Canis lupus familiaris (dog): 492059 Help Entry 492059            CDS       T01007                                  Symbol IRS4 Name (RefSeq) insulin receptor substrate 4   KO K17446   insulin receptor substrate 4 Organism cfa  Canis lupus familiaris (dog) Pathway cfa04022   cGMP-PKG signaling pathway cfa04068   FoxO signaling pathway cfa04081   Hormone signaling cfa04140   Autophagy - animal cfa04152   AMPK signaling pathway cfa04211   Longevity regulating pathway cfa04213   Longevity regulating pathway - multiple species cfa04910   Insulin signaling pathway cfa04920   Adipocytokine signaling pathway cfa04923   Regulation of lipolysis in adipocytes cfa04930   Type II diabetes mellitus cfa04935   Growth hormone synthesis, secretion and action cfa05010   Alzheimer disease Brite KEGG Orthology (KO) [BR:cfa00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     492059 (IRS4)    04022 cGMP-PKG signaling pathway     492059 (IRS4)    04152 AMPK signaling pathway     492059 (IRS4)   09133 Signaling molecules and interaction    04081 Hormone signaling     492059 (IRS4)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     492059 (IRS4)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     492059 (IRS4)    04923 Regulation of lipolysis in adipocytes     492059 (IRS4)    04920 Adipocytokine signaling pathway     492059 (IRS4)    04935 Growth hormone synthesis, secretion and action     492059 (IRS4)   09149 Aging    04211 Longevity regulating pathway     492059 (IRS4)    04213 Longevity regulating pathway - multiple species     492059 (IRS4)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     492059 (IRS4)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     492059 (IRS4) SSDB OrthologParalogGFIT Motif Pfam:  IRS PH Motif Other DBs NCBI-GeneID:  492059 NCBI-ProteinID:  XP_005641715 Ensembl:  ENSCAFG00000018028 VGNC:  42100 UniProt:  A0A8I3P6F6 LinkDB All DBs Position X Genome browser AA seq 1274 aa AA seqDB search MASCSCARDQATRRLSAAAAATAAALAVVATTPLLPLGTSTALIGTGSSCPGAMWLSTAT GSRSDSESDEEDLPVGDEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH SVRAAAAAAAAAASGAAVPALIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV AENESEQESWYLLLSRLILESKRRRCGTPGAQPDGEPTALAAAAAAEPPFYKDVWQVIVK PRGLGHRKELSGVFRLCLTDEEVLFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSTRRH LDTLPREPGGWLRRSRFEQFCHLRAIGDGEDEMLLARRYMTPSEPVLPSRRGRLHLPRAR RSRRAISVPASLCRRLPPSPVRVPHPAEVPNDRACLSPEASGSGNSGDEGSPQGQEGQEG NGGDYMPMNNWGSGNGRGSGGGQGASGQGSSSQSSGGNQCSGGGQGSGGGQDSSGGQGSG GQGMGGNQRSGAGQGTAGGHGSGGGQGAGGGHGSGDGQGPGDGHGSRRGKNSGGGKGSGG GKTSDGSGDRGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGATGGKGKSGGRFRLY FCADRGAQKDRKEAKEVKDKADSPEGAARGPLRARAFDEDEDDPYVPMRPGVAAPLASSS DYMPMAPQNFSASKHHSRSPFEDSRGYMMMFPRMSPPPAPSAQKEPDPEKEDESKDNDSE SDYMFMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFQGSPLGRSDHSEYVPMLPGKF LGNSLDKAPTSNWGPKHAVSKPPVEGSFSKPRDGGTCWKPSDNGPPKNKAKRPNRLSFIT KGNKIKPKSQKPTRAQREADSSSVYVNIDFTKSGSNMPAPFIQGLPGSWGIMAGPRPSAF SHYVNVEFEVLFPHPAQNFSHLFRAIPGANPLFLEGARWPLVPLPPSATGGSASEEEGDY IEVIFNPAMTPAVPFGDSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQ EEQQLERRRPQDRSQSFFPSARAAVSAFPTDSLERDLPASLASAAAAAAASAAAPALALG RALAAASALAAAPGIGAAARGLEAAAGFDSASVRWFQPVAGSAAAAAAAVRGTQAVAAGS NPRARHPSADLAGGENWATAAVSPPPPPPPPRRPVPSPPEQQVSDNDDDDDDDTYVRMDF ARPDNKKSDSPRRE NT seq 3825 nt NT seq  +upstreamnt  +downstreamnt atggcgagttgctcctgcgctcgcgaccaagcgaccaggaggctgagcgctgcagcggcg gcaacagcggcagctctagctgtggtggcgaccaccccacttctccccttgggcacctcg accgcactcattgggaccgggtcgtcttgtccgggagccatgtggctctccacggccact ggctcccggtcagactcggagtccgacgaggaggacctccccgtcggggacgaagtctgc aaacgcggctacctgcggaagcagaagcatgggcacaggcgctacttcgtgctcaaactc