KEGG   Camelus dromedarius (Arabian camel): 105096450
Entry
105096450         CDS       T04642                                 
Symbol
ADCY8
Name
(RefSeq) adenylate cyclase type 8 isoform X2
  KO
K08048  adenylate cyclase 8 [EC:4.6.1.1]
Organism
cdk  Camelus dromedarius (Arabian camel)
Pathway
cdk00230  Purine metabolism
cdk01100  Metabolic pathways
cdk01522  Endocrine resistance
cdk04015  Rap1 signaling pathway
cdk04020  Calcium signaling pathway
cdk04022  cGMP-PKG signaling pathway
cdk04024  cAMP signaling pathway
cdk04062  Chemokine signaling pathway
cdk04072  Phospholipase D signaling pathway
cdk04081  Hormone signaling
cdk04082  Neuroactive ligand signaling
cdk04114  Oocyte meiosis
cdk04211  Longevity regulating pathway
cdk04213  Longevity regulating pathway - multiple species
cdk04261  Adrenergic signaling in cardiomyocytes
cdk04270  Vascular smooth muscle contraction
cdk04371  Apelin signaling pathway
cdk04540  Gap junction
cdk04611  Platelet activation
cdk04713  Circadian entrainment
cdk04714  Thermogenesis
cdk04720  Long-term potentiation
cdk04723  Retrograde endocannabinoid signaling
cdk04724  Glutamatergic synapse
cdk04725  Cholinergic synapse
cdk04727  GABAergic synapse
cdk04742  Taste transduction
cdk04750  Inflammatory mediator regulation of TRP channels
cdk04911  Insulin secretion
cdk04912  GnRH signaling pathway
cdk04913  Ovarian steroidogenesis
cdk04914  Progesterone-mediated oocyte maturation
cdk04915  Estrogen signaling pathway
cdk04916  Melanogenesis
cdk04918  Thyroid hormone synthesis
cdk04921  Oxytocin signaling pathway
cdk04923  Regulation of lipolysis in adipocytes
cdk04925  Aldosterone synthesis and secretion
cdk04926  Relaxin signaling pathway
cdk04927  Cortisol synthesis and secretion
cdk04928  Parathyroid hormone synthesis, secretion and action
cdk04934  Cushing syndrome
cdk04935  Growth hormone synthesis, secretion and action
cdk04970  Salivary secretion
cdk04971  Gastric acid secretion
cdk04972  Pancreatic secretion
cdk04976  Bile secretion
cdk05032  Morphine addiction
cdk05163  Human cytomegalovirus infection
cdk05166  Human T-cell leukemia virus 1 infection
cdk05200  Pathways in cancer
cdk05207  Chemical carcinogenesis - receptor activation
cdk05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:cdk00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    105096450 (ADCY8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    105096450 (ADCY8)
   04371 Apelin signaling pathway
    105096450 (ADCY8)
   04020 Calcium signaling pathway
    105096450 (ADCY8)
   04072 Phospholipase D signaling pathway
    105096450 (ADCY8)
   04024 cAMP signaling pathway
    105096450 (ADCY8)
   04022 cGMP-PKG signaling pathway
    105096450 (ADCY8)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    105096450 (ADCY8)
   04081 Hormone signaling
    105096450 (ADCY8)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    105096450 (ADCY8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    105096450 (ADCY8)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105096450 (ADCY8)
   04062 Chemokine signaling pathway
    105096450 (ADCY8)
  09152 Endocrine system
   04911 Insulin secretion
    105096450 (ADCY8)
   04923 Regulation of lipolysis in adipocytes
    105096450 (ADCY8)
   04912 GnRH signaling pathway
    105096450 (ADCY8)
   04913 Ovarian steroidogenesis
    105096450 (ADCY8)
   04915 Estrogen signaling pathway
    105096450 (ADCY8)
   04914 Progesterone-mediated oocyte maturation
    105096450 (ADCY8)
   04921 Oxytocin signaling pathway
    105096450 (ADCY8)
   04926 Relaxin signaling pathway
    105096450 (ADCY8)
   04935 Growth hormone synthesis, secretion and action
    105096450 (ADCY8)
