KEGG   ORTHOLOGY: K05856
Entry
K05856                      KO                                     

Symbol
LCK
Name
lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
Pathway
map04064  NF-kappa B signaling pathway
map04380  Osteoclast differentiation
map04650  Natural killer cell mediated cytotoxicity
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map05135  Yersinia infection
map05166  Human T-cell leukemia virus 1 infection
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04660 T cell receptor signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04658 Th1 and Th2 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04659 Th17 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09163 Immune disease
   05340 Primary immunodeficiency
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Other DBs
GO: 0004715
Genes
HSA: 3932(LCK)
PTR: 456715(LCK)
PPS: 100979670(LCK)
GGO: 101151112(LCK)
PON: 100436326(LCK)
NLE: 100585201(LCK)
MCC: 717704(LCK)
MCF: 102140916(LCK)
CSAB: 103225952(LCK)
CATY: 105594825(LCK)
PANU: 101006803(LCK)
RRO: 104654761(LCK)
RBB: 108518588(LCK)
TFN: 117092949(LCK)
PTEH: 111547561(LCK)
SBQ: 101041579(LCK)
MMUR: 105871813(LCK)
MMU: 16818(Lck)
MCAL: 110292164(Lck)
MPAH: 110322849(Lck)
RNO: 313050(Lck)
MCOC: 116096709(Lck)
MUN: 110548547(Lck)
CGE: 100759316(Lck)
PLEU: 114705667(Lck)
NGI: 103745927(Lck)
HGL: 101714396(Lck)
CPOC: 100728811(Lck)
CCAN: 109692973(Lck)
OCU: 100349102(LCK)
OPI: 101518566(LCK)
TUP: 102468526(LCK)
CFA: 478151(LCK)
VVP: 112931744(LCK)
VLG: 121497458(LCK)
AML: 100477981(LCK)
UMR: 103666444(LCK)
UAH: 113268359(LCK)
ORO: 101383028(LCK)
ELK: 111142990
MPUF: 101682422(LCK)
EJU: 114217100(LCK)
MLX: 118019751(LCK)
FCA: 101098805(LCK)
PYU: 121025386(LCK)
PBG: 122480237(LCK)
PTG: 102967826(LCK)
PPAD: 109255318(LCK)
AJU: 106982436(LCK)
HHV: 120232408(LCK)
BTA: 508890(LCK)
BOM: 102264903(LCK)
BIU: 109572368(LCK)
BBUB: 102406784(LCK)
CHX: 102171746(LCK)
OAS: 100216439(LCK)
ODA: 120854212(LCK)
CCAD: 122426634(LCK)
SSC: 100233188(LCK)
CFR: 102507741(LCK)
CBAI: 105066766(LCK)
CDK: 105085793(LCK)
BACU: 102998192(LCK)
LVE: 103069516(LCK)
OOR: 101271418(LCK)
DLE: 111175513(LCK)
PCAD: 102992010(LCK)
PSIU: 116759447(LCK)
ECB: 100146139(LCK)
EPZ: 103552084(LCK)
EAI: 106829050(LCK)
MYB: 102242493(LCK)
MYD: 102764895(LCK)
MMYO: 118677022(LCK)
MLF: 102428805(LCK)
MNA: 107542423(LCK)
PKL: 118723752(LCK)
HAI: 109390746(LCK) 109390751
DRO: 112299317(LCK)
SHON: 118997726(LCK)
AJM: 119052321(LCK)
PDIC: 114497642(LCK) 114503225
MMF: 118626449(LCK)
RFQ: 117027840(LCK)
PALE: 102891182(LCK)
PGIG: 120581990(LCK)
RAY: 107513587(LCK)
MJV: 108407415(LCK)
TOD: 119235229(LCK)
LAV: 100666557(LCK)
TMU: 101358037
MDO: 100025680(LCK)
GAS: 123243232(LCK)
SHR: 100922118(LCK)
PCW: 110206265(LCK)
OAA: 100078190(LCK)
GGA: 396460(LCK)
PCOC: 116229968(LCK)
MGP: 100547084(LCK)
CJO: 107323874(LCK)
NMEL: 110387471(LCK)
ACYG: 106037891(LCK)
TGU: 115498263(LCK)
LSR: 110475352(LCK)
SCAN: 103823477(LCK)
