Canis lupus familiaris (dog): 477199
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Entry
477199 CDS
T01007
Symbol
ITCH
Name
(RefSeq) E3 ubiquitin-protein ligase Itchy homolog isoform X2
KO
K05632
E3 ubiquitin-protein ligase Itchy [EC:
2.3.2.26
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa04120
Ubiquitin mediated proteolysis
cfa04144
Endocytosis
cfa04330
Notch signaling pathway
cfa04668
TNF signaling pathway
cfa04932
Non-alcoholic fatty liver disease
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
477199 (ITCH)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
477199 (ITCH)
04668 TNF signaling pathway
477199 (ITCH)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
477199 (ITCH)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
477199 (ITCH)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
cfa04131
]
477199 (ITCH)
04121 Ubiquitin system [BR:
cfa04121
]
477199 (ITCH)
Enzymes [BR:
cfa01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
477199 (ITCH)
Membrane trafficking [BR:
cfa04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
477199 (ITCH)
Ubiquitin system [BR:
cfa04121
]
Ubiquitin ligases (E3)
HECT type E3
477199 (ITCH)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HECT
WW
C2
Motif
Other DBs
NCBI-GeneID:
477199
NCBI-ProteinID:
XP_005635007
Ensembl:
ENSCAFG00000007528
VGNC:
42117
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All DBs
Position
24:23124607..23276323
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AA seq
830 aa
AA seq
DB search
MSGSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIFETLKSNNMKLEEVVVTL
QLVGDKEPTETIGDLSVCLDGLQLESEVVTNGETTCSESVPQNDDGSRPKDETRTNTNGS
DEPEDTGTGENRKVNGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
GSSTGSLPPTNINSNTSEGATSGLIIPLTISGGSGPRPLNPVPQAPLPPGWEQRVDQHGR
VYYVDHIEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
LQRSQLQGAMQQFNQRFIYGNQDLFTTSQNKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ
IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFNPQDLRRRLWVIF
PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGL
EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDN
EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTC
NT seq
2493 nt
NT seq
+upstream
nt +downstream
nt
atgtctggcagtggatcgcagcttggttcaatgggtagcctgaccatgaaatcacaactt
cagatcactgtcatttcagcaaaacttaaagaaaataaaaagaattggtttggaccaagc
ccttatgtggaagtcacagtagatggacagtcaaagaagacagaaaaatgcaacaatacg
aacagtcccaaatggaagcaaccccttacagttatcgtcacccctgtgagtaaattacat
tttcgtgtgtggagtcaccagacactgaaatctgatgttttgttgggaactgctgcatta
gatatctttgaaaccttaaagtcaaacaacatgaaacttgaggaagtagttgtgacttta
cagcttgtaggtgacaaagagccaacagagacaataggagacttgtctgtctgtcttgat
gggctgcagttagagtctgaagttgttaccaatggtgaaactacatgttcagaaagtgtt
ccacagaatgatgatggctctagaccgaaggatgaaacaagaacaaacacaaatggatca
gatgagcctgaggatactgggactggtgaaaataggaaggtcaatggaaataattctcca
tcactctcaaatggtggttttaaaccttctaggcctccaagaccttcacgaccacctcca
cctaccccacgtagacctgcatctgtcaatggttcaccatctgccacttctgaaagtgat
ggatccagtacaggctctctgccaccaacaaatataaattcaaatacatctgaaggagca
acatctggattaataattcctcttactatatctggaggctcaggccctaggccattaaat
cctgtacctcaggctcccctaccacctggttgggaacagagagtggaccagcatgggcga
gtttactatgtagatcatattgaaaaaagaacaacgtgggatagaccggaacctctacct
cctggctgggaacggcgggttgacaacatgggacgtatttactatgttgaccatttcaca
agaacaacaacgtggcagaggccgacattggaatctgtccggaattatgaacagtggcag
ctccaacgtagtcagcttcaaggagcaatgcagcagtttaaccagagatttatttatggg
aatcaagatttgtttactacatcacaaaataaagaatttgatccccttggtcccctgcca
cctggatgggagaagagaacagacagcaatggtagagtatattttgtcaaccacaacact
cgtattacacaatgggaagaccccagaagtcaaggtcagttaaatgaaaagcccttacct
gaaggctgggaaatgagattcacagttgatggaattccatattttgtggaccacaataga
agaacaaccacctatattgatccccgcactggaaaatctgcactagacaatggaccacag
atagcctatgtacgggacttcaaggcaaaagttcagtatttccggttctggtgtcagcaa
ctggccatgccacagcacataaagattacagtgacaagaaaaacgttgtttgaagattcc
tttcagcagataatgagcttcaatccccaagatctgcgaagacgtttgtgggtgattttt
ccaggagaagaaggtttagattatggaggtgtagcaagagagtggttctttcttttgtca
cacgaggtgttgaacccaatgtattgcctgtttgaatatgcagggaaggataactactgc
ttgcagatcaatcccgcttcttacatcaatccagatcacctgaaatattttcgttttatt
ggcaggtttattgctatggctctgttccatggaaaattcatagacacaggtttttctttg
ccattctataagcgtatattgaacaaaccagttggactgaaggatttagaatctattgat
ccagaattttacaattctctcatctgggttaaagaaaacaatattgaggaatgtggtttg
gaaatgtacttctctgtcgataaagaaattttaggtgaaatcaagagtcatgatttgaaa
cctaatggtggcaatattcttgtgacagaagaaaataaagaggaatatatcagaatggta
gctgaatggaggttgtctcgaggtgttgaagaacaaacacaagctttctttgagggcttt
aatgaaatccttccccagcagtatttgcaatactttgacgcaaaggaattagaggtcctt
ttatgcggaatgcaagagattgatttgaatgactggcaaagacatgccatctaccgtcat
tacactaggacaagcaaacaaatcatgtggttttggcagtttgttaaagaaattgataat
gagaagagaatgagacttctgcagtttgttactggaacctgccgattgccagttggagga
tttgctgacctcatggggagcaatggaccacaaaaattctgcattgaaaaagttgggaaa
gaaaattggttgcccagaagtcatacctgctaa
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