Cottoperca gobio: 115019446 Help Entry 115019446         CDS       T07513                                  Name (RefSeq) ryanodine receptor 1-like   KO K04961   ryanodine receptor 1 Organism cgob  Cottoperca gobio Pathway cgob04020   Calcium signaling pathway cgob04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cgob00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     115019446    04020 Calcium signaling pathway     115019446  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:cgob01009]     115019446   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:cgob04147]     115019446    04040 Ion channels [BR:cgob04040]     115019446 Protein phosphatases and associated proteins [BR:cgob01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      115019446 Exosome [BR:cgob04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    115019446 Ion channels [BR:cgob04040]  Voltage-gated cation channels   Ryanodine receptor    115019446 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 DUF1840 Motif Other DBs NCBI-GeneID:  115019446 NCBI-ProteinID:  XP_029304871 UniProt:  A0A6J2R3Z7 LinkDB All DBs Position 14:complement(8763278..8814850) Genome browser AA seq 5014 aa AA seqDB search MAEAADGEEEIQFLRTDDQVVLQCTAAILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLSNSSVDESSQGGGHRTLLYGHAILLKHTHSSMYLCCLT TSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHL SYASGDLMVDASFMQTLWTMTPVMSGCELAEGFLTGGYVLRLFHGHMDECLAIPGADQGD DQRRVAHYEGGAVCSHARSLWRLEPLRIAWSGGHIKWGQFFRIRHITTGRYLCLDEEKGL LLVDPEKANSKMSAFCFRISKEKIEVIKKRDVEGMGTPEIKYGESMCFVQHASTGLWLTY AAVDAKSARLGPLKRKAILHKEGHMDDALTVARSQTEESQAARMIFSTAGLFNQFIKGLD ALSGKNKSASSTSLPMDTVVLSLQDLIFYFRPPEEELEHEDKQFKLRSLKNRQNLFQEEG MITHVLDCVDRLNVYNTAAHFSEYAGEEAAESWKEIVNLLYELLASLIRGNRANCALFCD NLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDV LCSLCVCNGVAVRSNQNLITENLLPGRDFLLQTNIINYVTSMRPNIFLGTCEGSTQYKKW YFEVMVDQVEPFLTAQPYHLRVGWALTEGYSPYPGGGEGWGANGVGDDLYSYGFDGLHLW SGRVPRHVATPNHHILAAEDVISCCLDLSVPSISFRINGHPVQGMFENFNVDGLFFPVVS FSAGTKLRFLLGGRHGDFKFLPPPGYAPCYEAVLPRDRLRIEPIKEYKHDFEGVRNLLGP TQSLSHTAFTPGPVDTIQIVLPPHLERIREKLAENSHELWAVTRIEQGWTYGPFRDDNKK LHPCLVDFQSLPEPEKNYNLAMSGETLKTLLALGCHVGMGDEKAEENLKKTKLPKTYMQS SGYKPAPLDLSYVKLTPNQNTLVERLAENGHNVWARDRVHQGWTYSIVQDIMNKRNPRLV PYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSKSTGDKIRVFRAEKSYAVTQG KWYYEFEAVTVGEMRVGWARPSVRADTELGADEFAYVFNGFKAQRWHVGNEPFGRQWLSG DVVGCMIDLTEMNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCSLGLSQVSRINLGQ NVSSLRFFTICGLQEGFEPFAINMKRDITMWFSKSLPQFINAPTDHAHMEVSRVDGTVET APCIKITHKTFGSQNANTDLLFFRLSMPVDFHETFKVPAGTTLLTRTLTIPEDEVLEVDP DSDFEILKKSASRKEQEEEKKESSVPKETPAIKNGENEKDSSTEKSKKKGFLFKAKKVAL INPPPVVPTMPRLMEDVVPDDRDDVDIILNTTTYYYSVRVFAGQEPSGVWVGWITPDYHQ YDLHFDISKVRNVTVTVGDDKGNIHDSIKRSNCYMVWGGEFSSSQQTRVSQEDFVIGCLI