Canis lupus familiaris (dog): 403859 Help Entry 403859            CDS       T01007                                  Symbol ADCY5 Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism cfa  Canis lupus familiaris (dog) Pathway cfa00230   Purine metabolism cfa01100   Metabolic pathways cfa01522   Endocrine resistance cfa04015   Rap1 signaling pathway cfa04022   cGMP-PKG signaling pathway cfa04024   cAMP signaling pathway cfa04062   Chemokine signaling pathway cfa04072   Phospholipase D signaling pathway cfa04081   Hormone signaling cfa04082   Neuroactive ligand signaling cfa04114   Oocyte meiosis cfa04211   Longevity regulating pathway cfa04213   Longevity regulating pathway - multiple species cfa04261   Adrenergic signaling in cardiomyocytes cfa04270   Vascular smooth muscle contraction cfa04371   Apelin signaling pathway cfa04540   Gap junction cfa04611   Platelet activation cfa04713   Circadian entrainment cfa04714   Thermogenesis cfa04723   Retrograde endocannabinoid signaling cfa04724   Glutamatergic synapse cfa04725   Cholinergic synapse cfa04726   Serotonergic synapse cfa04727   GABAergic synapse cfa04728   Dopaminergic synapse cfa04750   Inflammatory mediator regulation of TRP channels cfa04911   Insulin secretion cfa04912   GnRH signaling pathway cfa04913   Ovarian steroidogenesis cfa04914   Progesterone-mediated oocyte maturation cfa04915   Estrogen signaling pathway cfa04916   Melanogenesis cfa04918   Thyroid hormone synthesis cfa04921   Oxytocin signaling pathway cfa04923   Regulation of lipolysis in adipocytes cfa04924   Renin secretion cfa04925   Aldosterone synthesis and secretion cfa04926   Relaxin signaling pathway cfa04927   Cortisol synthesis and secretion cfa04928   Parathyroid hormone synthesis, secretion and action cfa04934   Cushing syndrome cfa04935   Growth hormone synthesis, secretion and action cfa04970   Salivary secretion cfa04971   Gastric acid secretion cfa04972   Pancreatic secretion cfa04976   Bile secretion cfa05012   Parkinson disease cfa05030   Cocaine addiction cfa05031   Amphetamine addiction cfa05032   Morphine addiction cfa05034   Alcoholism cfa05163   Human cytomegalovirus infection cfa05166   Human T-cell leukemia virus 1 infection cfa05200   Pathways in cancer cfa05207   Chemical carcinogenesis - receptor activation cfa05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:cfa00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     403859 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     403859 (ADCY5)    04072 Phospholipase D signaling pathway     403859 (ADCY5)    04024 cAMP signaling pathway     403859 (ADCY5)    04022 cGMP-PKG signaling pathway     403859 (ADCY5)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     403859 (ADCY5)    04081 Hormone signaling     403859 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     403859 (ADCY5)    04062 Chemokine signaling pathway     403859 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     403859 (ADCY5)    04923 Regulation of lipolysis in adipocytes     403859 (ADCY5)    04913 Ovarian steroidogenesis     403859 (ADCY5)    04915 Estrogen signaling pathway     403859 (ADCY5)    04921 Oxytocin signaling pathway     403859 (ADCY5)    04926 Relaxin signaling pathway     403859 (ADCY5)    04935 Growth hormone synthesis, secretion and action     403859 (ADCY5)    04918 Thyroid hormone synthesis     403859 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     403859 (ADCY5)    04924 Renin secretion     403859 (ADCY5)    04925 Aldosterone synthesis and secretion     403859 (ADCY5)    04927 Cortisol synthesis and secretion     403859 (ADCY5)   09154 Digestive