K08041                      KO                                     
adenylate cyclase 1 [EC:]
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05142  Chagas disease
map05146  Amoebiasis
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
H00605  Deafness, autosomal recessive
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08041  ADCY1; adenylate cyclase 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04371 Apelin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04020 Calcium signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04072 Phospholipase D signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04024 cAMP signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04022 cGMP-PKG signaling pathway
    K08041  ADCY1; adenylate cyclase 1
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08041  ADCY1; adenylate cyclase 1
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08041  ADCY1; adenylate cyclase 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08041  ADCY1; adenylate cyclase 1
   04062 Chemokine signaling pathway
    K08041  ADCY1; adenylate cyclase 1
  09152 Endocrine system
   04911 Insulin secretion
    K08041  ADCY1; adenylate cyclase 1
   04923 Regulation of lipolysis in adipocytes
    K08041  ADCY1; adenylate cyclase 1
   04912 GnRH signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04913 Ovarian steroidogenesis
    K08041  ADCY1; adenylate cyclase 1
   04915 Estrogen signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04914 Progesterone-mediated oocyte maturation
    K08041  ADCY1; adenylate cyclase 1
   04921 Oxytocin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04926 Relaxin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04935 Growth hormone synthesis, secretion and action
    K08041  ADCY1; adenylate cyclase 1
   04918 Thyroid hormone synthesis
    K08041  ADCY1; adenylate cyclase 1
   04928 Parathyroid hormone synthesis, secretion and action
    K08041  ADCY1; adenylate cyclase 1
   04916 Melanogenesis
    K08041  ADCY1; adenylate cyclase 1
   04925 Aldosterone synthesis and secretion
    K08041  ADCY1; adenylate cyclase 1
   04927 Cortisol synthesis and secretion
    K08041  ADCY1; adenylate cyclase 1
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08041  ADCY1; adenylate cyclase 1
   04270 Vascular smooth muscle contraction
    K08041  ADCY1; adenylate cyclase 1
  09154 Digestive system
   04970 Salivary secretion
    K08041  ADCY1; adenylate cyclase 1
   04971 Gastric acid secretion
    K08041  ADCY1; adenylate cyclase 1
   04972 Pancreatic secretion
    K08041  ADCY1; adenylate cyclase 1
   04976 Bile secretion
    K08041  ADCY1; adenylate cyclase 1
  09156 Nervous system
