ORTHOLOGY: K04398
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Entry
K04398 KO
Symbol
CASP8
Name
caspase 8 [EC:
3.4.22.61
]
Pathway
map01524
Platinum drug resistance
map04115
p53 signaling pathway
map04210
Apoptosis
map04214
Apoptosis - fly
map04215
Apoptosis - multiple species
map04217
Necroptosis
map04620
Toll-like receptor signaling pathway
map04621
NOD-like receptor signaling pathway
map04622
RIG-I-like receptor signaling pathway
map04623
Cytosolic DNA-sensing pathway
map04624
Toll and Imd signaling pathway
map04625
C-type lectin receptor signaling pathway
map04657
IL-17 signaling pathway
map04668
TNF signaling pathway
map04932
Non-alcoholic fatty liver disease
map04936
Alcoholic liver disease
map05010
Alzheimer disease
map05016
Huntington disease
map05022
Pathways of neurodegeneration - multiple diseases
map05130
Pathogenic Escherichia coli infection
map05132
Salmonella infection
map05134
Legionellosis
map05142
Chagas disease
map05145
Toxoplasmosis
map05152
Tuberculosis
map05160
Hepatitis C
map05161
Hepatitis B
map05162
Measles
map05163
Human cytomegalovirus infection
map05164
Influenza A
map05165
Human papillomavirus infection
map05167
Kaposi sarcoma-associated herpesvirus infection
map05168
Herpes simplex virus 1 infection
map05169
Epstein-Barr virus infection
map05170
Human immunodeficiency virus 1 infection
map05200
Pathways in cancer
map05203
Viral carcinogenesis
map05416
Viral myocarditis
map05417
Lipid and atherosclerosis
Disease
H00048
Hepatocellular carcinoma
H00108
Autoimmune lymphoproliferative syndromes
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
K04398 CASP8; caspase 8
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
K04398 CASP8; caspase 8
04214 Apoptosis - fly
K04398 CASP8; caspase 8
04215 Apoptosis - multiple species
K04398 CASP8; caspase 8
04217 Necroptosis
K04398 CASP8; caspase 8
04115 p53 signaling pathway
K04398 CASP8; caspase 8
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
K04398 CASP8; caspase 8
04624 Toll and Imd signaling pathway
K04398 CASP8; caspase 8
04621 NOD-like receptor signaling pathway
K04398 CASP8; caspase 8
04622 RIG-I-like receptor signaling pathway
K04398 CASP8; caspase 8
04623 Cytosolic DNA-sensing pathway
K04398 CASP8; caspase 8
04625 C-type lectin receptor signaling pathway
K04398 CASP8; caspase 8
04657 IL-17 signaling pathway
K04398 CASP8; caspase 8
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K04398 CASP8; caspase 8
05203 Viral carcinogenesis
K04398 CASP8; caspase 8
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
K04398 CASP8; caspase 8
05161 Hepatitis B
K04398 CASP8; caspase 8
05160 Hepatitis C
K04398 CASP8; caspase 8
05164 Influenza A
K04398 CASP8; caspase 8
05162 Measles
K04398 CASP8; caspase 8
05168 Herpes simplex virus 1 infection
K04398 CASP8; caspase 8
05163 Human cytomegalovirus infection
