Crocuta crocuta (spotted hyena): 144232996 Help Entry 144232996         CDS       T11532                                  Symbol ADCY1 Name (RefSeq) adenylate cyclase type 1   KO K08041   adenylate cyclase 1 [EC:4.6.1.1] Organism ccru  Crocuta crocuta (spotted hyena) Pathway ccru00230   Purine metabolism ccru01100   Metabolic pathways ccru01522   Endocrine resistance ccru04015   Rap1 signaling pathway ccru04020   Calcium signaling pathway ccru04022   cGMP-PKG signaling pathway ccru04024   cAMP signaling pathway ccru04062   Chemokine signaling pathway ccru04072   Phospholipase D signaling pathway ccru04081   Hormone signaling ccru04082   Neuroactive ligand signaling ccru04114   Oocyte meiosis ccru04211   Longevity regulating pathway ccru04213   Longevity regulating pathway - multiple species ccru04261   Adrenergic signaling in cardiomyocytes ccru04270   Vascular smooth muscle contraction ccru04371   Apelin signaling pathway ccru04540   Gap junction ccru04611   Platelet activation ccru04713   Circadian entrainment ccru04714   Thermogenesis ccru04720   Long-term potentiation ccru04723   Retrograde endocannabinoid signaling ccru04724   Glutamatergic synapse ccru04725   Cholinergic synapse ccru04727   GABAergic synapse ccru04750   Inflammatory mediator regulation of TRP channels ccru04911   Insulin secretion ccru04912   GnRH signaling pathway ccru04913   Ovarian steroidogenesis ccru04914   Progesterone-mediated oocyte maturation ccru04915   Estrogen signaling pathway ccru04916   Melanogenesis ccru04918   Thyroid hormone synthesis ccru04921   Oxytocin signaling pathway ccru04923   Regulation of lipolysis in adipocytes ccru04925   Aldosterone synthesis and secretion ccru04926   Relaxin signaling pathway ccru04927   Cortisol synthesis and secretion ccru04928   Parathyroid hormone synthesis, secretion and action ccru04934   Cushing syndrome ccru04935   Growth hormone synthesis, secretion and action ccru04970   Salivary secretion ccru04971   Gastric acid secretion ccru04972   Pancreatic secretion ccru04976   Bile secretion ccru05032   Morphine addiction ccru05142   Chagas disease ccru05146   Amoebiasis ccru05163   Human cytomegalovirus infection ccru05166   Human T-cell leukemia virus 1 infection ccru05200   Pathways in cancer ccru05207   Chemical carcinogenesis - receptor activation ccru05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:ccru00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     144232996 (ADCY1)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     144232996 (ADCY1)    04371 Apelin signaling pathway     144232996 (ADCY1)    04020 Calcium signaling pathway     144232996 (ADCY1)    04072 Phospholipase D signaling pathway     144232996 (ADCY1)    04024 cAMP signaling pathway     144232996 (ADCY1)    04022 cGMP-PKG signaling pathway     144232996 (ADCY1)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     144232996 (ADCY1)    04081 Hormone signaling     144232996 (ADCY1)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     144232996 (ADCY1)   09144 Cellular community - eukaryotes    04540 Gap junction     144232996 (ADCY1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     144232996 (ADCY1)    04062 Chemokine signaling pathway     144232996 (ADCY1)   09152 Endocrine system    04911 Insulin secretion     144232996 (ADCY1)    04923 