KEGG ORTHOLOGY: K04398

ORTHOLOGY: K04398

Entry

K04398                      KO

Symbol

CASP8

Name

caspase 8 [EC:3.4.22.61]

Pathway

map01524

Platinum drug resistance

map04115

p53 signaling pathway

map04210

Apoptosis

map04214

Apoptosis - fly

map04215

Apoptosis - multiple species

map04217

Necroptosis

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04624

Toll and Imd signaling pathway

map04625

C-type lectin receptor signaling pathway

map04657

IL-17 signaling pathway

map04668

TNF signaling pathway

map04932

Non-alcoholic fatty liver disease

map04936

Alcoholic liver disease

map05010

Alzheimer disease

map05016

Huntington disease

map05022

Pathways of neurodegeneration - multiple diseases

map05130

Pathogenic Escherichia coli infection

map05132

Salmonella infection

map05134

Legionellosis

map05142

Chagas disease

map05145

Toxoplasmosis

map05152

Tuberculosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

map05203

Viral carcinogenesis

map05416

Viral myocarditis

map05417

Lipid and atherosclerosis

Disease

H00048

Hepatocellular carcinoma

H00108

Autoimmune lymphoproliferative syndromes

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K04398  CASP8; caspase 8
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04398  CASP8; caspase 8
   04214 Apoptosis - fly
    K04398  CASP8; caspase 8
   04215 Apoptosis - multiple species
    K04398  CASP8; caspase 8
   04217 Necroptosis
    K04398  CASP8; caspase 8
   04115 p53 signaling pathway
    K04398  CASP8; caspase 8
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04624 Toll and Imd signaling pathway
    K04398  CASP8; caspase 8
   04621 NOD-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04622 RIG-I-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04623 Cytosolic DNA-sensing pathway
    K04398  CASP8; caspase 8
   04625 C-type lectin receptor signaling pathway
    K04398  CASP8; caspase 8
   04657 IL-17 signaling pathway
    K04398  CASP8; caspase 8
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04398  CASP8; caspase 8
   05203 Viral carcinogenesis
    K04398  CASP8; caspase 8
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04398  CASP8; caspase 8
   05161 Hepatitis B
    K04398  CASP8; caspase 8
   05160 Hepatitis C
    K04398  CASP8; caspase 8
   05164 Influenza A
    K04398  CASP8; caspase 8
   05162 Measles
    K04398  CASP8; caspase 8
   05168 Herpes simplex virus 1 infection
    K04398  CASP8; caspase 8
   05163 Human cytomegalovirus infection
    K04398  CASP8; caspase 8
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04398  CASP8; caspase 8
   05169 Epstein-Barr virus infection
    K04398  CASP8; caspase 8
   05165 Human papillomavirus infection
    K04398  CASP8; caspase 8
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04398  CASP8; caspase 8
   05132 Salmonella infection
    K04398  CASP8; caspase 8
   05134 Legionellosis
    K04398  CASP8; caspase 8
   05152 Tuberculosis
    K04398  CASP8; caspase 8
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04398  CASP8; caspase 8
   05142 Chagas disease
    K04398  CASP8; caspase 8
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04398  CASP8; caspase 8
   05016 Huntington disease
    K04398  CASP8; caspase 8
   05022 Pathways of neurodegeneration - multiple diseases
    K04398  CASP8; caspase 8
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04398  CASP8; caspase 8
   05416 Viral myocarditis
    K04398  CASP8; caspase 8
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04398  CASP8; caspase 8
   04932 Non-alcoholic fatty liver disease
    K04398  CASP8; caspase 8
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04398  CASP8; caspase 8
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04398  CASP8; caspase 8
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     K04398  CASP8; caspase 8
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C14: caspase family
   K04398  CASP8; caspase 8

Other DBs

GO:

0097199

Genes

HSA:	841(CASP8)

PTR:	746477(CASP8)

PPS:	100978497(CASP8)

GGO:	101138898(CASP8)

PON:	100172115(CASP8)

NLE:	100586183(CASP8)

MCC:	702781(CASP8)

MCF:	101865354(CASP8)

MTHB:

126932110

CSAB:

103217637(CASP8)

CATY:

105580035(CASP8)

PANU:

101009470(CASP8)

TGE:	112636264(CASP8)

RRO:	104671864(CASP8)

RBB:	108532002(CASP8)

TFN:	117094661(CASP8)

PTEH:

111547169(CASP8)

CANG:

105517408(CASP8)

CJC:	100395220(CASP8)

SBQ:	101053601(CASP8)

CSYR:

103273365(CASP8)

MMUR:

105856959(CASP8)

LCAT:

123643895(CASP8)

PCOQ:

105819477(CASP8)

OGA:	100965468(CASP8)

MMU:	12370(Casp8)

MCAL:

110291975(Casp8)

MPAH:

110321675(Casp8)

RNO:	64044(Casp8)

MCOC:

116088467(Casp8)

MUN:	110557662(Casp8)

CGE:	100689369(Casp8)

MAUA:

101825474(Casp8)

PLEU:

114704437(Casp8)

MORG:

121444834 121458619

MFOT:

126511842

AAMP:

119803862(Casp8)

NGI:	103738672(Casp8)

HGL:	101702773(Casp8)

CPOC:

100713334(Casp8)

CCAN:

109689613(Casp8)

DORD:

105981481(Casp8)

DSP:	122096450(Casp8)

NCAR:

124980441

OCU:

100348477

OPI:	101521762(CASP8)

TUP:	102498355(CASP8)

GVR:	103597790(CASP8)

CFA:	488473(CASP8)

CLUD:

112656364(CASP8)

VVP:	112922873(CASP8)

VLG:	121480703(CASP8)

AML:	100472842(CASP8)

UMR:	103659742(CASP8)

UAH:	113250592(CASP8)

UAR:	123798200(CASP8)

ELK:

111141026

LLV:

125094998

MPUF:

101678102(CASP8)

ORO:	101365855(CASP8)

EJU:	114223527(CASP8)

ZCA:	113919983(CASP8)

MLX:	118012152(CASP8)

NSU:	110592166(CASP8)

LWW:	102733039(CASP8)

FCA:	100142684(CASP8)

PYU:	121030909(CASP8)

PBG:	122481641(CASP8)

LRUF:

124515468

PTG:	102962460(CASP8)

PPAD:

109260762(CASP8)

AJU:	106987995(CASP8)

HHV:	120220675(CASP8)

BTA:	507481(CASP8)

BOM:	102272602(CASP8)

BIU:	109569521(CASP8)

BBUB:

102412929(CASP8)

BBIS:

105003655(CASP8)

CHX:	102169919(CASP8)

OAS:	101107334(CASP8)

ODA:	120854621(CASP8)

CCAD:

122426570(CASP8)

SSC:	595105(CASP8)

CFR:	102508224(CASP8)

CBAI:

105082299(CASP8)

CDK:	105099181(CASP8)

VPC:	102542071(CASP8)

BACU:

103004642(CASP8)

LVE:	103077054(CASP8)

OOR:	101281780(CASP8)

DLE:	111171726(CASP8)

PCAD:

102988082(CASP8)

PSIU:

116757029(CASP8)

ECB:	100066502(CASP8)

EPZ:	103565685(CASP8)

EAI:	106823493(CASP8)

MYB:	102246377(CASP8)

MYD:	102761550(CASP8)

MMYO:

118661495(CASP8)

MLF:	102439369(CASP8)

MNA:	107533931(CASP8)

PKL:	118709494(CASP8)

HAI:	109379228(CASP8)

DRO:	112307787(CASP8)

SHON:

118985238(CASP8)

AJM:	119065511(CASP8)

PDIC:

114494575(CASP8)

PHAS:

123824482(CASP8)

