seq 1452 nt NT seq  +upstreamnt  +downstreamnt atggatttcagtgagtgtctttacaatattggggagcaacttgacagtgatgagttggcc tctctcaagttcctgagcctagactacatcccacaaaagaaacaagagcccatcaaggat actttgatgctattccagagactgcaggagaaaggaatgttggaggaaggcaatctgtcc ttcttgaaggagctgcttttccgaattaatagactggacctgctgcaaacttttctggcc acaaccaaggaagagatggaaaaagagctccagattctaggcagggcccagatttctgcc tacagggtaatgctttttcaagtttcagaagatgtagacaagcaggaattgaagtctttt aagttttttttgaacaaggagatctccaagtgtaagctggataatgacatgagtttgctc gatattttcacagagatggagaagagagtcctcctaggtgaaacaaacttggacatcctg aaaagaatctgtgagcaaatcaacaagagcctgctgggaaagatcaatgactatgaattg agaagatgtagcgacaatctgacagagagaagaatgagcattgaaggatgttcagattca tttttgaatggggaggggtccctcggagcactggcaatgtcagactctccaagagaacaa gacagtgagtcacagacatcggacaaagcttaccaaatgaaaaacaaaccaagaggatac tgtttaatcttcaacaattacgattttagcgtggcacggaaaagcgtacctaaacttcac aacattaaggataggaaaggaacagacttggatgaagagactttgagacaaacctttaag atgcttcattttgagataatactttacaaaaacgccacagcaaaggaaatctatgaggtt ctacaatcctatcaaactatggaccacaataacaaagactgctttgtctgctgtatcctc tcccatggagacaaaggcattgtctatggcaccgacggaaagcaggcctccatctatgaa ctgacatcttatttcactggttccaagtgcccttccctggctggaaaacccaaagtcttt tttattcaggcttgtcaaggggaaaactatcatcaagctatacctattgacactgactca gagcaggacacctatttagaaatggactcatcatctcaaaagagatatatcccagatgag gctgactttctgctggggatggccactgtgaccaactgtgtttcctaccgagaccccttg agagggacctggtttatccagtcactttgccggagtctgaaggaaagatgtcctctaggt gatgacattctcaccatcctaactgaagtaaactatgaagtgagcaataaagacgactgg aagaacatggggaaacagatgccacagcctaccttcacactaaggaaaaaactcttcttc cctcttaagtga

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