   04724 Glutamatergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04727 GABAergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04725 Cholinergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04720 Long-term potentiation
    K08041  ADCY1; adenylate cyclase 1
   04723 Retrograde endocannabinoid signaling
    K08041  ADCY1; adenylate cyclase 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08041  ADCY1; adenylate cyclase 1
  09149 Aging
   04211 Longevity regulating pathway
    K08041  ADCY1; adenylate cyclase 1
   04213 Longevity regulating pathway - multiple species
    K08041  ADCY1; adenylate cyclase 1
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08041  ADCY1; adenylate cyclase 1
   04714 Thermogenesis
    K08041  ADCY1; adenylate cyclase 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08041  ADCY1; adenylate cyclase 1
   05207 Chemical carcinogenesis - receptor activation
    K08041  ADCY1; adenylate cyclase 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08041  ADCY1; adenylate cyclase 1
   05163 Human cytomegalovirus infection
    K08041  ADCY1; adenylate cyclase 1
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K08041  ADCY1; adenylate cyclase 1
   05142 Chagas disease
    K08041  ADCY1; adenylate cyclase 1
  09165 Substance dependence
   05032 Morphine addiction
    K08041  ADCY1; adenylate cyclase 1
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08041  ADCY1; adenylate cyclase 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08041  ADCY1; adenylate cyclase 1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08041  ADCY1; adenylate cyclase 1
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)  adenylate cyclase
     K08041  ADCY1; adenylate cyclase 1
Other DBs
GO: 0008294
HSA: 107(ADCY1)
PTR: 463392(ADCY1)
PPS: 100984585(ADCY1)
GGO: 101125943(ADCY1)
PON: 100449504(ADCY1)
NLE: 100595636(ADCY1)
HMH: 116812469(ADCY1)
MCC: 697230(ADCY1)
MCF: 102147015(ADCY1)
MTHB: 126950155
MNI: 105494232(ADCY1)
CSAB: 103226115(ADCY1)
CATY: 105588320(ADCY1)
PANU: 100998237(ADCY1)
TGE: 112620936(ADCY1)
MLEU: 105541972
RRO: 104671165(ADCY1)
RBB: 108534793(ADCY1)
TFN: 117073333(ADCY1)
CANG: 105515072(ADCY1)
CJC: 100394265(ADCY1)
SBQ: 101027981(ADCY1)
CIMI: 108301433(ADCY1)
MMUR: 105870668(ADCY1)
LCAT: 123647256(ADCY1)
PCOQ: 105812499(ADCY1)
OGA: 100955472(ADCY1)
MMU: 432530(Adcy1)
MCAL: 110305998(Adcy1)
MPAH: 110330584(Adcy1)
RNO: 305509(Adcy1)
MCOC: 116069116(Adcy1)
ANU: 117712590(Adcy1)
MUN: 110555169(Adcy1)
CGE: 100764561(Adcy1)
MAUA: 101822607(Adcy1)
PROB: 127233912(Adcy1)
PLEU: 114693962(Adcy1)
MORG: 121459308(Adcy1)
MFOT: 126500995
AAMP: 119800365(Adcy1)
NGI: 103741433(Adcy1)
HGL: 101711366(Adcy1)
CPOC: 100715672(Adcy1)
CCAN: 109694874(Adcy1)
DORD: 105998287(Adcy1)
DSP: 122128067(Adcy1)