system    04970 Salivary secretion     403859 (ADCY5)    04971 Gastric acid secretion     403859 (ADCY5)    04972 Pancreatic secretion     403859 (ADCY5)    04976 Bile secretion     403859 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     403859 (ADCY5)    04727 GABAergic synapse     403859 (ADCY5)    04725 Cholinergic synapse     403859 (ADCY5)    04728 Dopaminergic synapse     403859 (ADCY5)    04726 Serotonergic synapse     403859 (ADCY5)    04723 Retrograde endocannabinoid signaling     403859 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     403859 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     403859 (ADCY5)    04213 Longevity regulating pathway - multiple species     403859 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     403859 (ADCY5)    04714 Thermogenesis     403859 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     403859 (ADCY5)    05207 Chemical carcinogenesis - receptor activation     403859 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     403859 (ADCY5)    05163 Human cytomegalovirus infection     403859 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     403859 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     403859 (ADCY5)    05031 Amphetamine addiction     403859 (ADCY5)    05032 Morphine addiction     403859 (ADCY5)    05034 Alcoholism     403859 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     403859 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     403859 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     403859 (ADCY5) Enzymes [BR:cfa01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      403859 (ADCY5) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom YdbH-like Motif Other DBs NCBI-GeneID:  403859 NCBI-ProteinID:  NP_001161932 Ensembl:  ENSCAFG00000012084 VGNC:  37622 UniProt:  P30803 Structure PDBPDBj LinkDB All DBs Position 33:complement(26367988..26513164) Genome browser AA seq 1265 aa AA seqDB search MSGPRSASPPGCAATRGGPEHRAAWGEAEARANGHPHAAGGATRGCSKKPGGAVTPQLQQ QQQQQQHEQQHEQQQHEQQQHVQQQQRLAKRWRGDDDPPLGGDDPLAGGFGFSFRSRSAW QERGGDDCGRGSRRRRRGAAGGGSSRAPPAGGGGGPAAAGGAEVRPRSVELGLDERRGRG RAEPEPEAEAGAPGGDRGARDGDGPAGPGACCRALLQIFRSKKFPSDKLERLYQRYFFRL NQSSLTMLMAVLVLVCLVMLAFHAARPPLRLPHLAVLAAAVGVILVMAVLCNRAAFHQDH MGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLL SALHLAIALRANAQDRFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQA RLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEG FTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCC VEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA GGKAGRIHITKATLSYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIA KMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVD EFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICF VQITIVPHSVFMLSFYLTCFLLLTLVVFVSVIYSCVKLFPGPLQSLSRKIVRSKTNSTLV GVFTITLVFLSAFVNMFMCNSEDLLGCLADEHNISTSRVNACHVAASAANLSLGDEQGFC GTPWPSCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLVVEVPRVTLFDN ADLLVTANAIDFNNNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDF LWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFAS IANFSEFYVELEANNEGVECLRVLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLN DSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQY DIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG GPPLS NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt atgtccgggccccgcagcgcgagccccccgggctgcgcggcgacccgggggggcccggag caccgcgcggcgtggggggaggcggaggcccgcgccaacggccacccgcacgccgccggg ggcgcgacccgcggctgcagcaagaagcccgggggggcggtgaccccgcagctgcagcag cagcagcagcagcagcagcacgagcagcagcacgagcagcagcagcacgagcagcagcag catgtgcagcagcagcagcgcctggccaagcgctggcgcggcgacgacgaccccccgctg