Regulation of lipolysis in adipocytes     144232996 (ADCY1)    04912 GnRH signaling pathway     144232996 (ADCY1)    04913 Ovarian steroidogenesis     144232996 (ADCY1)    04915 Estrogen signaling pathway     144232996 (ADCY1)    04914 Progesterone-mediated oocyte maturation     144232996 (ADCY1)    04921 Oxytocin signaling pathway     144232996 (ADCY1)    04926 Relaxin signaling pathway     144232996 (ADCY1)    04935 Growth hormone synthesis, secretion and action     144232996 (ADCY1)    04918 Thyroid hormone synthesis     144232996 (ADCY1)    04928 Parathyroid hormone synthesis, secretion and action     144232996 (ADCY1)    04916 Melanogenesis     144232996 (ADCY1)    04925 Aldosterone synthesis and secretion     144232996 (ADCY1)    04927 Cortisol synthesis and secretion     144232996 (ADCY1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     144232996 (ADCY1)    04270 Vascular smooth muscle contraction     144232996 (ADCY1)   09154 Digestive system    04970 Salivary secretion     144232996 (ADCY1)    04971 Gastric acid secretion     144232996 (ADCY1)    04972 Pancreatic secretion     144232996 (ADCY1)    04976 Bile secretion     144232996 (ADCY1)   09156 Nervous system    04724 Glutamatergic synapse     144232996 (ADCY1)    04727 GABAergic synapse     144232996 (ADCY1)    04725 Cholinergic synapse     144232996 (ADCY1)    04720 Long-term potentiation     144232996 (ADCY1)    04723 Retrograde endocannabinoid signaling     144232996 (ADCY1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     144232996 (ADCY1)   09149 Aging    04211 Longevity regulating pathway     144232996 (ADCY1)    04213 Longevity regulating pathway - multiple species     144232996 (ADCY1)   09159 Environmental adaptation    04713 Circadian entrainment     144232996 (ADCY1)    04714 Thermogenesis     144232996 (ADCY1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     144232996 (ADCY1)    05207 Chemical carcinogenesis - receptor activation     144232996 (ADCY1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     144232996 (ADCY1)    05163 Human cytomegalovirus infection     144232996 (ADCY1)   09174 Infectious disease: parasitic    05146 Amoebiasis     144232996 (ADCY1)    05142 Chagas disease     144232996 (ADCY1)   09165 Substance dependence    05032 Morphine addiction     144232996 (ADCY1)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     144232996 (ADCY1)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     144232996 (ADCY1)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     144232996 (ADCY1) Enzymes [BR:ccru01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      144232996 (ADCY1) SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom DUF6688 Motif Other DBs NCBI-GeneID:  144232996 NCBI-ProteinID:  XP_077621915 LinkDB All DBs Position Unknown AA seq 903 aa AA seqDB search MYGVFVRVLAERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLK PPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCR RIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVL CGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNSF LKAHDIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFS NVLTCEDDDKRRALRTASEKLRNRSSFSANAAYTTPGTRVNRYIGRLLEARQMELEMADL DFFTLKYKQAERERKYHQLQDEYFTSAVVLALVLAAVFGLVYLLIIPQNLVLLLLLVFCI CFLVACVLYLHVTRVQCFPGCLTIQIRTVLCIFVVVLIYSVAQGCVVGCLPWSWSSSPNG