KEGG   Crocuta crocuta (spotted hyena): 144242202
Entry
144242202         CDS       T11532                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ccru  Crocuta crocuta (spotted hyena)
Pathway
ccru01521  EGFR tyrosine kinase inhibitor resistance
ccru01522  Endocrine resistance
ccru01524  Platinum drug resistance
ccru04012  ErbB signaling pathway
ccru04014  Ras signaling pathway
ccru04015  Rap1 signaling pathway
ccru04024  cAMP signaling pathway
ccru04062  Chemokine signaling pathway
ccru04066  HIF-1 signaling pathway
ccru04068  FoxO signaling pathway
ccru04070  Phosphatidylinositol signaling system
ccru04071  Sphingolipid signaling pathway
ccru04072  Phospholipase D signaling pathway
ccru04081  Hormone signaling
ccru04140  Autophagy - animal
ccru04145  Phagocytosis
ccru04150  mTOR signaling pathway
ccru04151  PI3K-Akt signaling pathway
ccru04152  AMPK signaling pathway
ccru04210  Apoptosis
ccru04211  Longevity regulating pathway
ccru04213  Longevity regulating pathway - multiple species
ccru04218  Cellular senescence
ccru04360  Axon guidance
ccru04370  VEGF signaling pathway
ccru04380  Osteoclast differentiation
ccru04510  Focal adhesion
ccru04517  IgSF CAM signaling
ccru04518  Integrin signaling
ccru04550  Signaling pathways regulating pluripotency of stem cells
ccru04611  Platelet activation
ccru04613  Neutrophil extracellular trap formation
ccru04620  Toll-like receptor signaling pathway
ccru04625  C-type lectin receptor signaling pathway
ccru04630  JAK-STAT signaling pathway
ccru04650  Natural killer cell mediated cytotoxicity
ccru04660  T cell receptor signaling pathway
ccru04662  B cell receptor signaling pathway
ccru04664  Fc epsilon RI signaling pathway
ccru04666  Fc gamma R-mediated phagosome formation
ccru04668  TNF signaling pathway
ccru04670  Leukocyte transendothelial migration
ccru04722  Neurotrophin signaling pathway
ccru04725  Cholinergic synapse
ccru04750  Inflammatory mediator regulation of TRP channels
ccru04810  Regulation of actin cytoskeleton
ccru04910  Insulin signaling pathway
ccru04914  Progesterone-mediated oocyte maturation
ccru04915  Estrogen signaling pathway
ccru04917  Prolactin signaling pathway
ccru04919  Thyroid hormone signaling pathway
ccru04923  Regulation of lipolysis in adipocytes
ccru04926  Relaxin signaling pathway
ccru04929  GnRH secretion
ccru04930  Type II diabetes mellitus
ccru04931  Insulin resistance
ccru04932  Non-alcoholic fatty liver disease
ccru04933  AGE-RAGE signaling pathway in diabetic complications
ccru04935  Growth hormone synthesis, secretion and action
ccru04960  Aldosterone-regulated sodium reabsorption
ccru04973  Carbohydrate digestion and absorption
ccru05010  Alzheimer disease
ccru05017  Spinocerebellar ataxia
ccru05020  Prion disease
ccru05100  Bacterial invasion of epithelial cells
ccru05135  Yersinia infection
ccru05142  Chagas disease
ccru05146  Amoebiasis
ccru05160  Hepatitis C
ccru05161  Hepatitis B
ccru05162  Measles
ccru05163  Human cytomegalovirus infection
ccru05164  Influenza A
ccru05165  Human papillomavirus infection
ccru05166  Human T-cell leukemia virus 1 infection
ccru05167  Kaposi sarcoma-associated herpesvirus infection
ccru05168  Herpes simplex virus 1 infection
ccru05169  Epstein-Barr virus infection
ccru05170  Human immunodeficiency virus 1 infection
ccru05171  Coronavirus disease
ccru05200  Pathways in cancer
ccru05203  Viral carcinogenesis
ccru05205  Proteoglycans in cancer
ccru05206  MicroRNAs in cancer
ccru05207  Chemical carcinogenesis - receptor activation
ccru05208  Chemical carcinogenesis - reactive oxygen species
ccru05210  Colorectal cancer
ccru05211  Renal cell carcinoma
ccru05212  Pancreatic cancer
ccru05213  Endometrial cancer
ccru05214  Glioma
ccru05215  Prostate cancer
ccru05218  Melanoma
ccru05220  Chronic myeloid leukemia
ccru05221  Acute myeloid leukemia
ccru05222  Small cell lung cancer
ccru05223  Non-small cell lung cancer
ccru05224  Breast cancer
ccru05225  Hepatocellular carcinoma
ccru05226  Gastric cancer
ccru05230  Central carbon metabolism in cancer
ccru05231  Choline metabolism in cancer
ccru05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccru05415  Diabetic cardiomyopathy
ccru05417  Lipid and atherosclerosis
ccru05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccru00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    144242202 (PIK3R2)
   04014 Ras signaling pathway
    144242202 (PIK3R2)
   04015 Rap1 signaling pathway
    144242202 (PIK3R2)
   04370 VEGF signaling pathway
    144242202 (PIK3R2)
   04630 JAK-STAT signaling pathway
    144242202 (PIK3R2)
   04668 TNF signaling pathway
    144242202 (PIK3R2)
   04066 HIF-1 signaling pathway
    144242202 (PIK3R2)
   04068 FoxO signaling pathway
