Clupea harengus (Atlantic herring): 105888788 Help Entry 105888788         CDS       T09045                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism char  Clupea harengus (Atlantic herring) Pathway char04020   Calcium signaling pathway char04260   Cardiac muscle contraction char04261   Adrenergic signaling in cardiomyocytes char04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:char00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105888788 (ryr2a)    04020 Calcium signaling pathway     105888788 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     105888788 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     105888788 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:char04040]     105888788 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:char04990]     105888788 (ryr2a) Ion channels [BR:char04040]  Voltage-gated cation channels   Ryanodine receptor    105888788 (ryr2a) Domain-containing proteins not elsewhere classified [BR:char04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    105888788 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Hydantoinase_B Motif Other DBs NCBI-GeneID:  105888788 NCBI-ProteinID:  XP_031416798 Ensembl:  ENSCHAG00000012851 UniProt:  A0A6P8EL93 LinkDB All DBs Position 23:6630043..6747932 Genome browser AA seq 4978 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATINKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKHEGQVDVEKWKFMMKTAQGGGHRTLLYGHAVL LRHSYSGMYLCCLSTSRSSTDKLSFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNESLQVDAAFQQTLWSVAPICSGSEVAQGGYLSGFLIGGDVLR LLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSTHARSLWRLETLRVAWSGSHTRWGQPF RLRHVTTGKYLSLLDDKSLLLVDKERADIKSTAFCFRSSKEKLDLGLKKEVEGMGVAEIK YGDSVCYIQHVDTCLWLTYQAVDAKCARMGGIQRKAIVHHEGHMDDGLTLSRSQHEESHT ARVIRSTVFLFNSFIRGLDFLSKKGKTSTLDLPIESVSLSLEDLIGYFQPPEDHLEHEDK QNRLRALKNRQNLFQEEGMINLVLECIDQLHVYSSAAHFADVAGKEAGEAWKSILNSLYE LLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIK SIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTQLVNQVISM RPNIFLGISEGSAQYRKWYYELIVDTVEPFITAESSHLRVGWASTHGYSPYPGGGEGWGS NGVGDDLYSYGFDGLHLWSGCIARTVSSPSQHLLRSEDVVSCCLDLSAPSISFRINGQPV QGMFENFNSDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPSYAPCFEAVLPREKLRVE HTQEYKQDHGATRDLLGPTLTLSQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVM NKIELGWTYGVIRDDNKRQHPCLVEFSKLPEQERSYNLQMSVETLKTLLALGCHVGMADE HAVEKVKKLKLLSKYELSGGYKPAPMDLGHIRLVSPQEAMVDKLAENAHNVWARDRIRQG WTYGILQDVKSKRNPRLVPYALLDERTKKSNKDSLREAVRTLLGYGYSLEAPDQDHASRA DMNNMSAERFRIFRAEKTYSVSVGKWYFEFEMVTSGEMRVGWARPTCMPDQELGSDEHAF VFDGFKAQRWHQGNEHFGRPWLAGDVVGCMVDMSEHTMMFTLNGEVLLDDSGSELAFKDF EIWEGFIPVCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDLTMWLSKRL PQFIPVPSNHEHIEVTRIDGTVESSPCLKVTQRSFGSQNSSSDIVFYRLSMPIECAEVFC RSPGSALPSNGRFFSSKKDLDDLETESDFEVLMKSSHGHMGSSGPEKDTDEFNNHKDYNQ EKPSKFKPRFMLKKTKPEFNTSQSSARLPEEVMADERDDSGYIMQTSTYYYSVRIFPGQE PSSVWVGWVTSDFHQYDAAFQQDKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGDCTSPG QGRNNNGLEIGCLVDCVNGVLTFSSNGKELSTFYQVEPSTKLFPAVFAQATSPNVFQFEL GSIKNVMPLSAGLFKSERKNPMPQCPPRLHVQYLTPVLWSRVPNRFLRVEVARVSERLGW QVQCHEPLQFMSLHIPEENRSVDILELTEQRELLKFHYHTLRLYSAVCALGNNLVAHSLC SHVDESQLLYAIENKHMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTDETKSIT LFPDEQKKHGLPGIGLSTSLRPRMRFSSPSFVGTDKSLSGDCFQFSPEFPLEILKTKTME MLTEAVCEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGVFHNGDLRIILQLIEPSVFSK EDKSTSAPTHPAESAPLGEKTEAQRKGAGEVEGERTTKVPKEGLLQMKLPEPVKLQMCHL LQYLCDCQVRHRIEAVVGFSDDFVANLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPP QEQINMLLGFKDEKQDCPCPEEIREQLLDFHQDLMTHCGIELDDDKLGEVDGDFTIRGRL MCLVEKVNYLKKKMADLPKKKKVKKPSTLQQLISETMVRWAQECVIEDPELVRAMFVLLH RQYDGIGGQVRALPKTYTINTVSVEDTIHLLASLGQIRSLLSVRMGREEEKLMIRGLGDI MNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQ NQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYL AGCGLQSCMMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPE CFGPALRGEGGNGLLAAMREAIKISEDPCRDGPSPIAEASRTLSETLEDEEDDTIHMGNA IMTFYAALIDLLGRCAPEMHLIYAGKGEAIRIRAILRSLIPLDDLQGVIGIPFRMPTLAK DGSVVEPDMSGGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTPAL SATDMALALNRYLCTAVLPLLTKCAPLFAGTEPYASLIDSLLHTVYRLSKGCCLTKAQRD AIEECLLAVCGQLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYDRCWKYYCLSGGW GNFGVASDEELHLSRKLFWGIFDALSRKKYEQELFKLALPCLSAVAGALPPDYMESNYVA QMEKQSSMDAEGNFNPQPVDTANVVIPEKLDNFITKYAEHSHERWSMDKFTTGWAHGDQV CESAKTHPLLKPYKSLSEKDKEIYRWPIKESLKTVLAWEWIIERSREGDATSLHNRTRRM SLSSQHSMEGSHGFSPRPIDMSNVTLSRDLHAMAELLAENYHNIWAKNKKSELEAKGGGS HPLLVPYDTLTAKEKSRDREKAQDILKFFQINGYNVSRIKKEQELDTPSIEKRFAYTFLL QLITYVDQAHEHMLEFDASDQPKGDKMCHEQQMKFFGKVVLPLVDQYFKNHHLYFLSTAL RPLSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMK TGLDTVKAALRAFFDNSAEDLEKTLENLHQGQFTHTRTQPKGVTQIINYTTVALLPVLSS LFEHITQNMFGEDIILDEIQVSCYRILNSLYSLGTSKSMYVERHRPAIGECLAAFSGAFP VAFLEPQLNKYNSHSIYNEKPSRERTTLGLPAQVEEVCPLVPSLEKSLEEIMELAESGMS YTQMPHVMEVVLPMLCSYMSRWWDHGPENNPERTQSCCTSLTSNHMNTLLGNILKIIYNN LGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFLPLMEKLKKKSAIVHADEELMKAEGRGE MSESELLILDEFTVLVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEIFIFWA KSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKGAVSDQERKKNKKKGDRYSMQTSLIV AALKRLLPVGLNICAPGDQELIGLAKNRFSQKDTEAEVREIICNNLHLQGKLEDPAIRWQ MALYKDMPNRSEDTSDPQKTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAV VACFRMAPLYNLPRHRAVNLFLQGYLRSWIETEEHYFEDKLIEDLAKPGGEEPSEEDEAT KDIDPLHQLIQLFSRTALTEKCKLEEDALYMAYADIMAKSCHDEEDEDGEEVKSFEEKEM EKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAGLNGGNSTVQQKMLD YLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVISHERGEKVMQDD EFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYS GKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAH MQMKLSQDSSQIDLLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMI LKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETDFLLSCVETD ESELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPFL GRIEIMGSARRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFC EDTIFEMQLAAQMSDASERLASKEDSERGEKPEEESPELGFFSVTTVRTALLALRYNVMM LMKVLSMKSLKKQMKRAKKMTLQDLVMALAAFYWSVLIGLLHFAFSVSRGFFRIIYNTFL GGSLLDGAKPLKMSDLLTSLPDPTQEELRGEAEEGGEKKSIEKISTKEDLSDLAVAPDET EVLSDIFGLDLRREGGQYKLMAHNPNASLTSLTSPIPAPSPSPELRRRHEVKETSKEETE GTEAIKSQPEKAEEEHVEKVEDKKQLKPKQRVRQIHVTKSEEPDLQESALFKKIIIYQRK LLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSAVVEEKEVLRSPVDAGLHWNPLGD DPDRTMTVHFVLEESTGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARK LEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISEL LGMDKAALDFSDAHEKRKPKKDSSLAAVLNSIDLKYQIWKLGVVFTDNSSLYLAWYMTMS ILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFF RKFYNKSEDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDIT FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHT LQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14937 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggagaaggcgaagatgaaattcagtttttgcgaaccgacgatgaggtg gtgctgcagtgctctgccaccatcaacaaggagcagcagaagctgtgtctggcagcggag ggctttggaaacagactctgctttcttgaatctacttccaattcaaagaatgtcccccca gacctgtccatatgtactttcgtccttgagcaatcactctcggtccgcgcccttcaagag atgcttgcaaacacagaggaaaaacatgaggggcaagttgatgtggaaaaatggaaattc atgatgaagaccgcccagggtgggggccatcgtactttgctctatggccatgcagttctc cttagacactcgtatagtggaatgtacctatgttgtttatcaacttcacggtcctcaaca gataaactatcatttgatgttggtcttcaagaggacacaacaggtgaggcatgttggtgg actattcatcctgcctccaaacaacggtcagaaggagaaaaggtgcgcgtcggtgatgac ctcattctggtcagtgtttcctcagaacgctacttgcacctgtcctatgggaatgagagt ctgcaggtagatgcagccttccagcagaccctctggagcgttgcccctatctgctccggg agcgaggtggcacaaggtggatatctttctggcttcttgatcggaggggatgtgttgcgc ctgctccacggtcacatggacgagtgcctgacggtgccatctggagagcatggggaggag cagcgcaggactgtacactacgaggggggagctgtatccactcacgcccgctccctctgg agactggagactctgcgagttgcatggagtggcagtcacacgcggtggggccagcccttt cgtctccggcacgtaaccaccgggaagtacctgagcctcctggacgacaagagcctcctc ctcgtggacaaggagagggctgacatcaagtccacagccttctgcttccgttcctccaag gaaaagctggacttgggcttgaagaaagaggtggagggcatgggtgtggctgagattaaa tatggtgactctgtgtgctacatccagcatgtggacacgtgtctgtggctgacataccag gccgtagacgctaaatgtgctcggatgggtggaatacagaggaaggctatagtgcatcat gaaggtcacatggatgatgggctgacactgtcacgctctcagcatgaggagtcacacacc gcccgtgtcatccgcagcacagtcttcctcttcaacagcttcattaggggtctagatttc ttgagtaagaaagggaagacttccacgctagacttgcccattgaatctgtcagcttgagt ctagaggatctgattggctactttcagcctccagaggaccatttagaacatgaggacaaa cagaaccgcctccgtgctttgaagaaccggcagaacctctttcaagaggagggtatgatt aacctggtgttggagtgtattgaccagctacatgtatatagcagtgcagcccattttgct gatgttgctggaaaggaggctggggaagcttggaaatctatactgaactccttatatgag ctgctggctgccctcataaggggtaaccggaagaactgtgcccagttctcaggctctttg