DLDTGLMTFTANGKEINTFYQVEPHTKLFPAVFVLPSCQNMIQFELGKLKNIMPISAAMF RSERKNPVPQCPPRLDVQMLTPVIWSRMPNHFLAPETGRISERLGWVVQCQEPLSMMALH IPEENRCIDILELSERMDLLKFHYHTLKLYGLVCALGNNRVAHALCSHVDESQLFYAIEN TYLPGPMRSGFYDLLISMHLESAKRNRLGTNKEFIVPMTDETRSITLYTHALPGVGLTTC LRPKLHFSSIGFVGTDQTIYTLSPVIPLQVLKTKALNMLTEAVQDGGQAMRDPVGGSVEF HFVPILKLISTLLIMGVFDDEDVTHILKMLEPTVFKEEEEEEEEEEEDEYEDDGLGEEEE EEMLSIVLHEKTVDEAEQVNGEKGAEETEKEIKEENKEERFEQGLFQMKLPESVKLQMCT LLQYFCDCELRHRVEAITAFSDQFVSQIQSNQRQRYNELMLAFTMSAAETARKTREFRSP PQEQVNMLMNFKNCSEDDECPVPDEVRDALLIFHNFLLAHCGVHIEEEEQEEEVDNSLRG RLVRLLIKVKKVREKKVEVEPEPQEDKKPSTLQELISHTMIHWAQESFIQNPELVRMMFS LLHRQYDGLGELMRALPKAYTINGVSIHDTMDLLECLGQIRSLLIVQMGPEEERLMIQSI GDIMSNKVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRVVTNCCRFLCYFCRI SRQNQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVKYS AGCGLQSCPMLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPE CFGPALRGEGGNGLLAAIEEAIKISEDPARDGPSVKKDRRFPMFGGEEQHEENKVHLGNA IMSFYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLSVQIPSFGK DNSIIEPKMSASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAAF CTTEMALALNRYLCSAVLPLITKCAPLFAGSDHRAIMIDSMLHTIYRLSRGRAFTKAQRD IIEECLMALCKHLRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPNGW GNFGLSSEEELHLTRKLFWGIFESLAKFDAEIFKISMPCICAIAGAIPPDYVDASYSSKT EKKASVDAEGNFDPKPVETTNTIIPERLDPFINKYAEYTHDRWAFEKIQNNWSYGEVLDE NAKTHPMLRPYKTFSEKDKEIYRWPIKESVKAMLAWEWNLDKAREEEESEKKKAVSRKIS QTAQATYDPSQGYSPQPIDVTHMALSRDLQSMAEQLAENYHNTWGRKKKLELQSKGGGTH PLLVPYDTLTAKEKARDREKAYELLKFLQLNGYACTRGLKDMESDISSIEKRFAYGFLQK LLKWMEIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILMPLINQYFKNHCLYFLSTPA KVLGSGGHSSNKEKEMIASIFCKMSALVRHRVSLFGTDAQAIVNCLHILARSLDARTVMK SGPEIVKAGLRSFFESAADDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLPVLTS LFDHVAQHQFGDDVMLDDLQMSCYRIMCSIYSLGTVKNPHVERQRPALGECLAHLAAAMP VAYLEPNLNEFNAFSVYTTKSPRERAILGLPHEVQELCPDIPELDALLKEIGELAESGAR YTEMPHVIEITLPMLCNYLPRWWEKGLENFPDMDGQICTDVTSEHLNQLLGSIMKIVVNN LGIDEASWMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTSKVVAEEDHLRMEGKSE GDEEDGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIFWS KSHNFKREEQNFVVMNEINNMSFLTADSKSKMSKGGDSEGGGSDTERTKKKRRGDRYSVQ TSLIVAALKKMLPIGLNMCSPADQELINLAKIRYSLRDTDEEVREFLQNNLHLQGKVDNP SMRWQMALYKEMAGKAEDADAPIKVVKRVQEVSAVLYHLEVTEHPFKSKKMVWHKLLSKQ RRRAVVACFRMTPLYNIPRHRASNMFLEGYKRNWLHSEGYSFEDRMINDLSKAMEQEEGD EEEERETKPDPLHQLILHFSRTALTEKSKLDTDHLYMAYADIMAKSCHIGEEEEGGEEMG ENAEDEMPFEEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGPMVTTTLKLGISI LNGGNSEVQRKMLEYLRDKKDVGFFLSVQALMQTCSVLDLNAFERQNKAEGLGMVSEEGT NEKVMSDDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQESI SDFYWYYSGKDIIDEPGKKNFSKAMTVAKQIFNSLTEYIQGPCTGNQQSLTHSRLWDAIV GFLHVFAHMMMKLAQGKDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDML VESSSNVEMILKFFDMFLKLKDIVASDAFSDYVTDPRGLISKKDFQKAMDSQKQYSPSEI QFLLSCSEADENDMIHYEEFANRFQEPAKDIGFNIAVLLTNLSEHVPHDIRLQNFLEQAE SVLNYFRPFLGRIEIMGASRKIERIYFEITEVNRKQWEMPQVRESKRQFIFDVVNGGESE KMEMFVNFCEDTIFEMNIASQISEQEEEGKGEEDDEGEEVGGEAAQAGGSSGGGDEESNG EEGQPESSSAFADFINSMLSFFNIFTFRNLRRQYRRVRKMSFKEIVVALSTFFWTILMSI LHFIYNVCKGFFMIIWQTLFGGGLVEGAKNITVTEILASMPDPTQDDVHGDGPGELRTGE EQDTGGVMDTGETGSGEEEEEDTQDKEGGRIPGVDAPGGLGDMGVESPVEPPTPEGTPIT KRKVAPEETEASQKPPEPVPVVEPPPEPEKADVETAEKESQSKEEARLEVPKKSAKKKEK KPKREGGFQIWTELENQRNKFMNYLSRNFYNLRFLALFLAFALNFILLFYKVSDTPPEGD EMEGSGMSEGSGFFEGSGFFESSGEEAEGSGMNEEDEDEEDVPIYFYLEESTGYMQPTLS FIAALHTVISFICIIGYNCLKIPLVIFKREKELARKLEFDGLYITEQPEDDDIKGQWDRL VLNTPSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGVDLASLDVSQQHDKKQEEPDSA VFAWTTTIDIKYQIWKFGVVFTDGTFLYLCWYTIMSLLGHYNNFFYACHLLDIAMGVKTL RTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCY LFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGEL RDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLDEHNLANYMFFLMYLINKDETEH TGQESYVWKMYQERCWDFYPAGDCFRKQYEDQLS NT seq 15045 nt NT seq  +upstreamnt  +downstreamnt atggcagaagctgcagatggagaggaagagattcagttcctgcgtacagatgatcaggtg gtgctacagtgcactgcagctattctgaaggaacagatcaagctgtgcctgtcttgtgaa ggatttgggaatcgtttgtgtttccttgagaccacctcgaacgctcagaatgtcccccca gacctcgctatctgctgctttattttggagcagtccctgtctgtgcgggcattacaggag atgctgtccaactcttctgtggatgagtcgtctcaaggtgggggtcaccgaaccctgctg tatggacatgccatcctcctgaagcacactcactccagcatgtacttgtgctgtttgact acttcacgctcactgacagacaaattggcttttgacgtgggcttgcaggaagactccaca ggagaggcatgctggtggaccatccatccagcctccaagcaaaggtctgaaggcgagaag gtcagggtgggagatgacctcattcttgtcagtgtttcttcggagcgatacctgcatctg tcctacgccagcggagacttgatggtagatgcctctttcatgcaaacactgtggaccatg acccctgtgatgtctggatgtgagctggctgaaggttttctgaccggagggtatgtgctc aggctgttccatggtcacatggacgagtgtttggcaatcccaggagctgaccaaggggac gaccagcgcagagttgctcattatgaaggaggggctgtgtgcagtcatgctcgatcctta tggagacttgagccactgcgtatcgcttggagcggaggccacattaaatggggccagttt ttccggatacgtcacataacgacaggcagatacctttgcctggatgaagagaaaggactg ctgttggtggacccggagaaggcaaattccaagatgtcagccttctgcttcagaatttca aaggaaaaaatcgaagtgatcaagaagcgagatgtggaaggcatgggcacgcctgagatc aaatatggagagtccatgtgcttcgtacagcatgcttcaactggcctctggcttacatat gctgctgttgatgccaaatctgcccgcctgggtcctctaaagagaaaggccatactccat aaagaaggtcacatggatgatgcgctcacagtggcacgatctcagaccgaagagtcccaa gctgccagaatgattttcagcacagcaggcctcttcaaccagttcatcaaaggtctagat gctcttagtgggaaaaacaaatctgccagctccacatctctgcctatggacaccgtggtg ctctccctgcaggacctcattttctacttccgaccccccgaggaggagctggagcacgag gacaaacagttcaagctccgctccctcaagaacagacagaacctcttccaggaggaggga atgattactcatgtcctggactgtgtagatcggctcaatgtctacaacacagctgcccac ttctcagagtatgctggggaagaagccgcagagtcatggaaggagatagtgaacttactg tatgaattgctagcttctttgatccgaggtaatcgtgctaactgtgccctgttctgtgac