Coregonus clupeaformis (lake whitefish): 121541906 Help Entry 121541906         CDS       T08357                                  Name (RefSeq) ryanodine receptor 1-like   KO K04961   ryanodine receptor 1 Organism cclu  Coregonus clupeaformis (lake whitefish) Pathway cclu04020   Calcium signaling pathway cclu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cclu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121541906    04020 Calcium signaling pathway     121541906  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:cclu01009]     121541906   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:cclu04147]     121541906    04040 Ion channels [BR:cclu04040]     121541906 Protein phosphatases and associated proteins [BR:cclu01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      121541906 Exosome [BR:cclu04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    121541906 Ion channels [BR:cclu04040]  Voltage-gated cation channels   Ryanodine receptor    121541906 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  121541906 NCBI-ProteinID:  XP_041707222 LinkDB All DBs Position 27:35575368..35653304 Genome browser AA seq 5081 aa AA seqDB search MAEGGDGEEEIQFLRTDDQVVLQCTASILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLANTMELNEAVDLDKWSSQGGGHRTLLYGHAILLKHTHS SMYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV SSERYLHLSYASGDLMVDASFMQTLWTMNPVMSGCELAEGFLTGGYVLRLFHGHMDECLA IPAAEQGDDQRRIAHYEGGAVCSHARSLWRLEPLRIGWSGGHMKWGQSFRVRHITTGRYL CLDEEKGLLVVDPEKAHAKMSAFCFRISKEKVEVVKKRDVEGMGTPEIKYGESMCFVQHV STGLWLTYASVDAKSARLGPLKRKAILHKEGHMDDALTVTRSQTEEFQAARMIYNTAGLF TQFIKALDSLSGKNKSSSGPLALPMDSVVLSLQDLIFYFQPPEEELEHEEKQTKLRSLKN RQNLFQEEGMITLVLDCIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGN RANCALFCDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKH GRNHKVLDVLCSLCVCNGVAVRSNQNLITENLLPGRDLLLQSNIINYVTSVRPNIFLGTC EGSTQYKKWYFEVMVDHVEPFLTAQAFHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYS YAFDGLHLWSGRVPRHVASPNMHILAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNL DGLFFPVVSFSAGVKVRFLLGGRHGDFKFLPPPGYAPCYEAVLPKDRLHIEPIKEYKHDF NGVRNLLGPTQSLSHTAFTPCPVDTVQIVLPPHLERIREKLAENSHELWAVTRIEQGWTY GTFRDDNKKLHPCLVDFQSLPEPEKNYNLAMSGETLKTLLAVGCHVGMGDEKAEENLKNI KMPKTYMMSSGYKPAPLDLNHVKLTPNQTNLVERLAENGHNVWACDRVHQGWTYSIVQDI MNKRNPRLVPYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGHGEGNSRGDKI RVFRAEKSYAVTQGKWYFEFEAVTVGEMRVGWARPSVRADTELGADELAYVFNGFKAQRW HVGNEPFGRIWLPGDVVGCMIDLVEQNIFFTLNGEMLISDSGSEMAFKDIDIGDGFIPVC SLGLSQVGRLNLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFIPVPTEH PHVEVSRVDGTVDNAPCLKLTHKTFGSQNANTDLLFLRLSMPVEFHETFKVMAGTTPLTR TLTIPEDQVLEVDPDSDFEVLKKSASRTEKEEEKEPSVPKEIPVNGGENVKDASTEKSKK KGFLFKAKKAAFTPPPVVPTMPRLMEEVVPDDRDDDDIILNTTTYYYSVRVIAGQEPSGV WVGWITPDYHQYDLHFDLSKVRNVTVTVGDDKGNIHDSMKRSNCYMVWGGEFSSSQQTRV