KEGG   Canis lupus familiaris (dog): 485874
Entry
485874            CDS       T01007                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04020  Calcium signaling pathway
cfa04062  Chemokine signaling pathway
cfa04064  NF-kappa B signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04072  Phospholipase D signaling pathway
cfa04360  Axon guidance
cfa04370  VEGF signaling pathway
cfa04613  Neutrophil extracellular trap formation
cfa04650  Natural killer cell mediated cytotoxicity
cfa04658  Th1 and Th2 cell differentiation
cfa04659  Th17 cell differentiation
cfa04660  T cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04666  Fc gamma R-mediated phagocytosis
cfa04670  Leukocyte transendothelial migration
cfa04722  Neurotrophin signaling pathway
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04919  Thyroid hormone signaling pathway
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04935  Growth hormone synthesis, secretion and action
cfa05012  Parkinson disease
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05135  Yersinia infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05171  Coronavirus disease - COVID-19
cfa05200  Pathways in cancer
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05214  Glioma
cfa05223  Non-small cell lung cancer
cfa05225  Hepatocellular carcinoma
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05417  Lipid and atherosclerosis
Module
cfa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    485874 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    485874 (PLCG1)
   04014 Ras signaling pathway
    485874 (PLCG1)
   04015 Rap1 signaling pathway
    485874 (PLCG1)
   04370 VEGF signaling pathway
    485874 (PLCG1)
   04064 NF-kappa B signaling pathway
    485874 (PLCG1)
   04066 HIF-1 signaling pathway
    485874 (PLCG1)
   04020 Calcium signaling pathway
    485874 (PLCG1)
   04070 Phosphatidylinositol signaling system
    485874 (PLCG1)
   04072 Phospholipase D signaling pathway
    485874 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    485874 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    485874 (PLCG1)
   04660 T cell receptor signaling pathway
    485874 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    485874 (PLCG1)
   04659 Th17 cell differentiation
    485874 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    485874 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    485874 (PLCG1)
   04670 Leukocyte transendothelial migration
    485874 (PLCG1)
   04062 Chemokine signaling pathway
    485874 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    485874 (PLCG1)
   04919 Thyroid hormone signaling pathway
    485874 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    485874 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    485874 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    485874 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    485874 (PLCG1)
   05206 MicroRNAs in cancer
    485874 (PLCG1)
   05205 Proteoglycans in cancer
    485874 (PLCG1)
   05231 Choline metabolism in cancer
    485874 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    485874 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    485874 (PLCG1)
   05214 Glioma
    485874 (PLCG1)
   05223 Non-small cell lung cancer
    485874 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    485874 (PLCG1)
   05171 Coronavirus disease - COVID-19
    485874 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    485874 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    485874 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    485874 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    485874 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    485874 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    485874 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    485874 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    485874 (PLCG1)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     485874 (PLCG1)
Membrane trafficking [BR:cfa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    485874 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    485874 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 485874