K04398 CASP8; caspase 8
05167 Kaposi sarcoma-associated herpesvirus infection
K04398 CASP8; caspase 8
05169 Epstein-Barr virus infection
K04398 CASP8; caspase 8
05165 Human papillomavirus infection
K04398 CASP8; caspase 8
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
K04398 CASP8; caspase 8
05132 Salmonella infection
K04398 CASP8; caspase 8
05134 Legionellosis
K04398 CASP8; caspase 8
05152 Tuberculosis
K04398 CASP8; caspase 8
09174 Infectious disease: parasitic
05145 Toxoplasmosis
K04398 CASP8; caspase 8
05142 Chagas disease
K04398 CASP8; caspase 8
09164 Neurodegenerative disease
05010 Alzheimer disease
K04398 CASP8; caspase 8
05016 Huntington disease
K04398 CASP8; caspase 8
05022 Pathways of neurodegeneration - multiple diseases
K04398 CASP8; caspase 8
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
K04398 CASP8; caspase 8
05416 Viral myocarditis
K04398 CASP8; caspase 8
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
K04398 CASP8; caspase 8
04932 Non-alcoholic fatty liver disease
K04398 CASP8; caspase 8
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
K04398 CASP8; caspase 8
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors
K04398 CASP8; caspase 8
Enzymes [BR:
ko01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.61 caspase-8
K04398 CASP8; caspase 8
Peptidases and inhibitors [BR:
ko01002
]
Cysteine peptidases
Family C14: caspase family
K04398 CASP8; caspase 8
BRITE hierarchy
Other DBs
GO:
0097199
Genes
HSA:
841
(CASP8)
PTR:
746477
(CASP8)
PPS:
100978497
(CASP8)
GGO:
101138898
(CASP8)
PON:
100172115
(CASP8)
NLE:
100586183
(CASP8)
MCC:
702781
(CASP8)
MCF:
101865354
(CASP8)
MTHB:
126932110
CSAB:
103217637
(CASP8)
CATY:
105580035
(CASP8)
PANU:
101009470
(CASP8)
TGE:
112636264
(CASP8)
RRO:
104671864
(CASP8)
RBB:
108532002
(CASP8)
TFN:
117094661
(CASP8)
PTEH:
111547169
(CASP8)
CANG:
105517408
(CASP8)
CJC:
100395220
(CASP8)
SBQ:
101053601
(CASP8)
CSYR:
103273365
(CASP8)
MMUR:
105856959
(CASP8)
LCAT:
123643895
(CASP8)
PCOQ:
105819477
(CASP8)
OGA:
100965468
(CASP8)
MMU:
12370
(Casp8)
MCAL:
110291975
(Casp8)
MPAH:
110321675
(Casp8)
RNO:
64044
(Casp8)
MCOC:
116088467
(Casp8)
MUN:
110557662
(Casp8)
CGE:
100689369
(Casp8)
MAUA:
101825474
(Casp8)
PLEU:
114704437
(Casp8)
MORG:
121444834
121458619
MFOT:
126511842
AAMP:
119803862
(Casp8)
NGI:
103738672
(Casp8)
HGL:
101702773
(Casp8)
CPOC:
100713334
(Casp8)
CCAN:
109689613
(Casp8)
DORD:
105981481
(Casp8)
DSP:
122096450
(Casp8)
NCAR:
124980441
OCU:
100348477
OPI:
101521762
(CASP8)
TUP:
102498355
(CASP8)
GVR:
103597790
(CASP8)
CFA:
488473
(CASP8)
CLUD:
112656364
(CASP8)
VVP:
112922873
(CASP8)
VLG:
121480703
(CASP8)
AML:
100472842
(CASP8)
UMR:
103659742
(CASP8)
UAH:
113250592
(CASP8)
UAR:
123798200
(CASP8)
ELK:
111141026
LLV:
125094998
MPUF:
101678102
(CASP8)
ORO:
101365855
(CASP8)
EJU:
114223527
(CASP8)
ZCA:
113919983
(CASP8)
MLX:
118012152