aaccttgactggctggtcagtaaattggatcgtttggaggcatcttcaggaatcctggag gtgttgtattgtgttctgattgagagtccagaggtgctgaatatcatccaggagaatcac atcaaatcaatcatctctctgctggataagcacgggcgcaatcataaggtcttggacgtg ctctgctctctgtgtgtgtgtaacggggtggccgtgaggtcaaatcagaatctcatcaca gagaatctgcttccaggtcgtgacttccttcttcaaaccaacattatcaactatgttacc agcatgagacccaacattttccttggaacttgtgaaggatccactcagtataagaagtgg tactttgaggtcatggtggaccaagtggagccgttcctcacagctcagccgtatcacctg cgtgtgggttgggctctgacggagggctacagtccttaccctggtggaggcgaaggctgg ggggccaacggggttggggatgacctctactcctacggtttcgacggccttcacctctgg tcaggacgtgttccgcgtcatgttgccacaccgaatcatcacatcctggcagcagaggac gtgatcagctgctgtttggatctgagcgtgcccagtatatccttccgcatcaatgggcat cctgttcagggcatgtttgagaacttcaacgtggatggcttgttcttccctgttgtcagc ttctctgcaggcactaagttgagatttcttctcggaggccgccatggggatttcaagttc ctcccacctccaggctatgctccgtgctatgaagctgtgctgccaagagaccgtttgcgg attgagcccatcaaggagtataagcatgatttcgaaggtgtccgcaacctgttgggtcca actcagtctctctcacatacagccttcactcctggccctgtggacactatacagattgta cttcctcctcatttggagcgcattcgagagaagcttgctgaaaacagccatgagttatgg gctgttactcgcattgagcaaggatggacctatggaccatttcgtgatgacaacaagaag ctgcacccctgccttgtagatttccagagcctgcctgaaccagagaagaactacaattta gcaatgtcaggagagacactcaagactctgctggcgctaggctgtcatgtaggaatggga gatgagaaagccgaggagaatctgaaaaagaccaagctcccaaaaacttacatgcagagc agtggatataagccagcccctctggacctcagctatgtgaagctaactcccaatcagaac actctagtggagagactggcagaaaatggacacaatgtgtgggcaagagaccgggtccac cagggttggacatacagtattgtgcaggatataatgaacaagcgcaatccccgcctggtt ccttacaacctcctggatgaaaagactaaaaagacaaacagagacacagtttgtgcagct gttcgtactctcatcggatacggttacaacatagaaccacccgaccaggagagcagtaag tcaactggtgataagatcagagtgttcagagcagagaaatcttatgctgtcactcagggg aagtggtactatgagttcgaggctgtgacagtcggggagatgcgagtgggctgggccagg cccagtgttcgcgcagacactgaacttggtgcagatgagtttgcgtatgtcttcaatggc ttcaaggcacaacgttggcatgtgggaaatgagccatttggtcgtcagtggctatctggt gatgtggtgggctgtatgattgacctcacagagatgaacatcatgttcacgctcaatgga gaaatgttgatcagtgactcaggctcggagatggcctttaaggatatcgagataggagag ggcttcatacctgtgtgcagtctgggcttgtcccaggtcagcaggatcaacttgggtcag aatgtcagcagtcttcgttttttcaccatctgtggcctgcaggagggatttgaacccttt gctatcaacatgaaaagagacattaccatgtggttcagcaagagccttccccagttcatc aatgcgcctactgatcatgctcacatggaggtgtctcgtgttgacgggacagtggaaact gccccttgtatcaaaataacccacaaaacattcggatctcagaacgccaacacagatctg ctattcttcagactcagcatgccagttgattttcacgagacctttaaagttccagcagga accacccttctcactcgtaccctgaccatccctgaggatgaggtgttagaggtggaccca gactctgactttgaaatactcaagaagtcagcttctcgcaaagagcaggaagaggagaag aaagaatcctctgtgcccaaagagacccccgccattaaaaatggagaaaatgagaaggat tcctcaacggagaaaagcaagaagaaaggattcctcttcaaagctaagaaggttgcattg ataaatccaccacctgttgttcccacaatgccccgcttaatggaagatgtggtgccggat gacagggatgacgtggacattatcctcaacaccacgacatactattattctgtgcgagtg tttgcggggcaggagcccagtggtgtgtgggtgggctggatcacgcctgactatcaccag