Castor canadensis (American beaver): 109700963 Help Entry 109700963         CDS       T04791                                  Symbol Irs2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism ccan  Castor canadensis (American beaver) Pathway ccan04022   cGMP-PKG signaling pathway ccan04068   FoxO signaling pathway ccan04081   Hormone signaling ccan04140   Autophagy - animal ccan04152   AMPK signaling pathway ccan04211   Longevity regulating pathway ccan04213   Longevity regulating pathway - multiple species ccan04910   Insulin signaling pathway ccan04920   Adipocytokine signaling pathway ccan04923   Regulation of lipolysis in adipocytes ccan04930   Type II diabetes mellitus ccan04931   Insulin resistance ccan04932   Non-alcoholic fatty liver disease ccan04935   Growth hormone synthesis, secretion and action ccan05010   Alzheimer disease ccan05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:ccan00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     109700963 (Irs2)    04022 cGMP-PKG signaling pathway     109700963 (Irs2)    04152 AMPK signaling pathway     109700963 (Irs2)   09133 Signaling molecules and interaction    04081 Hormone signaling     109700963 (Irs2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     109700963 (Irs2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     109700963 (Irs2)    04923 Regulation of lipolysis in adipocytes     109700963 (Irs2)    04920 Adipocytokine signaling pathway     109700963 (Irs2)    04935 Growth hormone synthesis, secretion and action     109700963 (Irs2)   09149 Aging    04211 Longevity regulating pathway     109700963 (Irs2)    04213 Longevity regulating pathway - multiple species     109700963 (Irs2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     109700963 (Irs2)   09164 Neurodegenerative disease    05010 Alzheimer disease     109700963 (Irs2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     109700963 (Irs2)    04932 Non-alcoholic fatty liver disease     109700963 (Irs2)    04931 Insulin resistance     109700963 (Irs2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  109700963 NCBI-ProteinID:  XP_020041910 UniProt:  A0A250Y7D4 LinkDB All DBs Position Unknown AA seq 1327 aa AA seqDB search MASPPLNGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA TAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE YFAVAAENEQEQEGWYRALTDLVSEGRASAGDAASSASCSASLPGALGGSAGAAAADDSY GLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMN IRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRS KSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCRVRTA SEGDGGTAAGTGTAVGRPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRASKVTLAPAGGA LQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGPHPHLPHPLHHPPAQRPSSG SASASGSPSDPGFMSLDEYGSSPGDLRAFCGHRSNTPESIAETPPARDGSGGELYGYMTM DRPLTHCGRPYRRVSGDGAPDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATF SGSSGRLCPSFPTSSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGAALMGA SASGCKSDDYMPMSPTSVSAPKQILQPRAGPAAALPPTGAAVPAPPSAAGRTFPVNGAGY KASSPAESSPEDSGYMRMWCGSKLSVENTDSKLLPNGDYLNMSPSEAGTAGTPPDFFSAA LHGGEEVLKGVPGYCYSSLPRSYKASYTCSGDGDQYVLMSSPVGRILEEERPETQSTPGT SQLASSFGAGGGNHIQSYHPAVPSPMRPGGGGGRPDGFLSHRCRAVRPTRLSLEGLQTLP SMLENPLPPEPKSPGEYINIDFGEAGTQLSPPAPPLLASAASSSSLLSASSPASSLGSGT PGTSSDSRQRSPLSDYMNLDFSSPKSPKPGTRSGDPMGSLDALLSPDVSSPYPPLPPRPS ASPSSLQQPPPPPGELYRLPPASAAATSQGPSATSSKSSEPGDNGDYTEMAFGVAATPPQ PITAPPKSEGARVTSPTSGLKRLSLMDQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRR RHSSETFSSTTTVTPVSPSFAHNPKRHSSASVENVSLRKSSEGGCSSILGGGLGGGDEPP TSPGQVQPPLPGPLPPQARPWTPGQPGGSPMRREISSGFQNSLNYIAIDVRDEPGLLPQP QPQHPQPGDKSSWGRTRSLGGLLSAVGGSSTSVGCGGPGPGALPSASTYASIDFLSHHLK EATVVKE NT seq 3984 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccgctgaatgggccccctgggccggcgggcggcgacggcccgaacctc aacaacaataacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgcgggcggcgacgaggcg acagcgggcggggggtcggcgccgcagccgccgcggctcgagtactacgagagcgagaag