KEGG   Canis lupus familiaris (dog): 482045
Entry
482045            CDS       T01007                                 
Symbol
ADCY8
Name
(RefSeq) adenylate cyclase type 8 isoform X2
  KO
K08048  adenylate cyclase 8 [EC:4.6.1.1]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00230  Purine metabolism
cfa01100  Metabolic pathways
cfa01522  Endocrine resistance
cfa04015  Rap1 signaling pathway
cfa04020  Calcium signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04024  cAMP signaling pathway
cfa04062  Chemokine signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04081  Hormone signaling
cfa04082  Neuroactive ligand signaling
cfa04114  Oocyte meiosis
cfa04211  Longevity regulating pathway
cfa04213  Longevity regulating pathway - multiple species
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04270  Vascular smooth muscle contraction
cfa04371  Apelin signaling pathway
cfa04540  Gap junction
cfa04611  Platelet activation
cfa04713  Circadian entrainment
cfa04714  Thermogenesis
cfa04720  Long-term potentiation
cfa04723  Retrograde endocannabinoid signaling
cfa04724  Glutamatergic synapse
cfa04725  Cholinergic synapse
cfa04727  GABAergic synapse
cfa04742  Taste transduction
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04911  Insulin secretion
cfa04912  GnRH signaling pathway
cfa04913  Ovarian steroidogenesis
cfa04914  Progesterone-mediated oocyte maturation
cfa04915  Estrogen signaling pathway
cfa04916  Melanogenesis
cfa04918  Thyroid hormone synthesis
cfa04921  Oxytocin signaling pathway
cfa04923  Regulation of lipolysis in adipocytes
cfa04925  Aldosterone synthesis and secretion
cfa04926  Relaxin signaling pathway
cfa04927  Cortisol synthesis and secretion
cfa04928  Parathyroid hormone synthesis, secretion and action
cfa04934  Cushing syndrome
cfa04935  Growth hormone synthesis, secretion and action
cfa04970  Salivary secretion
cfa04971  Gastric acid secretion
cfa04972  Pancreatic secretion
cfa04976  Bile secretion
cfa05032  Morphine addiction
cfa05163  Human cytomegalovirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05200  Pathways in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    482045 (ADCY8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    482045 (ADCY8)
   04072 Phospholipase D signaling pathway
    482045 (ADCY8)
   04024 cAMP signaling pathway
    482045 (ADCY8)
   04022 cGMP-PKG signaling pathway
    482045 (ADCY8)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    482045 (ADCY8)
   04081 Hormone signaling
    482045 (ADCY8)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    482045 (ADCY8)
   04062 Chemokine signaling pathway
    482045 (ADCY8)
  09152 Endocrine system
   04911 Insulin secretion
    482045 (ADCY8)
   04923 Regulation of lipolysis in adipocytes
    482045 (ADCY8)
   04913 Ovarian steroidogenesis
    482045 (ADCY8)
   04915 Estrogen signaling pathway
    482045 (ADCY8)
   04921 Oxytocin signaling pathway
    482045 (ADCY8)
   04926 Relaxin signaling pathway
    482045 (ADCY8)
   04935 Growth hormone synthesis, secretion and action
    482045 (ADCY8)
   04918 Thyroid hormone synthesis
    482045 (ADCY8)
   04928 Parathyroid hormone synthesis, secretion and action
    482045 (ADCY8)
   04925 Aldosterone synthesis and secretion
    482045 (ADCY8)
   04927 Cortisol synthesis and secretion
    482045 (ADCY8)
  09154 Digestive system
   04970 Salivary secretion
    482045 (ADCY8)
