Canis lupus familiaris (dog): 403922 Help Entry 403922            CDS       T01007                                  Symbol TNF Name (RefSeq) tumor necrosis factor   KO K03156   tumor necrosis factor superfamily, member 2 Organism cfa  Canis lupus familiaris (dog) Pathway cfa01523   Antifolate resistance cfa04010   MAPK signaling pathway cfa04060   Cytokine-cytokine receptor interaction cfa04061   Viral protein interaction with cytokine and cytokine receptor cfa04064   NF-kappa B signaling pathway cfa04071   Sphingolipid signaling pathway cfa04150   mTOR signaling pathway cfa04210   Apoptosis cfa04217   Necroptosis cfa04350   TGF-beta signaling pathway cfa04380   Osteoclast differentiation cfa04612   Antigen processing and presentation cfa04620   Toll-like receptor signaling pathway cfa04621   NOD-like receptor signaling pathway cfa04622   RIG-I-like receptor signaling pathway cfa04625   C-type lectin receptor signaling pathway cfa04640   Hematopoietic cell lineage cfa04650   Natural killer cell mediated cytotoxicity cfa04657   IL-17 signaling pathway cfa04660   T cell receptor signaling pathway cfa04664   Fc epsilon RI signaling pathway cfa04668   TNF signaling pathway cfa04920   Adipocytokine signaling pathway cfa04930   Type II diabetes mellitus cfa04931   Insulin resistance cfa04932   Non-alcoholic fatty liver disease cfa04933   AGE-RAGE signaling pathway in diabetic complications cfa04936   Alcoholic liver disease cfa04940   Type I diabetes mellitus cfa05010   Alzheimer disease cfa05014   Amyotrophic lateral sclerosis cfa05020   Prion disease cfa05022   Pathways of neurodegeneration - multiple diseases cfa05132   Salmonella infection cfa05133   Pertussis cfa05134   Legionellosis cfa05135   Yersinia infection cfa05140   Leishmaniasis cfa05142   Chagas disease cfa05143   African trypanosomiasis cfa05144   Malaria cfa05145   Toxoplasmosis cfa05146   Amoebiasis cfa05152   Tuberculosis cfa05160   Hepatitis C cfa05161   Hepatitis B cfa05163   Human cytomegalovirus infection cfa05164   Influenza A cfa05165   Human papillomavirus infection cfa05166   Human T-cell leukemia virus 1 infection cfa05168   Herpes simplex virus 1 infection cfa05169   Epstein-Barr virus infection cfa05170   Human immunodeficiency virus 1 infection cfa05171   Coronavirus disease - COVID-19 cfa05205   Proteoglycans in cancer cfa05310   Asthma cfa05321   Inflammatory bowel disease cfa05322   Systemic lupus erythematosus cfa05323   Rheumatoid arthritis cfa05330   Allograft rejection cfa05332   Graft-versus-host disease cfa05410   Hypertrophic cardiomyopathy cfa05414   Dilated cardiomyopathy cfa05417   Lipid and atherosclerosis cfa05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:cfa00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     403922 (TNF)    04350 TGF-beta signaling pathway     403922 (TNF)    04064 NF-kappa B signaling pathway     403922 (TNF)    04668 TNF signaling pathway     403922 (TNF)    04071 Sphingolipid signaling pathway     403922 (TNF)    04150 mTOR signaling pathway     403922 (TNF)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     403922 (TNF)    04061 Viral protein interaction with cytokine and cytokine receptor     403922 (TNF)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     403922 (TNF)    04217 Necroptosis     403922 (TNF)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     403922 (TNF)    04620 Toll-like receptor signaling pathway     403922 (TNF)    04621 NOD-like receptor signaling pathway     403922 (TNF)    04622 RIG-I-like receptor signaling pathway     403922 (TNF)    04625 C-type lectin receptor signaling pathway     403922 (TNF)    04650 Natural killer cell mediated cytotoxicity     403922 (TNF)    04612 Antigen processing and presentation     403922 (TNF)    04660 T cell receptor signaling pathway     403922 (TNF)    04657 IL-17 signaling pathway     403922 (TNF)    04664 Fc epsilon RI signaling pathway     403922 (TNF)   09152 Endocrine system    04920 Adipocytokine signaling pathway     403922 (TNF)   09158 Development and regeneration    04380 Osteoclast differentiation     