gattggctcatcagtcgtttagagcgccttgaggcttcttctggaatcttagaagttttg cattgtgtcttggtggaaagtccagaagccttaaacatcattaaagaggggcatatcaag tccattatctctcttctggacaaacatggacgtaaccataaggtgctggatgtcctgtgt tccctgtgtgtgtgccatggtgttgctgtgcgatccaaccagcacctcatctgtgataac ctcctgccaggacgagacctgctgctgcagacgcagctcgtcaaccaggtcatcagcatg aggcccaacatcttccttggcattagtgaaggttctgcccagtacaggaagtggtactat gagctcatcgtggacaccgtggagcccttcatcactgctgagtcgtcccacctgcgagtg ggctgggcctccacacacggctactctccctacccaggaggaggggagggctggggcagc aatggtgttggtgatgacctgtactcctacggcttcgatgggctacatctgtggtcaggt tgcattgcccgtacggtcagctcccccagccagcacctcctgcgctcagaggacgtggtc agctgctgcctggacctcagcgcccccagcatctcctttcgcatcaatggccagccggtc cagggcatgtttgagaacttcaactctgatgggctcttcttccctgtggtgagcttctca gctggagtcaaggtgcgtttcctgttgggtggtcgtcatggtgagtttaagttcctgccc ccaccaagctatgctccctgttttgaggcggtgcttcctcgagagaagctgcgcgtggag cacactcaggagtataagcaggaccatggagccaccagagacctgctggggcccacactc accctctcacaggctgccttcacccccatcccagtggacaccagccagatcgtgctgccc cctcacctggagcggattcgtgagaagcttgctgaaaacatccatgagctctgggtgatg aacaagattgagcttggctggacatatggcgtgatacgggatgacaacaagagacagcat ccctgtctggttgagttctccaagcttccggaacaagaacgcagctacaacctgcagatg tctgtggagacacttaagacccttctggcactaggctgccatgttggcatggcagatgaa cacgctgttgagaaagtcaagaagctgaagctcctatccaaatatgaactctccggtggg tacaagcccgctcccatggacctgggtcacatcagactcgtctccccccaggaggccatg gtggacaagctggcagagaatgcccacaatgtctgggccagggaccggatccggcagggc tggacgtatggcatcctacaggacgtgaagagcaagaggaacccacgactggttccatat gcgttgctcgatgaacggaccaagaaatccaacaaagacagcttgcgagaagcagtgcgt acattactaggctacggctacagccttgaggccccagaccaagaccatgcatccagagca gacatgaacaacatgtcagccgagaggtttcgtatcttccgtgctgagaagacctacagt gtgagcgtggggaagtggtactttgagtttgagatggtgacctctggggagatgagggta gggtgggcccgaccaacctgcatgcctgaccaggaactgggctctgatgaacacgcattt gtctttgatggcttcaaggctcagcggtggcaccagggcaatgaacacttcgggcgccca tggctggcaggagatgtggtgggatgcatggtggacatgagtgaacacaccatgatgttc actctcaatggagaggtgctgctggacgactctggatcagagctggcctttaaagatttt gaaatttgggaaggattcatccctgtgtgtagtctgggtgtgtgtcaggttggccgcatg aactttggcaaggatgtgagcacgttgaagtacttcacaatctgtggcctgcaggagggt tatgagccttttgctgtaaacatgaaccgtgatctgaccatgtggctaagcaagaggctc cctcagttcataccggtcccttcaaatcatgagcacattgaggtcacaaggatagatggg acagtggagagctcaccatgtctaaaggtcacccagaggtcatttggctcacagaacagc agcagcgacattgtcttttaccggttaagtatgcccatcgagtgtgcagaggtcttctgt cggtctccaggcagcgcactgccctcaaacggtagattcttctcctcaaagaaggacctg gatgacctagaaacagaatctgactttgaggtgttgatgaagagttcccatggtcacatg ggctccagcgggccagagaaggacactgatgagttcaacaaccacaaggactacaaccag gaaaagccatccaagttcaagccaaggtttatgcttaaaaagacaaagccagagtttaac accagccagtcatcagcacgtctgcctgaagaggtgatggcagatgagagggatgactct gggtatatcatgcagacctcaacgtactattactctgtaaggatcttccctggccaggag ccatcgagtgtgtgggtgggttgggttacatcggatttccatcagtatgatgctgccttt cagcaagataaggttcggacggttactgtgacccttggagacgagaaaggaaaggtccat