(CASP8)
NSU:
110592166
(CASP8)
LWW:
102733039
(CASP8)
FCA:
100142684
(CASP8)
PYU:
121030909
(CASP8)
PBG:
122481641
(CASP8)
LRUF:
124515468
PTG:
102962460
(CASP8)
PPAD:
109260762
(CASP8)
AJU:
106987995
(CASP8)
HHV:
120220675
(CASP8)
BTA:
507481
(CASP8)
BOM:
102272602
(CASP8)
BIU:
109569521
(CASP8)
BBUB:
102412929
(CASP8)
BBIS:
105003655
(CASP8)
CHX:
102169919
(CASP8)
OAS:
101107334
(CASP8)
ODA:
120854621
(CASP8)
CCAD:
122426570
(CASP8)
SSC:
595105
(CASP8)
CFR:
102508224
(CASP8)
CBAI:
105082299
(CASP8)
CDK:
105099181
(CASP8)
VPC:
102542071
(CASP8)
BACU:
103004642
(CASP8)
LVE:
103077054
(CASP8)
OOR:
101281780
(CASP8)
DLE:
111171726
(CASP8)
PCAD:
102988082
(CASP8)
PSIU:
116757029
(CASP8)
ECB:
100066502
(CASP8)
EPZ:
103565685
(CASP8)
EAI:
106823493
(CASP8)
MYB:
102246377
(CASP8)
MYD:
102761550
(CASP8)
MMYO:
118661495
(CASP8)
MLF:
102439369
(CASP8)
MNA:
107533931
(CASP8)
PKL:
118709494
(CASP8)
HAI:
109379228
(CASP8)
DRO:
112307787
(CASP8)
SHON:
118985238
(CASP8)
AJM:
119065511
(CASP8)
PDIC:
114494575
(CASP8)
PHAS:
123824482
(CASP8)
MMF:
118625346
(CASP8)
RFQ:
117025976
(CASP8)
PALE:
102878181
(CASP8)
PGIG:
120587528
(CASP8)
PVP:
105298127
(CASP8)
RAY:
107503155
(CASP8)
MJV:
108398898
(CASP8)
TOD:
119256101
(CASP8)
SARA:
101543078
(CASP8)
LAV:
100660542
(CASP8)
100663575
TMU:
101344302
ETF:
101638051
(CASP8)
DNM:
101432853
(CASP8)
MDO:
100017025
(CASP18)
100617599
(CASP8)
GAS:
123240075
123242697
SHR:
100931580
(CASP8)
PCW:
110197193
(CASP8)
OAA:
100082949
(CASP8)
100087835
GGA:
395284
(CASP8)
693266
(CASP18)
PCOC:
116233978
116233979
MGP:
100541513
100541666
CJO:
107316523
107316524
NMEL:
110399293
110400694
APLA:
101803161
(CASP8)
106014283
ACYG:
106040002
106040004
(CASP8)
AFUL:
116490786
116491006
TGU:
100222284
100223333
LSR:
110484576
(CASP8)
110484625
SCAN:
103814506
103814507
(CASP8)
PMOA:
120497940
120498528
OTC:
121335473
121335530
PRUF:
121356474
121356691
GFR:
102044546
102044717
FAB:
101814031
101815602
PHI:
102110759
PMAJ:
107207226
(CASP8)
117244691
CCAE:
111931990
CCW:
104693779
120410336
CBRC:
103612136
(CASP8)
ETL:
114055714
114055715
ZAB:
102073111
(CASP8)
102073459
ACHL:
103803668
103805840
(CASP8)
FPG:
101916968
(CASP8)
106113022
FCH:
106630990
(CASP8)
CLV:
102084608
102084797
EGZ:
104130511
(CASP8)
NNI:
104010196
(CASP8)
PLET:
104623365
104625043
(CASP8)
PCRI:
104032112
PCAO:
104042978
104051994
(CASP8)
ACUN:
113482526
113482527
TALA:
104356172
104357512
(CASP8)
PADL:
103923440
103924262
(CASP8)
AFOR:
103903455
(CASP8)
103903456
ACHC:
115342550
115343326
HALD:
104319289
104322668
HLE:
104830055
(CASP8)
104830116
AGEN:
126048220
GCL:
127018346
127018651
CCRI:
104156046
(CASP8)
104158038
CSTI:
104549333
104555644
EHS:
104504336
104514809
(CASP8)
CMAC:
104478549
(CASP8)
104485083
MUI:
104536360
104536361
FGA:
104082182
GSTE:
104255507
(CASP8)
104262083
LDI:
104342577
(CASP8)
104346345
MNB:
103772020
(CASP8)
OHA:
104334215
(CASP8)
NNT:
104406622
104409396
(CASP8)
DPUB:
104296653
(CASP8)
104296667
PGUU:
104459593
104467331
(CASP8)
ACAR:
104523966
104532423
(CASP8)
CPEA:
104397385
104397386
AVIT:
104280785
(CASP8)
CVF:
104290991
(CASP8)
CUCA:
104058292
104058293
TEO:
104375427
(CASP8)
BRHI:
104492696
(CASP8)
104500748
AAM:
106492412
106492473
(CASP8)
AROW:
112976408
(CASP8)
112976426
NPD:
112956289
112956309
TGT:
104577131
104577132
DNE:
112988234
(CASP8)
112988375
SCAM:
104150167
(CASP8)
104150169
ASN:
102384848
102385102
AMJ:
102573591
(CASP8)
102575862
(CASP18)
CPOO:
109323090
GGN:
109301903
PSS:
102446244
102447455
CMY:
102931356
102934251
CPIC:
101934006
101934828
TST:
117884831
117885137
CABI:
116836075
(CASP8)
116836078
MRV:
120374759
(CASP8)
120374760
XLA:
373559
(casp8.L)
XTR:
100495471
(casp8)
NPR:
108795080
RTEM:
120943730
BBUF:
121008461
BGAR:
122945081
DRE:
100049706
(casp8l1)
557302
(casp8l2)
561021
(casp22)
58022
(casp8)
SRX:
107705601
107747226
107748560
107748577
107756543
SANH:
107660005
107660083
107660089
107670339
107672910
107680357
107688858
107688860
107689487
SGH:
107555418
107555445
107560797
107566313
107597346
CCAR:
109052822
109053966
109053967
109053969
109064153
109083181
109090355
CAUA:
113048839
113050791
113050793
113088368
113093418
113093474
113108941
PPRM:
120469557
(casp10)
120470089
(casp22)
120491686
MAMB:
125266561
(casp22)
125268421
125269841
(casp10)
125274320
(casp8l1)
125274321
IPU:
100304635
108266930
(casp10)
108273098
(casp8)
108273129
PHYP:
113524385
113525919
113538271
SMEO:
124382628
(casp8)
124382766
(casp10)
TFD:
113634469
(casp8)
113654221
(casp10)
AMEX:
103021896
103036076
103036379
103037118
EEE:
113574024
113582334
113588302
TRU:
101061322
101075191
101075631
TNG:
GSTEN00031473G001
LCO:
104924422
104938225
104938227
NCC:
104948647
104966261
CGOB:
115022634
115022799
115026772
ELY:
117249157
(casp10)
117271493
(casp8)
117271616
EFO:
125899933
(casp10)
125902003
(casp8)
125902004
PLEP:
121939222
121949527
(casp10)
121951363
(casp8)
121951365
SLUC:
116048004
(casp10)
116055058
116055079
(casp8)
ECRA:
117953418
(casp10)
117954805
(casp8)
117954806
ESP:
116698760
116698766
PFLV:
114563975
114565779
114565858
GAT:
100653426
(casp8)
100653427
(casp10)
120816322
PPUG:
119209177
(casp8)
119209185
119209565
119209566
119229023
(casp10)
MSAM:
119902446
119902447
119902448
119904125
(casp10)
CUD:
121520232
121520520
121520654
121522126
(casp10)
ALAT:
119010726
119011511
119026092
(casp10)
MZE:
101470036
101475706
101478827
101481407
106674852
106676518
112430088
112430089
ONL:
100702139
100702676
102079913
109194206
OAU:
116321529
116321530
116321532
116321534
116321548
116322912
(casp10)
OLA:
100049400
(casp8)
100125536
OML:
112147424
(casp8)
112147426
XMA:
102237443
102237850
111608841
XCO:
114147136
114147142
114147894
114151637
XHE:
116721891