   04971 Gastric acid secretion
    482045 (ADCY8)
   04972 Pancreatic secretion
    482045 (ADCY8)
   04976 Bile secretion
    482045 (ADCY8)
  09156 Nervous system
   04724 Glutamatergic synapse
    482045 (ADCY8)
   04727 GABAergic synapse
    482045 (ADCY8)
   04725 Cholinergic synapse
    482045 (ADCY8)
   04720 Long-term potentiation
    482045 (ADCY8)
   04723 Retrograde endocannabinoid signaling
    482045 (ADCY8)
  09157 Sensory system
   04742 Taste transduction
    482045 (ADCY8)
   04750 Inflammatory mediator regulation of TRP channels
    482045 (ADCY8)
  09149 Aging
   04211 Longevity regulating pathway
    482045 (ADCY8)
   04213 Longevity regulating pathway - multiple species
    482045 (ADCY8)
  09159 Environmental adaptation
   04713 Circadian entrainment
    482045 (ADCY8)
   04714 Thermogenesis
    482045 (ADCY8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    482045 (ADCY8)
   05207 Chemical carcinogenesis - receptor activation
    482045 (ADCY8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    482045 (ADCY8)
   05163 Human cytomegalovirus infection
    482045 (ADCY8)
  09165 Substance dependence
   05032 Morphine addiction
    482045 (ADCY8)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    482045 (ADCY8)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    482045 (ADCY8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    482045 (ADCY8)
Enzymes [BR:cfa01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     482045 (ADCY8)
SSDB
Motif
Pfam: Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD
Other DBs
NCBI-GeneID: 482045
NCBI-ProteinID: XP_005627997
Ensembl: ENSCAFG00000001097
VGNC: 37625
UniProt: A0A8C0T647 A0A8I3NUB8
LinkDB
Position
13:complement(27690009..27910417)
AA seq 1221 aa
MELSEVRCLGGSEELYTIHPTPPAGDGGGSARPQRLLWQTAVRHITEQRFMHGHRGGGGG
GSRGSGKAAAPAGGGPNHPAAQLCGDAALPLYSLGPAERAHGTGGTKVFPERSGSGSGSG
SGGGGDLGFLHLDCAPSNSDFFLSGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRK
SEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHT
YLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTS
LLQVVLQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEAR
LRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV
KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAH
CCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKL
ESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPED
IVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHV
QSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAF
ILLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWINE
TYLARNVIIFASILINFLGAILNIYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYA
LLTETIYAGLFLRYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWR
VQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPG
FADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEK
QQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDI
WGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL
LGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTL
LTPSGPEPGAQAEGTDKSDLP
NT seq 3666 nt   +upstreamnt  +downstreamnt
atggagctctccgaggtgcgctgcctgggcggcagcgaggagctctacaccatccacccg
acgcccccggccggcgacggcggcggcagcgctcggccgcagcggctgctatggcaaacg
gcggtgcggcacatcacggagcagcgcttcatgcacgggcaccggggcggcggcggcggc
gggagcagaggctccggcaaagccgcggcccctgcgggcggcggccccaaccaccccgcg
gcgcagctgtgcggagacgcggcgctgcccctctactcgctgggccccgcggagagggcg
cacggcaccgggggcaccaaagtcttcccggagcgcagcggcagcggcagcggcagcggc
