K05856                      KO                                     

lymphocyte cell-specific protein tyrosine kinase [EC:]
map04064  NF-kappa B signaling pathway
map04380  Osteoclast differentiation
map04650  Natural killer cell mediated cytotoxicity
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map05135  Yersinia infection
map05166  Human T-cell leukemia virus 1 infection
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05340  Primary immunodeficiency
H00093  Combined immunodeficiency
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04660 T cell receptor signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04658 Th1 and Th2 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04659 Th17 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09163 Immune disease
   05340 Primary immunodeficiency
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases  non-specific protein-tyrosine kinase
     K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Other DBs
GO: 0004715
HSA: 3932(LCK)
PTR: 456715(LCK)
PPS: 100979670(LCK)
GGO: 101151112(LCK)
PON: 100436326(LCK)
NLE: 100585201(LCK)
MCC: 717704(LCK)
MCF: 102140916(LCK)
CSAB: 103225952(LCK)
CATY: 105594825(LCK)
PANU: 101006803(LCK)
RRO: 104654761(LCK)
RBB: 108518588(LCK)
TFN: 117092949(LCK)
PTEH: 111547561(LCK)
SBQ: 101041579(LCK)
MMUR: 105871813(LCK)
MMU: 16818(Lck)
MCAL: 110292164(Lck)
MPAH: 110322849(Lck)
RNO: 313050(Lck)
MCOC: 116096709(Lck)
MUN: 110548547(Lck)
CGE: 100759316(Lck)
PLEU: 114705667(Lck)
NGI: 103745927(Lck)
HGL: 101714396(Lck)
CPOC: 100728811(Lck)
CCAN: 109692973(Lck)
OCU: 100349102(LCK)
OPI: 101518566(LCK)
TUP: 102468526(LCK)
CFA: 478151(LCK)
VVP: 112931744(LCK)
VLG: 121497458(LCK)
AML: 100477981(LCK)
UMR: 103666444(LCK)
UAH: 113268359(LCK)
ORO: 101383028(LCK)
ELK: 111142990
MPUF: 101682422(LCK)
EJU: 114217100(LCK)
MLX: 118019751(LCK)
FCA: 101098805(LCK)
PYU: 121025386(LCK)
PBG: 122480237(LCK)
PTG: 102967826(LCK)
PPAD: 109255318(LCK)
AJU: 106982436(LCK)
HHV: 120232408(LCK)
BTA: 508890(LCK)
BOM: 102264903(LCK)
BIU: 109572368(LCK)
BBUB: 102406784(LCK)
CHX: 102171746(LCK)
OAS: 100216439(LCK)
ODA: 120854212(LCK)
CCAD: 122426634(LCK)
SSC: 100233188(LCK)
CFR: 102507741(LCK)
CBAI: 105066766(LCK)
CDK: 105085793(LCK)
BACU: 102998192(LCK)
LVE: 103069516(LCK)
OOR: 101271418(LCK)
DLE: 111175513(LCK)
PCAD: 102992010(LCK)
PSIU: 116759447(LCK)
ECB: 100146139(LCK)
EPZ: 103552084(LCK)
EAI: 106829050(LCK)
MYB: 102242493(LCK)
MYD: 102764895(LCK)
MMYO: 118677022(LCK)
MLF: 102428805(LCK)
MNA: 107542423(LCK)
PKL: 118723752(LCK)
HAI: 109390746(LCK) 109390751
DRO: 112299317(LCK)
SHON: 118997726(LCK)
AJM: 119052321(LCK)
PDIC: 114497642(LCK) 114503225
MMF: 118626449(LCK)
RFQ: 117027840(LCK)
PALE: 102891182(LCK)
PGIG: 120581990(LCK)
RAY: 107513587(LCK)
MJV: 108407415(LCK)
TOD: 119235229(LCK)
LAV: 100666557(LCK)
TMU: 101358037
MDO: 100025680(LCK)
GAS: 123243232(LCK)
SHR: 100922118(LCK)
PCW: 110206265(LCK)