SQEDFVIGCLIDLDTGLMTFTANGKEINTFYQVEPNTKLFPAVFVLPSSQNMLQVELGKL KNIMPISAAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNHFLSPETGRVNERHGWMVE CREPLTMMALHIPEENRCIDVLELSEHMDLLKFHYHTLKLYGSVCALGNNRVAHALCSHV DESQLFYAIENTYLPGPMRSGYYDLLISMHLESAKRNRLMTNKEFIVPMTDETRSINLYS DTDKSHALPGVGLTTCLRPKLHFSPTGFVGTDLDIYTLSPFIPLHVLKAKALTMLTEAVQ DGGQAMRDPVGGSVEFHFVPILKLISTLLIMGVFENEDVKHILKMIEPTVFSGEAAAQGE GAQTLALKERGLEVKEEEEGAVESGHETEDEGMGEEDEEMEAELEELEPIEKEEDEGEDD SEKVDGEKGAEKTEEEEKPGKADEEAEEQVGLEEGLLHMKLPESVKLQMCTLLQYFCDCE LRHRVEAIIAFSDQFVSQVQANQRARYNELMLAFTMSAAETARKTREFRSPPQEQVNMLM NFKNIAEDEDCPVPDEVRDALQAFHKNLLAHCGVHIEEEELEEELDMSLKGRLLRMLDKL RHLRKKKVEEEEPVEDTKPSTLQELISHTMVHWAQESFIQNPELVRLMFSLLHRQYDGLG ELIRALPKAYTINAISIKDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMSNKVFY QHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRMVTNCCRFLCYFCRISRQNQRSMFD HLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEKVVKYLAGCGLQSCPQ LLAKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEG GNGLLAAIEEAIKISEDPARDGPTVKKDRRFPGMFPGGEEQHEENKVHLGNAIMSFYSAL IDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLSVQIPDFGKDNSIIEPK MSSSFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAAFCTTEMALA LNRYLSLAVLPLITKCAFLFAGTDHRAIMIDSMLHTIYRLSRGRAFTKAQRDVIEECLMA LCKNLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWGNFGLSSE EELHLTRKLFWGIFESLAHKKFDAELFKIAMPCICAIAGAIPPDYVDASYSSKTEKKALV DAEGNFDPKPVETTNTIIPERLDGFINKYAEYTHDKWAFEKIQNNWTYGEILDENEKTHP MLRPYKTFSEKDKEIYRWPIKESMKAMIAWEWTLDQTREGEEAKTEQKKAARKISQTAQA TYDPSHGYSPQPIEISHTALSRELQSMAEQLAENYHNTWGRKKKMELQSKGGGSHPLLVP YDTLTAKEKARDREKAHELLKFLQLNGFAVTRGMKDMESDISSIEKRFAYGFLQKLLKWM EIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFKNHCLYFLSTPAKVLGS GGHSSNKEKEMIASIFCKMAALVRHRVSLFGNDAPAIVNCLHILARSLDARTVMKSGPEI VKAGLRSFFEGAADDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLPVLTSLFDHI SQHQFGDDVMLDDLQTSCYRIMCAIYSLGTVKNPHVERQRPAMGECLAHLAAAMPVAYLE PHLNEYNTFSVYTTKTPRERAILGLPNEVQELCQDIPELDILLKEIGDLAESGARYTEMP HVIEITLPMLCNYLPRWWERGVENFPELEGQICTDVTSEQLNQLLGSIMKIVVNNLGIDE ASWMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTGKVVAEEDHLRMEGKAEGDEEE GTIRDEFSVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIFWSKSHNF KREEQNFVVMNEINNMSFLTADSKSKMSKGNDSEAGGSDVERTKKKRRGDRYSVQTSLIV AALKKMLPIGLNMCSPADQELINLAKIRYSLRDTDEEVREFLQNNLHLQGKVENPSMRWQ MSLYKEMAGKAEDADAPEKVVKRVQEVSAVLYHIEVTEHPFKSKKMVWHKLLSKQRRKAV VACFRMTPLYNLPRHRASNMFLEGYKRNWIHTEGYSFEDRMIDDLSKAMEQEGEEEEETE TKPDPLHQLILHFSRTALTEKSKLDTDYLYMAYADIMAESCHIGEEDEGGEEVEEGAEDE MSFEEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGSMVSSTLKLGISILNGGNV EVQQKMLEYLKDKKDVGFFLSVQALMQTCSVLDLNAFERQNKAEGLGMVSEEGTSEKVMS DDEFTCDLFRMLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQESISDFYWY YSGKEIIDEPGKKNFSKAMIVAKQIFNSLTEYIQGPCTGNQQSLTHSRLWDAVVGFLHVF AHMMMKLAQGKDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSN VEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKAMDSQKQYSPSEIQFLLSC SEADENDMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDLRLKNFLEQAESVLNYF RPFLGRIEIMGASRKIERIYFEISEVNRTQWEMPQVRESKRQFIFDVVNEGGESEKMEMF VNFCEDTIFEMNIASQISEQEEEEKEEDDDEPAEGETEAAGGGGDEEGNGEEGEPESISA FADFINSLLNFLSIFTFRNLRRQYRRVRKMTIKQIVVGLATFFWTILIGILHFIYSVCKG FFLLIWQTLFGGGLVEGAKNITVTEILASMPDPTQDEVHGDLPGEPGVGEEQEAGGVTDQ MDTGGGEEEEEDNQDKEGGGTPRIDAPGGLGDMGIEATVEPPTPEGTPLTKRKRQPEEGA AAAADGQAADGQAAEPAPAPALEEPPPEPEKADAENGEKAEKEAETKEEKQEEAIKKKPK AKKDKKQHREQGFQLWTELDIQRNKFLNYLSRNFYNLRFLALFIAFALNFILLFYKVSDS PPGEGDEVEGSGMFEGSGVGALFEGSGLFEGSAEEMEGSGGEEGGDEEGPVYFFLEESTG YMQPTLTFLATLHTVIAFLCIIGYNCLKIPLVIFKREKELARKLEFDGLYITEQPEDDDI KGQWDRLVLNTISFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLASLDVSQQTDKK PEEPDNSTLAWFTSVDFKYQIWKFGVVFTDGTFLYLCWYTIMSLLGHYNNFFYACHLLDI AIGVKDLRTILSSVTHNGKQLMMTLGLLAVVVYLYTVVAFIFFRKFYNKSEDEDEPDMKC DDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDVYELYRVVFDITFFFFVIVILLAIIQGLI IDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLI NKDETEHTGQESYVWKMYQERAWDFFPAGDCFRKQYEDQLA NT seq 15246 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggaggagacggtgaggaggagattcagttcttgcgtacggatgaccaggtt gtgctacaatgcacagcctccattttgaaagaacagatcaaactgtgtctgtcatgcgaa ggctttgggaaccgtttgtgcttcctggagaccacttccaatgctcagaatgtgccacct gatttggcgatctgctgcttcatcctggagcagtccctgtcggtacgagccttacaggag atgctggccaacaccatggagctcaatgaggcagtcgatttggacaaatggtcatctcaa ggagggggccaccgtaccctgctgtatggccatgctatcctactgaaacacactcactcc agcatgtacctcagctgtctgactacctcaaggtcactcacagacaaactggcctttgat gtgggcttacaggaagattccacaggggaggcgtgctggtggaccattcatcctgcatcc aagcagaggtcagagggagagaaggtcagggtgggagatgacctcatcctggtcagtgtg tcctctgagagatacctgcatctctcctatgccagtggtgacctcatggtggacgcctcc ttcatgcagaccctgtggaccatgaaccctgtgatgtctggctgtgagcttgctgaaggc tttctgactggaggctatgttcttagactgttccatggtcacatggacgagtgcttggct atccctgctgccgagcaaggagacgaccagcgcagaattgctcattatgaggggggtgct gtctgtagccatgcccggtcactatggagactagaacctctccggattggatggagtgga ggtcacatgaaatggggccagtcgttccgtgtgcgtcacataaccacaggtcgctacctc tgcctggatgaagagaaaggactgctggtggtggaccctgaaaaagcccacgccaagatg tcagccttctgcttcagaatctccaaggagaaggtggaggtggttaagaagcgagatgtg gagggcatgggcacaccagagatcaagtatggggagtccatgtgttttgtacagcacgtc tccacgggcctctggcttacgtacgcctctgtcgatgccaagtccgcccgcctgggacct ctgaagaggaaggccatccttcataaggagggtcacatggacgatgccctgaccgtgacc cgctcccagacagaggagttccaggctgctcgtatgatctacaacacagcaggcctcttc acccagttcatcaaagcactggactctctgagtgggaagaacaagtcttcttcaggcccc ctggctctgcccatggactccgtggtcctctccctgcaggacctcatcttctacttccag ccccctgaggaggagctggagcacgaggagaaacagaccaaactacgctccctcaagaac agacagaacctcttccaagaggagggcatgatcactctggtgctggactgtattgaccga ctcaatgtctacaacacggcggcccacttctccgagtttgcaggggaagaggctgccgag