KEGG   ORTHOLOGY: K17446
Entry
K17446                      KO                                     
Symbol
IRS4
Name
insulin receptor substrate 4
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04081  Hormone signaling
map04140  Autophagy - animal
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
Disease
H00250  Congenital nongoitrous hypothyroidism (CHNG)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04022 cGMP-PKG signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04152 AMPK signaling pathway
    K17446  IRS4; insulin receptor substrate 4
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    K17446  IRS4; insulin receptor substrate 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K17446  IRS4; insulin receptor substrate 4
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04923 Regulation of lipolysis in adipocytes
    K17446  IRS4; insulin receptor substrate 4
   04920 Adipocytokine signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04935 Growth hormone synthesis, secretion and action
    K17446  IRS4; insulin receptor substrate 4
  09149 Aging
   04211 Longevity regulating pathway
    K17446  IRS4; insulin receptor substrate 4
   04213 Longevity regulating pathway - multiple species
    K17446  IRS4; insulin receptor substrate 4
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K17446  IRS4; insulin receptor substrate 4
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K17446  IRS4; insulin receptor substrate 4
Genes
HSA: 8471(IRS4)
PTR: 473846(IRS4)
PPS: 100991292(IRS4)
GGO: 109024862(IRS4)
PON: 100458662(IRS4)
PPYG: 129024624(IRS4)
NLE: 100588594(IRS4)
HMH: 116811948(IRS4)
SSYN: 129476056(IRS4)
MCC: 703846(IRS4)
MCF: 102128819(IRS4)
MTHB: 126945702
MNI: 105490457(IRS4)
CSAB: 103232472(IRS4)
CATY: 105598463(IRS4)
PANU: 101027041(IRS4)
TGE: 112616118(IRS4)
MLEU: 105541408(IRS4)
RRO: 104676250(IRS4)
RBB: 108541574(IRS4)
TFN: 117077563(IRS4)
PTEH: 111536706(IRS4)
CANG: 105518616(IRS4)
CJC: 100410200(IRS4)
SBQ: 101035392(IRS4)
CIMI: 108316556(IRS4)
ANAN: 105716928(IRS4)
CSYR: 103262177(IRS4)
MMUR: 105863379(IRS4)
LCAT: 123628131(IRS4)
ERUF: 138379101(IRS4)
PCOQ: 105810971(IRS4)
OGA: 100953605(IRS4)
MMU: 16370(Irs4)
MCAL: 110287491(Irs4)
MPAH: 110313986(Irs4)
RNO: 315350(Irs4)
MCOC: 116089083(Irs4)
ANU: 117695265(Irs4)
ASYL: 127675783(Irs4)
MUN: 110540163(Irs4)
CGE: 100773159
MAUA: 101840584(Irs4)
PROB: 127217141(Irs4)
PLEU: 114698331(Irs4)
PMAV: 102911330(Irs4)
MORG: 121436878 121437242
MFOT: 126489634
AAMP: 119805566(Irs4)
CNL: 130867847(Irs4)
NGI: 103750027(Irs4)
HGL: 101719321(Irs4)
CPOC: 100717360(Irs4)
CCAN: 109675517(Irs4)
DORD: 105992800(Irs4)
DSP: 122116357(Irs4)
DMER: 138839426(Irs4)
PLOP: 125344181(Irs4)
NCAR: 124972126
ITI: 101959997(Irs4)
OCU: 103351932