116722140
116722737
PRET:
103459939
103478931
103478932
108167062
PFOR:
103134398
103151557
103151574
PLAI:
106958504
106961428
PMEI:
106924075
106924079
106926427
106934087
GAF:
122840130
(casp10)
122840676
122840680
122840684
122840687
122841345
CVG:
107082055
107086818
107086824
CTUL:
119779267
119779311
119780252
(casp10)
GMU:
124869876
124870505
(casp8)
124871764
(casp10)
NFU:
107384290
107384292
107389982
KMR:
108238317
(casp8)
108238318
108239714
(casp10)
ALIM:
106512618
106512902
106517939
NWH:
119414875
(casp8)
119414876
119418871
(casp10)
AOCE:
111586360
111588089
111588095
111588107
MCEP:
125018228
(casp10)
CSEM:
103396237
103396239
POV:
109631024
109637364
109641073
SSEN:
122760804
(casp10)
122761240
(casp8)
122775595
HHIP:
117755099
(casp10)
117778078
(casp8)
117778299
HSP:
118117212
118117657
(casp8)
118120504
(prkra)
118120505
LCF:
108881527
108883888
(casp8)
SDU:
111218362
111229030
(casp8)
SLAL:
111648895
111666542
(casp8)
XGL:
120799083
(casp8)
120799085
120801861
(casp10)
HCQ:
109520533
BPEC:
110166585
110173494
(casp8)
110173519
MALB:
109958094
BSPL:
114844036
(casp8)
114844038
114847689
(casp10)
SASA:
106569473
106582462
106586254
STRU:
115155490
115157338
115160794
115169467
OTW:
112225661
(casp10)
112226687
(casp8)
112245958
112247430
OMY:
101268911
(casp8)
110502170
110508466
110520142
110530629
OGO:
124009734
124041578
(casp8)
124043892
ONE:
115102767
115109425
115114693
115119721
SALP:
111956905
111957166
111959935
111975582
111979249
111979568
SNH:
120020199
(casp8)
120056102
120058267
120063683
CCLU:
121536756
(casp10)
121554909
121581147
ELS:
105006190
105009870
105021259
105021271
105024762
SFM:
108918550
108918555
108920617
108920619
(casp8)
108932283
PKI:
111852220
111852221
111859671
111859672
AANG:
118214013
118222448
LOC:
102697443
(casp8)
102697635
102697829
PSPA:
121321941
121322097
121322099
121322100
121322854
121322856
121323064
121323616
ARUT:
117408587
117414260
117426351
117426603
117426878
PSEX:
120531926
LCM:
102349989
102355925
102356202
CMK:
103171902
RTP:
109915462
109929740
109932037
BFO:
118406076
118419602
118420396
118420457
118428976
118430951
BBEL:
109470585
109473442
109476237
109476238
109481944
CIN:
100183123
SCLV:
120339721
SPU:
105445989
585496
APLC:
110982622
110986601
SKO:
100369664
100375416
DME:
Dmel_CG7486
(Dredd)
DER:
6555550
DSE:
6615883
DSI:
Dsimw501_GD16467
(Dsim_Dredd)
DYA:
Dyak_GE16575
(Dyak_Dredd)
DAN:
6504896
DSR:
110182574
DPO:
4816060
DPE:
6599948
DMN:
108153528
DWI:
6644580
DGR:
6565876
DMO:
Dmoj_GI21675
DAZ:
108619540
DNV:
108656798
DHE:
111592986
DVI:
6633308
CCAT:
101452999
BOD:
106618890
RZE:
108370168
MDE:
101900122
SCAC:
106085869
LCQ:
111685143
111685144
LSQ:
119606412
119614517
119614518
AGA:
AgaP_AGAP011693
(CASPL1)
ACOZ:
120958709
AARA:
120903661
ASTE:
118505920
AAG:
5563818
AALB:
115262725
CQU:
CpipJ_CPIJ014995