tcttggaaggagatagttaatctcctgtacgagctgctggcctctctgatcagggggaac cgagccaactgtgcactgttctgtgataatctggattggctggtcagcaaactggaccgt ctcgaggcctcctcaggcatcttggaggtgctatactgtgttctaattgagagtccagag gttttgaacattatccaggagaaccacattaaatctatcatttctctactggataagcat ggacgcaatcacaaggtgttggatgtgctctgctctttgtgtgtgtgtaatggggtggct gtaaggtccaatcagaatctcatcacagagaatctgcttccgggtcgtgatctcctcctg cagtccaacatcatcaattatgtcaccagtgtgaggcccaacatcttcctaggaacgtgt gagggatcaactcagtataagaagtggtattttgaggtgatggtggaccatgtagagccc ttcctgacggcccaggccttccacctgcgtgtgggctgggctctgactgagggctacagc ccctaccctggaggtggtgagggctggggtggcaacggggtgggggacgacctctactca tacgcctttgatggacttcacctgtggtcaggacgagtcccacggcatgttgcctccccc aacatgcacattctagcggcagacgatgtggtcagctgctgcctcgatcttagcgtgccc agtatctcgttccgtatcaacgggcacccggtgcagggcatgtttgagaacttcaacctg gacggcctcttcttccctgtcgtcagcttctctgcaggcgtcaaggttcgttttctcctg ggagggcgtcatggggactttaaattcctcccaccgccaggctatgccccgtgctatgag gctgtgctacccaaggatcgactgcatattgagcccatcaaggagtataagcatgatttc aatggcgtccgcaacctgttggggcccacacagtccctctcgcacacagccttcaccccc tgccctgtggacacagtacagattgtgcttccacctcacttggagcgcattcgggagaag ctggcagaaaacagccatgagctatgggccgtcactcgcattgaacaaggatggacctac gggacgttccgagatgacaacaagaaactgcacccttgcctggtagatttccagagcctg ccagagccagagaagaattacaaccttgccatgtcaggagaaacactcaagaccctgctg gcggtgggctgccatgtgggcatgggtgatgagaaagcagaggagaacctgaagaacatc aagatgcccaagacatatatgatgagtagtggatacaagcctgcccctctggacctcaac cacgtcaagctgacacccaaccagaccaacctagtggagagactggcagagaatggacac aatgtgtgggcttgtgaccgggttcaccagggatggacctacagcattgtacaggacata atgaacaagcgcaacccgcggctggtgccatacaacctgctggacgaaaagaccaagaag accaacagagacactgtctgtgcagctgtccgcactctcatcggctacggttacaacatt gagccacctgaccaggagagcagtggtcatggggaaggtaattcccgtggagataagatc cgggtgttccgggctgagaagtcgtacgcggtgacccaggggaagtggtactttgagttt gaggctgtgactgtgggggagatgagagtgggttgggccagacccagtgtccgcgctgac acagagctgggagcagatgagctcgcctatgtcttcaatggtttcaaggctcagcgttgg catgtgggcaatgagccgtttggtcgtatctggttgccaggtgacgtggtgggctgtatg atcgacctggtagagcagaacatcttcttcaccctgaacggagagatgctgatcagtgac tctggctctgagatggccttcaaggacatagacataggagatggctttatccctgtgtgt agtctgggcctgtctcaggttggccggctcaacctgggccagaacgtcagcagccttcgt tacttcaccatctgtggcctgcaggagggctttgaaccctttgccatcaacatgaagaga gacatcaccatgtggttcagcaagagcctgccccagttcatccctgtacctactgaacac cctcacgttgaggtgtcccgtgtggatgggacggtggacaacgctccctgtctgaaactg acccataagacctttggctctcagaacgccaacacagacctgctgttcctgaggcttagt atgcccgtggagttccacgagacctttaaagtcatggccgggaccacccccctgacccga accctgaccatccccgaggaccaggtcctggaggtggacccagattctgactttgaggtg ctgaagaagtctgccagccgcacagagaaagaggaggagaaggagccctctgttcctaag gagatccccgttaacggaggagagaatgtgaaagatgcctctacagagaagagcaagaag aaggggttcctgttcaaggccaagaaggcagcgttcactccgccccctgttgttcccacc atgccccgtctgatggaggaagtggtcccagacgacagagacgacgatgacatcatcctc aacactaccacatactattattcagtgcgggtgattgcgggacaagagcccagcggggtg