   04918 Thyroid hormone synthesis
    105096450 (ADCY8)
   04928 Parathyroid hormone synthesis, secretion and action
    105096450 (ADCY8)
   04916 Melanogenesis
    105096450 (ADCY8)
   04925 Aldosterone synthesis and secretion
    105096450 (ADCY8)
   04927 Cortisol synthesis and secretion
    105096450 (ADCY8)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105096450 (ADCY8)
   04270 Vascular smooth muscle contraction
    105096450 (ADCY8)
  09154 Digestive system
   04970 Salivary secretion
    105096450 (ADCY8)
   04971 Gastric acid secretion
    105096450 (ADCY8)
   04972 Pancreatic secretion
    105096450 (ADCY8)
   04976 Bile secretion
    105096450 (ADCY8)
  09156 Nervous system
   04724 Glutamatergic synapse
    105096450 (ADCY8)
   04727 GABAergic synapse
    105096450 (ADCY8)
   04725 Cholinergic synapse
    105096450 (ADCY8)
   04720 Long-term potentiation
    105096450 (ADCY8)
   04723 Retrograde endocannabinoid signaling
    105096450 (ADCY8)
  09157 Sensory system
   04742 Taste transduction
    105096450 (ADCY8)
   04750 Inflammatory mediator regulation of TRP channels
    105096450 (ADCY8)
  09149 Aging
   04211 Longevity regulating pathway
    105096450 (ADCY8)
   04213 Longevity regulating pathway - multiple species
    105096450 (ADCY8)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105096450 (ADCY8)
   04714 Thermogenesis
    105096450 (ADCY8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105096450 (ADCY8)
   05207 Chemical carcinogenesis - receptor activation
    105096450 (ADCY8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105096450 (ADCY8)
   05163 Human cytomegalovirus infection
    105096450 (ADCY8)
  09165 Substance dependence
   05032 Morphine addiction
    105096450 (ADCY8)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    105096450 (ADCY8)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105096450 (ADCY8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    105096450 (ADCY8)
Enzymes [BR:cdk01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     105096450 (ADCY8)
SSDB
Motif
Pfam: Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD
Other DBs
NCBI-GeneID: 105096450
NCBI-ProteinID: XP_010987092
LinkDB
Position
25:complement(32987328..33175152)
AA seq 1226 aa
MELSDVRCLSGSEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRSGGGG
GGGGGGSGGSCKASDPGGGGPNHHASQLSGDSALPLYSLGPGERAHSTGGTKVFPERSGS
GSARGSGGGGDLGFLHLDCAPSNSDFFLSGGYSYRGVIFPTLRNSFKSRDLERLYQRYFL
GQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKD
TTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILA
GLGTSLLQVVLQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRR
CVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSI
LFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPR
QDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVD
IANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLL
SLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLA
QALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSN
LVCAFIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTC
CWINETYLARNVIIFASILINFLGAILNIYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIM
IAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARL
DFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMF
ASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSG
LSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKK
PQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKI
KTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKAHY
NRRTLLTPSGPEPGAQAEGADKSELP
NT seq 3681 nt   +upstreamnt  +downstreamnt
atggagctctccgatgtgcgctgcctcagcggcagcgaggaactctacaccatccacccg
acgcccccggccggcgacggcgggagcggctcgcggccgcagcggctgctgtggcagacg
