KEGG   Crocuta crocuta (spotted hyena): 144239466
Entry
144239466         CDS       T11532                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ccru  Crocuta crocuta (spotted hyena)
Pathway
ccru01521  EGFR tyrosine kinase inhibitor resistance
ccru01522  Endocrine resistance
ccru01524  Platinum drug resistance
ccru04012  ErbB signaling pathway
ccru04014  Ras signaling pathway
ccru04015  Rap1 signaling pathway
ccru04024  cAMP signaling pathway
ccru04062  Chemokine signaling pathway
ccru04066  HIF-1 signaling pathway
ccru04068  FoxO signaling pathway
ccru04070  Phosphatidylinositol signaling system
ccru04071  Sphingolipid signaling pathway
ccru04072  Phospholipase D signaling pathway
ccru04081  Hormone signaling
ccru04140  Autophagy - animal
ccru04150  mTOR signaling pathway
ccru04151  PI3K-Akt signaling pathway
ccru04152  AMPK signaling pathway
ccru04210  Apoptosis
ccru04211  Longevity regulating pathway
ccru04213  Longevity regulating pathway - multiple species
ccru04218  Cellular senescence
ccru04360  Axon guidance
ccru04370  VEGF signaling pathway
ccru04380  Osteoclast differentiation
ccru04510  Focal adhesion
ccru04517  IgSF CAM signaling
ccru04518  Integrin signaling
ccru04550  Signaling pathways regulating pluripotency of stem cells
ccru04611  Platelet activation
ccru04613  Neutrophil extracellular trap formation
ccru04620  Toll-like receptor signaling pathway
ccru04625  C-type lectin receptor signaling pathway
ccru04630  JAK-STAT signaling pathway
ccru04650  Natural killer cell mediated cytotoxicity
ccru04660  T cell receptor signaling pathway
ccru04662  B cell receptor signaling pathway
ccru04664  Fc epsilon RI signaling pathway
ccru04666  Fc gamma R-mediated phagocytosis
ccru04668  TNF signaling pathway
ccru04670  Leukocyte transendothelial migration
ccru04722  Neurotrophin signaling pathway
ccru04725  Cholinergic synapse
ccru04750  Inflammatory mediator regulation of TRP channels
ccru04810  Regulation of actin cytoskeleton
ccru04910  Insulin signaling pathway
ccru04914  Progesterone-mediated oocyte maturation
ccru04915  Estrogen signaling pathway
ccru04917  Prolactin signaling pathway
ccru04919  Thyroid hormone signaling pathway
ccru04923  Regulation of lipolysis in adipocytes
ccru04926  Relaxin signaling pathway
ccru04929  GnRH secretion
ccru04930  Type II diabetes mellitus
ccru04931  Insulin resistance
ccru04932  Non-alcoholic fatty liver disease
ccru04933  AGE-RAGE signaling pathway in diabetic complications
ccru04935  Growth hormone synthesis, secretion and action
ccru04960  Aldosterone-regulated sodium reabsorption
ccru04973  Carbohydrate digestion and absorption
ccru05010  Alzheimer disease
ccru05017  Spinocerebellar ataxia
ccru05020  Prion disease
ccru05100  Bacterial invasion of epithelial cells
ccru05135  Yersinia infection
ccru05142  Chagas disease
ccru05146  Amoebiasis
ccru05160  Hepatitis C
ccru05161  Hepatitis B
ccru05162  Measles
ccru05163  Human cytomegalovirus infection
ccru05164  Influenza A
ccru05165  Human papillomavirus infection
ccru05166  Human T-cell leukemia virus 1 infection
ccru05167  Kaposi sarcoma-associated herpesvirus infection
ccru05168  Herpes simplex virus 1 infection
ccru05169  Epstein-Barr virus infection
ccru05170  Human immunodeficiency virus 1 infection
ccru05171  Coronavirus disease - COVID-19
ccru05200  Pathways in cancer
ccru05203  Viral carcinogenesis
ccru05205  Proteoglycans in cancer
ccru05206  MicroRNAs in cancer
ccru05207  Chemical carcinogenesis - receptor activation
ccru05208  Chemical carcinogenesis - reactive oxygen species
ccru05210  Colorectal cancer
ccru05211  Renal cell carcinoma
ccru05212  Pancreatic cancer
ccru05213  Endometrial cancer
ccru05214  Glioma
ccru05215  Prostate cancer
ccru05218  Melanoma
ccru05220  Chronic myeloid leukemia
ccru05221  Acute myeloid leukemia
ccru05222  Small cell lung cancer
ccru05223  Non-small cell lung cancer
ccru05224  Breast cancer
ccru05225  Hepatocellular carcinoma
ccru05226  Gastric cancer
ccru05230  Central carbon metabolism in cancer
ccru05231  Choline metabolism in cancer
ccru05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccru05415  Diabetic cardiomyopathy
ccru05417  Lipid and atherosclerosis
ccru05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccru00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    144239466 (PIK3R1)
   04014 Ras signaling pathway
    144239466 (PIK3R1)
   04015 Rap1 signaling pathway
    144239466 (PIK3R1)
   04370 VEGF signaling pathway
    144239466 (PIK3R1)
   04630 JAK-STAT signaling pathway
    144239466 (PIK3R1)
   04668 TNF signaling pathway
    144239466 (PIK3R1)
   04066 HIF-1 signaling pathway
    144239466 (PIK3R1)
   04068 FoxO signaling pathway
