KEGG   Canis lupus familiaris (dog): 487235
Entry
487235            CDS       T01007                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa01524  Platinum drug resistance
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04024  cAMP signaling pathway
cfa04062  Chemokine signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04081  Hormone signaling
cfa04140  Autophagy - animal
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04152  AMPK signaling pathway
cfa04210  Apoptosis
cfa04211  Longevity regulating pathway
cfa04213  Longevity regulating pathway - multiple species
cfa04218  Cellular senescence
cfa04360  Axon guidance
cfa04370  VEGF signaling pathway
cfa04380  Osteoclast differentiation
cfa04510  Focal adhesion
cfa04550  Signaling pathways regulating pluripotency of stem cells
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04620  Toll-like receptor signaling pathway
cfa04625  C-type lectin receptor signaling pathway
cfa04630  JAK-STAT signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04660  T cell receptor signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04666  Fc gamma R-mediated phagocytosis
cfa04668  TNF signaling pathway
cfa04670  Leukocyte transendothelial migration
cfa04722  Neurotrophin signaling pathway
cfa04725  Cholinergic synapse
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04810  Regulation of actin cytoskeleton
cfa04910  Insulin signaling pathway
cfa04914  Progesterone-mediated oocyte maturation
cfa04915  Estrogen signaling pathway
cfa04917  Prolactin signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa04923  Regulation of lipolysis in adipocytes
cfa04926  Relaxin signaling pathway
cfa04929  GnRH secretion
cfa04930  Type II diabetes mellitus
cfa04931  Insulin resistance
cfa04932  Non-alcoholic fatty liver disease
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04935  Growth hormone synthesis, secretion and action
cfa04960  Aldosterone-regulated sodium reabsorption
cfa04973  Carbohydrate digestion and absorption
cfa05010  Alzheimer disease
cfa05017  Spinocerebellar ataxia
cfa05020  Prion disease
cfa05100  Bacterial invasion of epithelial cells
cfa05135  Yersinia infection
cfa05142  Chagas disease
cfa05146  Amoebiasis
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05162  Measles
cfa05163  Human cytomegalovirus infection
cfa05164  Influenza A
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05168  Herpes simplex virus 1 infection
cfa05169  Epstein-Barr virus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05171  Coronavirus disease - COVID-19
cfa05200  Pathways in cancer
cfa05203  Viral carcinogenesis
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05210  Colorectal cancer
cfa05211  Renal cell carcinoma
cfa05212  Pancreatic cancer
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05218  Melanoma
cfa05220  Chronic myeloid leukemia
cfa05221  Acute myeloid leukemia
cfa05222  Small cell lung cancer
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
cfa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    487235 (PIK3R1)
   04015 Rap1 signaling pathway
    487235 (PIK3R1)
   04630 JAK-STAT signaling pathway
    487235 (PIK3R1)
   04668 TNF signaling pathway
    487235 (PIK3R1)
   04066 HIF-1 signaling pathway
    487235 (PIK3R1)
   04068 FoxO signaling pathway
    487235 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    487235 (PIK3R1)
   04072 Phospholipase D signaling pathway
    487235 (PIK3R1)
   04071 Sphingolipid signaling pathway
    487235 (PIK3R1)
   04024 cAMP signaling pathway
    487235 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    487235 (PIK3R1)
   04152 AMPK signaling pathway
    487235 (PIK3R1)
   04150 mTOR signaling pathway
    487235 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    487235 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    487235 (PIK3R1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    487235 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    487235 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    487235 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    487235 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    487235 (PIK3R1)
   04660 T cell receptor signaling pathway
    487235 (PIK3R1)
   04662 B cell receptor signaling pathway
    487235 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    487235 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    487235 (PIK3R1)
   04670 Leukocyte transendothelial migration
    487235 (PIK3R1)
   04062 Chemokine signaling pathway
    487235 (PIK3R1)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    487235 (PIK3R1)
   04929 GnRH secretion
    487235 (PIK3R1)
   04915 Estrogen signaling pathway
    487235 (PIK3R1)
   04917 Prolactin signaling pathway
    487235 (PIK3R1)
   04926 Relaxin signaling pathway
    487235 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    487235 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    487235 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    487235 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    487235 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    487235 (PIK3R1)