    144242202 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    144242202 (PIK3R2)
   04072 Phospholipase D signaling pathway
    144242202 (PIK3R2)
   04071 Sphingolipid signaling pathway
    144242202 (PIK3R2)
   04024 cAMP signaling pathway
    144242202 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    144242202 (PIK3R2)
   04152 AMPK signaling pathway
    144242202 (PIK3R2)
   04150 mTOR signaling pathway
    144242202 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    144242202 (PIK3R2)
   04517 IgSF CAM signaling
    144242202 (PIK3R2)
   04518 Integrin signaling
    144242202 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    144242202 (PIK3R2)
   04140 Autophagy - animal
    144242202 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    144242202 (PIK3R2)
   04218 Cellular senescence
    144242202 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    144242202 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    144242202 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    144242202 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    144242202 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    144242202 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    144242202 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    144242202 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    144242202 (PIK3R2)
   04660 T cell receptor signaling pathway
    144242202 (PIK3R2)
   04662 B cell receptor signaling pathway
    144242202 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    144242202 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    144242202 (PIK3R2)
   04670 Leukocyte transendothelial migration
    144242202 (PIK3R2)
   04062 Chemokine signaling pathway
    144242202 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    144242202 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    144242202 (PIK3R2)
   04929 GnRH secretion
    144242202 (PIK3R2)
   04915 Estrogen signaling pathway
    144242202 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    144242202 (PIK3R2)
   04917 Prolactin signaling pathway
    144242202 (PIK3R2)
   04926 Relaxin signaling pathway
    144242202 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    144242202 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    144242202 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    144242202 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    144242202 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    144242202 (PIK3R2)
   04722 Neurotrophin signaling pathway
    144242202 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    144242202 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    144242202 (PIK3R2)
   04380 Osteoclast differentiation
    144242202 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    144242202 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    144242202 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    144242202 (PIK3R2)
   05206 MicroRNAs in cancer
    144242202 (PIK3R2)
   05205 Proteoglycans in cancer
    144242202 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    144242202 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    144242202 (PIK3R2)
   05203 Viral carcinogenesis
    144242202 (PIK3R2)
   05230 Central carbon metabolism in cancer
    144242202 (PIK3R2)
   05231 Choline metabolism in cancer
    144242202 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    144242202 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    144242202 (PIK3R2)
   05212 Pancreatic cancer
    144242202 (PIK3R2)
   05225 Hepatocellular carcinoma
    144242202 (PIK3R2)
   05226 Gastric cancer
    144242202 (PIK3R2)
   05214 Glioma
    144242202 (PIK3R2)
   05221 Acute myeloid leukemia
    144242202 (PIK3R2)
   05220 Chronic myeloid leukemia
    144242202 (PIK3R2)
   05218 Melanoma
    144242202 (PIK3R2)
   05211 Renal cell carcinoma
    144242202 (PIK3R2)
   05215 Prostate cancer
    144242202 (PIK3R2)
   05213 Endometrial cancer
    144242202 (PIK3R2)
   05224 Breast cancer
    144242202 (PIK3R2)
   05222 Small cell lung cancer
    144242202 (PIK3R2)
   05223 Non-small cell lung cancer
    144242202 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    144242202 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    144242202 (PIK3R2)
   05161 Hepatitis B
    144242202 (PIK3R2)
   05160 Hepatitis C
    144242202 (PIK3R2)
   05171 Coronavirus disease
    144242202 (PIK3R2)
   05164 Influenza A
    144242202 (PIK3R2)
   05162 Measles
    144242202 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    144242202 (PIK3R2)
   05163 Human cytomegalovirus infection
    144242202 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    144242202 (PIK3R2)