    144239466 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    144239466 (PIK3R1)
   04072 Phospholipase D signaling pathway
    144239466 (PIK3R1)
   04071 Sphingolipid signaling pathway
    144239466 (PIK3R1)
   04024 cAMP signaling pathway
    144239466 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    144239466 (PIK3R1)
   04152 AMPK signaling pathway
    144239466 (PIK3R1)
   04150 mTOR signaling pathway
    144239466 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    144239466 (PIK3R1)
   04517 IgSF CAM signaling
    144239466 (PIK3R1)
   04518 Integrin signaling
    144239466 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    144239466 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    144239466 (PIK3R1)
   04218 Cellular senescence
    144239466 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    144239466 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    144239466 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    144239466 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    144239466 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    144239466 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    144239466 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    144239466 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    144239466 (PIK3R1)
   04660 T cell receptor signaling pathway
    144239466 (PIK3R1)
   04662 B cell receptor signaling pathway
    144239466 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    144239466 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    144239466 (PIK3R1)
   04670 Leukocyte transendothelial migration
    144239466 (PIK3R1)
   04062 Chemokine signaling pathway
    144239466 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    144239466 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    144239466 (PIK3R1)
   04929 GnRH secretion
    144239466 (PIK3R1)
   04915 Estrogen signaling pathway
    144239466 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    144239466 (PIK3R1)
   04917 Prolactin signaling pathway
    144239466 (PIK3R1)
   04926 Relaxin signaling pathway
    144239466 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    144239466 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    144239466 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    144239466 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    144239466 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    144239466 (PIK3R1)
   04722 Neurotrophin signaling pathway
    144239466 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    144239466 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    144239466 (PIK3R1)
   04380 Osteoclast differentiation
    144239466 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    144239466 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    144239466 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    144239466 (PIK3R1)
   05206 MicroRNAs in cancer
    144239466 (PIK3R1)
   05205 Proteoglycans in cancer
    144239466 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    144239466 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    144239466 (PIK3R1)
   05203 Viral carcinogenesis
    144239466 (PIK3R1)
   05230 Central carbon metabolism in cancer
    144239466 (PIK3R1)
   05231 Choline metabolism in cancer
    144239466 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    144239466 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    144239466 (PIK3R1)
   05212 Pancreatic cancer
    144239466 (PIK3R1)
   05225 Hepatocellular carcinoma
    144239466 (PIK3R1)
   05226 Gastric cancer
    144239466 (PIK3R1)
   05214 Glioma
    144239466 (PIK3R1)
   05221 Acute myeloid leukemia
    144239466 (PIK3R1)
   05220 Chronic myeloid leukemia
    144239466 (PIK3R1)
   05218 Melanoma
    144239466 (PIK3R1)
   05211 Renal cell carcinoma
    144239466 (PIK3R1)
   05215 Prostate cancer
    144239466 (PIK3R1)
   05213 Endometrial cancer
    144239466 (PIK3R1)
   05224 Breast cancer
    144239466 (PIK3R1)
   05222 Small cell lung cancer
    144239466 (PIK3R1)
   05223 Non-small cell lung cancer
    144239466 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    144239466 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    144239466 (PIK3R1)
   05161 Hepatitis B
    144239466 (PIK3R1)
   05160 Hepatitis C
    144239466 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    144239466 (PIK3R1)
   05164 Influenza A
    144239466 (PIK3R1)
   05162 Measles
    144239466 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    144239466 (PIK3R1)
   05163 Human cytomegalovirus infection
