KEGG   Camelus ferus (Wild Bactrian camel): 102513205
Entry
102513205         CDS       T02979                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
cfr  Camelus ferus (Wild Bactrian camel)
Pathway
cfr01521  EGFR tyrosine kinase inhibitor resistance
cfr01522  Endocrine resistance
cfr01524  Platinum drug resistance
cfr04012  ErbB signaling pathway
cfr04014  Ras signaling pathway
cfr04015  Rap1 signaling pathway
cfr04024  cAMP signaling pathway
cfr04062  Chemokine signaling pathway
cfr04066  HIF-1 signaling pathway
cfr04068  FoxO signaling pathway
cfr04070  Phosphatidylinositol signaling system
cfr04071  Sphingolipid signaling pathway
cfr04072  Phospholipase D signaling pathway
cfr04081  Hormone signaling
cfr04140  Autophagy - animal
cfr04150  mTOR signaling pathway
cfr04151  PI3K-Akt signaling pathway
cfr04152  AMPK signaling pathway
cfr04210  Apoptosis
cfr04211  Longevity regulating pathway
cfr04213  Longevity regulating pathway - multiple species
cfr04218  Cellular senescence
cfr04360  Axon guidance
cfr04370  VEGF signaling pathway
cfr04380  Osteoclast differentiation
cfr04510  Focal adhesion
cfr04550  Signaling pathways regulating pluripotency of stem cells
cfr04611  Platelet activation
cfr04613  Neutrophil extracellular trap formation
cfr04620  Toll-like receptor signaling pathway
cfr04625  C-type lectin receptor signaling pathway
cfr04630  JAK-STAT signaling pathway
cfr04650  Natural killer cell mediated cytotoxicity
cfr04660  T cell receptor signaling pathway
cfr04662  B cell receptor signaling pathway
cfr04664  Fc epsilon RI signaling pathway
cfr04666  Fc gamma R-mediated phagocytosis
cfr04668  TNF signaling pathway
cfr04670  Leukocyte transendothelial migration
cfr04722  Neurotrophin signaling pathway
cfr04725  Cholinergic synapse
cfr04750  Inflammatory mediator regulation of TRP channels
cfr04810  Regulation of actin cytoskeleton
cfr04910  Insulin signaling pathway
cfr04914  Progesterone-mediated oocyte maturation
cfr04915  Estrogen signaling pathway
cfr04917  Prolactin signaling pathway
cfr04919  Thyroid hormone signaling pathway
cfr04923  Regulation of lipolysis in adipocytes
cfr04926  Relaxin signaling pathway
cfr04929  GnRH secretion
cfr04930  Type II diabetes mellitus
cfr04931  Insulin resistance
cfr04932  Non-alcoholic fatty liver disease
cfr04933  AGE-RAGE signaling pathway in diabetic complications
cfr04935  Growth hormone synthesis, secretion and action
cfr04960  Aldosterone-regulated sodium reabsorption
cfr04973  Carbohydrate digestion and absorption
cfr05010  Alzheimer disease
cfr05017  Spinocerebellar ataxia
cfr05020  Prion disease
cfr05100  Bacterial invasion of epithelial cells
cfr05135  Yersinia infection
cfr05142  Chagas disease
cfr05146  Amoebiasis
cfr05160  Hepatitis C
cfr05161  Hepatitis B
cfr05162  Measles
cfr05163  Human cytomegalovirus infection
cfr05164  Influenza A
cfr05165  Human papillomavirus infection
cfr05166  Human T-cell leukemia virus 1 infection
cfr05167  Kaposi sarcoma-associated herpesvirus infection
cfr05168  Herpes simplex virus 1 infection
cfr05169  Epstein-Barr virus infection
cfr05170  Human immunodeficiency virus 1 infection
cfr05171  Coronavirus disease - COVID-19
cfr05200  Pathways in cancer
cfr05203  Viral carcinogenesis
cfr05205  Proteoglycans in cancer
cfr05206  MicroRNAs in cancer
cfr05207  Chemical carcinogenesis - receptor activation
cfr05208  Chemical carcinogenesis - reactive oxygen species
cfr05210  Colorectal cancer
cfr05211  Renal cell carcinoma
cfr05212  Pancreatic cancer
cfr05213  Endometrial cancer
cfr05214  Glioma
cfr05215  Prostate cancer
cfr05218  Melanoma
cfr05220  Chronic myeloid leukemia
cfr05221  Acute myeloid leukemia
cfr05222  Small cell lung cancer
cfr05223  Non-small cell lung cancer
cfr05224  Breast cancer
cfr05225  Hepatocellular carcinoma
cfr05226  Gastric cancer
cfr05230  Central carbon metabolism in cancer
cfr05231  Choline metabolism in cancer
cfr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfr05415  Diabetic cardiomyopathy
cfr05417  Lipid and atherosclerosis
cfr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102513205 (PIK3R2)
   04014 Ras signaling pathway
    102513205 (PIK3R2)
   04015 Rap1 signaling pathway
    102513205 (PIK3R2)
   04370 VEGF signaling pathway
    102513205 (PIK3R2)
   04630 JAK-STAT signaling pathway
    102513205 (PIK3R2)
   04668 TNF signaling pathway
    102513205 (PIK3R2)
   04066 HIF-1 signaling pathway
    102513205 (PIK3R2)
   04068 FoxO signaling pathway
    102513205 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    102513205 (PIK3R2)