OPI: 101528328(IRS4)
OCZ: 121169504(IRS4)
TUP: 102489416(IRS4)
GVR: 103603730(IRS4)
CFA: 492059(IRS4)
CLUD: 112649305(IRS4)
VVP: 112932035(IRS4)
VLG: 121483169(IRS4)
NPO: 129518021(IRS4)
AML: 105240373(IRS4)
UMR: 103679770(IRS4)
UAH: 113241174(IRS4)
UAR: 123780203(IRS4)
ELK: 111161266
LLV: 125092461
MPUF: 101680131(IRS4)
MNP: 132007037(IRS4)
MLK: 131821025(IRS4)
NVS: 122897407(IRS4)
ORO: 101371781(IRS4)
EJU: 114198362(IRS4)
ZCA: 113930850(IRS4)
MLX: 118010742(IRS4)
MANO: 123844431(IRS4)
NSU: 110570454(IRS4)
LWW: 102737797(IRS4)
FCA: 101093251(IRS4)
PYU: 121025718(IRS4)
PCOO: 112871206(IRS4)
PBG: 122477260(IRS4)
PVIV: 125156854(IRS4)
LRUF: 124513799
LGF: 123594738(IRS4)
AJU: 106973150
PTG: 102952189(IRS4)
PPAD: 109253661(IRS4)
PUC: 125931893
HHV: 120232651(IRS4)
CCRU: 144239537(IRS4)
BTA: 514607(IRS4)
BOM: 102273597(IRS4)
BIU: 109555543(IRS4)
BJV: 133243027(IRS4)
BBUB: 102400715(IRS4)
BKE: 129639070(IRS4)
BBIS: 104983354(IRS4)
CHX: 102179643(IRS4)
OAS: 101112456(IRS4)
OCAN: 138930551(IRS4)
BTAX: 128070573(IRS4)
CSUM: 138070692(IRS4)
ODA: 120881381(IRS4)
CCAD: 122435154(IRS4)
MREE: 136153511(IRS4)
OVR: 110140103(IRS4)
MBEZ: 129564117(IRS4)
SSC: 100622674(IRS4)
CFR: 102521714(IRS4)
CBAI: 105061987(IRS4)
CDK: 105099556(IRS4)
VPC: 102528920(IRS4)
BACU: 102998877(IRS4)
BMUS: 118888242(IRS4)
LVE: 103068740(IRS4)
OOR: 101290244(IRS4)
LALB: 132512890(IRS4)
GMF: 115841607(IRS4)
DDP: 132418881(IRS4)
DLE: 111165800(IRS4)
PCAD: 102989579(IRS4)
PSIU: 116748068(IRS4)
PPHC: 136143078(IRS4)
NASI: 112401927(IRS4)
ECB: 100059954(IRS4)
EPZ: 103545515(IRS4)
EAI: 106839711(IRS4)
MYB: 102242347(IRS4)
MYD: 102753243(IRS4)
MMYO: 118654640(IRS4)
MLF: 102418401(IRS4)
MDT: 132224716(IRS4)
PKL: 118731903(IRS4)
EFUS: 103299461(IRS4)
MNA: 107526265(IRS4)
DRO: 112296869(IRS4)
SHON: 118984183(IRS4)
AJM: 119065177(IRS4)
PDIC: 114505548(IRS4)
PHAS: 123805137(IRS4)
MMF: 118636678(IRS4)
PPAM: 129076254(IRS4)
HAI: 109393345(IRS4)
RFQ: 117026277(IRS4)
PALE: 102895007(IRS4)
PGIG: 120616378(IRS4)
PVP: 105301581(IRS4)
RAY: 107506967(IRS4)
MJV: 108406099(IRS4)
TOD: 119245973(IRS4)
SARA: 101540547(IRS4)
SFUM: 130034243(IRS4)
SETR: 125999066(IRS4)
LAV: 100667324(IRS4)
TMU: 101350401
ETF: 101652949(IRS4)
DNM: 101416233(IRS4)
 » show all
Reference
PMID:9261155
  Authors
Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE
  Title
A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family.
  Journal
J Biol Chem 272:21403-7 (1997)
DOI:10.1074/jbc.272.34.21403
  Sequence
[hsa:8471]
Reference
PMID:12639902
  Authors
Schreyer S, Ledwig D, Rakatzi I, Kloting I, Eckel J
  Title
Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.
  Journal
Endocrinology 144:1211-8 (2003)
DOI:10.1210/en.2002-220723
  Sequence
[hsa:8471]
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