tatgacctacattttgacatcagcaaagtgagaaatgtaacagtcactgtaggtgatgat aaaggaaacattcatgacagtataaaacgcagtaactgctacatggtatggggaggagag ttcagcagctcccagcagactcgagtcagtcaagaggactttgtgattggctgtcttatt gatctggatacaggactcatgactttcactgctaatggaaaagagatcaacacgttttac caggtggagccacacacaaaactgttcccagcggtgtttgtccttccttcctgtcagaat atgattcagttcgaactaggcaagctcaagaacattatgccgatctcagctgccatgttc cggagtgaacgcaagaaccctgtccctcagtgccctcctagactggatgtccagatgtta actccggtcatctggagccgcatgcccaaccacttcctggctccagagacggggcgcatt agtgagagactgggctgggtggtgcagtgtcaggagccattgtccatgatggccctccac atccctgaggagaacaggtgcattgatatcctggagctttctgaacgtatggacttgctg aagtttcactatcacactctgaagctgtatggcttagtgtgcgctttgggaaacaaccgt gtggctcacgctctgtgcagccacgtggacgagtcccagctcttctacgccatagagaac acttacctacctggaccaatgaggagcggcttctatgacctgctcatcagcatgcacctg gagtctgccaagaggaaccgactgggaaccaacaaggaattcatagttcccatgacagac gaaacgcgcagtataactctgtacactcatgctttacctggggttggcctcacgacatgt ctgcgtcccaagctccatttctcctccattgggtttgttggaacagatcaaaccatctac acactgagtccagtcatccctttacaggtgctaaagaccaaggcccttaacatgctaact gaggctgtgcaagatggaggtcaagccatgagagaccctgtgggaggtagtgttgagttt cattttgttccaatcctgaagctcatcagtaccctcctcatcatgggtgtgtttgatgat gaagatgtcacacacatcctgaagatgcttgagcccacagtcttcaaagaagaagaagaa gaagaagaagaggaagaagaagatgaatatgaggatgatggcttgggtgaagaggaggag gaagaaatgctatccatcgtgctacatgaaaaaacggtggatgaggctgagcaagtaaat ggcgagaaaggcgctgaagaaacagagaaagagattaaagaggagaataaagaagaacgt ttcgagcagggactcttccagatgaagctaccagagtccgtcaaattgcagatgtgtacc ctactgcagtatttctgtgactgcgagctacgtcacagagtggaggccatcactgccttt tcggaccagtttgtgagccagatacagtccaaccagagacagcgctacaacgaacttatg ctggccttcaccatgagtgcagctgagaccgcgcggaagacgcgtgaatttcgttcccca ccacaggagcaggtcaacatgctcatgaacttcaagaactgtagtgaggatgatgagtgc cctgttcctgatgaagtccgcgacgctctgctgatttttcacaatttcctgctggctcac tgtggtgttcatattgaagaggaagaacaagaggaagaagtggacaattctctccgtggc cggctggtccgtttgttgataaaggtgaaaaaggtccgtgagaagaaggtagaagtggag cctgagccacaggaagataaaaaaccaagcacattgcaggagctgatttcccatactatg atccattgggcccaggagtcatttatccagaacccagagctcgtgcgcatgatgtttagc ctccttcacagacaatatgatgggctgggtgagctcatgcgtgctcttcccaaggcctac accatcaacggcgtgtcaattcacgacaccatggacctgctggagtgcttgggccagatc cgctcactgcttattgtccagatgggtccagaagaggagaggcttatgattcaaagcatc ggagacatcatgagtaacaaagtgttctatcagcaccccaacttgatgcgagctctgggc atgcatgaaaccgtcatggaggtcatggttaatgtacttggcggaggggactccaaggag atcagattccctcgagtggtgacgaactgctgccgctttctctgctatttctgtcgcatt agtcgtcaaaaccagcgctccatgtttgaccacctcagctaccttctccagaacagtggc atcggccttggaatgcggggctccacccccttggacgtggctgcagcgtcttgcatcgac aacaacgagctggcattggctctccaagagcaggacctagaaatggtggtgaaatattca gcagggtgtggacttcagagctgtccaatgctactgtctaaaggctaccctgacattggc tggaatccttgtgggggagagaaataccttgacttccttcgttttgctgtgtttgtcaat ggagagagtgtagaagagaatgccaatgtggtggtacgtctcctcattcgcaggcctgag