   05169 Epstein-Barr virus infection
    144242202 (PIK3R2)
   05165 Human papillomavirus infection
    144242202 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    144242202 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    144242202 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    144242202 (PIK3R2)
   05142 Chagas disease
    144242202 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    144242202 (PIK3R2)
   05017 Spinocerebellar ataxia
    144242202 (PIK3R2)
   05020 Prion disease
    144242202 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    144242202 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    144242202 (PIK3R2)
   05415 Diabetic cardiomyopathy
    144242202 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    144242202 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    144242202 (PIK3R2)
   04931 Insulin resistance
    144242202 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    144242202 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    144242202 (PIK3R2)
   01524 Platinum drug resistance
    144242202 (PIK3R2)
   01522 Endocrine resistance
    144242202 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ccru04131]
    144242202 (PIK3R2)
Membrane trafficking [BR:ccru04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    144242202 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 ODF2_C SH3_9 ATG11 Ribosomal_L22e
Other DBs
NCBI-GeneID: 144242202
NCBI-ProteinID: XP_077633138
LinkDB
Position
Unknown
AA seq 767 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGSERCPQTVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPLLVKLIEAIERTGLDSESLYRPELPAPRTGERTLGWAGYDVEQWDAAALTDGVK
SFLLALPAPLVTPEAAAEARRALREATGPVGPALEPPTLPLHRALTLRFLLQHLGRVARR
APAQGPAVRALGATFGPLLLRTPPPSPPPGGAPDGTEPSPDFPALLVEKLLQEHLEEQEV
APPALPPKPPKAKPAPASLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDA
SSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKL
DTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMK
RTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHE
SRTKLEHELRAQASDNREIDKRMNSLKPDLLQLRKIRDQYLVWLTQKGARQKKINEWLGI
KNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYAC
SVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVC
PPGPGPPPASLPVAKPESALQDRAWWDGSVVVGVGESERRRGLEGQV
NT seq 2304 nt   +upstreamnt  +downstreamnt
atggccggtgccgagggcttccagtaccgcgcgctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtggtgagccgggcggccctgcaggtg
ctgggcgtggccgagggcagcgagcgctgcccacagaccgtgggctggatgcccggcctc
aacgagcgcacgcggcagcgaggcgacttccccggcacctacgtcgagttcctgggtccc
gtagccctggcccggcctggccctcggccacgtggcccccgcccactgcccgccaggccc
cgcgatgggccccctgagccaggcctcacgctccctgacctgccagagcagttctccccc
cctgatgtggccccccctctcctggtgaagctcatagaggccattgagcggacagggctg
gacagtgaatccctctacaggcctgagctgcccgccccgcgcacaggtgagcggacgctt
ggatgggcagggtacgacgtggagcagtgggacgccgcagccctgacagatggcgtcaag
agcttcctgctggcgctgcccgcgcccctcgtgacgcccgaggctgcggccgaggcgcgc
cgggccctgcgggaggccacggggcccgtggggccggcgctggagcctccgacgctgcca
ctacaccgcgcgctcacgctgcgcttcctactccagcacctgggccgggtggcccggcgt
gcccccgctcagggccccgcggtgcgtgccctgggcgccacctttgggccgctgctgctg
cgcacgccgccgccctcgccgccgccagggggcgcgcccgacgggactgagcccagcccc
gacttcccagcgttgctggtggagaagttgcttcaggagcatctggaggagcaggaggtc
gcacccccagcgctgccgcctaaaccccccaaggccaagccagcccctgccagccttgcc
aacggggggagcccgccctcgctgcaggatgccgagtggtactggggtgacatctccagg
gaggaggtgaacgagaaactccgggacacgcctgacggcacctttctggtccgagatgca
tctagcaagatccagggggaatacacgctgactctcaggaaaggcgggaacaacaagctg
attaaggtcttccatcgcgacgggcactatggcttctcagagccgctcaccttctgctcc
gttgtggacctcatcacccactaccgccacgagtcactggcccagtacaatgccaaactg
gacacacggctcctctacccagtgtccaagtaccagcaggaccagatcgtcaaggaggac
agcgtggaggcggtgggtgcccagctcaaagtctatcaccagcagtaccaggacaagagc
cgagagtatgaccagctctacgaggagtacacacgcacctctcaggaactgcagatgaag
cggacggcaattgaggccttcaatgagaccatcaagatctttgaagagcagggccagacc
caagagaagtgtagcaaggaatatctggagcgcttccgccgagagggcaatgagaaggag
atgcagaggatcctgctgaactcagagcggctcaagtctcgcatcgcggagattcatgag
agccgcactaagctggagcacgagctgcgtgcacaggcctcggacaaccgagagatcgac
aagcgcatgaacagcctcaagccggacctcctgcagctgcgcaagatccgcgaccagtac
ctcgtgtggcttacccagaaaggtgcccggcagaagaaaatcaacgagtggttggggatc
aaaaacgagactgaggaccagtatgccctgatggaggatgaggatgatctcccccaccac
gaggaacgcacgtggtacgtgggcaagatcaaccggacgcaggctgaggaaatgctgagt
ggcaagcgggatggtaccttcctcatccgtgagagcagccagcggggctgctacgcctgc
tccgtggtggtggacggcgacaccaagcactgtgtcatctaccgcacggccacgggcttc
ggcttcgcggagccctacaacctgtacgggtcgctgaaggagctggtgctgcactaccag
cacgcctcgctggtgcagcacaacgacgcgctcaccgtcacgctcgcccaccccgtgtgc
ccccccggccccgggcccccgccggcntcccttcctgtggccaagcctgagtcagccctg
caggaccgcgcttggtgggacgggagcgtcgtcgtcggggtgggggagtctgagaggagg
agggggctcgaggggcaggtctga

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