Coregonus clupeaformis (lake whitefish): 121567835 Help Entry 121567835         CDS       T08357                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b isoform X4   KO K04961   ryanodine receptor 1 Organism cclu  Coregonus clupeaformis (lake whitefish) Pathway cclu04020   Calcium signaling pathway cclu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cclu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121567835 (ryr1b)    04020 Calcium signaling pathway     121567835 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:cclu01009]     121567835 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:cclu04147]     121567835 (ryr1b)    04040 Ion channels [BR:cclu04040]     121567835 (ryr1b) Protein phosphatases and associated proteins [BR:cclu01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      121567835 (ryr1b) Exosome [BR:cclu04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    121567835 (ryr1b) Ion channels [BR:cclu04040]  Voltage-gated cation channels   Ryanodine receptor    121567835 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  121567835 NCBI-ProteinID:  XP_041734088 LinkDB All DBs Position 6:31550807..31766563 Genome browser AA seq 5091 aa AA seqDB search MAEGGEGEEEIQFLRTDDQVVLQCTASVLKEQIKLCLACEGFGNRLCYLETTSNAQNCPP DLAICAFILEQSLSVRALQEMLANTVDMSESSQGGGHRTLLYGHAILLRHYHSGMYLSCL TTSRSLTDKLSFDVGLQEDCVGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSYASGDLMVDASFMQTLWNMNPVCSGCELAEGFLAGGQVLRLFHGHMDECLAISMPDDG DDKRSTAHYEGGAVCSQARSLWRLEPLRISWSGSHMKWGQSFRVRHITTGRYLCLDEEKG LMVLDPERANTKLSAFSFRVSKEKVEQARKRDVEGMGIPEIKYGESMCFVQHVSTSLWLT YASLDAKAARLGTMKRKAILHQEGHMDDALSVARSQTEESQAARMIFSTTGLFRQFIKGL DSLQGKNKSPGPVSLPLDGVVLSLQDLIFYFRPPEEELEHEEKQTKLRSLRNRQNLFQEE GMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFC DNLDWLVSKLDRLEASSGILEVLHCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLRSLCVCNGVAVRSNQNLITENLFPGRDLLLQTNIVNYVTSVRPNIFLGTCEGSTQYKK WYFEMMVDYVEPFVTATPSHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHL WSGHVPRQVASPNQHALAADDVVSCCLDLSVPSISFRVNGHPVQGMFENFNVDGLFFPVI SFSAGVKARLLLGGRHGDFKFLPPPGYAPCYEALLPKERMRIEPIKEYKHDFDGVRNLLG PTQSLTHTSFTPNPVDTVQIVLPPHLEKIREKLAENIHELWAITRIEQGWTYGIFRDDNK KLHPCLVDFQTLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKIIKMPKTYIM SNGYKPAPLDLSHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDIMNKRNPRL VPYNLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQESTGLGLDDVRGDKVRIFRAEKS YAVTSGKWYFEFEAVTTEEMRVGWARPNVRADNELGADELAWVFNGKTAQRWHVGNDPFG RQWQSGDVVGCMIDLTEQNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCTLGLSQVG RINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFAPVPTNHQHIEVSRV DGTVDSAPCLKLSHKTFGSQNANTDMLFLRLSMPVEFDEVFKIPAGTTPLTHKLTIHEDE VLEVEPDSEFEVLKKSASKKEQEEKEKEPSVAKETPEIEKDTVSEKGKKRGLFARAKKAA TINPPPTPPLVPRLQQDVVPDDRDDVEIIQNTTTYYYSVRIFAGQEPSGVWIGWVTPDYH