OAA: 100078190(LCK)
GGA: 396460(LCK)
PCOC: 116229968(LCK)
MGP: 100547084(LCK)
CJO: 107323874(LCK)
NMEL: 110387471(LCK)
ACYG: 106037891(LCK)
TGU: 115498263(LCK)
LSR: 110475352(LCK)
SCAN: 103823477(LCK)
PMOA: 120511706(LCK)
OTC: 121342819(LCK)
PRUF: 121359973(LCK)
GFR: 102044922(LCK)
FAB: 101820768(LCK)
PHI: 102102392(LCK)
PMAJ: 107214075(LCK)
CCAE: 111945885
ETL: 114073234
FPG: 101919897(LCK)
FCH: 102055232(LCK)
CLV: 102085229(LCK)
EGZ: 104134930(LCK)
NNI: 104017767(LCK)
ACUN: 113488171(LCK)
PADL: 103923795(LCK)
AAM: 106493274(LCK)
AROW: 112975690(LCK)
NPD: 112950754(LCK)
DNE: 112982044(LCK)
ASN: 102374716(LCK)
AMJ: 102562977(LCK)
CPOO: 109318500(LCK)
GGN: 109294070(LCK)
PSS: 102450693(LCK)
CMY: 102938279(LCK)
CPIC: 101942842(LCK)
TST: 117868367(LCK)
CABI: 116829146(LCK)
MRV: 120389216(LCK)
ACS: 100556474(lck)
PVT: 110082790(LCK)
SUND: 121916163(LCK)
PBI: 103065569(LCK)
PMUR: 107285506(LCK)
PGUT: 117663289(LCK)
VKO: 123020879(LCK)
PMUA: 114601668(LCK)
ZVI: 118087446(LCK)
GJA: 107107743(LCK)
XLA: 100036955(lck.L) 108708930(lck.S)
XTR: 100497656(lck)
NPR: 108795316(LCK)
DRE: 414333(lck)
SGH: 107582994(lck) 107583665
IPU: 108270195(LCK)
PHYP: 113545028
AMEX: 103032401(lck)
EEE: 113576333
TRU: 101075948(lck)
LCO: 104919312(lck)
NCC: 104946729(lck)
CGOB: 115027294(lck)
ELY: 117266641(lck)
PLEP: 121953214(lck)
SLUC: 116042509(lck)
ECRA: 117935545(lck)
PFLV: 114546842(lck)
GAT: 120833302(lck)
PPUG: 119228056(lck)
MSAM: 119910103(lck)
CUD: 121526410(lck)
MZE: 101474633(lck)
ONL: 100712193(lck)
OAU: 116311076(lck)
OLA: 100170631(lck) 101163706(blk)
OML: 112144897(lck) 112158066(blk)
XMA: 102224821(lck) 102225667(blk)
XCO: 114134400(lck) 114158151(blk)
XHE: 116709277(lck) 116733655(blk)
PRET: 103458632(lck)
GAF: 122825490(blk) 122846479(lck)
CVG: 107082827 107096412(lck)
CTUL: 119774176(lck) 119788352(blk)
NFU: 107392534(lck)
KMR: 108232471(lck) 108242452(blk)
ALIM: 106518262(lck) 106525299
AOCE: 111578479(lck)
CSEM: 103382672(lck)
POV: 109627923(lck)
SSEN: 122761263(lck)
HHIP: 117756594(lck) 117758461(blk)
LCF: 108898014
SDU: 111225420(lck)
SLAL: 111650089(lck)
XGL: 120795167(lck)
HCQ: 109520801(lck)
BPEC: 110155252(lck) 110155529
MALB: 109964987(lck)
SASA: 100194878(lck) 106578585(lck)
SALP: 111963179 111968811(lck)
ELS: 105015810(lck)
SFM: 108931279(lck)
PKI: 111833034(lck)
AANG: 118214135(lck)
LOC: 102690129(lck)
PSPA: 121308352
LCM: 102361989(LCK)
CMK: 103184977 103185670(lck)
RTP: 109923406
BGT: 106080295
 » show all
Koga Y, Caccia N, Toyonaga B, Spolski R, Yanagi Y, Yoshikai Y, Mak TW
A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.
Eur J Immunol 16:1643-6 (1986)
Weiss A, Littman DR
Signal transduction by lymphocyte antigen receptors.
Cell 76:263-74 (1994)
Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM
Centrosome docking at the immunological synapse is controlled by Lck signaling.
J Cell Biol 192:663-74 (2011)

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