tgggtaggctggatcacccctgactaccaccagtacgacctgcactttgacctcagcaaa gtcagaaatgtcactgtcaccgtgggagatgacaaaggcaacatacatgacagtatgaag cgcagtaactgctacatggtgtgggggggggagttcagcagctcccagcagacccgtgtc agtcaggaggactttgtgattggctgccttattgacctggacacaggcctcatgactttc acagccaatgggaaagagatcaacaccttctaccaggtggagcccaacactaaactgttc ccagctgtgtttgtcctgccctccagtcagaacatgctgcaagtggagctgggcaagctc aagaacatcatgcctatctcggcagccatgttccgcagtgagcgtaagaacccagtccct cagtgtcctcccaggctggacgtccagatgctgaccccagtcatctggagccgcatgcca aaccacttcctgtccccagagacgggccgtgtgaacgagaggcacggctggatggtggag tgtagagagcctctcaccatgatggccctgcacatccctgaggagaacagatgtattgac gtcctggagctgtcggagcatatggacctgctgaagttccactaccacactctgaagctg tacggctcggtctgtgctctggggaacaaccgcgtggctcacgccctgtgcagccatgtt gacgagtcccagctattctacgccatagagaacacctacctgcctggaccaatgaggagc ggctactacgacctgctcatcagtatgcacctggagtcggccaagaggaaccgcctcatg accaataaggagttcatcgttcccatgacagatgagacgcgtagcatcaacctctactca gacactgacaagtcccatgctttaccaggggtgggcctcactacctgcctgcgccccaaa ctccacttctcccccactgggtttgtggggacagacctggacatctacaccctcagcccc ttcatccccctacatgtgctgaaggcgaaggccctgaccatgctgacagaagctgtacaa gatggtggtcaggccatgagggatcctgtaggaggcagtgttgagttccactttgtcccc atcctcaagctcatcagcaccctgctcatcatgggtgtgtttgagaatgaagatgtcaag cacatcctgaagatgattgagcccactgtgttcagtggagaggccgctgcccagggagag ggggcccaaacactggccctcaaagaacgggggttggaggtgaaggaagaagaggaggga gcagtagagagtggacatgaaacggaggatgaggggatgggtgaggaagatgaggaaatg gaagcagagcttgaggagttggagcctattgaaaaagaggaagatgagggggaggacgac agcgagaaagtggatggagagaaaggtgctgagaagacggaggaggaggaaaagcctggc aaggcagatgaagaggcagaagagcaagtaggtctggaagagggattactgcacatgaag ctaccagagtctgtcaaactacagatgtgcactctgctgcagtatttctgtgactgtgag ttgcgccatagggtggaggccatcatagccttctcagaccagtttgtgagccaggtgcag gccaaccagagagcacgctacaacgagctcatgctggcgttcaccatgagcgccgccgag accgcccgcaagacccgcgagttccgctccccaccacaggagcaggtcaacatgctgatg aacttcaagaacattgcagaggatgaggattgtcctgtgcctgacgaggtccgtgatgca ctgcaggcttttcacaagaacctgctggctcactgtggtgtacatattgaagaggaagag ttggaggaggagttggatatgtctctcaaaggacgactcctccgaatgctggacaagttg aggcacctccgtaagaagaaggtagaggaggaggaacctgtcgaagacaccaaacccagc accctccaggagctgatctcccacaccatggtccactgggcccaggagtcgttcatccag aaccctgagctggtgcgtctgatgttcagcctgcttcaccgtcagtatgacgggctgggg gagctgatccgggccctgcccaaggcctacaccatcaacgccatctccataaaggatacc atggacctgctggagtgcctgggacagatccgctcactgctcatcgttcagatgggcccc gaggaggagaggctcatgatccagagcatcgggaacatcatgagcaacaaagttttttat cagcaccccaacctgatgcgagcgctgggcatgcacgagactgtcatggaggtgatggtc aacgtgctgggtggtggcgactccaaggagatcagattccctcgtatggtcaccaactgc tgtcgtttcctgtgttacttctgtcgcatcagtcgtcagaaccagcgctccatgttcgat cacctcagctacctgcttcagaacagtggcatcggccttggaatgcgtggctccacacct ctagatgtagctgcagcatcctgcattgataacaatgagctggctctggcgctacaggaa caagacctggagaaggtggtgaagtacctcgcaggctgtgggcttcagagctgtccccag ctcctggctaagggttaccctgacattggctggaacccctgtggcggggagaaatacctg