    144239466 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    144239466 (PIK3R1)
   05169 Epstein-Barr virus infection
    144239466 (PIK3R1)
   05165 Human papillomavirus infection
    144239466 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    144239466 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    144239466 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    144239466 (PIK3R1)
   05142 Chagas disease
    144239466 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    144239466 (PIK3R1)
   05017 Spinocerebellar ataxia
    144239466 (PIK3R1)
   05020 Prion disease
    144239466 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    144239466 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    144239466 (PIK3R1)
   05415 Diabetic cardiomyopathy
    144239466 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    144239466 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    144239466 (PIK3R1)
   04931 Insulin resistance
    144239466 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    144239466 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    144239466 (PIK3R1)
   01524 Platinum drug resistance
    144239466 (PIK3R1)
   01522 Endocrine resistance
    144239466 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ccru04131]
    144239466 (PIK3R1)
Membrane trafficking [BR:ccru04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    144239466 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 CEP135_TSGA10_CC SH3_9 CCDC113_CCDC96_CC ODF2_C Laminin_I Exonuc_VII_L
Other DBs
NCBI-GeneID: 144239466
NCBI-ProteinID: XP_077629648
LinkDB
Position
Unknown
AA seq 726 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDVLTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKAEADSEQQQQALALPDL
AEQFAPPDIAPPLLVKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDAASVDLEMVD
VHVLGDAFKRYLTDLPNPVIPVAVYNEMLYLAQEVQSSEEYIQLLKKLIRAPNIPHQYWL
TLQYLLKHFFKLSQTSSKNLLNARVLSELFSPLLFRFPATSSENTEHLIKVVEILISTEW
NERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVR
DASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNP
KLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQ
MKRTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEI
VDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWL
GNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYA
CSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV
YAQQRR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctaccagtaccgggcgctgtatgattacaaaaaggaacgagaagaa
gatattgacttgcacttgggcgatgtattgactgtgaacaaagggtctttagtagccctt
ggattcagtgacggacaggaagccaggcctgaagaaattggctggttaaatgggtataat
gagacgacgggggaaagaggggactttccaggaacttatgttgaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccgaccacctcgaccccttcctgttgcaccggga
tcttcgaaagctgaagcagacagtgagcagcaacagcaagctttggctctgccggatctt
gctgagcagtttgcccctcctgacattgctccaccccttcttgtgaagctcgtggaagcc
attgaaaagaaaggtctggaatgttcaactttatacagaacacagagctccagcaacctg
gcagaattacgacagcttcttgattgtgatgccgcctccgtggacttggaaatggtcgat
gtgcacgttttaggagacgctttcaaacgctatcttacagacttaccgaatcctgtcatt
ccagtagccgtttacaacgaaatgctttatttagcccaagaagtacaaagctctgaagaa
tatatccagctgttgaagaagctcattagggcacctaacatacctcatcagtattggctt
acacttcagtatttgctcaaacatttcttcaagctctctcaaacctccagcaagaatctt
ctgaacgcaagagtactctctgaacttttcagccctctgcttttcagattcccggcaacc
agctctgagaatactgaacacctcataaaagttgtagaaattttaatctcaacggagtgg
aatgaacgacagcctgcaccagcgttgcctcctaaaccacccaaacccaccactgtagcc
aacaacggtatgaataacaatatgtccttacaagatgctgaatggtactggggcgatatc
tcaagggaagaagtgaatgaaaaacttcgagatacagctgacgggacctttttggtacga
gacgcatctactaaaatgcatggggattacactcttacactaaggaaaggaggaaataac
aagttaatcaaaatatttcaccgagatgggaaatatggcttctctgacccactaaccttc
aactctgtggttgaactaataaaccactaccggaatgagtccctagctcagtataatccc
aaactggacgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaa
gaagataatattgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaa
aaaagtcgggaatatgatagattatatgaagattatacccgtacttcccaggaaatccaa
atgaaaagaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgc
caaagccaagaacggtacagcaaagaatacatagaaaaatttaaacgcgaaggcaatgag
aaagaaatacaaaggattatgcataattatgaaaagttgaagtctcgcatcagcgagatt
gtggacagtagacgacgactggaggaagacttgaagaagcaggcagctgagtatcgggag
attgacaaacgcatgaacagcattaaaccagacctcattcagctgagaaagacaagagac
caatacttgatgtggttgactcagaaaggtgttcggcaaaagaagctgaacgagtggctg
ggcaacgaaaataccgaagaccaatactcgctggtggaggacgatgaggatttgccgcac
cacgacgagaagacctggaacgtcggcagcagcaacagaaacaaggctgaaaacctgctc
cggggaaaacgggacggcaccttcctggtccgggaaagcagtaaacagggctgctacgcc
tgctccgtggtggtggacggcgaagtgaagcactgtgtcatcaacaaaacggcaaccggc
tacggctttgccgagccctataacttgtacagctccctgaaggagctggtgctacattac
caacacacctccctcgtgcagcacaatgactccctcaacgtcacactagcctacccggta
tatgcacagcagaggcgatga

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