ggcggcgacgaccccctggccgggggcttcggcttcagcttccgctccaggtcggcctgg caggagcgcggcggcgacgactgcgggcgcggcagccggcggcggcggcggggcgcggcg ggcgggggcagctcccgggcgccccctgcgggcggcggcggcggcccggcggcggcgggc ggggcggaggtgcgcccccgctcggtggagctgggcctggacgagcggcggggccggggc cgcgccgagcccgagcccgaggccgaggccggcgcccccgggggcgaccgcggggcgcgg gacggcgacggccccgcagggccgggcgcctgctgccgcgcgctgctgcagatcttccgc tccaagaagttcccgtcggacaagctggagcggctgtaccagcgctacttcttccgcctg aaccagagcagcctcaccatgctcatggccgtgctggtgctcgtgtgcctcgtgatgctg gccttccacgcggcgcggcccccgctgcggctgccccacctggccgtgctggcggccgcg gtcggggtcatcctggtcatggccgtgctctgcaaccgcgccgccttccaccaggaccac atgggcctggcctgctacgcgctcatcgccgtggtgctggccgtgcaggtggtgggcctg ctgctgccccagccgcgcagcgcctccgagggcatctggtggaccgtgttcttcatctac accatctacacgctgctgcccgtgcgcatgcgggccgccgtcctcagcggagtgctcctg tcggccctgcacctggccatcgccctgcgcgccaacgcccaggaccggttcctgctcaag cagctcgtctccaatgtcctcattttctcctgcaccaacatcgtgggtgtctgtacccac tacccggctgaggtctcccagagacaggccttccaagagacccgggagtgcatccaggca cggctccactcgcaacgggagaaccagcaacaggagcggctcctgctgtctgtcctgccc cgacacgttgccatggagatgaaagcagacatcaatgccaagcaggaggatatgatgttc cataagatttacatccagaaacatgacaacgtgagcatcctgtttgctgacatcgagggc ttcaccagcttggcatcccagtgcactgcccaggagctggtcatgacgctcaatgagctc ttcgcccgcttcgacaagctggctgcggagaatcactgtttacgtattaagatcctgggg gattgttattactgtgtctctgggctgcctgaagcgagggccgaccacgcccactgctgc gtggagatgggcatggacatgattgaggccatctcgttggtccgggaggtgacaggggtg aacgtgaacatgcgcgtgggaattcacagcgggcgagtacactgcggtgtccttggtctc aggaagtggcagttcgacgtctggtctaatgacgtcacgctggccaaccatatggaagct ggaggcaaggctgggcgcatccacatcaccaaggccacactcagctacctgaacggtgac tacgaggtggagccaggctgcgggggcgagcgcaacgcctacctcaaggagcacagtatc gagaccttcctcatcctgcgctgcacccagaagcggaaagaagaaaaggccatgatcgcc aagatgaatcgccagagaaccaactccattgggcacaacccgccccactggggggccgaa cgtcccttctacaaccacctaggaggcaaccaggtgtccaaggagatgaagcgcatgggc ttcgaagaccccaaggacaagaacgcccaggaaagtgcgaaccctgaggatgaagtggat gaatttctgggccgcgccattgacgccaggagcatcgacaggctgcggtcggagcacgtc cgcaagttcctcctgaccttcagggagcctgacttagaaaagaagtactccaagcaggtg gatgaccgattcggtgcctacgtggcatgtgcctcgcttgtcttcctcttcatctgcttt gtccagatcaccatcgtaccccactccgtgttcatgttgagtttctacttgacctgtttc ctgctgctgacgttggtggtatttgtgtccgtgatctattcctgcgtgaagctcttcccg ggcccgctccagagcctctcgaggaagatcgtgcgctccaagaccaacagcaccctggtc ggggtgttcaccatcaccctggtgttcctgtcggctttcgtcaacatgttcatgtgtaac tccgaggacctgttgggctgcctggcggacgagcacaacatcagcaccagccgggtcaac gcgtgccacgtggcggcgtcggcggccaacctcagcctgggcgacgagcagggcttctgc ggcacgccctggcccagctgcaacttccccgagtacttcacctacagcgtgctgctcagc ctgctggcctgctccgtgttcctgcagatcagctgcatcgggaagctggtgctcatgctg gccattgagctcatatacgtgctcgtcgtcgaggtgccccgggtcacactgtttgacaac gctgacctgctggtcaccgccaacgccatagacttcaacaacaacaacgggacctcgcag tgccctgagcacgcgaccaaggtggcgctgaaggtggtgacgcccatcatcatctccgtc ttcgtgctggccctgtacctgcatgcccagcaagtggagtccaccgcccgcctcgacttc ctctggaaactgcaggccacggaggagaaggaggagatggaggagctgcaggcctacaac cggcggctgctgcacaacatcctgcccaaggacgtggctgcccacttcctggcccgtgag cgacgcaacgacgagctctactaccagtcgtgcgagtgcgtggctgtcatgttcgcctcc atcgccaacttctccgagttctacgtggagcttgaggccaacaatgagggtgtcgagtgc ctgcgcgtgctcaatgagatcatcgctgactttgatgagatcatcagcgaggatcggttc aggcagctggagaagatcaagaccattggcagcacctacatggccgcctcaggcctcaat gactctacatacgacaaggtgggcaagacccacatcaaagccctggctgactttgccatg aagctcatggaccaaatgaagtacatcaatgagcactccttcaacaacttccagatgaag atcgggctcaacatcggccccgtggtggccggggtgatcggggctcgcaagcctcagtac gacatctggggcaatacggtgaatgtggccagccgcatggacagcaccggcgtgccggac cgcatccaggtcaccacggacatgtaccaggtgttggctgccaacacgtaccagctggag tgcaggggtgtggtcaaggtcaagggcaaaggcgagatgatgacctacttcctcaacggt gggcccccgctcagttag

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