   04722 Neurotrophin signaling pathway
    487235 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    487235 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    487235 (PIK3R1)
   04380 Osteoclast differentiation
    487235 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    487235 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    487235 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    487235 (PIK3R1)
   05206 MicroRNAs in cancer
    487235 (PIK3R1)
   05205 Proteoglycans in cancer
    487235 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    487235 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    487235 (PIK3R1)
   05203 Viral carcinogenesis
    487235 (PIK3R1)
   05230 Central carbon metabolism in cancer
    487235 (PIK3R1)
   05231 Choline metabolism in cancer
    487235 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    487235 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    487235 (PIK3R1)
   05212 Pancreatic cancer
    487235 (PIK3R1)
   05225 Hepatocellular carcinoma
    487235 (PIK3R1)
   05226 Gastric cancer
    487235 (PIK3R1)
   05214 Glioma
    487235 (PIK3R1)
   05221 Acute myeloid leukemia
    487235 (PIK3R1)
   05220 Chronic myeloid leukemia
    487235 (PIK3R1)
   05218 Melanoma
    487235 (PIK3R1)
   05211 Renal cell carcinoma
    487235 (PIK3R1)
   05215 Prostate cancer
    487235 (PIK3R1)
   05213 Endometrial cancer
    487235 (PIK3R1)
   05224 Breast cancer
    487235 (PIK3R1)
   05222 Small cell lung cancer
    487235 (PIK3R1)
   05223 Non-small cell lung cancer
    487235 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    487235 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    487235 (PIK3R1)
   05161 Hepatitis B
    487235 (PIK3R1)
   05160 Hepatitis C
    487235 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    487235 (PIK3R1)
   05164 Influenza A
    487235 (PIK3R1)
   05162 Measles
    487235 (PIK3R1)
   05163 Human cytomegalovirus infection
    487235 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    487235 (PIK3R1)
   05169 Epstein-Barr virus infection
    487235 (PIK3R1)
   05165 Human papillomavirus infection
    487235 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    487235 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    487235 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    487235 (PIK3R1)
   05142 Chagas disease
    487235 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    487235 (PIK3R1)
   05017 Spinocerebellar ataxia
    487235 (PIK3R1)
   05020 Prion disease
    487235 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    487235 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    487235 (PIK3R1)
   05415 Diabetic cardiomyopathy
    487235 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    487235 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    487235 (PIK3R1)
   04931 Insulin resistance
    487235 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    487235 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    487235 (PIK3R1)
   01524 Platinum drug resistance
    487235 (PIK3R1)
   01522 Endocrine resistance
    487235 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    487235 (PIK3R1)
Membrane trafficking [BR:cfa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    487235 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 AAA_13 CCDC113_CCDC96_CC Laminin_I Legum_prodom DUF2203 Transcrip_act
Other DBs
NCBI-GeneID: 487235
NCBI-ProteinID: XP_003433863
Ensembl: ENSCAFG00000007626
VGNC: 44560
UniProt: A0A8P0NVD8 A0A8I3NJ30
LinkDB
Position
2:50408936..50489628
AA seq 424 aa
MHNLQTLPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIVD
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 1275 nt   +upstreamnt  +downstreamnt
atgcacaacctgcaaacattgcctcctaaaccaccgaaacccaccactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcaagg
gaagaagtgaatgaaaaacttcgagatacagccgatgggacctttttggtacgagatgca
tctactaaaatgcatggtgattatactcttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatgggaaatatggcttctctgacccactgaccttcaactct
gtggttgaactaataaaccactaccggaatgagtctctagctcagtataaccccaaactg
gacgtgaaattactctatccagtatccaaataccaacaggatcaggttgtcaaagaggat
aatattgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaaagt
cgggaatacgataggttatatgaagattatacccgtacttcccaggaaattcaaatgaag
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagagcagtgccaaagc
caggaacggtacagcaaagaatacatagaaaaatttaagcgtgaaggcaacgaaaaagaa
atacaaaggattatgcataattatgaaaagttaaagtcccgaattagtgagattgtggac
agtagaaggcgcctggaggaagacctgaagaagcaggcggctgagtaccgggagatcgac
aagcgcatgaacagcattaagcccgacctcattcagctgaggaagacgagagaccagtac
ttgatgtggttgactcagaaaggtgttcggcaaaagaagttgaatgagtggctgggcaac
gagaatacggaagaccaatactcgctggtggaagatgatgaggacctgcctcaccacgac
gagaagacctggaacgtgggcagtagcaacaggaacaaagctgagaaccttctacggggg
aaacgggacggcaccttcctggtccgggagagcagtaaacagggctgctacgcttgctcc
gtggtggtggacggcgaggtcaagcattgcgtcatcaacaaaacggccactggctacggc
tttgccgagccctataacctgtacagctccctgaaagaactggtgctccattaccaacac
acctccctggtgcagcacaacgactctctcaacgtcacactagcctacccggtatatgca
cagcagaggcgatga

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