KEGG   Cricetulus griseus (Chinese hamster): 100771181
Entry
100771181         CDS       T02813                                 
Symbol
Pik3r2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta isoform X2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
cge  Cricetulus griseus (Chinese hamster)
Pathway
cge01521  EGFR tyrosine kinase inhibitor resistance
cge01522  Endocrine resistance
cge01524  Platinum drug resistance
cge04012  ErbB signaling pathway
cge04014  Ras signaling pathway
cge04015  Rap1 signaling pathway
cge04024  cAMP signaling pathway
cge04062  Chemokine signaling pathway
cge04066  HIF-1 signaling pathway
cge04068  FoxO signaling pathway
cge04070  Phosphatidylinositol signaling system
cge04071  Sphingolipid signaling pathway
cge04072  Phospholipase D signaling pathway
cge04081  Hormone signaling
cge04140  Autophagy - animal
cge04150  mTOR signaling pathway
cge04151  PI3K-Akt signaling pathway
cge04152  AMPK signaling pathway
cge04210  Apoptosis
cge04211  Longevity regulating pathway
cge04213  Longevity regulating pathway - multiple species
cge04218  Cellular senescence
cge04360  Axon guidance
cge04370  VEGF signaling pathway
cge04380  Osteoclast differentiation
cge04510  Focal adhesion
cge04550  Signaling pathways regulating pluripotency of stem cells
cge04611  Platelet activation
cge04613  Neutrophil extracellular trap formation
cge04620  Toll-like receptor signaling pathway
cge04625  C-type lectin receptor signaling pathway
cge04630  JAK-STAT signaling pathway
cge04650  Natural killer cell mediated cytotoxicity
cge04660  T cell receptor signaling pathway
cge04662  B cell receptor signaling pathway
cge04664  Fc epsilon RI signaling pathway
cge04666  Fc gamma R-mediated phagocytosis
cge04668  TNF signaling pathway
cge04670  Leukocyte transendothelial migration
cge04722  Neurotrophin signaling pathway
cge04725  Cholinergic synapse
cge04750  Inflammatory mediator regulation of TRP channels
cge04810  Regulation of actin cytoskeleton
cge04910  Insulin signaling pathway
cge04914  Progesterone-mediated oocyte maturation
cge04915  Estrogen signaling pathway
cge04917  Prolactin signaling pathway
cge04919  Thyroid hormone signaling pathway
cge04923  Regulation of lipolysis in adipocytes
cge04926  Relaxin signaling pathway
cge04929  GnRH secretion
cge04930  Type II diabetes mellitus
cge04931  Insulin resistance
cge04932  Non-alcoholic fatty liver disease
cge04933  AGE-RAGE signaling pathway in diabetic complications
cge04935  Growth hormone synthesis, secretion and action
cge04960  Aldosterone-regulated sodium reabsorption
cge04973  Carbohydrate digestion and absorption
cge05010  Alzheimer disease
cge05017  Spinocerebellar ataxia
cge05020  Prion disease
cge05100  Bacterial invasion of epithelial cells
cge05135  Yersinia infection
cge05142  Chagas disease
cge05146  Amoebiasis
cge05160  Hepatitis C
cge05161  Hepatitis B
cge05162  Measles
cge05163  Human cytomegalovirus infection
cge05164  Influenza A
cge05165  Human papillomavirus infection
cge05166  Human T-cell leukemia virus 1 infection
cge05167  Kaposi sarcoma-associated herpesvirus infection
cge05168  Herpes simplex virus 1 infection
cge05169  Epstein-Barr virus infection
cge05170  Human immunodeficiency virus 1 infection
cge05171  Coronavirus disease - COVID-19
cge05200  Pathways in cancer
cge05203  Viral carcinogenesis
cge05205  Proteoglycans in cancer
cge05206  MicroRNAs in cancer
cge05207  Chemical carcinogenesis - receptor activation
cge05208  Chemical carcinogenesis - reactive oxygen species