agcggcggcgggggcgacctgggcttcctgcacctcgactgcgccccgagcaactcggat
ttcttcctcagcgggggctacagctaccgaggggtcattttccccactctgcgcaactct
ttcaagtcccgggatctggagcgcctctaccagcgctatttcctgggccagaggcgcaaa
tccgaagtggtgatgaacgtgctggacgtgctgaccaaactcaccctcttggtcctccac
ttgagcctggcctcggcccccatggacccgctcaagggcatcctcctgggcttcttcacg
ggcatcgaggtggtgatctgcgccctggtggtggtcaggaaggacaccacctcgcacacg
tacctgcagtacagcggtgtggtcacttgggtggccatgaccacccagatcttggcagca
ggcctcggctatgggcttctgggtgatggcatcggctacgtcctcttcacgctgttcgcc
acctacagcatgctgccactgccgctcacctgggccatcctggccggcctgggcacctcg
ctgctgcaggtggtcctgcaggtggtcatcccccggctggcggtcatttccatcaaccag
gtggtggcccaggcggtgttattcatgtgtatgaacacggctggaatcttcatcagttac
ctgtcagatcgggcccagcgccaagccttcctagagactcggaggtgtgtggaggccagg
ctgcgcctggagacggaaaaccagagacaggaacggctcgttttatctgtgcttcctcgg
tttgtcgtcctggaaatgatcaacgacatgaccaatgttgaagatgaacacttgcagcac
cagttccatcggatctacatccatcgttacgagaatgtcagtattctttttgcagatgtt
aaaggatttaccaacctctccacgaccttatccgcccaggagctggtcaggatgctcaac
gagctctttgccagatttgatcgactggcccatgagcatcactgccttcgcattaaaatc
ctgggggactgttactactgtgtttcagggcttcctgagccccgccaggaccacgcccac
tgctgcgttgaaatgggcctcagcatgatcaaaaccatcaggtatgtgaggtcaaggaca
aagcatgatgttgacatgcggatcggaatccactcgggctcggtgctgtgtggcgtgttg
ggcctgcggaagtggcagtttgatgtctggtcttgggatgtggacattgcgaacaaactt
gaatctggaggaatccccgggaggattcacatttccaaagccacgctggactgcctcaac
ggtgactataatgtggaagagggtcatgggaaagaaagaaacgaattcttgaggaagcat
aatatagagacctatttgattaagcagcctgaggagagtctgctgtcgttgcccgaagac
attgtcaaggagtcggtgagctcctcagacaggagaaacagtggggcgacgttcacagaa
ggatcctggagccccgaactgccctttgataacatagtggggaaacagaatactctggct
gccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcatgtc
cagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagtggc
gataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagcctg
gagcacaagtattctcaaatgagggatgaagtattcaagtcaaacttggtgtgtgcattt
atccttcttctgtttatcacggccatacaaagtttgcttccttcttcaagggtgatgcca
atggccatccagttttccatcctgattatgctgcattcggctctggtcctcatcacgaca
gcagaggattataagtgtttgccccttgtcctccggaagacatgctgttggattaacgag
acctatttggcccggaatgtcatcatctttgcatccatcctgattaacttcctgggcgcc
atcctgaatatttactttgtcttcactggggtgttggccatggtgacctgtgcggtattc
ctccgcctaaactctgtcctgaagctggctgtgctgctgattatgattgccatctacgcc
ctgctgactgagaccatctatgcaggcctctttctgcgctacgacaacctgaatcacagt
ggagaagattttctggggaccaaggaggcgtcgctgctgctaatggccatgttcctgctt
gctgtgttttaccacggacagcagctggagtacacagcccgccttgacttcctttggcga
gtacaggccaaagaggagatcaacgagatgaaagagctaagagaacacaatgagaacatg
ctccggaacattctacccagccacgtagcccgccacttcctggagaaagaccgggacaac
gaggagctgtattctcaatcctatgatgccgtcggggtgatgttcgcctccatcccgggg
tttgctgacttttactctcagactgaaatgaataaccaaggagtagaatgcctgcgcctg
ctgaatgagatcattgctgacttcgatgagctgctcggtgaagaccggtttcaagacatt
gaaaagatcaagaccattggcagcacctacatggctgtgtcaggcctgtcacctgaaaaa
cagcaatgtgaagacaagtggggccatttgtgtgccctggccgacttctccctcgccctg
actgagagcatacaggagatcaacaagcattccttcaacaatttcgaactccggattggc
atcagccatggctcggtggtagctggcgtcatcggcgcaaagaagccacagtatgacatt
tggggcaaaaccgtgaatctggcgagtcgaatggacagcacgggggtcagcggcaggatc
caagtccccgaggagacctatcttatcctgaaggaccagggctttgcctttgactaccga
ggggagatctacgtgaagggcatcagtgaacaggaaggaaagatcaaaacgtactttctg
ctgggaagagtccaacccaacccattcatcctgcctccgagaagactgcccgggcagtac
tccctggccgcggtggtcctgggcctggtccagtccctcaacaggcaaaggcagaagcag
cttctcaatgagaacaacaacacggggattatcaagggtcattacaaccggcggactttg
ttgacacccagcggaccagaacctggagcccaagctgaaggcaccgacaagtccgatttg
ccataa

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