SLLVLTPGGRNTVLPAAPCESAPHALLCGLVGTLPLAIFLRVSSLPKMILLLVLTTSYIL VLELSGYTRAPGGGAASGHSFEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERD DMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFDDFYIEL DGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTTGTKAKKCI SSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVN VASRMDSTGVQGRIQVTEEVHRLLRRGTYRFVCRGKVSVKGKGEMLTYFLEGRTDGDGSQ GKERKMCGYGRAGLQSRLGSGLPSVSPMAGLPVRAGLGALQGAGLPPCPHSQHLSPGAAG KEA NT seq 2712 nt NT seq  +upstreamnt  +downstreamnt atgtacggcgtctttgtgcgggtcctggccgagcgctcccagcggaaagccttcctgcag gcccggaactgcatcgaagatcggctgaggctggaggacgagaacgagaagcaggagcgg ctgctcatgagccttctgccccggaatgttgccatggagatgaaggaggacttcctgaag ccccccgagaggatttttcacaagatttacatccagcggcatgacaacgtgagcatcctc tttgcggacatcgtgggcttcacgggcctggcgtcacagtgcacagcacaggagctggtc aagctcctcaatgagctcttcggcaagtttgacgaactggccacggagaatcactgtcgc cgcatcaagatcctcggggactgttactactgtgtgtccggcctcacccagcctaagacc gaccacgcccactgctgcgtggagatgggtctggacatgattgacactatcacgtctgtg gccgaggccacagaggtggacctgaacatgcgtgtggggctgcacacgggcagggtcctc tgcggggtcctgggcctgcgcaagtggcagtatgacgtgtggtccaacgacgtgaccctg gccaatgtcatggaggcggctggcctgcctgggaaggtccacatcacgaagacgaccctg gcatgcctgaatggggactatgaggtggagccgggccatggacatgagaggaacagtttc ctgaaagctcacgacatcgagaccttcttcatcgtgccgtcacaccggcggaagatattt ccagggctgatcctctccgacataaaaccagccaagaggatgaagttcaagaccgtgtgc tacctgctggtacagctgatgcactgccggaagatgttcaaggcggagatccccttctcc aacgtcctgacgtgtgaggacgacgacaagcggagggcgctgagaaccgcatcagaaaag ctgcgaaaccgctcctcgttctcggcgaatgccgcctataccaccccaggcacccgcgtc aacaggtacattggccgccttctggaggcgcgccagatggagctggagatggcggacttg gacttcttcacactcaagtacaagcaggccgagcgggagcgcaagtaccaccagctccag gatgagtatttcaccagcgccgtggtcctggccctcgtcctcgccgccgtgttcggcctc gtctacctgctcatcatcccgcagaacctggtcctcctgctgctgctggtcttctgtatc tgcttcctggtagcctgtgtcctgtacctgcatgtcacccgggtccagtgttttccaggc tgcctgacgattcagatccgcacagtcttgtgtatctttgtcgtggtcttgatctactcc gtggcccaaggatgcgtggtgggctgcctgccctggtcctggagctccagccccaatggg tctttgctggtcctgacgcccggcggccggaacacagtgctgcccgccgcgccctgcgag tccgcgccccacgccctgctctgcggcctcgtgggcaccctcccgctggccatcttcctg cgggtgtcctctctgcccaaaatgatcctgcttctcgtgctcaccacgtcctacatcctg gtcctggagctcagcggctacactcgggcgcccgggggcggcgcggcctccgggcacagc ttcgagcccatcatggccatcctgctgttttcctgtaccctggccctgcacgcccggcag gtggacgtcaggctgcggctggactacctctgggcggcacaggccgaggaggagagggac gacatggagagggtgaagctggacaacaagaggattctcttcaacctcttgccggcccac gtggctcagcatttcctcatgtccaacccccggaacatggacctgtactaccagtcctac tcacaagtgggcgtcatgttcgcctccatccccaacttcgatgacttctacatcgagctg gacggcaacaacatgggggtggagtgtctgcgtctcctgaacgagatcatcgcggacttt gacgagctcatggacaaagacttttacaaggacttggagaagatcaagaccatcgggagc acctacatggccgccgtggggctggcgcccaccactgggaccaaggccaagaagtgcatc tcctcccacctaagcacgctggcggactttgccatcgagatgttcgatgtcctggatgaa atcaactaccagtcctacaacgactttgtgctccgtgtgggcatcaatgtcggccctgtg gtggctggggtgatcggggctcggaggccgcagtacgacatctggggaaacacagtcaat gtggccagtcggatggacagcaccggcgtccagggcagaatccaggtgaccgaggaggtt caccggctgctgcgccgggggacctaccgctttgtgtgccgcgggaaggtcagcgtcaag ggcaagggtgagatgctgacgtacttcctggaaggcaggacggatggagacggctcccaa ggcaaggagcggaaaatgtgtggctatgggcgagccggcctccagagcagactgggctcg ggcctgccctcggtgtcccccatggctggcctcccggtcagagccgggctgggggctctg cagggtgcggggctccccccctgcccccacagccagcacctgtctcccggagcagctggg aaggaggcttag

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