gacttcctccgcttcgctgtcttcgtcaatggagagagcgtagaggagaatgccaatgtg gtggtgcgtcttctgatccgtcggccagagtgttttgggccggccctgagaggagagggt gggaacggcctgctggctgctatagaggaggccatcaagatctctgaggatcctgccagg gacggccccactgtcaagaaagacagacgcttccccggcatgttccctggtggggaggag cagcatgaggagaacaaggttcacctggggaatgccatcatgtccttctactcagctctc attgacttgctgggacgctgcgctccagagatgcatttgatccaggctgggaagggtgag gcactgaggatcagggccatcctgaggtccctggtgcccatagaggacctggtgggagtc atcagcctgtctgttcagatcccagactttggaaaggataacagcatcattgaacccaag atgtcttccagttttgtgccggaccacaaggctcccatggtgctgttccttgacagagtg tatggtattgacaaccaggacttcctgctccatgtgctggaggtgggcttcctgcctgac atgagggcagctgcttctctggacacggcggctttctgcaccacagaaatggccctggct ctgaaccgctacctctctctagccgtgctgcccctcatcaccaagtgtgccttcctgttc gcgggcacagaccaccgggccatcatgatcgactccatgctgcacaccatctaccgtctg tcccgcggacgagccttcactaaggcccagagagatgtcattgaggagtgtctcatggct ttgtgcaaaaatctacggccatccatgttacaacacctgttgagaaggctggtatttgat gtaccaattctcaatgaatatgccaaaatgccacttaagcttttgaccaatcactatgag cgttgttggaagtactattgcctgcccaacggctggggcaactttggactgtcatcagag gaggagctgcatctcacccgcaaactcttctggggcatctttgagtccttggcccacaag aaatttgacgctgagctgttcaaaattgccatgccatgcatatgtgccattgctggggcc atccctccagattatgtagatgccagctactcctccaagactgagaagaaagccttggtg gatgcagagggaaactttgatcccaaaccagtggagaccacaaatactatcatccctgag agattggatggtttcatcaacaaatatgctgaatacacacatgacaagtgggcttttgaa aagattcagaataactggacatatggagagattttggatgaaaatgaaaaaactcaccca atgctccgaccgtacaaaacattctcagagaaggacaaagagatctaccgttggcccatc aaagagtccatgaaggctatgattgcatgggagtggactctggatcaaacgagggaagga gaggaagccaagactgagcagaagaaggcggctcggaagatctctcagactgcacaggca acatatgaccccagccatggctacagtccccaaccgattgaaatctcccacacggcactg tcaagagagctgcagtccatggcagaacagcttgcagagaactatcacaatacctggggt cgcaagaagaagatggagctgcagtccaaaggaggaggctcccaccctttgcttgtaccc tatgacaccctgacagcaaaagaaaaggcacgagacagggaaaaggctcatgagcttctc aaatttcttcaactcaatggatttgcagtcaccagggggatgaaagacatggagtcagac atctcatctatcgagaagcgctttgcctatggtttcctgcagaagctgttaaagtggatg gagatcgcccaggagttcatagctcatcttgaggctgtggtgagcagtggcagagtggag aagtcgcctcatgagcaggagatcaaattctttgcaaagatcctgttgcccctgatcaac cagtactttaaaaaccactgtctgtacttcctgtccacaccggccaaagtcctgggtagt ggaggacattcctctaacaaggagaaagagatgattgccagcatcttctgtaaaatggct gctctggtgagacacagagtttctctcttcggaaatgatgcccctgctattgtcaactgt cttcacatcctggcacgatctctcgacgcaaggacggtgatgaagtctgggcctgagatt gtgaaggcagggctccggtcgttctttgagggtgcagctgatgatatcgagaagatggtg gagaacctcaaactgggaaaggtgtctaaaggcaaccagcaggtgaaaggcgtgtcccag aacatcaactacaccaccatcgctctgctcccagtcctcacctccctgttcgaccacatc tcacagcaccagtttggagatgatgtcatgctggatgatctccagacgtcatgttaccgc atcatgtgtgccatctactccctgggcactgtcaagaaccctcatgtggagaggcagagg ccagctatgggggagtgtctggcccatctggcggctgctatgcctgtggcctacctggag ccccatctcaatgagtacaacaccttctctgtctacaccaccaagacccccagagaaaga