MMF:	118625346(CASP8)

RFQ:	117025976(CASP8)

PALE:

102878181(CASP8)

PGIG:

120587528(CASP8)

PVP:	105298127(CASP8)

RAY:	107503155(CASP8)

MJV:	108398898(CASP8)

TOD:	119256101(CASP8)

SARA:

101543078(CASP8)

LAV:	100660542(CASP8) 100663575

TMU:

101344302

ETF:	101638051(CASP8)

DNM:	101432853(CASP8)

MDO:	100017025(CASP18) 100617599(CASP8)

GAS:	123240075 123242697

SHR:	100931580(CASP8)

PCW:	110197193(CASP8)

OAA:	100082949(CASP8) 100087835

GGA:	395284(CASP8) 693266(CASP18)

PCOC:

116233978 116233979

MGP:	100541513 100541666

CJO:	107316523 107316524

NMEL:

110399293 110400694

APLA:

101803161(CASP8) 106014283

ACYG:

106040002 106040004(CASP8)

AFUL:

116490786 116491006

TGU:	100222284 100223333

LSR:	110484576(CASP8) 110484625

SCAN:

103814506 103814507(CASP8)

PMOA:

120497940 120498528

OTC:	121335473 121335530

PRUF:

121356474 121356691

GFR:	102044546 102044717

FAB:	101814031 101815602

PHI:

102110759

PMAJ:

107207226(CASP8) 117244691

CCAE:

111931990

CCW:	104693779 120410336

CBRC:

103612136(CASP8)

ETL:	114055714 114055715

ZAB:	102073111(CASP8) 102073459

ACHL:

103803668 103805840(CASP8)

FPG:	101916968(CASP8) 106113022

FCH:	106630990(CASP8)

CLV:	102084608 102084797

EGZ:	104130511(CASP8)

NNI:	104010196(CASP8)

PLET:

104623365 104625043(CASP8)

PCRI:

104032112

PCAO:

104042978 104051994(CASP8)

ACUN:

113482526 113482527

TALA:

104356172 104357512(CASP8)

PADL:

103923440 103924262(CASP8)

AFOR:

103903455(CASP8) 103903456

ACHC:

115342550 115343326

HALD:

104319289 104322668

HLE:	104830055(CASP8) 104830116

AGEN:

126048220

GCL:	127018346 127018651

CCRI:

104156046(CASP8) 104158038

CSTI:

104549333 104555644

EHS:	104504336 104514809(CASP8)

CMAC:

104478549(CASP8) 104485083

MUI:	104536360 104536361

FGA:

104082182

GSTE:

104255507(CASP8) 104262083

LDI:	104342577(CASP8) 104346345

MNB:	103772020(CASP8)

OHA:	104334215(CASP8)

NNT:	104406622 104409396(CASP8)

DPUB:

104296653(CASP8) 104296667

PGUU:

104459593 104467331(CASP8)

ACAR:

104523966 104532423(CASP8)

CPEA:

104397385 104397386

AVIT:

104280785(CASP8)

CVF:	104290991(CASP8)

CUCA:

104058292 104058293

TEO:	104375427(CASP8)

BRHI:

104492696(CASP8) 104500748

AAM:	106492412 106492473(CASP8)

AROW:

112976408(CASP8) 112976426

NPD:	112956289 112956309

TGT:	104577131 104577132

DNE:	112988234(CASP8) 112988375

SCAM:

104150167(CASP8) 104150169

ASN:	102384848 102385102

AMJ:	102573591(CASP8) 102575862(CASP18)

CPOO:

109323090

GGN:

109301903

PSS:	102446244 102447455

CMY:	102931356 102934251

CPIC:

101934006 101934828

TST:	117884831 117885137

CABI:

116836075(CASP8) 116836078

MRV:	120374759(CASP8) 120374760

XLA:	373559(casp8.L)

XTR:	100495471(casp8)

NPR:

RTEM:

BBUF:

BGAR:

DRE:	100049706(casp8l1) 557302(casp8l2) 561021(casp22) 58022(casp8)

SRX:	107705601 107747226 107748560 107748577 107756543

SANH:

107660005 107660083 107660089 107670339 107672910 107680357 107688858 107688860 107689487

SGH:	107555418 107555445 107560797 107566313 107597346

CCAR:

109052822 109053966 109053967 109053969 109064153 109083181 109090355

CAUA:

113048839 113050791 113050793 113088368 113093418 113093474 113108941

PPRM:

120469557(casp10) 120470089(casp22) 120491686

MAMB:

125266561(casp22) 125268421 125269841(casp10) 125274320(casp8l1) 125274321

IPU:	100304635 108266930(casp10) 108273098(casp8) 108273129

PHYP:

113524385 113525919 113538271

SMEO:

124382628(casp8) 124382766(casp10)

TFD:	113634469(casp8) 113654221(casp10)

AMEX:

103021896 103036076 103036379 103037118

EEE:	113574024 113582334 113588302

TRU:	101061322 101075191 101075631

TNG:	GSTEN00031473G001

LCO:	104924422 104938225 104938227

NCC:	104948647 104966261

CGOB:

115022634 115022799 115026772

ELY:	117249157(casp10) 117271493(casp8) 117271616

EFO:	125899933(casp10) 125902003(casp8) 125902004

PLEP:

121939222 121949527(casp10) 121951363(casp8) 121951365

SLUC:

116048004(casp10) 116055058 116055079(casp8)

ECRA:

117953418(casp10) 117954805(casp8) 117954806

ESP:	116698760 116698766

PFLV:

114563975 114565779 114565858

GAT:	100653426(casp8) 100653427(casp10) 120816322

PPUG:

119209177(casp8) 119209185 119209565 119209566 119229023(casp10)

MSAM:

119902446 119902447 119902448 119904125(casp10)

CUD:	121520232 121520520 121520654 121522126(casp10)

ALAT:

119010726 119011511 119026092(casp10)

MZE:	101470036 101475706 101478827 101481407 106674852 106676518 112430088 112430089

ONL:	100702139 100702676 102079913 109194206

OAU:	116321529 116321530 116321532 116321534 116321548 116322912(casp10)

OLA:	100049400(casp8) 100125536

OML:	112147424(casp8) 112147426

XMA:	102237443 102237850 111608841

XCO:	114147136 114147142 114147894 114151637

XHE:	116721891 116722140 116722737

PRET:

103459939 103478931 103478932 108167062

PFOR:

103134398 103151557 103151574

PLAI:

106958504 106961428

PMEI:

106924075 106924079 106926427 106934087

GAF:	122840130(casp10) 122840676 122840680 122840684 122840687 122841345

CVG:	107082055 107086818 107086824

CTUL:

119779267 119779311 119780252(casp10)

GMU:	124869876 124870505(casp8) 124871764(casp10)

NFU:	107384290 107384292 107389982

KMR:	108238317(casp8) 108238318 108239714(casp10)

ALIM:

106512618 106512902 106517939

NWH:	119414875(casp8) 119414876 119418871(casp10)

AOCE:

111586360 111588089 111588095 111588107

MCEP:

125018228(casp10)

CSEM:

103396237 103396239

POV:	109631024 109637364 109641073

SSEN:

122760804(casp10) 122761240(casp8) 122775595

HHIP:

117755099(casp10) 117778078(casp8) 117778299

HSP:	118117212 118117657(casp8) 118120504(prkra) 118120505

LCF:	108881527 108883888(casp8)

SDU:	111218362 111229030(casp8)

SLAL:

111648895 111666542(casp8)

XGL:	120799083(casp8) 120799085 120801861(casp10)

HCQ:

109520533

BPEC:

110166585 110173494(casp8) 110173519

MALB:

109958094

BSPL:

114844036(casp8) 114844038 114847689(casp10)