MYDPTFDLSKVRNVTLTVGDDKGNIHDSMKHSNCYMVWGGDFGSSSQQARFSQEDTVVGC LVDLATGLMTFTANGKEINTFYQVEPNTKLFPAVFVQPSSQNMVQLELGKLKNIMPISAA MFRSERKNPVPQCPPRLDIQMLTPVIWSRMPNHFLDPEVGRVSERLGWMVECTEPLTMMA LHIPEENRCIDILELSERLDLLKFHFHTLMLYCAVCALGNNRVAHALCSHVDESQLFYAM ENTYLPGPLRSGFYDLLISIHLESAKRARLGTNREFIVPMSPETLSITLYPDAEKASDLP GVGLTTCLRPKLHFSAINFVGTDPDLYTLSPVFPLQELKTKAISMLTEAVLDGSQAMRDP VGGSVEFHFVPILKLISTLLIMGIFNDEDVKHILKMIDPNVFAGKKEEVVEEEEEGEKAE GEDATAKEEGEEVKEKEEGEEEEEEEEEADDEGVGEEEEEDEELKNLEKEEGETEEEGEK EHKEEEKEKEEEGEEKEMTEEEKNIAATELELEKEEAALEEGLLQMKLPESVKLQMCTLL QYFCDCELRHRVEAIVAYSDQFVNAIQTNQRVRYNLLMQAFSMSAAETARKTREFRSPPQ DQVILLTNFKHGPEEEECPVPEETRDTLTDFHTDILIHCGVHIEAEEEEEEVDTSLRGRL GRLVGKVKNLRKKKEVVEEPKEEEEVKPSTLQELISHTMIHWAQEAFIQNPELVRLMFSL LHRQYDGLGELTRALPKAYAINAVSVQDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIG NIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGGDSKEIRFPQMVTNCCRFLCYFCRI SRQNQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEKVVTYL AGCGLQSCPMLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPE CFGPALRGEGGAGLLAAIEEAIKISEDPARDGPTIKKDRRFPMFGGEEQQEENRVHLGNA IMSFYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLSVQIPDYGK DGHTIEPKMSASFVPDHKASMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTLAF STTEMALALNRYLCSAVLPLITKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRALTKAQRD VIEECLMSLVKYLRPSMLQHLLRKLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPNGW ANFGVSSEEELHLSRKLFWGIFESLAHKKFDAELFKIAMPCICAIAGAIPPDYVDASYSS NTEKKASVDAEGNFDPKPVETTNTIIPEKLDAFINKYAEHTHDKWAFEKIQNNWSYGEVL DENAKTHPMLRPYKTFSEKDKEIYRWPIKESVKAMLAWEWTVEKAQAGEGEKVEMKTTTR KISQTAQATYDPSHGYSPSPVDITAMALSRELQSMAEQLAENYHNTWGRKKKMELMGKGG GAHPLLVPYDTLTAKEKARDREKAQDLLKFLQLNGYAVTRGLKDMEQDISSIEKRFAYGF LQKLLKWMDIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLVNQYFKNHCLYFLS TPAKLLGSGGHSSNKEKEMIASIFCKLAALVRHRVSLFGTDAGAVVNCLHILSRSLDART VMKSGPEIVKAGLRQFFESAADDIEKMVENLKLGKVSSRNQVKGVSQNINYTTIALLPVL TTLFDHIAQHQFGDDVILDDLQISCYRIMCSIYSLGTVKTPHAEKQRPALGECLANLAAA MPVAYLEPGLNEYNAYSVYTTKTPRERGILGLPNQVEELCTDIPELDVLMKEIGDLAESG ARYTEMPHVIEITLPMLCNYLPRWWERGLENYPDLEGQLCTDVTSEQLNQLLGSIMKIVV NNLGIDEASWMKRLAVFAQPIVSRAKPEMLKSHFIPTMEKLKKRSGKVVAEEEQLRLEGK SEVDSEEGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIF WSKSHNFKREEQNFVVMNEINNMSFLTADSKSKMSKAGGDEAGGSDVERTKKKRRGDRYS VQTSLIVAALKKMLPIGLNMCSPADQELINLAKIRYSLKDTDEEVREFLQNNMHLQGKVE DPSMRWQMALYKETSGKAEDAEDPEKVVKRVQEVSSVLYHIEVTEHPYKSKKMVWHKLLS KQRRKAVVACFRMSPLYNIPRHRGSNMFLNGYKRNWLQTEGYQFEDRMIDDLSKAMEEEE LGEEGEEEAETKPDPLHQLILHFSRTALTEKSKLEVDYLYMAYADIMAKSCHIGEEEEGG EEEAIEVTQTEMEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACRGETGSMVCSTLKLGI SILNTGNCDVQQRMLDYLKDKKDVGFFLSIQALMQTCSVLDLNAFERQNKAEGLGMVSEE GTNEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQE SISDFYWYYSGKDIIDEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDA VVGFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDML VESSSNVEMILKFFDMFLKLKDITGSDAFRDYVTDPRGLISKKDFYKAMDSQKQYSPSEI QFLLSCSEADENEMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAE SVLNYFRPFLGRIEIMGASRKIERIYFEISEANRNQWEMPQVRESKRQFIFDVVNEGGES EKMELFVNFCEDTIFEMNIASQISEVEEEEAVDSEDEEEEGGGEGGGGELDENGEEMPPE SSSAFSDFLTSVVNFFNMFTFKNLRRRYRKLRKMTLKEMVVGLATFIYTILFGILSFIYS VCKGFFMLIWSTLFGGELVEGAKKITVTELLASMPDPTQDEVHDELPPEPGAEEGQEGIE GGEDRDVGGGEEREEGGDGEEKEGGRMPGFDTPGGLGDFGETTAVEPPTPEGTPLLKRKL LEATSGGEGEEREETEPEEETPPEEEKADNENGEKAEKEAEPVVKEEEPAAKEDKLKTKA KKEKRPAEEGYELWNELEIQRIKFMNYLSRNFYNLRFLALFIAFALNFILLFYKVGYDVE AGSEDIEGSALFEGSALFEGSGLFESSGAVDEGGSGIDPFDDGGDDDDSGGDDDDEEEGP FFFYLEESTGYMQPCLSMLAIIHTVIAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLY VTEQPEDDDIKGQWDRLVLNTPSFPNNYWDKFVKTKVLAKYGDIYGRERIAELLGMDLAS LDVSAMTQEKKPEPESGMLSWIISIDIKYQIWKFGVVFTDNTFLYLVWYMVMSLLGHFNN FFFACHLMDIAVGVKDLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNMS EEEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIV ILLAIIQGLIIDAFGELRDQQEQVRENMETQCFICGIGSDYFDTTPHGFETHTLEEHNLA NYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKTYEDQLA NT seq 15276 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggaggagagggagaggaggagattcagttcctccgcacggatgaccaggtg gtgctgcagtgcactgcgtctgtcctgaaggaacagatcaaactgtgtctggcctgtgag ggcttcggaaaccgactatgttacctggagaccacatccaacgctcagaactgtcctcca gatctggccatctgtgccttcatcctggaacagtccctgtcagtccgtgcactgcaggag atgctggctaacaccgtggacatgagtgagtcgtcccaaggaggaggccatcgcaccctg ctatacggccatgctatcctgctcagacactaccactctggcatgtatctgagctgcctg accacgtctcggtcgctaacagacaagctgtccttcgatgtgggcctgcaggaagactgc gtaggcgaggcgtgctggtggaccatccaccctgcgtccaaacagaggtcagagggagag aaggtcagggtaggagatgacctcatcctggtcagtgtctcctcagagagatacctgcat ctgtcctatgccagtggtgatctgatggtggacgcttccttcatgcagactctatggaac atgaaccctgtgtgttcaggctgcgagctggctgagggtttcctggccggtggtcaagtc ctcagactgttccacggacacatggatgagtgtctggccatctccatgcctgacgacggg gacgacaaacgcagcaccgcccactatgaaggaggagctgtgtgtagccaggcccgttcg ctatggcgactggagcctctgagaatcagctggagcggcagccacatgaagtggggccag tcgttccgtgtacgccacatcaccacgggccgctacctctgtctggacgaggagaagggc ctgatggtcctcgaccctgagagggccaataccaaactgtctgctttcagcttccgcgtg tcaaaggagaaggtggaacaggcccgtaagcgagacgtggagggaatgggcatcccagag atcaagtatggagagtccatgtgttttgtccagcacgtctccaccagcctgtggctcacc tatgcctccttggacgctaaggctgctcgcctggggaccatgaagaggaaggccattctg caccaggagggccacatggacgatgccctgtctgtggcccggtcccagacggaggagtct caggctgctaggatgatcttcagcaccacggggctcttcaggcagttcatcaagggtctg gactccctgcaggggaagaataagtctcctggccctgtgtctctacccctggatggggta gtgctctccctgcaggatcttatcttctacttccgaccccccgaagaagagctggaacac gaggagaaacagaccaagctccgctccctccgcaaccgacagaacctcttccaagaggag ggtatgatcaccatcgtgctagagtgtatcgaccgtctgaatgtttacaacactgctgct cacttctctgagtttgctggagaggaggccgctgagtcctggaaggagatcgtcaacctg