PLOP: 125345732(Adcy1)
NCAR: 124990345
MMMA: 107146235(Adcy1)
OCU: 103347035
OPI: 101533323(ADCY1)
TUP: 102468873(ADCY1)
GVR: 103599611(ADCY1)
CFA: 607357(ADCY1)
CLUD: 112650921(ADCY1) 112670489
VVP: 112911455(ADCY1)
VLG: 121490100(ADCY1) 121492610
AML: 100472777(ADCY1)
UMR: 103674675(ADCY1)
UAH: 113257705(ADCY1)
UAR: 123789481(ADCY1)
ELK: 111157054
LLV: 125081029
MPUF: 101676834(ADCY1)
MNP: 132016088(ADCY1)
MLK: 131829179(ADCY1)
NVS: 122904661(ADCY1)
ORO: 101379158(ADCY1)
EJU: 114213699(ADCY1)
ZCA: 113911474(ADCY1)
MLX: 118024512(ADCY1)
NSU: 110592662(ADCY1)
LWW: 102739347(ADCY1)
FCA: 101101375(ADCY1)
PYU: 121016977(ADCY1)
PCOO: 112859788(ADCY1)
PBG: 122487650(ADCY1)
LRUF: 124524637
PTG: 102961712(ADCY1)
PPAD: 109267948(ADCY1)
PUC: 125930396
AJU: 106968223
HHV: 120238897(ADCY1)
BTA: 281601(ADCY1)
BOM: 102267116(ADCY1)
BIU: 109557525(ADCY1)
BBUB: 102415323(ADCY1)
BBIS: 104980414(ADCY1)
CHX: 102180724(ADCY1)
OAS: 101117327(ADCY1)
BTAX: 128046764(ADCY1)
ODA: 120877473(ADCY1)
CCAD: 122438514(ADCY1)
MBEZ: 129552085(ADCY1)
SSC: 100624934(ADCY1)
CFR: 102517882(ADCY1)
CBAI: 105080525(ADCY1)
CDK: 105095715(ADCY1)
VPC: 102538400(ADCY1)
BACU: 102998650(ADCY1)
LVE: 103081539(ADCY1)
OOR: 101278368(ADCY1)
DLE: 111184534(ADCY1)
PCAD: 102981199(ADCY1)
PSIU: 116759445(ADCY1)
NASI: 112400149(ADCY1)
ECB: 100065563(ADCY1)
EPZ: 103550430(ADCY1)
EAI: 106822932(ADCY1)
MYB: 102257679(ADCY1)
MYD: 102759978(ADCY1)
MMYO: 118665883(ADCY1)
MNA: 107526004(ADCY1)
PKL: 118720332(ADCY1)
EFUS: 103303616(ADCY1)
HAI: 109373011(ADCY1)
DRO: 112306844(ADCY1)
SHON: 118983483(ADCY1)
AJM: 119057313(ADCY1)
PDIC: 114490247
PHAS: 123811468(ADCY1)
MMF: 118620164(ADCY1)
RFQ: 117012305(ADCY1)
PPAM: 129068928(ADCY1)
PALE: 102887497(ADCY1)
PGIG: 120589581(ADCY1)
PVP: 105308299
RAY: 107512406(ADCY1)
MJV: 108403511(ADCY1)
TOD: 119231485(ADCY1)
SARA: 101557843(ADCY1)
LAV: 100671072(ADCY1)
TMU: 101354868
ETF: 101661014(ADCY1)
DNM: 101411559(ADCY1)
MDO: 100030463(ADCY1)
GAS: 123247570(ADCY1)
SHR: 100922193(ADCY1)
AFZ: 127544134
PCW: 110197533(ADCY1)
OAA: 103168601(ADCY1)
GGA: 420788(ADCY1)
PCOC: 116228264(ADCY1)
CJO: 107309766(ADCY1)
TPAI: 128087769(ADCY1)
LMUT: 125690968(ADCY1)
NMEL: 110390836(ADCY1)
APLA: 101804073(ADCY1)
ACYG: 106046455(ADCY1)
CATA: 118249703(ADCY1)
AFUL: 116486732(ADCY1)
TGU: 100226080(ADCY1)
LSR: 110477391(ADCY1)
SCAN: 103819377(ADCY1)
PMOA: 120503563(ADCY1)
OTC: 121333301(ADCY1)
PRUF: 121356124
GFR: 102040399(ADCY1)
FAB: 101807752(ADCY1)
OMA: 130249364(ADCY1)
PHI: 102110269(ADCY1)
PMAJ: 107201036(ADCY1)
CCAE: 111923918(ADCY1)
CCW: 104689252(ADCY1)
CBRC: 103614095(ADCY1)
ETL: 114068677(ADCY1)
ZAB: 102073009(ADCY1)
ACHL: 103807063(ADCY1)
SVG: 106853841(ADCY1)
MMEA: 130574316(ADCY1)
HRT: 120758617(ADCY1)
FPG: 101914769(ADCY1)