gccatcctgggtctgcccaacgaggtccaggagttatgccaggacataccagagctagac attctgttgaaagagatcggggacttggcagagtcaggtgcccgttacactgagatgccc catgtgatcgagataactctgcccatgctgtgtaactacctgccccgctggtgggaaaga ggagtagagaacttccctgagctggagggccagatctgcaccgacgtcacctctgagcag ctcaaccagctgctgggcagcatcatgaagatcgtggtcaacaacctgggaattgacgag gcctcctggatgaagaggctggctgtcttctcccagcctattgtgagcagggccaagcca gagatgctcaagtcccatttcatccccaccatggagaagctgaagaagaggactgggaag gtggtggcagaggaggaccacctgcgtatggaggggaaggctgagggggacgaggaggag ggcaccatcagggatgagttttctgtgctctgcagggacttgtacgctctctaccctctc ctcatccgctatgtggacaataacagggcgaggtggttgacatgcccagacccagatgca gaggagctcttcagaatggttggagaggtcttcatattctggtccaaatctcataacttc aagcgagaggagcagaactttgtggtgatgaatgagattaataacatgtctttcctgact gctgacagcaagagcaagatgagtaagggcaacgactcagaggctggtggctcagacgtg gagcgtaccaagaagaagagacggggtgatcgttactcagtgcagacgtcacttattgtg gctgccctgaaaaagatgctccccatcggcctcaacatgtgctcccctgctgatcaggag cttatcaacctggccaagatacgatactctttgagggacactgatgaggaagtaagggag ttcttgcaaaacaacctgcatcttcaaggcaaggtggagaacccgtccatgcgctggcag atgtccctatataaggagatggcagggaaggctgaggatgctgacgctcctgagaaagtg gttaagagggtgcaggaggtgtctgctgtgctctatcacattgaggtgacggagcacccc ttcaaatccaaaaagatggtgtggcacaaactgctgtccaagcagagacgcaaggctgtg gtagcctgctttaggatgacaccactctacaacctacccaggcatagagcttccaatatg ttcctggaaggatacaaacgcaactggatccatactgagggctactcctttgaggacaga atgatagacgacttgtctaaagccatggagcaggaaggagaagaggaggaagagacggag accaagccagacccccttcaccagctcattttgcatttcagccgtaccgctctcacagaa aagagtaaacttgatacagattatctatatatggcatatgctgatattatggcagagagc tgccacattggtgaggaggacgaagggggagaggaggtggaggaaggggctgaggatgag atgtcctttgaggaaaaagagatggagaagcagagactcctataccagcagtcccgtctc cacaaccgtggggcggctgagatggtgctgcagatgatcagtgcctgcaaaggtgagact ggctccatggtgtcctccacccttaaactgggcatctccatcctaaacggtggtaacgtt gaggttcaacagaaaatgcttgagtacctgaaggacaagaaggatgttggcttctttttg agtgtccaggctctaatgcagacatgcagtgtcctggacctgaatgcctttgagagacag aacaaggcagagggtctgggcatggtgtcggaggagggaacaagtgagaaagtcatgtcg gatgatgagtttacctgtgatctgttccgcatgttgcagctgctctgtgagggccacaat aacgatttccagaactacttgcgaacacagaccggcagcaccaccactatcaacatcatc atctgcactgtggattacctcctccgactgcaggagtcaatcagtgatttctactggtat tactctggtaaagagatcatcgatgagccaggcaagaagaacttctccaaggccatgata gtggctaaacagatcttcaacagtctgactgagtacatccagggtccatgtacaggcaat cagcagtccctgacccacagcaggctgtgggatgcagtggtaggcttcctccacgtcttt gcccacatgatgatgaagctggcacagggtaaagactccagccagattggacttctgaag gagctactggacctccagaaagacatggtggtcatgctactctctctactagagggtaat gtggtgaatggcaccattgcccgtcagatggtggacatgctggtggagtcctccagcaac gtggagatgatcctcaagttctttgacatgttcctcaaactgaaggacattgtggcgtca gacgccttccgtgattacgtgaccgacccccgagggttaatctctaagaaagactttcag aaggccatggacagccagaaacagtattctccctccgagatccaattcctgttgtcctgc tcagaggctgatgagaacgacatgataaactttgaggagtttgccgaccgcttccaggag ccagctaaagacattggctttaacattgcagtgttgctgaccaacctgtctgaacatgtg