   04072 Phospholipase D signaling pathway
    102513205 (PIK3R2)
   04071 Sphingolipid signaling pathway
    102513205 (PIK3R2)
   04024 cAMP signaling pathway
    102513205 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    102513205 (PIK3R2)
   04152 AMPK signaling pathway
    102513205 (PIK3R2)
   04150 mTOR signaling pathway
    102513205 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102513205 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102513205 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    102513205 (PIK3R2)
   04218 Cellular senescence
    102513205 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102513205 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102513205 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102513205 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102513205 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    102513205 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    102513205 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    102513205 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    102513205 (PIK3R2)
   04660 T cell receptor signaling pathway
    102513205 (PIK3R2)
   04662 B cell receptor signaling pathway
    102513205 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    102513205 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    102513205 (PIK3R2)
   04670 Leukocyte transendothelial migration
    102513205 (PIK3R2)
   04062 Chemokine signaling pathway
    102513205 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102513205 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    102513205 (PIK3R2)
   04929 GnRH secretion
    102513205 (PIK3R2)
   04915 Estrogen signaling pathway
    102513205 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    102513205 (PIK3R2)
   04917 Prolactin signaling pathway
    102513205 (PIK3R2)
   04926 Relaxin signaling pathway
    102513205 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    102513205 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    102513205 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102513205 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102513205 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    102513205 (PIK3R2)
   04722 Neurotrophin signaling pathway
    102513205 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102513205 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    102513205 (PIK3R2)
   04380 Osteoclast differentiation
    102513205 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    102513205 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    102513205 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102513205 (PIK3R2)
   05206 MicroRNAs in cancer
    102513205 (PIK3R2)
   05205 Proteoglycans in cancer
    102513205 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    102513205 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    102513205 (PIK3R2)
   05203 Viral carcinogenesis
    102513205 (PIK3R2)
   05230 Central carbon metabolism in cancer
    102513205 (PIK3R2)
   05231 Choline metabolism in cancer
    102513205 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102513205 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102513205 (PIK3R2)
   05212 Pancreatic cancer
    102513205 (PIK3R2)
   05225 Hepatocellular carcinoma
    102513205 (PIK3R2)
   05226 Gastric cancer
    102513205 (PIK3R2)
   05214 Glioma
    102513205 (PIK3R2)
   05221 Acute myeloid leukemia
    102513205 (PIK3R2)
   05220 Chronic myeloid leukemia
    102513205 (PIK3R2)
   05218 Melanoma
    102513205 (PIK3R2)
   05211 Renal cell carcinoma
    102513205 (PIK3R2)
   05215 Prostate cancer
    102513205 (PIK3R2)
   05213 Endometrial cancer
    102513205 (PIK3R2)
   05224 Breast cancer
    102513205 (PIK3R2)
   05222 Small cell lung cancer
    102513205 (PIK3R2)
   05223 Non-small cell lung cancer
    102513205 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102513205 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    102513205 (PIK3R2)
   05161 Hepatitis B
    102513205 (PIK3R2)
   05160 Hepatitis C
    102513205 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    102513205 (PIK3R2)
   05164 Influenza A
    102513205 (PIK3R2)
   05162 Measles
    102513205 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    102513205 (PIK3R2)
   05163 Human cytomegalovirus infection
    102513205 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102513205 (PIK3R2)