PMOA: 120511706(LCK)
OTC: 121342819(LCK)
PRUF: 121359973(LCK)
GFR: 102044922(LCK)
FAB: 101820768(LCK)
PHI: 102102392(LCK)
PMAJ: 107214075(LCK)
CCAE: 111945885
ETL: 114073234
FPG: 101919897(LCK)
FCH: 102055232(LCK)
CLV: 102085229(LCK)
EGZ: 104134930(LCK)
NNI: 104017767(LCK)
ACUN: 113488171(LCK)
PADL: 103923795(LCK)
AAM: 106493274(LCK)
AROW: 112975690(LCK)
NPD: 112950754(LCK)
DNE: 112982044(LCK)
ASN: 102374716(LCK)
AMJ: 102562977(LCK)
CPOO: 109318500(LCK)
GGN: 109294070(LCK)
PSS: 102450693(LCK)
CMY: 102938279(LCK)
CPIC: 101942842(LCK)
TST: 117868367(LCK)
CABI: 116829146(LCK)
MRV: 120389216(LCK)
ACS: 100556474(lck)
PVT: 110082790(LCK)
SUND: 121916163(LCK)
PBI: 103065569(LCK)
PMUR: 107285506(LCK)
PGUT: 117663289(LCK)
VKO: 123020879(LCK)
PMUA: 114601668(LCK)
ZVI: 118087446(LCK)
GJA: 107107743(LCK)
XLA: 100036955(lck.L) 108708930(lck.S)
XTR: 100497656(lck)
NPR: 108795316(LCK)
DRE: 414333(lck)
SGH: 107582994(lck) 107583665
IPU: 108270195(LCK)
PHYP: 113545028
AMEX: 103032401(lck)
EEE: 113576333
TRU: 101075948(lck)
LCO: 104919312(lck)
NCC: 104946729(lck)
CGOB: 115027294(lck)
ELY: 117266641(lck)
PLEP: 121953214(lck)
SLUC: 116042509(lck)
ECRA: 117935545(lck)
PFLV: 114546842(lck)
GAT: 120833302(lck)
PPUG: 119228056(lck)
MSAM: 119910103(lck)
CUD: 121526410(lck)
MZE: 101474633(lck)
ONL: 100712193(lck)
OAU: 116311076(lck)
OLA: 100170631(lck) 101163706(blk)
OML: 112144897(lck) 112158066(blk)
XMA: 102224821(lck) 102225667(blk)
XCO: 114134400(lck) 114158151(blk)
XHE: 116709277(lck) 116733655(blk)
PRET: 103458632(lck)
GAF: 122825490(blk) 122846479(lck)
CVG: 107082827 107096412(lck)
CTUL: 119774176(lck) 119788352(blk)
NFU: 107392534(lck)
KMR: 108232471(lck) 108242452(blk)
ALIM: 106518262(lck) 106525299
AOCE: 111578479(lck)
CSEM: 103382672(lck)
POV: 109627923(lck)
SSEN: 122761263(lck)
HHIP: 117756594(lck) 117758461(blk)
LCF: 108898014
SDU: 111225420(lck)
SLAL: 111650089(lck)
XGL: 120795167(lck)
HCQ: 109520801(lck)
BPEC: 110155252(lck) 110155529
MALB: 109964987(lck)
SASA: 100194878(lck) 106578585(lck)
SALP: 111963179 111968811(lck)
ELS: 105015810(lck)
SFM: 108931279(lck)
PKI: 111833034(lck)
AANG: 118214135(lck)
LOC: 102690129(lck)
PSPA: 121308352
LCM: 102361989(LCK)
CMK: 103184977 103185670(lck)
RTP: 109923406
BGT: 106080295
 » show all
Reference
PMID:3493153
  Authors
Koga Y, Caccia N, Toyonaga B, Spolski R, Yanagi Y, Yoshikai Y, Mak TW
  Title
A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.
  Journal
Eur J Immunol 16:1643-6 (1986)
DOI:10.1002/eji.1830161229
  Sequence
[hsa:3932]
Reference
PMID:8293463
  Authors
Weiss A, Littman DR
  Title
Signal transduction by lymphocyte antigen receptors.
  Journal
Cell 76:263-74 (1994)
DOI:10.1016/0092-8674(94)90334-4
Reference
  Authors
Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM
  Title
Centrosome docking at the immunological synapse is controlled by Lck signaling.
  Journal
J Cell Biol 192:663-74 (2011)
DOI:10.1083/jcb.201008140
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