KEGG   Castor canadensis (American beaver): 109694666
Entry
109694666         CDS       T04791                                 
Symbol
Pik3r1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ccan  Castor canadensis (American beaver)
Pathway
ccan01521  EGFR tyrosine kinase inhibitor resistance
ccan01522  Endocrine resistance
ccan01524  Platinum drug resistance
ccan04012  ErbB signaling pathway
ccan04014  Ras signaling pathway
ccan04015  Rap1 signaling pathway
ccan04024  cAMP signaling pathway
ccan04062  Chemokine signaling pathway
ccan04066  HIF-1 signaling pathway
ccan04068  FoxO signaling pathway
ccan04070  Phosphatidylinositol signaling system
ccan04071  Sphingolipid signaling pathway
ccan04072  Phospholipase D signaling pathway
ccan04081  Hormone signaling
ccan04140  Autophagy - animal
ccan04150  mTOR signaling pathway
ccan04151  PI3K-Akt signaling pathway
ccan04152  AMPK signaling pathway
ccan04210  Apoptosis
ccan04211  Longevity regulating pathway
ccan04213  Longevity regulating pathway - multiple species
ccan04218  Cellular senescence
ccan04360  Axon guidance
ccan04370  VEGF signaling pathway
ccan04380  Osteoclast differentiation
ccan04510  Focal adhesion
ccan04550  Signaling pathways regulating pluripotency of stem cells
ccan04611  Platelet activation
ccan04613  Neutrophil extracellular trap formation
ccan04620  Toll-like receptor signaling pathway
ccan04625  C-type lectin receptor signaling pathway
ccan04630  JAK-STAT signaling pathway
ccan04650  Natural killer cell mediated cytotoxicity
ccan04660  T cell receptor signaling pathway
ccan04662  B cell receptor signaling pathway
ccan04664  Fc epsilon RI signaling pathway
ccan04666  Fc gamma R-mediated phagocytosis
ccan04668  TNF signaling pathway
ccan04670  Leukocyte transendothelial migration
ccan04722  Neurotrophin signaling pathway
ccan04725  Cholinergic synapse
ccan04750  Inflammatory mediator regulation of TRP channels
ccan04810  Regulation of actin cytoskeleton
ccan04910  Insulin signaling pathway
ccan04914  Progesterone-mediated oocyte maturation
ccan04915  Estrogen signaling pathway
ccan04917  Prolactin signaling pathway
ccan04919  Thyroid hormone signaling pathway
ccan04923  Regulation of lipolysis in adipocytes
ccan04926  Relaxin signaling pathway
ccan04929  GnRH secretion
ccan04930  Type II diabetes mellitus
ccan04931  Insulin resistance
ccan04932  Non-alcoholic fatty liver disease
ccan04933  AGE-RAGE signaling pathway in diabetic complications
ccan04935  Growth hormone synthesis, secretion and action
ccan04960  Aldosterone-regulated sodium reabsorption
ccan04973  Carbohydrate digestion and absorption
ccan05010  Alzheimer disease
ccan05017  Spinocerebellar ataxia
ccan05020  Prion disease
ccan05100  Bacterial invasion of epithelial cells
ccan05135  Yersinia infection
ccan05142  Chagas disease
ccan05146  Amoebiasis
ccan05160  Hepatitis C
ccan05161  Hepatitis B
ccan05162  Measles
ccan05163  Human cytomegalovirus infection
ccan05164  Influenza A
ccan05165  Human papillomavirus infection
ccan05166  Human T-cell leukemia virus 1 infection
ccan05167  Kaposi sarcoma-associated herpesvirus infection
ccan05168  Herpes simplex virus 1 infection
ccan05169  Epstein-Barr virus infection
ccan05170  Human immunodeficiency virus 1 infection
ccan05171  Coronavirus disease - COVID-19
ccan05200  Pathways in cancer
ccan05203  Viral carcinogenesis
ccan05205  Proteoglycans in cancer
ccan05206  MicroRNAs in cancer
ccan05207  Chemical carcinogenesis - receptor activation
ccan05208  Chemical carcinogenesis - reactive oxygen species
ccan05210  Colorectal cancer
ccan05211  Renal cell carcinoma
ccan05212  Pancreatic cancer
ccan05213  Endometrial cancer
ccan05214  Glioma
ccan05215  Prostate cancer
ccan05218  Melanoma
ccan05220  Chronic myeloid leukemia
ccan05221  Acute myeloid leukemia
ccan05222  Small cell lung cancer
ccan05223  Non-small cell lung cancer
ccan05224  Breast cancer
ccan05225  Hepatocellular carcinoma
ccan05226  Gastric cancer
ccan05230  Central carbon metabolism in cancer
ccan05231  Choline metabolism in cancer
ccan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccan05415  Diabetic cardiomyopathy
ccan05417  Lipid and atherosclerosis
ccan05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccan00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    109694666 (Pik3r1)
