Canis lupus familiaris (dog): 478151 Help Entry 478151            CDS       T01007                                  Symbol LCK Name (RefSeq) tyrosine-protein kinase Lck   KO K05856   lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] Organism cfa  Canis lupus familiaris (dog) Pathway cfa04064   NF-kappa B signaling pathway cfa04380   Osteoclast differentiation cfa04650   Natural killer cell mediated cytotoxicity cfa04658   Th1 and Th2 cell differentiation cfa04659   Th17 cell differentiation cfa04660   T cell receptor signaling pathway cfa05135   Yersinia infection cfa05166   Human T-cell leukemia virus 1 infection cfa05235   PD-L1 expression and PD-1 checkpoint pathway in cancer cfa05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:cfa00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     478151 (LCK)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     478151 (LCK)    04660 T cell receptor signaling pathway     478151 (LCK)    04658 Th1 and Th2 cell differentiation     478151 (LCK)    04659 Th17 cell differentiation     478151 (LCK)   09158 Development and regeneration    04380 Osteoclast differentiation     478151 (LCK)  09160 Human Diseases   09161 Cancer: overview    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     478151 (LCK)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     478151 (LCK)   09171 Infectious disease: bacterial    05135 Yersinia infection     478151 (LCK)   09163 Immune disease    05340 Primary immunodeficiency     478151 (LCK)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:cfa01001]     478151 (LCK)   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:cfa03036]     478151 (LCK) Enzymes [BR:cfa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      478151 (LCK) Protein kinases [BR:cfa01001]  Non-receptor tyrosine kinases   SRC family    478151 (LCK) Chromosome and associated proteins [BR:cfa03036]  Eukaryotic type   Centrosome formation proteins    Kinases and associated factors     478151 (LCK) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_2 SH3_9 SH2_1 ABC1 Haspin_kinase SH3_16 SH3_3 Motif Other DBs NCBI-GeneID:  478151 NCBI-ProteinID:  XP_005617696 Ensembl:  ENSCAFG00000010625 VGNC:  42607 UniProt:  A0A8C0TE05 A0A8I3NAC6 LinkDB All DBs Position 2:complement(65521599..65545402) Genome browser AA seq 509 aa AA seqDB search MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLPMRNGSDVRDPLVIYEGSNPPASP LQDNLVIALHSYEPSHDGDLGFEKGEQLRILERNGEWWKAQSLTTGQEGFIPFNFVAKAN SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH YKIRNLDKGGFYISPRITFPGLHELVRHYTNSSDGLCTRLSRPCQTQKPQKPWWEDEWEV PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL VRLYAVVTQEPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNY IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMMLCWKER PEDRPTFDYLRSVLEDFFTATEGQYQPQP NT seq 1530 nt NT seq  +upstreamnt  +downstreamnt atgggctgtagctgcagctcaaaccctgaagatgactggatggaaaacatcgatgtatgt gaaaactgccattaccccatagtcccactggatggcaaggccacgctgcccatgcggaat ggctctgacgtgcgggatccactggttatctatgaaggctccaatcccccagcctcacca ctgcaagacaacctggttatcgctctgcacagctatgagccctctcacgatggagacttg ggtttcgagaagggtgaacagctccgtatcctggagcggaacggtgagtggtggaaggcg cagtccttgaccacgggccaggaaggcttcatccctttcaatttcgtggccaaagcgaac agcctggagcccgaaccctggttcttcaagaacctgagccgcaaggacgcggaacggcag ctcctggcgcccgggaacacccacggctccttcctgattcgggagagcgagagcaccgcg ggatcgttttcattgtctgtgcgggacttcgaccagaaccagggagaggtggtgaaacat tacaagatccgtaacctggacaaaggcggcttctacatctcccctcgcatcaccttccct ggcctgcacgagctggtccgccattacaccaattcttcagacgggctgtgcacgcggttg agtcgcccctgccagacccagaagccccagaagccttggtgggaggatgagtgggaggtt cccagggagacgctgaagctggtggagcggctaggggccggccagttcggggaggtgtgg atggggtactacaacgggcacacaaaggtggcagtgaagagcctgaagcagggcagcatg tcccctgacgccttcctggccgaggctaatctcatgaagcagctgcagcaccagaggctg gtccggctctatgcggtggtcacccaggagcccatctacatcatcacggaatacatggag aacgggagcctggtggatttcctcaagacccccccaggcatcaagctgactatcaacaaa ctcttggacatggcagcccaaattgcagagggcatggcattcattgaagagcggaattat atccaccgtgacctgagggctgccaatatcctggtgtctgacaccctgagctgcaagatc gcagactttggcctggcacgcctcatcgaggacaacgagtacacagcgagggagggagcc aagtttcccattaagtggacagcaccagaagccattaactacgggacattcaccatcaag tcggacgtgtggtcttttgggatcctgctgacagagattgtcacccatggccgcatccct tacccagggatgaccaatcctgaggtgattcagaacctggaacgaggctaccgcatggtg cgacctgacaactgtccagaggagctataccaactcatgatgctgtgttggaaggagcgc ccagaggatcggccaacctttgactacctgcgtagtgtgctggaggacttcttcacagcc acagagggccagtaccagccccagccctga

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