cge05210  Colorectal cancer
cge05211  Renal cell carcinoma
cge05212  Pancreatic cancer
cge05213  Endometrial cancer
cge05214  Glioma
cge05215  Prostate cancer
cge05218  Melanoma
cge05220  Chronic myeloid leukemia
cge05221  Acute myeloid leukemia
cge05222  Small cell lung cancer
cge05223  Non-small cell lung cancer
cge05224  Breast cancer
cge05225  Hepatocellular carcinoma
cge05226  Gastric cancer
cge05230  Central carbon metabolism in cancer
cge05231  Choline metabolism in cancer
cge05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cge05415  Diabetic cardiomyopathy
cge05417  Lipid and atherosclerosis
cge05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cge00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100771181 (Pik3r2)
   04014 Ras signaling pathway
    100771181 (Pik3r2)
   04015 Rap1 signaling pathway
    100771181 (Pik3r2)
   04370 VEGF signaling pathway
    100771181 (Pik3r2)
   04630 JAK-STAT signaling pathway
    100771181 (Pik3r2)
   04668 TNF signaling pathway
    100771181 (Pik3r2)
   04066 HIF-1 signaling pathway
    100771181 (Pik3r2)
   04068 FoxO signaling pathway
    100771181 (Pik3r2)
   04070 Phosphatidylinositol signaling system
    100771181 (Pik3r2)
   04072 Phospholipase D signaling pathway
    100771181 (Pik3r2)
   04071 Sphingolipid signaling pathway
    100771181 (Pik3r2)
   04024 cAMP signaling pathway
    100771181 (Pik3r2)
   04151 PI3K-Akt signaling pathway
    100771181 (Pik3r2)
   04152 AMPK signaling pathway
    100771181 (Pik3r2)
   04150 mTOR signaling pathway
    100771181 (Pik3r2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100771181 (Pik3r2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100771181 (Pik3r2)
  09143 Cell growth and death
   04210 Apoptosis
    100771181 (Pik3r2)
   04218 Cellular senescence
    100771181 (Pik3r2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100771181 (Pik3r2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100771181 (Pik3r2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100771181 (Pik3r2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100771181 (Pik3r2)
   04613 Neutrophil extracellular trap formation
    100771181 (Pik3r2)
   04620 Toll-like receptor signaling pathway
    100771181 (Pik3r2)
   04625 C-type lectin receptor signaling pathway
    100771181 (Pik3r2)
   04650 Natural killer cell mediated cytotoxicity
    100771181 (Pik3r2)
   04660 T cell receptor signaling pathway
    100771181 (Pik3r2)
   04662 B cell receptor signaling pathway
    100771181 (Pik3r2)
   04664 Fc epsilon RI signaling pathway
    100771181 (Pik3r2)
   04666 Fc gamma R-mediated phagocytosis
    100771181 (Pik3r2)
   04670 Leukocyte transendothelial migration
    100771181 (Pik3r2)
   04062 Chemokine signaling pathway
    100771181 (Pik3r2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100771181 (Pik3r2)
   04923 Regulation of lipolysis in adipocytes
    100771181 (Pik3r2)
   04929 GnRH secretion
    100771181 (Pik3r2)
   04915 Estrogen signaling pathway
    100771181 (Pik3r2)
   04914 Progesterone-mediated oocyte maturation
    100771181 (Pik3r2)
   04917 Prolactin signaling pathway
    100771181 (Pik3r2)
   04926 Relaxin signaling pathway
    100771181 (Pik3r2)
   04935 Growth hormone synthesis, secretion and action
    100771181 (Pik3r2)
   04919 Thyroid hormone signaling pathway
    100771181 (Pik3r2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100771181 (Pik3r2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100771181 (Pik3r2)
  09156 Nervous system