   04015 Rap1 signaling pathway
    109694666 (Pik3r1)
   04630 JAK-STAT signaling pathway
    109694666 (Pik3r1)
   04668 TNF signaling pathway
    109694666 (Pik3r1)
   04066 HIF-1 signaling pathway
    109694666 (Pik3r1)
   04068 FoxO signaling pathway
    109694666 (Pik3r1)
   04070 Phosphatidylinositol signaling system
    109694666 (Pik3r1)
   04072 Phospholipase D signaling pathway
    109694666 (Pik3r1)
   04071 Sphingolipid signaling pathway
    109694666 (Pik3r1)
   04024 cAMP signaling pathway
    109694666 (Pik3r1)
   04151 PI3K-Akt signaling pathway
    109694666 (Pik3r1)
   04152 AMPK signaling pathway
    109694666 (Pik3r1)
   04150 mTOR signaling pathway
    109694666 (Pik3r1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    109694666 (Pik3r1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109694666 (Pik3r1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    109694666 (Pik3r1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109694666 (Pik3r1)
   04613 Neutrophil extracellular trap formation
    109694666 (Pik3r1)
   04620 Toll-like receptor signaling pathway
    109694666 (Pik3r1)
   04650 Natural killer cell mediated cytotoxicity
    109694666 (Pik3r1)
   04660 T cell receptor signaling pathway
    109694666 (Pik3r1)
   04662 B cell receptor signaling pathway
    109694666 (Pik3r1)
   04664 Fc epsilon RI signaling pathway
    109694666 (Pik3r1)
   04666 Fc gamma R-mediated phagocytosis
    109694666 (Pik3r1)
   04670 Leukocyte transendothelial migration
    109694666 (Pik3r1)
   04062 Chemokine signaling pathway
    109694666 (Pik3r1)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    109694666 (Pik3r1)
   04929 GnRH secretion
    109694666 (Pik3r1)
   04915 Estrogen signaling pathway
    109694666 (Pik3r1)
   04917 Prolactin signaling pathway
    109694666 (Pik3r1)
   04926 Relaxin signaling pathway
    109694666 (Pik3r1)
   04935 Growth hormone synthesis, secretion and action
    109694666 (Pik3r1)
   04919 Thyroid hormone signaling pathway
    109694666 (Pik3r1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    109694666 (Pik3r1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109694666 (Pik3r1)
  09156 Nervous system
   04725 Cholinergic synapse
    109694666 (Pik3r1)
   04722 Neurotrophin signaling pathway
    109694666 (Pik3r1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109694666 (Pik3r1)
  09158 Development and regeneration
   04360 Axon guidance
    109694666 (Pik3r1)
   04380 Osteoclast differentiation
    109694666 (Pik3r1)
  09149 Aging
   04211 Longevity regulating pathway
    109694666 (Pik3r1)
   04213 Longevity regulating pathway - multiple species
    109694666 (Pik3r1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109694666 (Pik3r1)
   05206 MicroRNAs in cancer
    109694666 (Pik3r1)
   05205 Proteoglycans in cancer
    109694666 (Pik3r1)
   05207 Chemical carcinogenesis - receptor activation
    109694666 (Pik3r1)
   05208 Chemical carcinogenesis - reactive oxygen species
    109694666 (Pik3r1)
   05203 Viral carcinogenesis
    109694666 (Pik3r1)
   05230 Central carbon metabolism in cancer
    109694666 (Pik3r1)
   05231 Choline metabolism in cancer
    109694666 (Pik3r1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109694666 (Pik3r1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109694666 (Pik3r1)
   05212 Pancreatic cancer
    109694666 (Pik3r1)
   05225 Hepatocellular carcinoma
    109694666 (Pik3r1)
   05226 Gastric cancer
    109694666 (Pik3r1)
   05214 Glioma
    109694666 (Pik3r1)
   05221 Acute myeloid leukemia
    109694666 (Pik3r1)
   05220 Chronic myeloid leukemia
    109694666 (Pik3r1)
   05218 Melanoma
    109694666 (Pik3r1)
   05211 Renal cell carcinoma
    109694666 (Pik3r1)
   05215 Prostate cancer
    109694666 (Pik3r1)
   05213 Endometrial cancer
    109694666 (Pik3r1)
   05224 Breast cancer
    109694666 (Pik3r1)
   05222 Small cell lung cancer
    109694666 (Pik3r1)
   05223 Non-small cell lung cancer
    109694666 (Pik3r1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109694666 (Pik3r1)
   05170 Human immunodeficiency virus 1 infection
    109694666 (Pik3r1)
   05161 Hepatitis B
    109694666 (Pik3r1)
   05160 Hepatitis C