ctttatgagctgctggcctctctgatcagggggaaccgctctaactgtgcgctgttctgt gataacctggactggctggtcagcaaactggaccggctggaggcctcttcaggtatcttg gaggtgctgcactgtgtcctgattgagagtccagaggtcctgaatatcattcaggagaac cacatcaaatccatcatctctctgctggacaaacatggcagaaaccacaaggtgttggac gtcctccggtccctttgtgtgtgtaacggtgtcgctgtaaggtccaatcagaacctcatc acagagaatctatttccaggtcgcgacctcctgctgcagactaacatcgtcaactacgta accagtgtgaggcccaacatcttcctgggaacctgtgaaggctctactcagtataagaag tggtactttgagatgatggtagactacgttgagcccttcgtgacagccacaccctctcac ctgcgtgtgggctgggccctgacagaggggtactcaccctatcccgggggtggagagggc tgggggggcaacggggtgggggatgacctctactcatacggcttcgatggactgcacctg tggtcaggtcacgtcccccgccaggtggcgtcgcccaatcagcatgccctggcagctgat gatgtcgtgtcgtgctgtctggatctgagcgtgcccagtatctcgttccgtgtcaacggc cacccggtccagggcatgttcgagaacttcaacgtagatggactgttcttccccgtcatc agcttctctgctggagtcaaagctcgtttactgttgggtggtcgccatggagactttaag ttcctgccccccccaggctatgccccgtgctacgaggctctgctacccaaggaaaggatg aggatcgaacccatcaaggagtacaaacacgactttgacggagtccgaaacttgctgggg ccaacccagtccctcacacacacctcctttacccccaatcccgtagacactgttcagatc gtgttgccgccccacctggagaagatcagggagaagctggcagagaacatccatgagctg tgggccatcacccgcatcgagcagggctggacttatggaatattcagagacgacaacaag aagctgcatccctgtctggtagacttccagacccttccggaacctgagaggaactacaac ctgcagatgtctggtgaaacactcaagactctgctggccctgggctgccatgtgggcatg ggagatgagaaggctgaggagaacctgaagataatcaaaatgccaaagacctatataatg agcaatggatataaacccgcccccctggacctgagccacgtcaagctgacgcccaatcag aaccagctggtggagaagctggcagagaacggccacaatgtgtgggcgcgggaccgcgtg cgccagggatggacttacagcatcgtgcaggacatcatgaacaagcgtaacccacgtctg gttccttataacctgctggatgagagaaccaagaagaccaaccgagacagcgttaacaac gctgtgcgcactctcattggctatggatacaacatcgagcctccagaccaggagagcact ggccttggcctggacgacgtgcgtggggataaggtgcgcatcttccgtgctgagaagtcg tacgcggtcacgtctgggaagtggtactttgagtttgaggcagtgacgaccgaagagatg agagtgggctgggcccgacccaacgtcagggctgacaatgagctgggagcagacgagctg gcctgggtcttcaacggaaaaacggcccagcgctggcacgtgggtaatgacccgtttggt cgccagtggcagtcaggtgacgtggtggggtgtatgatcgacctgaccgaacagaacatt atgttcaccctgaacggagagatgctcatcagcgactctggctccgagatggctttcaag gacatagagataggagaaggcttcatcccagtatgtaccctgggcctgtctcaggtgggc aggatcaacctgggtcagaacgtcagcagcctgcgttacttcgccatctgtggtctccag gagggcttcgaaccgttcgccatcaacatgaagagagacattaccatgtggttcagcaag agcctgccacagttcgccccagtgccaactaaccaccaacatattgaggtgtcacgcgtg gacgggacagtggacagtgctccctgcctgaagctgagccacaagacattcggctcccag aacgccaacactgacatgctgttcctccgcctgagcatgcccgtggagtttgacgaagtc ttcaagatcccagccgggaccacgcccctgacccacaagttgaccatccacgaggatgag gttctggaggtggagccggactcagagtttgaggttctgaagaagtcggccagtaagaag gagcaggaagagaaggaaaaggaaccatctgtcgccaaggagacgcccgagatagagaag gacacggtgtcagagaagggcaagaagagagggttatttgctagggctaagaaggcggct acgatcaaccctcccccgacccctcccctggtgccacggttacagcaggacgtggtccca gatgacagagatgatgtggagattatccagaacaccaccacgtactactactcagtgagg atcttcgccggccaggagcccagtggggtgtggattggctgggtaacccccgactaccac