   04725 Cholinergic synapse
    100771181 (Pik3r2)
   04722 Neurotrophin signaling pathway
    100771181 (Pik3r2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100771181 (Pik3r2)
  09158 Development and regeneration
   04360 Axon guidance
    100771181 (Pik3r2)
   04380 Osteoclast differentiation
    100771181 (Pik3r2)
  09149 Aging
   04211 Longevity regulating pathway
    100771181 (Pik3r2)
   04213 Longevity regulating pathway - multiple species
    100771181 (Pik3r2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100771181 (Pik3r2)
   05206 MicroRNAs in cancer
    100771181 (Pik3r2)
   05205 Proteoglycans in cancer
    100771181 (Pik3r2)
   05207 Chemical carcinogenesis - receptor activation
    100771181 (Pik3r2)
   05208 Chemical carcinogenesis - reactive oxygen species
    100771181 (Pik3r2)
   05203 Viral carcinogenesis
    100771181 (Pik3r2)
   05230 Central carbon metabolism in cancer
    100771181 (Pik3r2)
   05231 Choline metabolism in cancer
    100771181 (Pik3r2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100771181 (Pik3r2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100771181 (Pik3r2)
   05212 Pancreatic cancer
    100771181 (Pik3r2)
   05225 Hepatocellular carcinoma
    100771181 (Pik3r2)
   05226 Gastric cancer
    100771181 (Pik3r2)
   05214 Glioma
    100771181 (Pik3r2)
   05221 Acute myeloid leukemia
    100771181 (Pik3r2)
   05220 Chronic myeloid leukemia
    100771181 (Pik3r2)
   05218 Melanoma
    100771181 (Pik3r2)
   05211 Renal cell carcinoma
    100771181 (Pik3r2)
   05215 Prostate cancer
    100771181 (Pik3r2)
   05213 Endometrial cancer
    100771181 (Pik3r2)
   05224 Breast cancer
    100771181 (Pik3r2)
   05222 Small cell lung cancer
    100771181 (Pik3r2)
   05223 Non-small cell lung cancer
    100771181 (Pik3r2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100771181 (Pik3r2)
   05170 Human immunodeficiency virus 1 infection
    100771181 (Pik3r2)
   05161 Hepatitis B
    100771181 (Pik3r2)
   05160 Hepatitis C
    100771181 (Pik3r2)
   05171 Coronavirus disease - COVID-19
    100771181 (Pik3r2)
   05164 Influenza A
    100771181 (Pik3r2)
   05162 Measles
    100771181 (Pik3r2)
   05168 Herpes simplex virus 1 infection
    100771181 (Pik3r2)
   05163 Human cytomegalovirus infection
    100771181 (Pik3r2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100771181 (Pik3r2)
   05169 Epstein-Barr virus infection
    100771181 (Pik3r2)
   05165 Human papillomavirus infection
    100771181 (Pik3r2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100771181 (Pik3r2)
   05100 Bacterial invasion of epithelial cells
    100771181 (Pik3r2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100771181 (Pik3r2)
   05142 Chagas disease
    100771181 (Pik3r2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100771181 (Pik3r2)
   05017 Spinocerebellar ataxia
    100771181 (Pik3r2)
   05020 Prion disease
    100771181 (Pik3r2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100771181 (Pik3r2)
   05418 Fluid shear stress and atherosclerosis
    100771181 (Pik3r2)
   05415 Diabetic cardiomyopathy
    100771181 (Pik3r2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100771181 (Pik3r2)
   04932 Non-alcoholic fatty liver disease
    100771181 (Pik3r2)
   04931 Insulin resistance
    100771181 (Pik3r2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100771181 (Pik3r2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100771181 (Pik3r2)
   01524 Platinum drug resistance
    100771181 (Pik3r2)