FCH: 102056699(ADCY1)
CLV: 102094612(ADCY1)
EGZ: 104125965(ADCY1)
NNI: 104015394(ADCY1)
EHS: 104510986(ADCY1)
PCAO: 104052958(ADCY1)
ACUN: 113477314(ADCY1)
TALA: 104361601(ADCY1)
PADL: 103916246(ADCY1)
AFOR: 103904001(ADCY1)
ACHC: 115352949(ADCY1)
HALD: 104319114(ADCY1)
HLE: 104837744(ADCY1)
AGEN: 126048595
GCL: 127013036
CSTI: 104559934
MUI: 104547636(ADCY1)
GSTE: 104257710(ADCY1)
LDI: 104346969(ADCY1)
MNB: 103768479(ADCY1)
OHA: 104334085(ADCY1)
NNT: 104406517(ADCY1)
SHAB: 115612821(ADCY1)
DPUB: 104298308(ADCY1)
PGUU: 104469426(ADCY1)
CPEA: 104392180(ADCY1)
CVF: 104295315(ADCY1)
RTD: 128905714(ADCY1)
CUCA: 104065956(ADCY1)
TEO: 104371857(ADCY1)
AAM: 106492856(ADCY1)
AROW: 112965172(ADCY1)
NPD: 112942706(ADCY1)
TGT: 104573631(ADCY1)
DNE: 112997517(ADCY1)
SCAM: 104150331(ADCY1)
ASN: 102372645(ADCY1)
AMJ: 102573818(ADCY1)
CPOO: 109310610(ADCY1)
GGN: 109291654(ADCY1)
PSS: 102445759(ADCY1)
CMY: 102939135(ADCY1)
CCAY: 125631858(ADCY1)
DCC: 119851996(ADCY1)
CPIC: 101935286(ADCY1)
TST: 117872635(ADCY1)
CABI: 116834610(ADCY1)
MRV: 120398088(ADCY1)
ACS: 100564004(adcy1)
ASAO: 132778512(ADCY1)
PVT: 110091617(ADCY1)
SUND: 121933610
PBI: 103068192
PMUR: 107287848(ADCY1)
CTIG: 120312767(ADCY1)
TSR: 106543976(ADCY1)
PGUT: 117664957(ADCY1)
APRI: 131198710(ADCY1)
PTEX: 113437370(ADCY1)
NSS: 113421046(ADCY1)
VKO: 123035478(ADCY1)
PMUA: 114607043(ADCY1)
PRAF: 128398543(ADCY1)
ZVI: 118077681(ADCY1)
HCG: 128329145(ADCY1)
GJA: 107119176(ADCY1)
STOW: 125440744(ADCY1)
EMC: 129337825(ADCY1)
XLA: 108705348(adcy1.S) 108718988(adcy1.L)
XTR: 100492373(adcy1)
NPR: 108796974(ADCY1)
RTEM: 120940455(ADCY1)
BBUF: 121001993(ADCY1)
BGAR: 122939040(ADCY1)
MUO: 115472502(ADCY1)
GSH: 117353894(ADCY1)
DRE: 557026(adcy1a) 569499(adcy1b)
PTET: 122325165(adcy1a) 122332448(adcy1b)
LROH: 127173117(adcy1b) 127183422(adcy1a)
OMC: 131527742(adcy1a) 131550870(adcy1b)
PPRM: 120461652(adcy1b) 120493956(adcy1a)
RKG: 130096140(adcy1a) 130100699(adcy1b)
MAMB: 125251308(adcy1b) 125279119(adcy1a)
TROS: 130554346 130565530(adcy1a)
TDW: 130415317(adcy1b) 130434981(adcy1a)
MANU: 129424293 129429335(adcy1a)
IPU: 108257925(adcy1a) 108267157(adcy1b)
IFU: 128601211(adcy1a)
PHYP: 113545185 113547307(adcy1)
SMEO: 124377387(adcy1a) 124387690(adcy1b)
TFD: 113662326(adcy1b) 113663988(adcy1a)
TVC: 132842435(adcy1a) 132849005(adcy1b)
CMAO: 118815470(adcy1a) 118826566(adcy1b)
CHAR: 105898467 105910685(adcy1a)
TRU: 101074661(adcy1)
TFS: 130529086 130538675(adcy1a)
NCC: 104962323
TBEN: 117489047 117495927(adcy1a)
OAU: 116314396(adcy1a) 116318699
OML: 112147429(adcy1a) 112150580
PLAI: 106948616(adcy1)
CTUL: 119787741(adcy1a) 119795701
NWH: 119407638(adcy1a) 119415057
POV: 109637504(adcy1) 109643317
SSEN: 122771664 122780642(adcy1a)
PEE: 133406201(adcy1a) 133411174