atgtacgaccccacctttgatctctccaaggtccggaacgtcaccttaaccgtgggagat gacaagggcaacatccacgacagtatgaagcatagtaactgctatatggtctggggtgga gacttcggcagcagctcccagcaggccaggttcagccaggaggacactgtggttggctgc ctggttgacctggcaacaggcctcatgaccttcacagccaatgggaaggagataaacacc ttctaccaggtggagcccaacacaaagctgtttcctgctgtgttcgtccagccctccagt cagaacatggtacagctggagctggggaaactcaagaacatcatgcccatctcggcagcc atgttccgtagtgagcgtaagaacccagtgcctcagtgcccaccccggctggacatccag atgttgacccccgtcatctggtcccgcatgcccaaccacttcctggacccagaggtcggc agggtcagcgagaggctgggctggatggtggagtgtaccgaaccactcaccatgatggcc ctgcatatacctgaggagaacaggtgtatagacatcctggagttgtctgagcggctggac ctactgaagttccacttccacactctgatgctgtactgcgctgtctgtgccctgggcaac aaccgtgtagcacacgccctctgctcacatgtcgacgaatcacagctcttctacgcaatg gagaacacctacctgcccggccccctccgcagcgggttctacgacctgctgatctccatc cacctggagtcagccaagcgggcacggctgggcaccaaccgggagttcatcgtgcccatg tcccccgagacgctgagcatcaccctgtaccctgatgctgagaaggcctccgacctcccg ggtgtcgggttaactacctgtctcaggcccaagctgcacttctcagccatcaactttgtt gggacggaccccgacctgtacactctcagccctgtattccctctgcaggaactgaagacc aaagccatcagcatgttgacagaggcagtgctggatggtagccaagctatgagggaccca gtagggggcagcgtagagttccacttcgtccccatcctgaagctcatcagcactctcctc atcatgggcatcttcaacgacgaagacgttaaacacatcctcaagatgattgacccaaat gtgttcgctgggaagaaagaggaggtggtggaggaggaggaggagggagagaaggcagag ggagaggatgctactgccaaggaagagggggaagaagtgaaggagaaggaagagggagag gaggaagaggaggaagaggaggaggcagatgatgaaggagtaggggaggaggaagaggag gatgaggaactgaaaaacctggagaaagaagaaggggagacggaggaggagggggagaag gaacacaaggaggaggagaaggagaaagaggaggagggggaggaaaaagagatgacagaa gaggagaagaacatagcggcgacagagttggagttagagaaggaggaggccgctttggag gagggactactgcagatgaagctgccagagtctgtcaaactgcagatgtgtacgctgctg cagtacttctgtgactgtgaactgaggcacagggtggaggctatcgtggcgtactcagat cagtttgtcaacgccattcagaccaatcagagggttcgctataacctgctgatgcaggcc ttctccatgagcgctgccgagaccgcacgcaagacacgagagttccgctccccacctcag gaccaggtgatcctgctgaccaacttcaagcatggtccggaggaggaggagtgtccagta ccggaggagaccagagacacactgaccgacttccacactgacatccttatacattgtggt gtgcacatcgaggcggaggaggaggaagaggaggtggacacctctctgagagggcgcctg ggccggctggtggggaaggtgaagaacttgaggaagaagaaggaggtggtggaggagcca aaggaggaggaggaggtcaaacccagcactctccaggagctgatctcccataccatgatc cactgggcccaggaggccttcatccagaaccctgagctggtgcgtctgatgttcagcctg ctccacaggcagtatgatgggctgggggagctgaccagagccctgcctaaagcctacgcc atcaacgctgtgtctgtccaggatacaatggacctgctggagtgcctgggccagatcaga tctctgctcatcgtccagatgggcccagaggaggagaggctcatgatccagagcatcggg aacatcatgaacaacaaggtgttctaccagcaccctaacctgatgagggctctggggatg catgagactgtcatggaggtgatggtcaacgtgctgggaggaggaggagattccaaggag atccgcttcccccagatggtgaccaactgctgtcggttcctgtgttacttctgtcgaatc agccgacagaaccagaggtccatgtttgatcacctcagctacctgctgcagaacagcggc atcggcctgggtatgcgtggctccacccctctagatgtggctgcagcttcctgtatcgac aacaacgagctggccttggctctacaggagcaggacctggagaaggtggtgacgtatctg gcgggctgtggactacaaagctgtccgatgctcctgtctaagggttaccctgacatcggc