    109694666 (Pik3r1)
   05171 Coronavirus disease - COVID-19
    109694666 (Pik3r1)
   05164 Influenza A
    109694666 (Pik3r1)
   05162 Measles
    109694666 (Pik3r1)
   05163 Human cytomegalovirus infection
    109694666 (Pik3r1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109694666 (Pik3r1)
   05169 Epstein-Barr virus infection
    109694666 (Pik3r1)
   05165 Human papillomavirus infection
    109694666 (Pik3r1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    109694666 (Pik3r1)
   05100 Bacterial invasion of epithelial cells
    109694666 (Pik3r1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109694666 (Pik3r1)
   05142 Chagas disease
    109694666 (Pik3r1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109694666 (Pik3r1)
   05017 Spinocerebellar ataxia
    109694666 (Pik3r1)
   05020 Prion disease
    109694666 (Pik3r1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109694666 (Pik3r1)
   05418 Fluid shear stress and atherosclerosis
    109694666 (Pik3r1)
   05415 Diabetic cardiomyopathy
    109694666 (Pik3r1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109694666 (Pik3r1)
   04932 Non-alcoholic fatty liver disease
    109694666 (Pik3r1)
   04931 Insulin resistance
    109694666 (Pik3r1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    109694666 (Pik3r1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109694666 (Pik3r1)
   01524 Platinum drug resistance
    109694666 (Pik3r1)
   01522 Endocrine resistance
    109694666 (Pik3r1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ccan04131]
    109694666 (Pik3r1)
Membrane trafficking [BR:ccan04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    109694666 (Pik3r1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 AAA_13 Laminin_I Bap31_Bap29_C
Other DBs
NCBI-GeneID: 109694666
NCBI-ProteinID: XP_020032354
UniProt: A0A8B7VMH8
LinkDB
Position
Unknown
AA seq 562 aa
MSFFLDAASMDLEMIDVQVLADAFKRYLLDLPNPVIPIAVSSEMISLAQEVQSSEDYIQL
LKKLIRSPHIPHQYWLTLQYLLKHFFKLSQASSKNFLNARILSEIFSPLLFRFPATSSEN
TEHLIKVIEILISTEWNERQPAPALPPKPPKPTAVANNGMNNNMSLQDAEWYWGDISREE
VNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVV
ELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNAQFQEKSRE
YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQ
RIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLM
WLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAETLLRGKR
DGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTS
LVQHNDSLNVTLAYPVYAQQRR
NT seq 1689 nt   +upstreamnt  +downstreamnt
atgtcttttttcctagatgctgcctccatggacttggaaatgatcgacgtgcaagtttta
gcagatgctttcaaacgctatctcctggacttaccaaatcctgtcattccaatagctgtt
tccagtgaaatgatttccttagcccaagaagtacagagctccgaagactacatccagctc
ttaaagaagcttattaggtcgcctcatatacctcatcagtattggcttacgcttcagtat
ttgctgaaacatttcttcaagctctctcaagcctccagcaaaaactttttgaatgcaaga
atactctctgaaattttcagccctctgcttttcagattcccagccaccagctctgaaaat
actgaacacctcataaaagttatagaaattttaatctcaactgaatggaatgaacgacag
ccagcaccagcactgccccccaagccacccaaacccactgcggtagccaacaacggtatg
aacaacaacatgtccttacaagatgctgaatggtactggggagatatctcaagggaagaa
gtgaatgaaaaacttcgagacacagcagatgggacctttttggtacgagacgcatcaact
aaaatgcatggcgattatactcttacactaaggaaaggaggaaataacaaattaatcaaa
atatttcaccgggatggaaaatatggcttctctgacccattaaccttcaactctgtggtt
gaattaataaaccactaccggaatgaatctctagctcagtacaatcccaaactggatgtg
aaattactgtatccagtatccaaataccaacaggatcaagttgtcaaagaagataatatt
gaagctgtagggaaaaaattacatgaatataacgctcagtttcaagaaaaaagtcgggaa
tatgatagattatatgaagaatatacccgtacttcccaggaaatccagatgaaaagaaca
gctattgaagcatttaatgaaactataaaaatatttgaagaacagtgccaaacccaggag
cggtacagcaaagaatacatagaaaagtttaaacgagaaggaaatgagaaagaaatccag
aggattatgcataactatgataagctaaagtctcgaatcagtgaaattattgacagcaga
agaaggttggaggaagacttgaagaagcaggcagctgagtatcgagagattgacaaacgt
atgaacagcattaagcccgacctcatccagctgagaaagacgagagaccagtacttgatg
tggctgactcaaaaaggtgttcggcaaaagaagttgaacgagtggctgggcaatgaaaac
accgaagaccagtattcgctggtggaggacgatgaggatctgccccaccatgacgagaag
acgtggaacgttggaagcagcaaccggaacaaagctgaaaccctactgcgggggaagcgg
gatggcactttcctggtccgggagagcagtaagcagggctgttatgcctgctctgtggtg
gtggatggcgaagtcaagcattgtgtcattaacaagacagcgactggctatggctttgct
gagccctacaacctgtacagctccctgaaggaactggtgctacattaccaacacacctcc
ctcgtgcagcacaatgactctctcaacgtcacactggcatacccggtatatgcacagcag
aggcgatga

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