PTAO: 133480709(adcy1a) 133489512
BPEC: 110159474(adcy1) 110172262
SJO: 128361501 128369208(adcy1a)
AANG: 118224561(adcy1a) 118233055
LOC: 102692556(adcy1)
PSEX: 120529518
CMK: 103187011
RTP: 109910491
CPLA: 122549912
HOC: 132816069
LERI: 129710284
PMRN: 116941104 116947844(ADCY1)
DME: Dmel_CG9533(rut)
DER: 6550736
DSE: 6619554
DSI: Dsimw501_GD15838(Dsim_rut)
DAN: 6504270
DSR: 110182103
DPO: 6901423
DPE: 6598394
DMN: 108161375
DWI: 6653130
DGR: 6564853
DAZ: 108618185
DNV: 108656529
DHE: 111600202
DVI: 6631926
CCAT: 101452382
BOD: 106625393
BDR: 105225223
TDA: 119671131
MDE: 101890662
SCAC: 106085694
LCQ: 111684525
LSQ: 119608374
GFS: 119633415
ECOE: 129947535
HIS: 119658368
AGA: 1272318
ACOZ: 120959989
AARA: 120906721
AMER: 121590606
ASTE: 118511090
AFUN: 125766985
AALI: 118468659
AAG: 5571379
AALB: 109401880
CPII: 120420252
CNS: 116346299
BCOO: 119081617
TCA: 661438(rut)
DPA: 109546607
SOY: 115880233
AGRG: 126749160
ATD: 109599121
CSET: 123312770
AGB: 108904553
LDC: 111515079
NVL: 108566779
APLN: 108736715
PPYR: 116176544
OTU: 111427516
BMOR: 101741402
BMAN: 114248717
MSEX: 115454133
BANY: 112053190
MJU: 123880988
NIQ: 126770280
VCD: 124533457
MCIX: 123653493
PMAC: 106720337
PPOT: 106109142
PXU: 106127108
PRAP: 110991594
PBX: 123720704
PNAP: 125054267
ZCE: 119834784
CCRC: 123690912
LSIN: 126976461
HAW: 110369899
HZE: 124631248
TNL: 113501500
SLIU: 111351639
OFU: 114365405
PXY: 105380532
PGW: 126367434
CCRN: 123296813
API: 100164676
DNX: 107168960
AGS: 114126041
RMD: 113559605
ACOO: 126837253
DVT: 126898505
BTAB: 109030117
DCI: 103514692
CLEC: 106662482
NLU: 111062756
HVI: 124366297
MQU: 129004284
FOC: 113210518
TPAL: 117645669
ZNE: 110826860
CSEC: 111871901
FCD: 110861546
DPX: DAPPUDRAFT_48469(Adcy2)
DMK: 116925520
DPZ: 124313984
PVM: 113821369
PJA: 122256518
PCHN: 125036314
PMOO: 119592519
HAME: 121871085
PCLA: 123759647
PTRU: 123510504
ESN: 127000221
EAF: 111709929
LSM: 121126640
PPOI: 119109966
DSV: 119442413
RSAN: 119386353
RMP: 119159511
TUT: 107360550
DPTE: 113792109
DFR: 124498931
CSCU: 111626639
PTEP: 107453371
UDV: 129219156
SDM: 118191600
PVUL: 126831524
PCAN: 112564559
BGT: 106067245
GAE: 121380643
HRF: 124125393
HRJ: 124278151
CRG: 105340585
CANU: 128162932
OED: 125665530
MYI: 110465124
PMAX: 117343252
MMER: 123533026
RPHI: 132712910
DPOL: 127855248
OBI: 106868905
OSN: 115219753
LAK: 106159379
 » show all
Abdel-Majid RM, Leong WL, Schalkwyk LC, Smallman DS, Wong ST, Storm DR, Fine A, Dobson MJ, Guernsey DL, Neumann PE
Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex.
Nat Genet 19:289-91 (1998)
Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR
Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase.
Genomics 16:473-8 (1993)

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