tggaatccctgtggaggagagaaatacctggacttcctccgctttgccgtctttgtcaac ggagagagtgtggaggagaatgccaacgtggtggtgcgtctactgattcgtcggccagag tgttttggccccgccctgagaggagaggggggtgctggtctgctggcggcaatagaggag gccatcaagatctcagaggacccagccagggacggacctaccatcaagaaggacaggcgg ttccccatgtttggtggtgaggagcagcaggaggagaaccgtgtccatcttggaaacgcc atcatgtccttctactctgccctcatcgacctgctgggacgatgtgctcctgagatgcac ttgatccaggcgggcaaaggtgaggctctgaggatccgggccatcctgaggtctctggtc cctatagaagacctggtgggagtcatcagtctgtctgtgcagatacctgactatgggaaa gatggtcacaccatagagcccaagatgtctgcgagctttgtcccagaccacaaggcatcc atggttctgtttctggaccgtgtgtatggtatcgacaaccaggacttcctgcttcatgtt ctggaggtgggcttcctgccagacatgagggctgccgcctccctggacacgctggcattc agcaccacagagatggccctggcactgaaccgctacctgtgttccgctgtgctgcccctc atcaccaagtgtgcccccctgttcgcgggcaccgaccaccgcgccatcatgattgactcc atgttgcacaccatctataggctgtcccgcggtcgagccctcaccaaggctcagagagac gttatcgaggagtgcctcatgtccctcgtcaagtaccttcgaccttccatgctgcagcat ctgctgaggaagctggtgtttgacgtgccaatcctcaacgagtttgctaagatgcctctg aagctcctgaccaatcactatgagcgttgttggaagtactactgcctgcctaacggttgg gccaactttggggtgtcgtcagaggaggagctgcatctgtcacgcaaactcttctgggga atctttgagtctctggcacacaagaaattcgatgctgagctgtttaagatcgccatgcca tgtatctgtgccatcgctggtgccatccctccggactatgtggacgccagctactcctcc aacacagagaagaaggcttcggtggacgctgagggaaactttgaccctaaacccgtggag accaccaacaccattatcccagagaagctggatgccttcatcaacaagtatgcagaacac actcacgacaagtgggccttcgagaagatccagaacaactggtcgtacggagaggtgctg gatgaaaacgccaagacccaccccatgctgcgtccgtacaagaccttctctgagaaggac aaggagatctaccggtggcccatcaaggagtccgtcaaggccatgctggcctgggagtgg acggtggagaaggctcaagcaggcgagggagagaaggtggagatgaagaccaccacacgg aagatctcccagactgctcaggcgacctatgaccccagccacggctacagcccttcgcct gtggacatcactgccatggcactgtccagagagctgcagtccatggctgagcagctggct gaaaactaccacaacacctggggcaggaagaagaagatggagctgatggggaaaggtggc ggtgcccatcccctgctggtaccctacgacaccttgacggctaaggagaaggccagagac agagagaaagcccaggacctgctcaagttcctgcagctcaatggatacgccgtcactagg ggcctgaaggatatggagcaggacatatcctccatagagaagaggtttgcctatggtttc ctccagaaactgctgaagtggatggacattgcccaggagttcatcgcccatctggaggct gtggttagcagtggcagagtggagaagtctccacacgaacaggagatcaagttctttgcc aaaattctcctgccgctggtcaaccagtactttaagaaccactgcctttacttcctctcc acgcctgccaagttgctgggcagtggaggccactcctccaacaaggagaaggagatgatc gccagtatcttctgtaaattggcagctctggtgagacacagagtatctctctttggaacg gatgctggtgccgtggttaattgtctgcacatcctgtcacgatcactggatgctaggacg gtaatgaagtcaggtcctgagatcgtgaaggcaggactgcgtcagttctttgagagcgct gcagatgacatagagaagatggtagagaacctgaaactgggcaaggtttctagcaggaac caggtgaagggcgtgtcccagaacattaactacaccaccatcgccctgctccctgtcctt accaccctgttcgatcacatcgcccagcaccagtttggggacgacgtcatcttggacgac ctccagatctcgtgttacaggatcatgtgttcgatctactctctgggcaccgtcaagacg cctcacgctgagaagcagaggccggctctgggggaatgtttggcaaatctagccgctgcc atgcctgtagcctatctggagcccggcctcaacgagtacaacgcctactctgtctacacc accaagacgcccagagagagaggcatcctgggcctgcccaaccaagtagaggagctgtgt