gcggtgcggcacatcaccgagcagcgcttcattcacgggcaccggagcggcggcggcggc
ggcggaggcggcggcgggagcggaggctcctgcaaagcctcggaccctggaggcggcggc
cccaaccaccacgcgtcgcagctgtccggcgactcagcgctgcccctctactcgctgggc
cctggggagagagcgcacagcaccggcggcaccaaagtcttcccggaacgcagcgggagc
ggcagcgccaggggcagcgggggcgggggcgacctgggcttcctgcacctcgactgcgcc
ccgagcaactcggatttcttcctcagtgggggctatagctaccgaggggtcattttcccc
accctgcgcaactccttcaagtcccgggatctggagcgcctctaccagcgctatttcctg
ggccagaggcgcaaatcggaggtggtgatgaacgtgctggacgtgctgaccaaactcacc
ctcttggttctccacttgagcctggcctcggcccccatggacccgctcaagggcatcctg
ctgggcttcttcactggcatagaggtggtgatctgcgccctggtggtggtcaggaaggac
accacctcgcacacgtacctgcagtacagcggcgtggtcacctgggtggccatgaccacc
cagatcttagccgcaggtctcggctacgggctgctgggggacggcatcggctacgtgctc
ttcacgctcttcgccacctacagcatgctgccgctgccgctcacctgggccatcctggcc
ggcctgggcacctccttgctgcaggtagtcctccaagtggtcatccccaggctggcggtc
atttccatcaaccaggttgtggctcaggcagtgttattcatgtgtatgaacacagctggc
atcttcatcagttacctgtcagatcgggcccagcgccaagccttcctggagacgcggagg
tgcgtggaggccaggctgcggctggagacggaaaaccaaagacaggagcggcttgtgctg
tccgtgctgccccggtttgttgtcctggaaatgatcaacgacatgaccaacgtggaagac
gagcacctgcagcaccaattccatcggatctacatccaccgctatgagaacgtcagtatt
ctttttgcagatgttaaaggatttaccaacctctccacgaccttgtctgctcaggagctg
gtcaggatgctcaacgagctctttgccagatttgatcgactggcccatgagcatcactgc
cttcgcattaaaatcctgggggactgctactactgcgtttcgggacttcccgagccccgc
caggaccacgcccactgctgcgttgaaatgggcctcagcatgatcaaaactatcaggtac
gtgaggtcaaggacgaagcacgacattgacatgcggatcggaatccactcgggctccgtg
ctgtgtggcgtgttgggcctgcggaagtggcagtttgatgtctggtcttgggatgtggac
attgcgaacaaacttgaatctggaggaatccccgggaggattcacatttctaaagccacc
ctggactgcctcaacggggactataatgtggaagagggccacggaaaagagaggaatgaa
ttcctgaggaagcataacatagagacctatttaattaagcagcctgaggacagtctactg
tctttgcccgaagacattgtcaaggagtctgtgagctcctcagacaggagaaacagtggg
gcaacgttcacagaaggatcctggagccctgaactgcccttcgataacatagtggggaaa
cagaacactctggctgccctaacaagaaattcaataaatctacttccaaaccatcttgca
caagctttgcatgtccagtctgggcctgaggagattaacaagagaatagaacataccatc
gacttgcggagtggcgataaattgagaagagagcatatcaagccattctcactgatgttt
aaagactccagcctggagcacaagtattctcaaatgagggatgaagtattcaagtcaaac
ttggtctgtgcatttatcgtccttctgtttatcacggcaatacaaagtttgcttccttct
tcaagggtgatgccaatggccatccagttttccatcctgattatgctgcactcggctctg
gtcctcatcaccacagcagaggattataagtgtttgcccctggtcctccggaaaacttgc
tgttggattaacgagacctatttggccagaaacgtcatcatctttgcatccatcttgatt
aatttcctgggcgccatcttaaatatctacttcgtcttcacgggggtgctggccatggtg
acatgtgcggttttcctccgacttaattccgtcctgaagctggctgtgctgctgattatg
atcgctatctatgccctgctgactgagaccatctatgcaggactctttctgcgctacgac
aacctgaaccacagtggagaagatttcctggggaccaaggaggcatcgctgctgctgatg
gccatgttcctcctcgctgtgttctaccatggacagcagctggagtacaccgcccgcctg
gacttcctttggcgagtgcaggccaaagaggagatcaacgagatgaaggagctgagggag
cacaacgagaacatgctgcggaacatcctgcccagccacgtggcccgccacttcctggag
aaggaccgggacaacgaggagctgtattcccagtcctatgatgccgttggagtgatgttt
gcctccatcccagggtttgcagacttttactctcaaactgaaatgaataaccaaggagtg
gaatgcctacgcctgctgaatgagatcattgccgacttcgatgagctgctcggtgaagac
cgatttcaagacattgagaagattaagaccattggcagcacctacatggctgtgtccggc
ctgtcacctgagaaacagcaatgtgaagacaagtgggggcatctgtgcgccctggccgac
ttctctcttgccctgaccgaaagcatacaggagatcaacaagcactctttcaacaatttc
gagctccggattggcatcagccacggctcagtggtcgctggcgttatcggcgctaagaag
ccacagtacgacatttggggcaagaccgtgaacctggcaagtcggatggacagcacgggg
gtcagcggccggatccaggtcccagaggagacctatctcatcctgaaggaccagggcttt
gcctttgactaccgcggggagatctacgtgaagggcatcagtgagcaggaaggaaaaatc
aaaacgtactttctcctgggaagagtccaacccaacccattcatcctgcccccgagaaga
ctgcctgggcagtactccttggccgcggtggtcctgggcctcgtgcagtccctcaacagg
cagaggcagaagcagctcctgaacgagaacaacaacacaggcatcatcaaggcccattac
aaccggcggactttgttgacgcccagcgggccagagccgggagcccaagccgaaggcgcc
gacaagtccgagttgccataa

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