   01522 Endocrine resistance
    100771181 (Pik3r2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cge04131]
    100771181 (Pik3r2)
Membrane trafficking [BR:cge04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100771181 (Pik3r2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 Ribosomal_L22e SH3_1 SH3_9
Other DBs
NCBI-GeneID: 100771181
NCBI-ProteinID: XP_027250539
UniProt: A0A9J7F6F3
LinkDB
Position
1
AA seq 721 aa
MAGSEGFQYRAVYPFRRERPEDLELLPGDLLVVSRVALQALGVADGGERCPHNVGWMPGF
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLDGPSESGLTLADLAEQFSP
PDPAPPILVKLVEAIEQAGLDSECYSRPELPAPRTDWSLSDVEQWDRNALYDAVKGFLLA
LPTPVVTPEAAAEAHRALREAAGPVGPVLEPPMLPLHHALTLRFLLQHLGRVARRAPVQA
TAVHSLASAFGPLLLRTPPPGGDTDGSEPGPGFPVLLLERLLQEHVDEQDAAPPALPPKP
SKAKPAPTALANGGNPPSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYT
LTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVS
KYQQDQVVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNE
TIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQDL
RAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEWLGIKNETEDQYS
LMEDEDALPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTK
HCVIYRTATGFGFAEPYNLYASLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPTA
R
NT seq 2166 nt   +upstreamnt  +downstreamnt
atggcgggcagtgagggcttccagtacagggctgtgtacccattccgccgggagcggcct
gaggacctggagctactgcctggagacctactggtggtgagccgtgtggctctgcaggca
ctgggcgtggcagatggaggggagcgctgtccacacaacgtgggctggatgcctggcttc
aatgagcgcacccggcagcgaggggacttccctggaacgtatgtggagttcctagggcct
gtggctctggctcgaccaggacctcgcccacgaggcccccgtccattgcccgccaggccc
ttggatgggccctctgagtcaggcctcacactggcagacctggcagagcagttctcccca
cctgaccctgctccgcccattctggtgaagctggtagaggccattgagcaagcagggctg
gacagtgaatgctatagtcggccggagctgcccgcacctcggacagactggtccctgagt
gatgtggagcagtgggatcgaaacgccttgtacgatgctgttaagggcttcctgctggcg
ctgcctacacctgtggtgactcctgaggctgcagcagaggcacaccgggcactgcgggag
gctgcagggcccgtggggccagtgctggaacccccaatgctgccactgcaccatgcgctc
acactgcggttcctgctgcagcacctgggccgtgtggcccgcagagcacctgtgcaggcc
acagctgtccactcgctggccagcgcctttgggccgctcctactgcgcacacctccgcca
gggggtgacactgatgggagtgagcctgggccaggcttcccagtgctgctgttggagagg
ctgctgcaggaacacgtggatgagcaggatgccgcccccccagcactgccacccaaaccc
tctaaggcaaagccggcccccacagctctggctaatggagggaacccgccctcgcttcag
gatgcagagtggtactggggggacatctccagggaagaggtgaatgagagactccgggac
acgcccgatggcacattcttggtccgagatgcatccagcaagatccaaggagagtacacg
ctcaccctcaggaaaggcgggaacaacaagctgatcaaagtcttccaccgggatggccac
tacggcttctccgagcccctcaccttctgctccgtggtggagctcatttcccactaccgc
cacgagtcgctggcccagtacaacgccaagctggacacacgcctgctctaccctgtgtcc
aagtaccagcaggaccaggtggtgaaggaggacagtgtggaggctgtgggtgcccagctc
aaggtctaccaccagcagtaccaggacaagagccgcgaatacgatcagctgtatgaggaa
tacacacggacctcccaggagcttcagatgaagcgcacagccatagaggccttcaatgag
accatcaagatcttcgaagaacagggccagacgcaggaaaagtgcagcaaggagtatttg
gagcgcttccggcgagagggcaatgagaaggagatgcagaggatcttgctaaactctgag
cggctcaagtcacgcatcgcagaaatccatgagagccgcacaaaactggaacaggacctg
cgggcgcaggcctcggacaaccgtgagatcgacaagcgcatgaacagcctcaagccggac
ctcatgcagctgcgcaagatccgggaccagtacctcgtgtggctcacccagaaaggtgcc
cgacagaggaagatcaacgagtggctggggatcaagaacgagactgaggaccagtattca
ctgatggaggatgaggacgccctcccccaccacgaggagcgcacgtggtacgtgggcaag
atcaaccgcacacaggcagaggagatgctgagtggcaaacgggacgggaccttcctcatc
cgggagagcagccagcgaggctgttacgcatgctccgtggtggtggatggcgacaccaag
cactgtgtcatctaccgcacggccacaggcttcggcttcgcggagccctacaacctgtac
gcgtcactgaaggagctggtgctgcactaccagcacgcctccctcgtgcagcacaatgat
gcgctcacggtcaccctcgcgcaccctgtgcgcgcccccgggcctggcccacccacggcc
cgctga

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