   05169 Epstein-Barr virus infection
    102513205 (PIK3R2)
   05165 Human papillomavirus infection
    102513205 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102513205 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    102513205 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102513205 (PIK3R2)
   05142 Chagas disease
    102513205 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102513205 (PIK3R2)
   05017 Spinocerebellar ataxia
    102513205 (PIK3R2)
   05020 Prion disease
    102513205 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102513205 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    102513205 (PIK3R2)
   05415 Diabetic cardiomyopathy
    102513205 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102513205 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    102513205 (PIK3R2)
   04931 Insulin resistance
    102513205 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102513205 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102513205 (PIK3R2)
   01524 Platinum drug resistance
    102513205 (PIK3R2)
   01522 Endocrine resistance
    102513205 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfr04131]
    102513205 (PIK3R2)
Membrane trafficking [BR:cfr04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102513205 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9 ATG11
Other DBs
NCBI-GeneID: 102513205
NCBI-ProteinID: XP_032321142
UniProt: A0A8B8RU44
LinkDB
Position
22:complement(16314539..16327034)
AA seq 723 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGSERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPILVKLVEAIDRTGLDSYRPEPPAARTDWSLSDMEQWDAATLSDGVKGFLLALPS
PLVTPEAAAEAHRALREAAGPVGPVLEPPTLPLHHALTLRFLLQHLGRVARRAPAPGPVV
RALGATFGPLLLRAPPPSPPPGGAPDGTEPIPDFPALLVEKLLQEHLEEQEVAPPALPPK
PPKAKPASTGLANGGNPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEY
TLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLLYPV
SKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFN
ETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQE
LRVQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQY
SLMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDT
KHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPP
AAR
NT seq 2172 nt   +upstreamnt  +downstreamnt
atggctggggctgagggcttccaataccgtgctctgtacccattccgccgggaacggcca
gaggacctggagctgctgccaggtgatgtccttgtggtgagccgggcggccctacaggca
ctgggcgtggctgagggcagcgagcgttgcccacagagtgtgggctggatgcctggcctc
aacgagcgtacacggcagcgcggcgacttccctggcacctacgttgagttcctggggcct
gtggccctggcccggcctggccctcgcccacgtggcccccgcccgctgcccgccaggccc
cgagatgggccccctgagccaggcctcacactccctgacctacctgagcagttctcccca
cctgatgtggcgccccctatcctggtgaagcttgtggaggccattgatcggacagggcta
gacagctacagacctgagccacctgccgcacgcacagactggtccctaagtgacatggag
cagtgggacgcggcaaccctgtcagatggcgtgaagggcttcctgctagcgctgccctct
ccccttgtgacacctgaggccgcggccgaagcacatcgagccctgcgggaggccgcaggg
cccgtggggccagtgctggagcccccgacgctgccactgcaccacgcgctcacgctgcgc
ttcctgctccagcatctgggccgggtggcccggcgcgccccagcgccgggccccgtggtg
cgtgccctgggcgccaccttcgggccgctgctgctgcgtgcgccaccgccctcgccgcca
ccagggggcgcgcccgacgggactgagcccatccccgacttccctgctctgctggtggag
aagttgcttcaggaacatctggaggagcaggaggttgcgcccccagcactgccgcctaaa
ccccccaaggcaaagccggcctccacaggcctggccaatggggggaacccgccctccctg
caggatgctgaatggtactggggtgacatctccagggaggaggtaaacgagaaactccgg
gacacacctgatggtacctttctggtccgagatgcatccagcaagatccagggggagtac
acgctgacccttaggaaaggcgggaacaacaagctgatcaaggtcttccaccgagacggt
cactacggcttctcagagccgctcaccttctgctctgtcgtggacctcatcacccactac
cgccatgagtcactggcccagtacaatgccaagctggacactcggctcctctacccagtg
tccaagtaccagcaggaccagattgtcaaggaggacagcgtggaagcagtgggcgcccag
cttaaagtctatcaccagcagtaccaagacaagagccgcgagtacgaccagctctatgag
gagtacacacgcacctcccaggaactgcagatgaagcgcacagccatcgaggccttcaat
gagaccatcaagatctttgaagagcagggccagacgcaagagaagtgcagcaaggagtat
ctggagcgcttccggcgtgagggcaatgagaaggagatgcagaggatcctgctgaactcc
gagcggctcaagtctcgcattgctgagatccacgagagccgcacaaagctggagcaggag
ctacgggtgcaggcctctgacaaccgagagatcgacaagcgcatgaacagcctcaagcca
gacctcatgcagctgcgcaagatccgagaccagtaccttgtgtggctcactcagaaaggt
gcccggcagaagaaaatcaacgaatggttgggaatcaaaaacgagactgaggaccagtac
tcactgatggaagatgaggatgaccttccccaccatgaggaacgcacgtggtatgtaggc
aagatcaaccgcacacaagctgaggaaatgctgagtggcaagcgggatggcaccttcctc
atccgtgagagcagccagcgcggctgctacgcctgctccgtggtggtggatggtgacacc
aaacactgcgttatctaccgcacagccacgggcttcggctttgcagagccctataacttg
tacgggtcgctgaaggagctggtgctgcactaccagcatgcctcactggtgcagcacaac
gacgcgctcaccgtcacgctcgcccatcccgtgcgcgccccaggccccgggcccccacct
gccgcccgctga

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