cctcatgacctcaggctgaagaacttcctagagcaggcagagagtgttctcaactacttc cgccccttcctgggccgtatagagatcatgggtgccagcaggaagatagagcgtatttac tttgagatcagcgaggtcaaccgcacacagtgggagatgcctcaggtcagagagtccaaa cggcagttcatctttgacgtggtcaatgaggggggcgagtcggagaagatggagatgttt gtcaacttctgtgaggacaccatctttgagatgaacatcgcctcccagatctcggagcaa gaggaggaggagaaggaggaggatgatgatgagccggctgaaggagaaactgaggcagca ggaggaggtggagatgaagagggcaatggagaggaaggagagccagagtccatctctgcc tttgcagacttcatcaacagcttattgaacttcctgagtatcttcaccttccgtaacctg cgacggcagtaccgcagagtgaggaagatgactatcaagcagatagtggtgggtctggct accttcttctggactatcctcatcggcatcctgcacttcatctacagtgtatgtaagggc ttcttcctgctcatctggcaaactctatttggcggaggcctggtggagggagccaagaac atcacggtgacagagatcctggccagtatgcccgacccaacccaggacgaggtgcatggg gacctgccaggggagcctggggttggggaggagcaggaggcaggaggggtgactgaccaa atggacacaggcggtggagaggaggaggaggaggacaatcaagacaaggaaggtgggggg acaccacgcatcgatgctcctggaggacttggtgacatgggaattgaggccactgttgag cctcctactcccgagggtactcctttgaccaagaggaaacggcaaccagaggagggtgct gctgcagctgctgatggccaagctgctgatggccaagctgctgagccagctcctgctcct gccttagaggagccccctccagagcctgagaaggcagacgctgaaaatggagagaaggcc gagaaagaagctgagaccaaagaggagaagcaggaggaagcgataaaaaagaagcccaag gctaagaaagataagaagcaacacagggagcaagggttccaactctggactgagctggac atccaaagaaacaaattcttgaactacctctctcggaacttttacaatctgcgttttctg gcactgttcattgcatttgccctgaactttattctactcttctacaaggtgtcggacagc ccccctggagaaggtgatgaggtggagggctctggcatgtttgagggctctggggtgggg gcgctgtttgagggcagtgggctgtttgagggctcagcggaggagatggagggatctggt ggggaggaaggaggagacgaggagggcccagtctacttcttcttggaggagagcactggc tacatgcagcccaccctcaccttcctggccaccctgcacaccgtcatcgccttcctctgc atcatcggctacaactgtctaaagatccctctggtgatctttaagagagagaaggagctg gccaggaagctggagtttgatggtctttacatcacagagcagcctgaggatgatgacatc aaaggccaatgggacagactggtcctcaacacaatctctttcccaaacaactactgggac aagtttgttaagcgaaaggtcctggataagtatggcgacatttacggcagagagaggatt gcagagctcctaggcatggatttagcctcgctggatgtcagtcaacaaactgataagaag ccggaggaacccgacaattccacgttggcctggtttacatctgttgacttcaagtaccag atctggaaatttggagttgtgttcacagacgggacttttctctatctatgttggtacacg atcatgtccttgcttggacattacaacaacttcttctatgcctgtcacttgctggacata gccatcggtgtgaaggatctacgtactatcctgtcctccgtcacccacaatgggaagcag ctcatgatgacattgggcttgttggcagtggtggtgtatctctacactgtagtggccttt atcttcttccgcaagttttacaacaagagtgaagatgaggatgagccggatatgaaatgt gatgacatgatgacttgctacctcttccacatgtacgtgggcgtgcgtgctggcggtggc ataggggacgagatcgaggacccggcgggagacgtgtacgagctctaccgggtcgtcttt gacatcaccttcttcttctttgtcattgtcatcctgttggccatcatccagggtctgatc attgacgccttcggagagctcagagaccaacaggagcaggttaaggaagacatggagacc aagtgcttcatctgtggaattggaagcgactactttgatacgacgccgcatggcttcgag acccacaccctagaggaacacaacttggccaactacatgttcttcttaatgtacctcatc aacaaagacgagacagagcacactggccaggagtcgtatgtgtggaagatgtaccaggag cgagcgtgggacttcttccctgctggcgactgtttcaggaagcaatatgaggatcagctt gcataa

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