Canis lupus familiaris (dog): 611939
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Entry
611939 CDS
T01007
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa01521
EGFR tyrosine kinase inhibitor resistance
cfa01522
Endocrine resistance
cfa04010
MAPK signaling pathway
cfa04012
ErbB signaling pathway
cfa04014
Ras signaling pathway
cfa04015
Rap1 signaling pathway
cfa04022
cGMP-PKG signaling pathway
cfa04024
cAMP signaling pathway
cfa04066
HIF-1 signaling pathway
cfa04068
FoxO signaling pathway
cfa04071
Sphingolipid signaling pathway
cfa04072
Phospholipase D signaling pathway
cfa04140
Autophagy - animal
cfa04148
Efferocytosis
cfa04150
mTOR signaling pathway
cfa04151
PI3K-Akt signaling pathway
cfa04210
Apoptosis
cfa04218
Cellular senescence
cfa04270
Vascular smooth muscle contraction
cfa04370
VEGF signaling pathway
cfa04371
Apelin signaling pathway
cfa04517
IgSF CAM signaling
cfa04519
Cadherin signaling
cfa04540
Gap junction
cfa04550
Signaling pathways regulating pluripotency of stem cells
cfa04613
Neutrophil extracellular trap formation
cfa04620
Toll-like receptor signaling pathway
cfa04650
Natural killer cell mediated cytotoxicity
cfa04660
T cell receptor signaling pathway
cfa04662
B cell receptor signaling pathway
cfa04664
Fc epsilon RI signaling pathway
cfa04720
Long-term potentiation
cfa04722
Neurotrophin signaling pathway
cfa04730
Long-term depression
cfa04810
Regulation of actin cytoskeleton
cfa04910
Insulin signaling pathway
cfa04912
GnRH signaling pathway
cfa04915
Estrogen signaling pathway
cfa04916
Melanogenesis
cfa04917
Prolactin signaling pathway
cfa04919
Thyroid hormone signaling pathway
cfa04921
Oxytocin signaling pathway
cfa04926
Relaxin signaling pathway
cfa04929
GnRH secretion
cfa04934
Cushing syndrome
cfa04935
Growth hormone synthesis, secretion and action
cfa05010
Alzheimer disease
cfa05022
Pathways of neurodegeneration - multiple diseases
cfa05132
Salmonella infection
cfa05135
Yersinia infection
cfa05160
Hepatitis C
cfa05161
Hepatitis B
cfa05163
Human cytomegalovirus infection
cfa05164
Influenza A
cfa05165
Human papillomavirus infection
cfa05166
Human T-cell leukemia virus 1 infection
cfa05167
Kaposi sarcoma-associated herpesvirus infection
cfa05170
Human immunodeficiency virus 1 infection
cfa05200
Pathways in cancer
cfa05205
Proteoglycans in cancer
cfa05206
MicroRNAs in cancer
cfa05207
Chemical carcinogenesis - receptor activation
cfa05208
Chemical carcinogenesis - reactive oxygen species
cfa05210
Colorectal cancer
cfa05211
Renal cell carcinoma
cfa05213
Endometrial cancer
cfa05214
Glioma
cfa05215
Prostate cancer
cfa05216
Thyroid cancer
cfa05218
Melanoma
cfa05219
Bladder cancer
cfa05220
Chronic myeloid leukemia
cfa05221
Acute myeloid leukemia
cfa05223
Non-small cell lung cancer
cfa05224
Breast cancer
cfa05225
Hepatocellular carcinoma
cfa05226
Gastric cancer
cfa05230
Central carbon metabolism in cancer
cfa05231
Choline metabolism in cancer
cfa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
611939 (MAP2K2)
04012 ErbB signaling pathway
611939 (MAP2K2)
04014 Ras signaling pathway
611939 (MAP2K2)
04015 Rap1 signaling pathway
611939 (MAP2K2)
04370 VEGF signaling pathway
611939 (MAP2K2)
04371 Apelin signaling pathway
611939 (MAP2K2)
04066 HIF-1 signaling pathway
611939 (MAP2K2)
04068 FoxO signaling pathway
611939 (MAP2K2)
04072 Phospholipase D signaling pathway
611939 (MAP2K2)
04071 Sphingolipid signaling pathway
611939 (MAP2K2)
04024 cAMP signaling pathway
611939 (MAP2K2)
04022 cGMP-PKG signaling pathway
611939 (MAP2K2)
04151 PI3K-Akt signaling pathway
611939 (MAP2K2)
04150 mTOR signaling pathway
611939 (MAP2K2)
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
611939 (MAP2K2)
04519 Cadherin signaling
611939 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
611939 (MAP2K2)
04148 Efferocytosis
611939 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
611939 (MAP2K2)
04218 Cellular senescence
611939 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
611939 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
611939 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
611939 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
611939 (MAP2K2)
04620 Toll-like receptor signaling pathway
611939 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
611939 (MAP2K2)
04660 T cell receptor signaling pathway
611939 (MAP2K2)
04662 B cell receptor signaling pathway
611939 (MAP2K2)
