| Entry |
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| Symbol |
LCK
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| Name |
lymphocyte cell-specific protein tyrosine kinase [EC: 2.7.10.2]
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| Pathway |
| map04650 | Natural killer cell mediated cytotoxicity |
| map04658 | Th1 and Th2 cell differentiation |
| map04660 | T cell receptor signaling pathway |
| map05166 | Human T-cell leukemia virus 1 infection |
| map05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
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| Disease |
| H00093 | Combined immunodeficiency |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
04660 T cell receptor signaling pathway
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
04658 Th1 and Th2 cell differentiation
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
04659 Th17 cell differentiation
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
09158 Development and regeneration
04380 Osteoclast differentiation
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
09171 Infectious disease: bacterial
05135 Yersinia infection
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
09163 Immune disease
05340 Primary immunodeficiency
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
Enzymes [BR:ko01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
SRC family
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
Centrosome formation proteins
Kinases and associated factors
K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
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| Other DBs |
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| Genes |
» show all
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| Reference |
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| Authors |
Koga Y, Caccia N, Toyonaga B, Spolski R, Yanagi Y, Yoshikai Y, Mak TW |
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| Title |
A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Weiss A, Littman DR |
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| Title |
Signal transduction by lymphocyte antigen receptors. |
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| Journal |
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| Reference |
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| Authors |
Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM |
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| Title |
Centrosome docking at the immunological synapse is controlled by Lck signaling. |
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| Journal |
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| LinkDB |
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