403922 (TNF)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     403922 (TNF)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     403922 (TNF)    05170 Human immunodeficiency virus 1 infection     403922 (TNF)    05161 Hepatitis B     403922 (TNF)    05160 Hepatitis C     403922 (TNF)    05171 Coronavirus disease - COVID-19     403922 (TNF)    05164 Influenza A     403922 (TNF)    05168 Herpes simplex virus 1 infection     403922 (TNF)    05163 Human cytomegalovirus infection     403922 (TNF)    05169 Epstein-Barr virus infection     403922 (TNF)    05165 Human papillomavirus infection     403922 (TNF)   09171 Infectious disease: bacterial    05132 Salmonella infection     403922 (TNF)    05135 Yersinia infection     403922 (TNF)    05133 Pertussis     403922 (TNF)    05134 Legionellosis     403922 (TNF)    05152 Tuberculosis     403922 (TNF)   09174 Infectious disease: parasitic    05146 Amoebiasis     403922 (TNF)    05144 Malaria     403922 (TNF)    05145 Toxoplasmosis     403922 (TNF)    05140 Leishmaniasis     403922 (TNF)    05142 Chagas disease     403922 (TNF)    05143 African trypanosomiasis     403922 (TNF)   09163 Immune disease    05310 Asthma     403922 (TNF)    05322 Systemic lupus erythematosus     403922 (TNF)    05323 Rheumatoid arthritis     403922 (TNF)    05321 Inflammatory bowel disease     403922 (TNF)    05330 Allograft rejection     403922 (TNF)    05332 Graft-versus-host disease     403922 (TNF)   09164 Neurodegenerative disease    05010 Alzheimer disease     403922 (TNF)    05014 Amyotrophic lateral sclerosis     403922 (TNF)    05020 Prion disease     403922 (TNF)    05022 Pathways of neurodegeneration - multiple diseases     403922 (TNF)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     403922 (TNF)    05418 Fluid shear stress and atherosclerosis     403922 (TNF)    05410 Hypertrophic cardiomyopathy     403922 (TNF)    05414 Dilated cardiomyopathy     403922 (TNF)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     403922 (TNF)    04940 Type I diabetes mellitus     403922 (TNF)    04936 Alcoholic liver disease     403922 (TNF)    04932 Non-alcoholic fatty liver disease     403922 (TNF)    04931 Insulin resistance     403922 (TNF)    04933 AGE-RAGE signaling pathway in diabetic complications     403922 (TNF)   09176 Drug resistance: antineoplastic    01523 Antifolate resistance     403922 (TNF)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:cfa04052]     403922 (TNF)    00536 Glycosaminoglycan binding proteins [BR:cfa00536]     403922 (TNF) Cytokines and neuropeptides [BR:cfa04052]  Cytokines   Tumor necrosis fators    403922 (TNF) Glycosaminoglycan binding proteins [BR:cfa00536]  Heparan sulfate / Heparin   Cytokines    403922 (TNF) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  TNF Motif Other DBs NCBI-GeneID:  403922 NCBI-ProteinID:  NP_001003244 Ensembl:  ENSCAFG00000000517 VGNC:  47647 UniProt:  P51742 A9LMQ0 Structure PDBPDBj LinkDB All DBs Position 12:1211002..1212867 Genome browser AA seq 233 aa AA seqDB search MSTESMIRDVELAEEPLPKKAGGPPGSRRCFCLSLFSFLLVAGATTLFCLLHFGVIGPQR EELPNGLQLISPLAQTVKSSSRTPSDKPVAHVVANPEAEGQLQWLSRRANALLANGVELT DNQLIVPSDGLYLIYSQVLFKGQGCPSTHVLLTHTISRFAVSYQTKVNLLSAIKSPCQRE TPEGTEAKPWYEPIYLGGVFQLEKGDRLSAEINLPNYLDFAESGQVYFGIIAL NT seq 702 nt NT seq  +upstreamnt  +downstreamnt atgagcactgaaagcatgatccgggacgtggagctggccgaggagccgctccccaagaag gcggggggccccccgggctccagaaggtgcttctgcctcagcctcttctccttcctcctc gtcgcaggggccaccacactcttctgcctgctgcactttggagtgatcggcccccagagg gaagagctcccaaatggcctccaactaatcagccctcttgcccagacagtcaaatcatct tctcgaaccccaagtgacaagccagtagctcatgttgtagcaaaccccgaagctgagggg cagctccagtggctgagccgacgtgccaatgccctcctggccaacggcgtggagctgaca gacaaccagctgatagtgccgtcagatgggttgtacctcatctactcccaggtcctcttc aagggccaagggtgcccttccacccatgtgctcctcacccacaccatcagccgcttcgcc gtctcctaccagacaaaggtcaacctactctctgccatcaagagcccttgccaaagggag accccagaggggaccgaggccaagccctggtacgagcccatctacctgggaggggtcttc caactggagaagggtgatcgactcagcgctgagatcaatctgcctaactatctggacttt gccgagtccgggcaggtgtactttggaatcattgccctgtaa

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