tgctttggtccagccctgagaggcgagggtggtaatggtctgctggctgcaatagaggag gccattaaaatatcagaggaccctgcaagggatggccctagtgttaagaaagacagacgc tttcccatgtttggaggggaggagcagcatgaggagaacaaggtgcacttgggaaatgcc atcatgtccttctactccgcccttattgacttgctgggacgctgtgctccagagatgcat ttgatccaggctggtaagggtgaggctctgaggatcagggccatcctgaggtctctggtc cctatcgaggatctggtgggagtcatcagcctttctgttcagattccatcttttggaaaa gacaacagcatcatagaaccaaagatgtcagctagctttgtgccagatcacaaggctccc atggttctgttcctggacagagtgtacggtattgacaaccaggatttcctgctccatgtt ctggaggtgggctttctgcctgacatgagggctgctgcctctctggacacggctgctttc tgcaccacagagatggccctcgctttgaaccgctacctgtgttctgctgtgttgccactc atcacaaagtgtgccccactcttcgctggcagcgaccacagagccataatgattgactcg atgttgcacacaatctaccggctgtctcgtggacgagccttcacaaaggcccaaagagac atcattgaagagtgcctcatggctttgtgcaaacatctacgtccatccatgcttcagcac ctgctaagacggctggtgtttgatgtgcccattctcaatgagtttgccaaaatgccactg aagcttttgaccaatcactatgagcgttgttggaagtattattgcctccctaatggttgg ggcaactttggactctcatcagaagaggagctgcatctgacccgcaaactgttttggggg atctttgaatcgctagcaaaatttgatgctgagattttcaaaatttcaatgccatgcatc tgcgccattgctggagccattcctcccgactatgtggacgccagctactcctccaaaacg gagaaaaaggcctctgtagatgcagagggaaactttgatcccaaaccagtagagaccaca aacactatcatccctgaaagactggatcccttcatcaacaaatatgctgaatatactcat gacagatgggcctttgaaaagatccagaataactggtcatatggtgaggtgctggatgaa aatgcaaaaactcatcccatgctcagaccttacaaaaccttctcagagaaggacaaagag atctaccgttggccaatcaaagagtcagtcaaagccatgctggcatgggagtggaacctc gataaagctagagaggaagaagagtcagagaagaagaaggcagtgtcacggaaaatctca cagactgctcaggcaacttatgacccaagccagggctacagtccacagcccattgatgtc acacacatggctctttcaagagacctgcagtctatggcagagcaactggcagaaaattac cataacacctggggacggaagaaaaagttggagctgcagtccaaaggaggtggaacacat cctctgctggtgccctacgatactctgactgcaaaagaaaaggctcgagatagagagaag gcttatgagctgctcaagttcctgcagcttaatggatatgcttgcacaaggggcttgaaa gatatggagtctgacatctcgtccatcgagaagagatttgcttatggtttcctgcagaag ctgttgaaatggatggaaattgcccaggagttcatcgctcatcttgaggctgtggtaagc agtgggcgagtggaaaagtctcctcatgagcaggaaatcaaattctttgccaagatcttg atgcctcttatcaaccaatatttcaaaaaccactgcctctacttcttgtcgacacctgcg aaagttctggggagtggtggacattcttccaataaggagaaggagatgattgcaagtatc ttctgtaaaatgtccgctctggtgaggcacagagtttctctctttggaacggacgctcaa gcaattgttaactgtcttcacattctggcacggtccttggatgcaaggacagtaatgaag tcggggcctgagatcgtgaaagcagggctgcggtcattctttgagagtgctgctgatgat atagagaagatggtagagaacctcaaactgggcaaagtatccaaaggcaatcagcaagtg aaaggcgtgtcccagaacataaactacacaaccatcgccctgctgcccgtgcttacctcc ctgtttgatcacgttgctcagcaccagtttggagatgatgtcatgctggatgatctacag atgtcttgctatcgcatcatgtgtagcatctactcccttgggactgtcaagaatccacat gttgagaggcagcggccagctctgggagaatgtttggctcaccttgcagcagctatgcca gtggcctatttagagcctaatctaaatgaattcaacgctttctctgtctacaccacgaag tcacccagggagagagccatcttgggccttccccatgaggtccaggaattatgtccagac attcctgagctggatgctctgctaaaggagattggggagttggcagagtcgggggctcgt