gagaccgccgacgccccggctcggctggaatactacgaaaatgccaggaagttccggcac agtgtccgcgccgcggcggctgcggctgcggcggccgcctctggagccgcggtccccgcg ctcatcccgccgcgacgcgtgatcaccctgtaccagtgcttctccgtgagccagcgagcc gatgccaggtaccgccacctcatcgccctcttcacccaggacgagtacttcgccatggtg gccgagaacgagtcggagcaggagagctggtacttgctgctcagccgcctcatcctcgag agcaagcgccgccgctgcggcacgcccggcgcgcagccggatggagagccgaccgcgctg gcggctgcagcggcggcggagccacccttctacaaagatgtgtggcaggtaatagtcaag cccagggggctggggcaccgaaaagagctgagcggcgtgttccggctttgtcttaccgac gaggaggtgctgttcgtgaggctgaataccgaggtggccagcgtggtcgtccagctcctg agcatccgtcgctgcgggcactcagagcagtacttcttcttggaggtcggtaggtccacc gtcattggtcccggggagctctggatgcaggtcgatgactgtgtagtggcccaaaacatg cacgagttgtttttggagaagatgagagccctgtgcgcagacgaatacagagcccgctgc cgcagctacagcatcagcatcggcgcccacctgttaaccctgctgtccactaggaggcac ctggacacgctgccgcgtgagcccggtggctggctgagaaggtcccgctttgagcagttt tgccacctcagggccatcggggacggggaagacgagatgctcctcgccaggcgctacatg acacccagcgaacctgtgctcccctccaggcgaggaagactgcacctgcccagagcgcgc cgctccaggagagcgatttcggttccagccagcctttgccgccgcctcccgcccagcccg gtgcgtgtcccgcatcccgccgaagtcccgaacgacagagcttgcctgtctcctgaagct tctggctctggcaactctggggatgaagggagtcctcagggccaagagggacaggaagga aacggaggtgactacatgcccatgaacaactggggctcgggaaatggccggggctccgga ggtggccagggcgcaagtggccaaggctccagtagccagagttcagggggaaaccagtgc tcaggtggggggcagggctctggaggtggccaggactctagcggtggccagggctcaggg ggccagggtatgggaggaaaccaacgttcaggagctggccaaggcactgcaggtggacac ggctctggcggcggccagggagccggaggtggacacggctcaggcgatgggcagggaccg ggcgatggccatggctcccgccgtggcaagaactctggagggggcaaaggctcaggaggt gggaagacttccgatggcagtggtgaccgtggaaaatctctgaagaaaagatcctacttt ggcaaactaactcaaagcaagcagcagcagatgccaccacctccacctcctccaccccca cccccaccagcgggagcaactggtggtaaagggaagtctgggggaaggttccgactttat ttttgtgccgacagaggagcccagaaagatcgcaaggaggccaaagaggtcaaggacaag gcagacagcccagaaggtgcagctcggggccccctcagagccagggcttttgatgaagat gaggatgacccctatgtgccaatgaggccaggggtggctgcccctcttgcaagctctagc gattatatgccaatggctccccaaaacttctctgcttcaaaacaccactctcgatcacct ttcgaagattcaagggggtacatgatgatgtttcctaggatgagcccaccaccagcccca agtgcccagaaagagccagatcccgagaaggaggatgagtcaaaggacaatgacagtgag agtgactatatgtttatggctcctggagccggtgcaattccaaaaaaccccagaaatcct cagggcggctcttcctctaaaagctggagctcctacttctctctgccaaatccttttcag ggctccccattgggacggagtgaccacagtgagtatgtaccaatgttacctggaaaattc ttgggaaatagcctggacaaggcacccacgtctaactggggccccaaacatgcagtttca aagcctccagtcgaggggtcattctcaaagcctagggatggggggacatgctggaagcct tcagataatgggccccccaagaacaaggccaaaagacccaaccgtctctcttttattaca aaaggaaataaaatcaagcccaaatcacagaagcccacacgtgcgcagagagaagctgac agctctagtgtctacgtcaacattgacttcactaaaagcgggagcaatatgccagccccc tttattcaaggactgcccggttcatgggggatcatggctggccccagaccgtcagccttt tctcactatgtgaacgttgagttcgaagtgctatttccacacccggcacaaaacttctcg catcttttcagagctattccaggtgccaacccccttttcctggaaggtgctaggtggcca ctcgtgcctcttcctcccagcgccacaggtggcagtgccagtgaggaagagggtgactac atcgaagtgattttcaacccagcaatgacaccggccgtgcctttcggtgacagcgccatc cgctatgacgcggaaacaggtcgaatctatgtggttgaccccttttccgagtgctgtatg gacatttctctctcccccagccgctgctccgaaccgccacctgtagccaggctgctgcag gaagaacaacagctggagcggaggcgcccgcaagaccgttcgcagagtttctttccgtcc gcccgggcggcggtctcggctttccccaccgacagtctcgagagagacctccccgcctcc cttgcctcggccgccgccgccgccgccgcctccgccgccgcgccggccttagctttgggc cgggcgttagccgccgcctccgccctcgccgcggccccgggcatcggtgcagccgccagg ggcttggaggccgctgctgggtttgactccgcctccgtccgctggttccaacctgttgca ggctcggcagccgccgccgccgccgcggtgcgggggacccaagccgtggccgctggctcg aacccgagagcccggcacccatctgcagacttggctggaggtgagaactgggccacagcg gccgtctccccgccgccgccaccaccgccgcctcgccgcccggtgccgagtccccctgag caacaggtttctgacaacgacgacgacgacgacgacgatacctacgtgagaatggacttt gccagacctgacaacaagaagtctgactctccccgcagagagtga

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