actgacatcccagagctagacgtcttgatgaaggagatcggggacctggcagagtcaggg gctcgctacactgagatgccccacgttatcgagatcaccttgcccatgctgtgtaactac ctgccccgctggtgggaaagaggtctggagaactaccccgacctggagggccaactctgt actgacgtcacctcagaacaactcaaccagttgctgggcagcatcatgaagatagtagtc aacaacctggggatagatgaagcctcctggatgaaacgactggcagtgttcgcccagccc atcgttagcagggccaagcctgagatgttgaagtcccatttcatcccaaccatggagaag ctgaagaagcgtagtgggaaggtggtggctgaggaggagcagctgaggctggaggggaag tctgaggtggacagtgaggaaggaaccattagggatgagtttgctgttctctgtagagac ctctatgctctgtaccctctactgatcagatatgtggataacaacagggctcgatggctg acctgtccagacccagatgctgaggaactcttcaggatggtgggagaggtgttcatcttc tggtccaagtctcataacttcaagcgtgaggagcagaactttgtggtgatgaatgagatc aacaacatgtctttcctgactgctgacagcaagagcaagatgagtaaggccggaggggac gaggctggaggttctgacgtggagcgtaccaagaagaagcgaaggggggaccgctattcg gtgcagacatcgctgatcgtagcagcgctgaagaagatgcttcctattggccttaacatg tgttcccctgctgaccaagaactgattaacctggccaagatacgctacagtctgaaagac acagatgaggaggtgagagagtttctacagaacaacatgcatctgcagggcaaggtggag gacccgtcaatgcgctggcagatggcgctgtataaggagacgtcagggaaggccgaggat gctgaggaccctgagaaggtggtcaagagagtccaggaggtctcctctgtcctctaccac atagaggtgacggagcacccgtacaagtctaagaagatggtttggcacaagctgctttct aaacaacggcgcaaagctgttgtggcctgcttcaggatgtcacccctctacaacatcccc aggcatcggggctccaacatgttcctgaatgggtacaagaggaactggctgcagactgaa ggataccagtttgaagaccgcatgatcgacgacttgtctaaagccatggaggaggaggag ctgggagaggagggagaggaggaggcggaaaccaaacctgaccctctgcatcagctcatc ctgcacttcagccggaccgctctcacagagaagagcaaactggaagttgactacttatac atggcttatgctgatattatggccaagagttgccacatcggtgaggaggaggagggagga gaagaggaggccattgaagtgacccagactgagatggagaaagagatggagaagcagagg ctcctgtaccagcagtcccgtctccacaacagaggagctgcagagatggtgctgcagatg atcagtgcctgcagaggtgagacgggatccatggtgtgctccaccctcaagctgggaatc tcaatcctcaacacaggcaactgtgacgtacaacagaggatgctggactacctgaaggac aaaaaggatgtgggcttcttcctgagtattcaggccctgatgcagacctgcagcgttcta gacctgaatgcctttgagagacagaacaaggctgagggtctggggatggtgtcagaggag ggaacaaatgagaaggtgatggcagacgatgagtttacctgtgacctgttccgcttcctg cagctgctctgtgagggacacaacaacgatttccagaactatctgcggacccagactggc agcaccaccaccatcaacatcattatctgcactgtggactacctgctccgcctgcaggag tctatcagtgacttctactggtactactctgggaaggacataatagatgagccaggcaag aggaacttctccaaggccatgactgtggctaaacaggtgttcaacagtctgactgagtat atccagggtccgtgtacagggaaccagcagtctctggcccacagcaggttgtgggacgct gtggttggcttcctgcacgtctttgctcacatgatgatgaagctggctcaggactccagt cagattggtctgctgaaggaactcctggacctgcagaaagacatggtggtgatgctgttg tctctactggaaggcaacgtggtgaacggcaccatcgcccgccagatggtggacatgcta gtggagtcctccagcaacgtggagatgatcctcaagttcttcgacatgttcctcaagctg aaggacatcaccgggtccgacgccttccgggactacgtgaccgacccccgtggcctcatc tccaaaaaggacttctacaaggcaatggacagccagaagcagtactctccttctgagatc cagttccttctgtcttgttccgaggccgacgaaaacgagatgatcaactttgaagagttt gccgaccgcttccaggagccggccaaggacatcggcttcaacatcgccgtgctactcacc aacctgtctgagcacgtcccccacgacacacgcctacagaacttccttgagcaggccgag