tatactgagatgcctcatgtgattgaaatcactctgcccatgctgtgtaactacctgcct cgctggtgggagaagggacttgagaacttccctgatatggatgggcagatctgcactgat gtcacatcagaacacctcaatcagctgctgggcagcatcatgaaaatagttgtgaacaac ttgggtatcgatgaagcctcttggatgaagaggttggctgtgttttcacagcccattgtc agcagggcaaagccagaaatgctcaagtcccattttatcccaacaatggagaagctgaag aaacgcacttcaaaggtggtggctgaagaagaccatttgcggatggaggggaaatcagag ggggatgaggaagacggcactatacgtgatgagtttgctgtcctctgcagagacttgtat gccctctaccctctacttattcgctacgtggacaacaacagggcaagatggctgacatgc ccagacccagatgcagaagagcttttccgaatggttggagaggtctttattttctggtcc aaatctcataacttcaaacgagaggaacagaactttgtggtgatgaatgagatcaataac atgtcattccttaccgctgacagcaagagcaaaatgagcaagggcggggactcagagggt ggaggctcagatacagaacgcaccaagaagaaaagacgtggagatcgttactctgtgcag acttcacttattgtggctgccttgaaaaagatgctccccataggcctcaacatgtgctct cccgccgatcaggagcttatcaacttggccaagatccgatactctttgagagacacagat gaggaagtaagagagttcctgcagaataacctccatcttcagggcaaggtggacaatcca tcaatgcgctggcagatggctctgtacaaggagatggcggggaaggctgaagatgctgac gctccaataaaagttgtcaagagagtgcaggaggtttctgctgtcctctatcaccttgaa gtgacggaacacccgtttaaatccaagaagatggtgtggcacaaacttttgtccaagcag agacgccgggctgtggtcgcttgctttaggatgacgccactatacaacattccaaggcac agagcgtcaaacatgttccttgagggatacaaacgcaattggcttcactctgagggttac tcatttgaagacaggatgataaatgacttatctaaagcaatggagcaagaggaaggagat gaagaggaggaaagagaaacaaagccagatcccctccaccagcttattctgcatttcagt cgtaccgctctgacagaaaagagtaaacttgatactgatcatctttatatggcatatgca gatattatggcaaagagttgccatattggtgaggaagaagaaggaggagaggaaatgggg gaaaatgctgaggatgagatgccgtttgaggaaaaagaaatggagaaacaaaggctcctg taccagcagtcccgacttcataaccgtggtgctgcagagatggtcctgcaaatgattagt gcctgcaaaggtgagactggcccaatggtgactacaaccctcaagctgggcatctctatc ctgaatggcggaaacagtgaggttcaacggaaaatgctggagtacttgagggataagaag gatgtaggcttctttttgagtgtccaggcattgatgcagacatgcagtgtcctggatcta aatgcctttgagaggcagaacaaagcagagggtctgggcatggtgtcagaggagggcact aatgagaaagtgatgtcggacgatgagttcacctgtgacctcttccgtttcttgcagctg ctttgtgagggtcacaacaatgatttccagaactacttgcggacacagacaggcagcaca actaccatcaacatcatcatctgtactgtagattacctccttcgactccaggagtccatc agtgatttctactggtattactctggcaaggacatcattgatgaaccaggcaaaaagaat ttctccaaagccatgacagtggcaaaacagattttcaacagcctaactgaatatattcag ggcccatgcaccggcaaccagcagtccctgacccacagcaggctgtgggacgctattgtt gggttccttcatgtctttgcccacatgatgatgaagcttgcacagggtaaagactccagc cagattggtctgctgaaggagcttcttgacctacagaaagacatggttgttatgttgctc tcactgttggagggaaacgtggtgaatggtacaattgcccgccagatggtagacatgttg gtagagtcctccagcaacgtggagatgatccttaagttctttgacatgttcctcaaactg aaggacattgtggcatcggatgctttcagtgattacgtcacagaccctcgaggtctcatc tccaagaaggacttccagaaggccatggacagtcagaaacagtactccccttctgagatc cagtttcttttgtcctgctcggaagcagatgagaacgacatgatccactatgaggagttt gccaatcgctttcaggaacctgccaaggacatcggattcaacatcgcagtgctgctcaca aacctgtctgagcacgtccctcatgacatcaggctacagaacttcctagaacaagcagaa