CPII:
120417982
CNS:
116339550
BCOO:
119074810
AME:
724930
ACER:
107999646
ALAB:
122718768
BIM:
100741190
BBIF:
117214682
BVK:
117233219
BVAN:
117166605
BTER:
100652115
BPYO:
122568216
CCAL:
108627268
OBB:
114878450
NMEA:
116429669
CGIG:
122403524
SOC:
105205440
MPHA:
105828235
AEC:
105147270
ACEP:
105625685
PBAR:
105429159
VEM:
105558011
HST:
105190451
DQU:
106743797
CFO:
105248277
FEX:
115238151
LHU:
105678455
PGC:
109856665
OBO:
105280305
PCF:
106791240
PFUC:
122515454
VPS:
122635758
NVI:
100680000
CSOL:
105360146
MDL:
103579887
CGLO:
123267651
FAS:
105274222
DAM:
107048127
AGIF:
122861074
CCIN:
107273653
TCA:
661095
(Dredd)
DPA:
109534720
SOY:
115878704
ATD:
109598530
CSET:
123312727
AGB:
108903568
LDC:
111513505
NVL:
108556913
APLN:
108732887
PPYR:
116164321
116164534
OTU:
111420306
111421814
BMOR:
100141428
(Dredd)
BMAN:
114248879
MSEX:
115442338
115442360
119188347
DPL:
KGM_212093
BANY:
112043434
PMAC:
106720189
PPOT:
106109353
PXU:
106127201
PRAP:
110996855
ZCE:
119835017
HAW:
110369675
HZE:
124631255
TNL:
113491750
OFU:
114354995
PXY:
105390324
CLEC:
106661122
NLU:
111054479
PHU:
Phum_PHUM574530
FOC:
113202554
TPAL:
117639241
117654141
ZNE:
110835030
CSEC:
111866938
DMK:
116930618
PVM:
113822604
PJA:
122245041
122251197
122251198
122266756
PCHN:
125025732
125041108
125044277
125044384
HAME:
121855632
121871725
PCLA:
123765010
123765863
123765865
PTRU:
123508576
123508705
123518818
HAZT:
108668981
108675143
EAF:
111715246
PPOI:
119093108
119093774
DSV:
119466258
RSAN:
119371744
RMP:
119179927
CSCU:
111615099
PCAN:
112560982
BGT:
106054001
106078261
106078428
GAE:
121372573
121384420
121387437
121387656
121387773
HRF:
124110723
124110963
124111376
124111841
124112816
124132113
124134993
124143787
124149539
124152864
124152865
HRJ:
124257135
124262809
124265296
124267644
124273512
124273718
124275672
124277624
124279661
124279734
124280614
124284330
124288477
CRG:
105318843
105332613
105340890
105346084
117691806
117691813
117692646
MYI:
110449259
PMAX:
117317156
117317363
117327557
117328816
117328818
MMER:
123527736
123538317
123551007
123553922
123553927
123557524
LAK:
106152179
106171044
SMM:
Smp_141270
NVE:
5505811
EPA:
110231936
ATEN:
116289374
116297720
116298542
116298545
ADF:
107335805
AMIL:
114961919
PDAM:
113682606
SPIS:
111335203
DGT:
114530339
114534211
114539385
XEN:
124458193
HMG:
100203004
100207763
100579132
(casp8)
105843821
105846973
AQU:
100638885
105313668
105315966
105316143
105316853
109581722
109584594
» show all
Taxonomy
UniProt
Reference
PMID:
9931493
Authors
Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ
Title
Structure and chromosome localization of the human CASP8 gene.
Journal
Gene 226:225-32 (1999)
DOI:
10.1016/S0378-1119(98)00565-4
Sequence
[hsa:
841
]
LinkDB
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DBGET
integrated database retrieval system