Canis lupus familiaris (dog): 486148 Help Entry 486148            CDS       T01007                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism cfa  Canis lupus familiaris (dog) Pathway cfa04022   cGMP-PKG signaling pathway cfa04068   FoxO signaling pathway cfa04081   Hormone signaling cfa04140   Autophagy - animal cfa04150   mTOR signaling pathway cfa04151   PI3K-Akt signaling pathway cfa04152   AMPK signaling pathway cfa04211   Longevity regulating pathway cfa04213   Longevity regulating pathway - multiple species cfa04722   Neurotrophin signaling pathway cfa04910   Insulin signaling pathway cfa04920   Adipocytokine signaling pathway cfa04923   Regulation of lipolysis in adipocytes cfa04930   Type II diabetes mellitus cfa04931   Insulin resistance cfa04932   Non-alcoholic fatty liver disease cfa04935   Growth hormone synthesis, secretion and action cfa04960   Aldosterone-regulated sodium reabsorption cfa05010   Alzheimer disease cfa05206   MicroRNAs in cancer cfa05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:cfa00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     486148 (IRS1)    04022 cGMP-PKG signaling pathway     486148 (IRS1)    04151 PI3K-Akt signaling pathway     486148 (IRS1)    04152 AMPK signaling pathway     486148 (IRS1)    04150 mTOR signaling pathway     486148 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     486148 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     486148 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     486148 (IRS1)    04923 Regulation of lipolysis in adipocytes     486148 (IRS1)    04920 Adipocytokine signaling pathway     486148 (IRS1)    04935 Growth hormone synthesis, secretion and action     486148 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     486148 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     486148 (IRS1)   09149 Aging    04211 Longevity regulating pathway     486148 (IRS1)    04213 Longevity regulating pathway - multiple species     486148 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     486148 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     486148 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     486148 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     486148 (IRS1)    04932 Non-alcoholic fatty liver disease     486148 (IRS1)    04931 Insulin resistance     486148 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  486148 NCBI-ProteinID:  XP_543274 VGNC:  54317 LinkDB All DBs Position 25:complement(40246368..40306296) Genome browser AA seq 1240 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGASAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTTRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN GHYILPRGGNGHRYIPGAGLGTSPALAADEAAAAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLDRRGGHHR PDAAALHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPGSSSSGSAAPSGSSYGKLWTNGVGGHHPHALPHPKLPVESG SGKLLSCTGDYMNMSPVGDSNTSSPSDGYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELE ESARHQHLRLSSSSGRLLYAATAEDSSSSTSSDSLGPGGYCGVRPDPGLPHIHHQVLQPH LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQHPPPLLHPPEPKSPGEYVNIEF GSDQPGYLSGPVAARSSPSVRCPPQLQPAPREEETGTEEYMNMDLGPGRRAAWQEGAGVQ PGRVGPAPPGAASVCRPTRAVPSSRGDYMTMQVGCPGQGYVDTSPVAPISYADMRTGIVV EEASLPGATAAAPSSASAASASPTAPPKAGELVARSSLLGGPQGPGGMSAFTRVNLSPNR NQSAKVIRADPQGCRRRHSSETFSSTPSATRAGNAVPFGGGAALGGSGGGSSAEDMKRHS SASFENVWLRPGELGGAPKEPAPHAGAAGGLENGLNYIDLDLVKDFKQCSQERPPQPQPP PPPAPHQPLGSSESSSTSRSSEDLSAYASISFQKQPEDLQ NT seq 3723 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcggactccaagaac aagcacctggtggccctttacacccgggacgagcactttgccatcgcggcggacagcgag gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgggccaagggccac cacgacggcgcctcggcccccggggcgggaggcggcgggggcagctgcagcggcagctcg ggcctcggggaggccggcgaggacttgagctacggggacgtgcccccgggacctgcgttc aaggaggtctggcaggtgatcctgaaacccaagggcctggggcagacaaagaacctgatt ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactccgag gcggcggccgtggtgctgcagctgatgaacatccgacgttgcggccactcggagaacttc ttcttcatcgaagtgggccgttccgcagtgacgggacccggcgagttctggatgcaggtg gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg agcgacgagttccgccctcggagtaagagccagtcctcctccaactgctccaaccccatc agcgtccccctgcgccggcaccacctcaacaacccccctcccagccaggtggggctgacg cgccgctcgcgcaccgagagcatcaccgccacctctccggccagcatggtgggcgggaag cagggctccttccgtgtgcgcgcgtccagcgacggcgagggcaccatgtcccgcccggcc tcggtggacggcagccccgtgagcccgagcaccaccaggacccacgcgcaccggcatcgc ggcagctcccggctgcaccccccgctcaaccacagccgctccatccccatgccttcctct cgctgctcgccttccgccaccagcccggtcagcctgtcgtccagcagcaccagtggccac ggctccacctcggactgcctcttcccccggcgctctagtgcctctgtgtcgggttccccc agcgacggtggtttcatctcctctgacgagtacggctcgagtccctgcgatttccgaagt tccttccgcagtgtcaccccggattccctgggccacacccccccggcccgcggcgaggag gagctgagcaactacatctgcatgggaggcaaagggtcctccaccctcaccgcccccaac ggtcactacattttgcctcggggtggcaatggccaccgctacatcccgggggctggcttg ggcaccagcccggccctggctgcggatgaagcggccgctgcggccgacctggataaccgg ttccgaaagcggactcactccgcgggcacatcccctaccatttcccaccagaagaccccg tcccagtcttctgtggcttccattgaggagtacacggagatgatgcctgcctacccgcca ggaggtggcagtggaggccgactgcctggctaccggcactctgccttcgtgcccacccac tcctaccccgaggagggtctggaaatgcaccctctggacaggcgtgggggccaccaccgg ccggacgccgccgccctccacacggatgatggctacatgcccatgtccccgggagtggca ccggtgcccagcagccggaagggcagtggggactatatgcccatgagccccaagagcgtg tccgcgccgcagcagatcatcaaccccattagacgccatccccagagggtggaccccaat ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggtgggcccggc agcagcagcagcggcagcgccgccccttctgggagcagctatggcaagctgtggacaaac ggggtagggggccaccaccctcacgccctgccgcaccccaaactccccgtggagagcggg agtggcaagctcctgtcttgtaccggcgactacatgaacatgtcgccggtgggggactcc aacaccagcagcccctccgacggctactacggcccagaggacccccagcacaagccagtt ctctcctactactcattgccaaggtcctttaagcacacccagcgccctggggagctggag gagagcgcccggcaccagcacctccgcctctcctccagctcgggtcgtcttctctacgcc gcgacggcggaagattcctcctcctccaccagcagcgacagcctgggcccagggggatac tgtggggtcaggccggatcccggcctcccgcatatccaccatcaggtcctgcagcctcac ctgcctcggaaggtggacacggccgcgcagaccaacagccgcctggctcggcccacgagg ctgtccctgggggaccccaaggccagcaccttacctcgggttcgagagcagcagcacccg ccgcccctgctgcaccctccggagcccaagagccccggggaatatgtgaatattgagttc gggagcgatcagccgggctacttatcggggccggtggctgcccgcagctcgccttctgtc aggtgcccaccccagctccagccagctccccgcgaggaagagactggcaccgaggagtac atgaacatggacctggggcctggccggagggcagcctggcaggagggtgctggggtccag cccggcagggtgggccccgcgccccccggggccgctagcgtgtgcaggcccacccgggca gtgcccagcagccggggcgactacatgaccatgcaggtgggctgtcccggccagggctac gtggacacctcgccagtggcccccatcagctacgctgacatgcggacaggcattgtcgtg gaggaggccagcctgccgggggccacagcggccgccccctcctcggcctcggcagcctcg gcttcccccacggcgcctccaaaagcgggggagctggtggcccgctcctccctgctgggg ggcccgcagggacccgggggcatgagcgccttcacccgggtgaacctcagccccaaccgc aaccagagtgccaaagtgatccgcgccgacccgcaggggtgccggaggcggcatagctct gagaccttctcctccacgcccagtgccacccgggcgggcaacgcagtgcccttcggcggg ggggcggccctggggggcagcggtggcggcagcagcgcggaggatatgaaacgccacagt tcggcttcctttgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggag ccggccccgcacgctggggccgccgggggtttggagaatgggcttaactacatagacctg gatttggtcaaggacttcaaacagtgctctcaggagcgcccccctcaaccgcagccgccc ccgcccccggcccctcatcagcctctgggcagcagtgagagcagttcaaccagccgctcc agcgaggatctaagcgcctatgccagcatcagtttccagaagcagccagaggacctccag tag

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