aagtggcggagcaaggcgggcgccccgaagcgggtgatcgcgcttgactgctgtctgaac atcaacaagcgagccgacgccaagcacaagtacctcatcgccctctacactaaggacgag tacttcgcggtggcggccgagaacgagcaggagcaggagggctggtaccgcgctctcacc gacctggtcagcgagggccgcgcgagcgctggcgacgcggccagctccgcgtcctgcagc gcctccctgccgggcgccctgggcggctctgccggcgccgcggcggccgatgacagctat gggctcgtggcacccgccacggccgcctaccgcgaggtgtggcaggtgaacctgaagccc aagggcttgggccagagcaagaacctgacgggcgtgtaccgcctgtgcctgtcggcgcgc accatcggcttcgtgaagctcaactgcgagcagccgtcggtgacgctgcagctcatgaac atccgccgctgcggccactcagacagcttcttcttcatcgaggtgggccgctcggccgtc acaggccccggcgagctgtggatgcaggccgacgactcggtggtggcgcagaacatccac gagaccatcctggaggccatgaaggcgctcaaggagctcttcgagttccggccgcgcagt aagagccagtcgtccgggtcttcggccacccaccccatcagcgtccccggcgcgcgccgt caccaccacctggtcaacctgccccctagccagacaggcctggtgcggcgctcacgcacc gacagcctggctgccaccccgccggccgccaagtgcagctcctgccgcgttcgcacggcc agcgagggcgatggcggcacggcggcagggaccgggacagcggtcggcaggccagtgtcg gtggccgggagccccctgagtcccgggccggtgcgcgcgcccctgagccgctcgcacacc ctgagcggcggctgcggtggccgcgcgagcaaagtgacgctggcaccggcagggggcgct ctgcaacacagtcgctccatgtccatgccggtggcgcactcacccccggccgccaccagc cccggcagcctgtcgtccagcagcgggcacggctcaggctcctacccgctgcccccaggc ccgcacccgcacctgccgcacccattgcaccaccccccagctcagcgcccctccagcggc agcgcctctgcctccggttcccccagcgaccccggcttcatgtcgctggacgagtacggc tccagccctggcgacctgagggccttctgcggccacaggagtaacacgcccgagtccatc gcggagacgccccctgccagggatggcagcgggggcgagctgtatgggtacatgaccatg gacaggcccctgacccactgtggccgcccctaccgcagagtctctggagatggggccccg gacttggatagagggctgagaaagaggacttactcgctgaccacacctgcccggcagcgg ccggtgccccagccctcctctgcctccctggatgagtacaccctaatgcgggccaccttc tcaggcagctcaggccgcctctgcccgtcattccccacctcctcccccaaagtggcctat cacccctatcccgaggactatggggatatcgagattgggtctcacaggagctccagcagc aacctgggggcagatgatggctacatgcccatgacccctggcgcagccctcatgggtgcc agcgccagcggctgcaaaagcgacgattacatgcccatgagccccaccagcgtgtctgcc cccaaacagatcctgcagcccagagctggtcccgcagctgccttgccccccacaggagca gcagtgccagcgcccccctctgcagctggcaggaccttcccagtgaatggggccggctac aaggccagctccccggcagagagctccccagaggacagtgggtacatgcgcatgtggtgt ggatccaagctgtccgtggagaacaccgactcaaagctgcttcccaatggggactacctc aacatgtcccccagtgaggcgggcactgctggcaccccacccgacttcttctcggcagcc ttgcatggtggggaggaggtgctcaaaggtgtcccagggtactgctacagctccctcccc cgctcctacaaggcttcctacacctgcagtggggacggcgaccagtacgtgctcatgagc tcccccgtggggcggatcctggaagaggagaggcctgagactcagtctaccccagggact tcccagttggccagcagctttggggctggtggaggcaaccacattcagtcttatcatcca gcagtaccttcacctatgaggccaggtggcggaggtggccgcccagatggcttcctgagc catcgctgccgggcagtgcgacccacacgcttgtccttagaggggttgcagaccctgccc agcatgctcgagaacccactgcccccagaacccaagagccctggcgagtacatcaacata gactttggcgaggcaggaacccagctgtcaccgcctgcccctccgctgctggcatcagcg gcctcgtcctcttcactgctgtctgctagcagcccagcctcatccctgggctcaggcacc ccgggcacaagcagtgacagccggcagcgctccccactctctgactacatgaacctggac ttcagctcccccaagtcccccaagcctggcacccgcagcggggaccccatgggctctctg gatgcccttctttcccctgatgtctcctccccctatccaccactgccccctcgtccctct gcctccccgtcctctctacagcagcccccaccccccccaggggagctgtaccgcctgcct ccagcatctgccgctgccacctcccagggccccagtgctacttcctcgaagtcctctgaa cctggggacaatggtgactacaccgaaatggcctttggtgtggctgccaccccgccacaa cccattacggcacccccaaagtccgaaggtgcccgagtgaccagccccacatcgggcctg aagaggctgagtctgatggatcaggtgtctggagttgaggccttcttgcaggccagtcag ccccccgatccccaccggggggccaaagtcatccgggcagacccgcaggggggccgccgc cgtcacagctcagagaccttctcctccaccaccacagtcactcctgtgtccccgtccttt gctcacaaccctaagcgccacagctcagcctctgtggaaaacgtgtctctcaggaaaagc agtgagggcggttgcagcagcattctaggagggggccttggaggaggtgacgagccaccc acatccccaggacaggtgcagcccccgctccctgggcccctgccaccacaggcacggcct tggaccccaggtcagcctggtgggtctcccatgcgaagagagatctcctcgggtttccaa aacagcctcaactacatcgctatcgatgtgagggatgagcctgggctcttgccccaacct cagccccagcacccacagccaggagacaagagctcctggggccggacccgtagcctgggg ggtctcctcagcgctgtggggggcagcagcaccagtgtgggctgtgggggtccgggcccc ggtgccctgccctctgccagcacctacgccagcattgacttcctgtcgcatcacctgaag gaggccacagttgtgaaagagtga

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