agtgtgctgaactacttccgccccttcttgggccgtattgaaataatgggcgccagcaga aagattgagcgcatctactttgaaatcactgaagtaaaccgcaaacagtgggagatgcca caggtcagagagtccaagagacagtttatctttgatgttgtcaatggcggtgaatcagag aagatggaaatgtttgtcaacttctgtgaggacaccatctttgagatgaatatagcctcg caaatttcagagcaggaggaagagggaaaaggggaagaagatgacgaaggagaggaagtt ggaggtgaggcagcacaagcagggggatcaagcggaggaggtgatgaggagagtaacgga gaggaagggcagccagaatcaagctctgcctttgcagatttcataaacagcatgcttagc ttctttaacattttcaccttccgtaaccttcgcagacaatatcgcagagtgagaaagatg tccttcaaggagattgtggtggctttgtccacctttttctggaccatcctcatgagtata ctgcacttcatttacaacgtgtgcaaaggcttctttatgatcatctggcaaactctgttt ggaggtggcttagtcgagggagctaaaaatatcaccgtgactgagattctagcgagcatg ccagatcccacgcaggatgatgtgcatggagatggaccgggggagctaaggacaggggaa gaacaagacaccggaggtgtaatggacactggggagactgggagtggagaggaggaagag gaggatacccaggacaaagagggtgggaggataccaggtgttgatgctccaggtggactt ggagacatgggtgtagaatcacctgttgaacctccaacacctgaaggaactcccataaca aagagaaaagtggcaccagaagagacggaagctagccagaaaccgcctgaacctgttcct gtagtggaacctcctccagaaccagaaaaggctgatgttgaaacagcagagaaagaatcc cagagcaaggaggaggcgcggctagaagtcccaaagaaatctgctaagaaaaaggaaaag aagccgaaaagggaaggaggttttcaaatctggactgagctggaaaaccaaagaaataaa tttatgaactacctctccagaaacttctacaacctgcgtttcttggctctgtttcttgct tttgccctgaactttattctcctgttctacaaggtgtctgacaccccacctgagggtgac gagatggaaggatctggaatgtcggaggggagcgggtttttcgaaggctctgggttcttt gaaagctcaggggaagaggccgaggggtctggaatgaatgaagaagatgaggacgaggag gacgtaccaatttatttctatttagaggagagtactggctacatgcagcccacattgtca ttcattgctgccctgcacacagtcatctcattcatctgtatcattggttacaactgcctc aagattccactggtgatctttaaaagagagaaggaacttgccagaaagctggagtttgac ggcctctacatcactgagcagcctgaggacgatgacattaagggccagtgggaccgactg gtcttgaatacaccctctttcccaaacaactattgggataaatttgtcaaaagaaaggtt ctggataagtacggagacatttatggcagagaaagaatcgctgagcttctgggtgtcgat ttagcctccctggatgtgagtcaacaacatgacaagaaacaggaggaaccagacagcgct gtgtttgcatggacgaccaccattgacatcaagtaccagatctggaaatttggcgttgtg ttcacagacggtaccttcctatatctctgttggtacacgataatgtctttgcttgggcat tacaacaacttcttctacgcctgccacttgctggatattgccatgggtgtcaagactctg cgcactatcctgtcctcagtcacacacaatggcaaacagctcatgatgacagtgggcttg ttggcggtggtggtgtacctttacactgtagttgccttcaacttcttccgcaagttctac aacaagagtgaagatgaagatgaaccagatatgaaatgcgacgacatgatgacttgttac ctgttccacatgtacgtgggtgtgcgtgctggtggaggcatcggagatgagatagaggat cctgctggagatgaatatgagctttatcgagtggtctttgatataacgttcttcttcttc gtcattgtcattctactggccatcattcagggtctcatcattgacgcctttggagaactc agagaccaacaagagcaggtcaaggaagacatggagacaaaatgcttcatatgtggcatt ggaagcgactactttgatacaacgccacatggctttgagacccacactttggatgaacac aacttggccaattacatgttcttcttaatgtaccttatcaacaaagatgagacggagcac actgggcaggagtcctacgtgtggaagatgtatcaagagcgttgctgggacttctaccct gctggagactgtttcagaaagcaatatgaggatcagctttcctag

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