agcgtcctcaactactttagacccttcctgggccggatagagatcatgggcgccagcagg aagatcgagaggatctactttgagatcagcgaggccaacaggaatcagtgggagatgccg caggtcagagagtccaagagacagttcatcttcgacgtggtcaacgagggcggggagagc gagaagatggagctctttgtcaacttctgcgaggacaccatctttgagatgaacatcgcc tcacagatttctgaggtggaggaggaggaggcagtagactcagaggatgaagaggaagaa ggaggaggagaaggaggaggaggagagttggatgaaaatggagaagagatgcctcccgag tccagctcggcgttctctgacttcctgacaagcgtagtgaacttcttcaacatgttcacc ttcaagaacctgcggcggcgctaccgcaagcttaggaagatgactctgaaggagatggtg gtgggcttggccacgttcatctacaccatcctgtttggtatcctgtctttcatctacagc gtgtgtaagggcttcttcatgcttatctggagcaccctgtttggaggagaactggtagag ggtgccaagaagatcacggtgactgagctcctggccagcatgccagacccaacgcaagat gaggtgcacgatgaactgccacctgagccgggtgccgaggagggtcaggaggggatagaa ggaggagaggatagagacgtgggaggaggagaggaaagagaggagggaggggacggtgag gagaaggagggaggacggatgcctgggttcgacacccctggggggctgggagactttggg gagaccacggctgtagaaccccccactccagagggaaccccactgctcaagaggaaactg ttggaagcaacgtccggaggagagggggaagaaagagaagagacagaaccagaggaagag acacccccagaggaggagaaggctgacaatgagaatggagagaaggcagagaaggaggct gagcccgtggtaaaagaggaagaaccggcagcgaaggaggacaaattgaagaccaaggca aagaaggagaagagacctgcagaggagggctatgagctgtggaatgagctagagatccag aggatcaaattcatgaactatctgtctcgtaacttctacaacctgcgcttcctggctctc ttcatcgcctttgccctcaacttcatcctgctcttctacaaggttggatatgatgtagag gcggggtcagaggacatcgagggctccgccctgttcgagggctccgccctgttcgagggt tctgggttgtttgagagttccggagctgtggacgagggtggttctggcattgatccattt gacgatggtggtgatgatgacgatagtggtggtgatgatgatgatgaggaggaagggccc ttttttttctacttggaggagagtacgggctacatgcaaccctgtttgtccatgctggcc atcatacacactgtcatcgctttcctctgtatcatcggatacaactgcctcaaggttcct ctggtcatctttaagagggagaaggagttggctaggaagctggagtttgatggtctctac gtcaccgagcaaccagaagacgatgacatcaagggacagtgggaccgactggtgctcaac accccgtcattccctaacaactactgggacaagtttgtgaagacaaaggtgctggctaag tacggggacatctacggcagggagaggatcgcagagctgcttgggatggacctggcctct ctggatgtcagcgccatgacacaagagaagaaacccgaaccagagagtggcatgttaagc tggattatctccattgacatcaaataccagatctggaagttcggggtggtcttcactgac aacacattcctctatctagtctggtacatggtcatgtctctgctgggacacttcaacaac ttcttcttcgcctgtcacttgatggacatcgccgttggtgtgaaggatctgcgcaccatc ctgtcctccgtcacacacaacggcaaacagctgatgatgactgtgggtctactagcagtg gtggtgtatctctacaccgtcgtggctttcaacttcttcaggaagttctacaacatgagc gaggaggaggatgaaccggacatgaagtgtgatgacatgatgacctgttacctgttccac atgtacgtgggtgtgcgtgccggcgggggtataggagacgagattgaggacccggcgggt gatgagtacgagctctaccgtgtcgtcttcgacatcaccttcttcttcttcgttatcgtc atcctgctggccatcatccagggtctgatcattgatgcgtttggcgagctgagagaccaa caggagcaggtcagagagaacatggagactcagtgcttcatctgtggtatcggtagcgac tactttgatacgactccgcacggcttcgagacgcacaccttggaagagcataatttagcc aactacatgttcttcctgatgtacctaatcaataaagatgaaacggagcacacaggacag gagtcgtatgtgtggaagatgtaccaggagagatgctgggacttcttccctgctggagac tgtttcaggaagacgtatgaggatcagctggcctag

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