NCBI-ProteinID: XP_038313582
Ensembl: ENSCAFG00000009082
VGNC: 44651
UniProt: A0A8C0Z363 A0A8I3SCI7
LinkDB
Position
24:28823106..28859401
AA seq 1290 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEDKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPYAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIDVFPAKQENGDLSPFGMSLRERGSDASGQLFHGRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcttccccctgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggagcggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgagaaatcaaggag
atccgcccagggaagacctcacgggattttgatcgctaccaagaggaccctgctttccga
ccagaccagtcacactgcttcgtcatcctgtatgggatggaattccgcctgaagactctg
agcctgcaagctacatctgaggatgaagtgaacatgtggatcaagggtttaacttggctg
atggaggatacattgcaggcagccacacctctgcagattgagaggtggctgcggaagcag
ttctactcagtggatcggaatcgtgaggatcgtatatcagccaaggacttgaagaacatg
ctgtcccaggtcaactaccgggttcccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggca
ggggagcgcccggagctctgtcgtgtgtcccttcctgagtttcagcagttcctcctcgag
taccagggggagctgtgggctgttgatcggcttcaggtgcaggagttcatgctcagcttc
cttcgagatcctttacgagaaattgaagagccttacttcttcctggacgagtttgtcacc
ttcttgttctccaaagagaacagcgtgtggaattcacagctggatgcagtgtgcccggac
accatgaacaaccctctgtcccactactggatctcctcctcccacaacacgtacctgact
ggggaccagttctccagcgagtcctctctggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggatggcccagatgggatgccagtcatttaccat
gggcacacccttaccaccaagatcaagttctcagatgttctacataccatcaaggagcat
gccttcgtggcttcagagtatccggtcatcctgtccatcgaggaccactgcagcatcgcc
cagcagagaaacatggcgcagtacttcaagaaggtgcttggggacacactcctcaccaag
cctgtggacatcgccgctgacgggctcccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggcagagggcagtgcctacgaagaggtgcctacgtcagtgatg
tactccgagaacgatatcagcaactccatcaagaatggcatcctctacctggaggacccg
gtgaaccatgagtggtacccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaatgaggatgaggaggaacccaaggaggccagtggc
agcacagagctgcactccagtgagaagtggttccacgggaagcttggagcaggacgggat
ggacggcacattgccgagcgcctgctcaccgagtattgcattgagaccggggcccctgat
ggctccttcctcgtgcgggagagcgagaccttcgtgggcgactataccctctctttctgg
aggaacgggaaagtccagcactgtcggatccattcccggcaggatgctggggcccccaag
ttcttcttgacagacaacctggtctttgattcgctctatgacctcatcacgcactaccag
caagtgcccctgcgctgcaacgaatttgagatgcgcctttcagagccggtcccacagacc
aatgcccacgagagcaaagagtggtaccacgccagcctgaccagagctcaggccgagcac
atgctgatgcgtgttccccgggatggggccttcctggtgaggaaacggaatgagcccaac
tcctatgccatctctttccgggccgagggcaagatcaaacattgccgcgtccagcaggag
ggccagactgtgatgctgggcaactctgagtttgacagcctcgtggacctcatcagctac
tatgagaagcacccgctataccgcaaaatgaagctgcgctatcccatcaatgaggaagcg
ctggagaagataggcacagctgagcctgactatggagccctgtatgagggacgcaaccct
ggcttctatgtggaggcaaatcctatgccgacttttaagtgtgccgtcaaagccctcttt
gactacaaggctcagagggatgacgagctgacattcacgaagagcgccatcatccagaat
gtggagaagcaagaaggtggctggtggcggggggactacggggggaaaaagcagctctgg
ttcccgtcaaactacgtagaagagatggtcagccctgcagccctggagcctgagagggag
cacttggatgagaacagccccctgggggatttgctccgtggggtcttggatgtgccagcc
tgtcagattgctatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcttcagtggcacactggtccttggatgtcgctgctgattcacaggaagagctgcag
gactgggtgaagaagatccgagaagtggcccagacggcagacgccaggctcacggagggg
aagatgatggagcgcaggaagaagatcgccctggagctctccgagctggttgtctactgc
aggccggttcccttcgatgaagacaagattggcacagaacgtgcctgctaccgggacatg
tcatcctttccggaaaccaaggctgagaaatatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctgcagctctcacgcatctaccccaagggccagcggctagactcc
tccaattatgaccccctgcccatgtggatctgtggcagtcagctcgtagccctcaacttc
cagaccccagacaagcccatgcagatgaaccaggccctcttcatggccggcggccactgc
ggctacgtgctgcagccgagcaccatgcgggacgaggcctttgatccctttgacaagagc
agcctccgaggcctggaaccatatgccatctgcattgaggtgctgggggctcggcacctg
ccaaagaatggccgaggcatcgtgtgtcctttcgtggagattgaagtggccggagcagag
tacgacagcatcaagcagaagacagagttcgtggtggacaatggactgaaccctgtgtgg
cctgctaagcccttccacttccagatcagtaacccagaattcgcctttttgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcctggctcaggctacattcccggtg
aaaggcctgaagacaggatacagagctgtgcctttgaagaacaactacagtgaggaccta
gagctggcctccctgctcgtcaagatcgacgtgttccctgccaagcaggagaatggggac
ctcagtcccttcgggatgtctcttcgggagcgaggctctgatgcctcaggccagctgttc
catggccgggcccgtgaaggttcctttgaggcccgctaccagcagccatttgaggacttt
cgtatctcccaggagcacctggcagaccattttgacagtcgggaacggagggccccacgg
aggacacgggtcaacggagacaaccgcctctag

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