SASA:

106569473 106582462 106586254

STRU:

115155490 115157338 115160794 115169467

OTW:	112225661(casp10) 112226687(casp8) 112245958 112247430

OMY:	101268911(casp8) 110502170 110508466 110520142 110530629

OGO:	124009734 124041578(casp8) 124043892

ONE:	115102767 115109425 115114693 115119721

SALP:

111956905 111957166 111959935 111975582 111979249 111979568

SNH:	120020199(casp8) 120056102 120058267 120063683

CCLU:

121536756(casp10) 121554909 121581147

ELS:	105006190 105009870 105021259 105021271 105024762

SFM:	108918550 108918555 108920617 108920619(casp8) 108932283

PKI:	111852220 111852221 111859671 111859672

AANG:

118214013 118222448

LOC:	102697443(casp8) 102697635 102697829

PSPA:

121321941 121322097 121322099 121322100 121322854 121322856 121323064 121323616

ARUT:

117408587 117414260 117426351 117426603 117426878

PSEX:

120531926

LCM:	102349989 102355925 102356202

CMK:

103171902

RTP:	109915462 109929740 109932037

BFO:	118406076 118419602 118420396 118420457 118428976 118430951

BBEL:

109470585 109473442 109476237 109476238 109481944

CIN:

100183123

SCLV:

120339721

SPU:	105445989 585496

APLC:

110982622 110986601

SKO:	100369664 100375416

DME:	Dmel_CG7486(Dredd)

DER:

6555550

DSE:

6615883

DSI:	Dsimw501_GD16467(Dsim_Dredd)

DYA:	Dyak_GE16575(Dyak_Dredd)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21675

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:

MDE:

SCAC:

LCQ:	111685143 111685144

LSQ:	119606412 119614517 119614518

AGA:	AgaP_AGAP011693(CASPL1)

ACOZ:

AARA:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ014995

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:	661095(Dredd)

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:	111420306 111421814

BMOR:

100141428(Dredd)

BMAN:

114248879

MSEX:

115442338 115442360 119188347

DPL:	KGM_212093

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

HZE:

TNL:

OFU:

PXY:

CLEC:

NLU:

PHU:	Phum_PHUM574530

FOC:

TPAL:

ZNE:

CSEC:

DMK:

PVM:

PJA:	122245041 122251197 122251198 122266756

PCHN:

125025732 125041108 125044277 125044384

HAME:

121855632 121871725

PCLA:

123765010 123765863 123765865

PTRU:

123508576 123508705 123518818

HAZT:

EAF:

PPOI:

DSV:

RSAN:

RMP:

CSCU:

PCAN:

BGT:	106054001 106078261 106078428

GAE:	121372573 121384420 121387437 121387656 121387773

HRF:	124110723 124110963 124111376 124111841 124112816 124132113 124134993 124143787 124149539 124152864 124152865

HRJ:	124257135 124262809 124265296 124267644 124273512 124273718 124275672 124277624 124279661 124279734 124280614 124284330 124288477

CRG:	105318843 105332613 105340890 105346084 117691806 117691813 117692646

MYI:

110449259

PMAX:

117317156 117317363 117327557 117328816 117328818

MMER:

123527736 123538317 123551007 123553922 123553927 123557524

LAK:	106152179 106171044

SMM:	Smp_141270

NVE:

5505811

EPA:

110231936

ATEN:

116289374 116297720 116298542 116298545

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114530339 114534211 114539385

XEN:

124458193

HMG:	100203004 100207763 100579132(casp8) 105843821 105846973

AQU:	100638885 105313668 105315966 105316143 105316853 109581722 109584594

» show all

Reference

PMID:9931493

Authors

Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ

Title

Structure and chromosome localization of the human CASP8 gene.

Journal

Gene 226:225-32 (1999)
DOI:10.1016/S0378-1119(98)00565-4

Sequence

[hsa:841]

LinkDB

DBGET integrated database retrieval system