04664 Fc epsilon RI signaling pathway
611939 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
611939 (MAP2K2)
04929 GnRH secretion
611939 (MAP2K2)
04912 GnRH signaling pathway
611939 (MAP2K2)
04915 Estrogen signaling pathway
611939 (MAP2K2)
04917 Prolactin signaling pathway
611939 (MAP2K2)
04921 Oxytocin signaling pathway
611939 (MAP2K2)
04926 Relaxin signaling pathway
611939 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
611939 (MAP2K2)
04919 Thyroid hormone signaling pathway
611939 (MAP2K2)
04916 Melanogenesis
611939 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
611939 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
611939 (MAP2K2)
04730 Long-term depression
611939 (MAP2K2)
04722 Neurotrophin signaling pathway
611939 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
611939 (MAP2K2)
05206 MicroRNAs in cancer
611939 (MAP2K2)
05205 Proteoglycans in cancer
611939 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
611939 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
611939 (MAP2K2)
05230 Central carbon metabolism in cancer
611939 (MAP2K2)
05231 Choline metabolism in cancer
611939 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
611939 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
611939 (MAP2K2)
05225 Hepatocellular carcinoma
611939 (MAP2K2)
05226 Gastric cancer
611939 (MAP2K2)
05214 Glioma
611939 (MAP2K2)
05216 Thyroid cancer
611939 (MAP2K2)
05221 Acute myeloid leukemia
611939 (MAP2K2)
05220 Chronic myeloid leukemia
611939 (MAP2K2)
05218 Melanoma
611939 (MAP2K2)
05211 Renal cell carcinoma
611939 (MAP2K2)
05219 Bladder cancer
611939 (MAP2K2)
05215 Prostate cancer
611939 (MAP2K2)
05213 Endometrial cancer
611939 (MAP2K2)
05224 Breast cancer
611939 (MAP2K2)
05223 Non-small cell lung cancer
611939 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
611939 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
611939 (MAP2K2)
05161 Hepatitis B
611939 (MAP2K2)
05160 Hepatitis C
611939 (MAP2K2)
05164 Influenza A
611939 (MAP2K2)
05163 Human cytomegalovirus infection
611939 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
611939 (MAP2K2)
05165 Human papillomavirus infection
611939 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
611939 (MAP2K2)
05135 Yersinia infection
611939 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
611939 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
611939 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
611939 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
611939 (MAP2K2)
01522 Endocrine resistance
611939 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
cfa01001
]
611939 (MAP2K2)
Enzymes [BR:
cfa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
611939 (MAP2K2)
Protein kinases [BR:
cfa01001
]
Serine/threonine kinases: STE group
STE7 family
611939 (MAP2K2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
APH
Motif
Other DBs
NCBI-GeneID:
611939
NCBI-ProteinID:
NP_001041601
Ensembl:
ENSCAFG00000019138
UniProt:
Q1HG70
LinkDB
All DBs
Position
20
Genome browser
AA seq
400 aa
AA seq
DB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGIEGEPHSISPRPRP
PGRPISGHGTDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMSHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagcagagctagaacttgatgagcagcagaagaagcgactggaagccttcctcacccag
aaggccaaggtcggggaactcaaggatgacgacttcgaacggatctcagagctgggagcc
gggaacggcggggtggtcaccaaggtccagcacagaccttctggcctcatcatggcgaga
aagctgatccacctggaaatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctgcacgagtgtaactccccatacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcatatggatggcggctctctggaccaggtgttgaag
gaagccaagagaatccctgaggagatcctggggaaggtcagcattgcggttctccggggt
ttggcgtatctccgggagaagcaccagatcatgcaccgagacgtgaaaccatccaacatc
ctcgtcaactcccgaggggagattaagctgtgtgattttggggtgagcggccagctcatc
gactccatggccaactccttcgtgggaactcggtcctacatgtctccagagcggttgcag
ggcactcattactcagtgcagtcggacatctggagcatgggcctgtccctggtggagctg
tccattggaaggtaccccatcccgccaccagatgccaaggagctagaggccatcttcggc
cggcccatggttgacgggatagaaggagagcctcacagcatctcaccacggccgagaccc
cctggacgccccatcagcggtcatgggacggacagccggccagctatggccatctttgag
ctgctggactatattgtgaacgagccgcctcccaagctgcccaatggtgtcttcacccag
gacttccaggagtttgtaaataaatgcctaataaagaacccagcagagcgagcagatctg
aagatgctcatgagccacacgttcatcaagcggtccgaggtggaagaggtggattttgcc
ggctggttgtgtaaaacgctgcggctgaatcagcccagcacgcccacgcgcaccgccgtg
tga
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