gagagcatcaagcgcagtaattgctacatggtatgggcaggcgactgcaccagccctggt cagggtcgaaacaacaatggcctggagatcggctgcctggtggactgtgtcaatggggtg cttaccttctccagcaatggcaaagagctcagcaccttttaccaggtggagcccagcacc aagctgttccctgcagtgttcgcccaggccaccagccccaacgtctttcagtttgagctg ggcagcatcaagaatgtgatgcccttgtctgctggcctttttaaaagtgaacgtaaaaac ccaatgcctcagtgtcctccccggctgcacgtgcaatacctgacgcccgtgctgtggagc cgcgtgcccaaccgcttcctgagagtggaggtagcacgtgtcagcgagcggcttggctgg caggtgcagtgtcacgagccgctgcagttcatgtccctccacatccctgaagaaaacagg tcagtggacatcctggagctcacagagcagagggagctgctgaagttccactaccacacg ctccgcctctactctgctgtctgcgcactgggaaacaacctcgtggcccactccctgtgc agccacgtggacgagtcccagctgctctacgccattgagaacaagcacatgcctggcctg ctgcgggccggctactatgatctgctgattgacatccacctgagcagctatgccaccgca cgcctcatgatgaacagtgagttcatcgtccccatgacagacgagactaaaagcatcact ctcttccctgatgagcagaagaagcatgggctcccgggcatcggcctgagcacctcactt cgccctcgcatgcgcttctcctcccccagcttcgtgggcacagacaagagtcttagtggt gactgcttccagttcagccctgagtttcctctggagatcctgaagaccaagaccatggag atgctgacggaggctgtgtgtgaggggagtctccatgtgcgtgaccctgtagggggaagc acagagttcctgtttgtgccactcatcaaactcttctacacactgctcattatgggcgtc ttccacaatggtgacctgagaatcattctgcaactcatcgagcccagtgtcttctccaag gaagacaagagcacctctgcccccacccacccagctgagagcgcccccctcggggagaag acagaggcacagaggaaaggagctggggaggtggaaggagaacggacaaccaaggttccc aaagaaggtctgctccagatgaagctgccagagccagtcaagcttcagatgtgtcatctg ctgcagtacctgtgtgactgtcaggtgcgtcaccggatcgaggcggtggtgggcttctct gatgattttgtggcaaacctgcaggacaaccagcgtttccgctacaatgaggtcatgcaa gccctgaacatgtcagcagcacttacagctcggaagaccaaagagttccgctcccctcca caggaacagattaacatgctgctaggcttcaaggatgagaagcaggactgtccctgtcct gaagagatcagagagcagctgttggacttccaccaagacctcatgactcactgcggaatt gagctggatgatgacaagcttggcgaagtggatggagacttcacaatacgtggtcgtctt atgtgtctggtggaaaaagtgaattacttgaaaaagaaaatggccgatctgccaaagaaa aaaaaagtaaagaaaccaagcactcttcagcagcttatctctgagactatggtgcgctgg gctcaggagtgtgtcatcgaggacccagagctggtcagagccatgtttgtgctcctgcat cggcagtatgatgggatagggggacaggtgcgggccttgcccaagacctacaccatcaat actgtatctgtggaggacaccatccacctgctagcctctctaggccagatacgctcactc ctcagcgtccggatgggccgtgaagaggagaagctcatgatccggggcctgggagatatt atgaacaacaaagttttctatcagcatccaaatctaatgagggccttggggatgcatgag acagtgatggaggtgatggtgaacgtgttgggtggtggagaatcaaaggaaattactttt cctaagatggtggccaactgctgtcgttttctctgctacttctgtcgcatcagtagacaa aaccaaaaagccatgtttgatcacctcagttacttgctggagaacagcagtgtgggactt gcctctccttccatgcgaggttcaactcctctggatgtggctgccgcctcagtgatggat aacaacgagcttgctttggccctgagggaaccagacctggagaaagtggtgcagtatctg gcaggctgtggactccaaagctgcatgatgttggtctcaaaaggctaccctgacattggc tggaaccctgttgaaggagagcgttacttggacttcctgcgttttgctgttttctgcaat ggagagagtgttgaggaaaatgctaatgtggttgtgaggctcctgattcggaggcctgag tgttttggacctgccttacgaggagagggtggaaatggcctcctggctgccatgagagaa gccatcaagatctcagaagacccctgtagggatggaccctcacctatcgctgaggccagc agaacactgagtgaaactctggaggatgaagaagatgacaccatccacatgggcaatgcc atcatgacattttacgctgccctcattgacctgctggggcgctgtgctccagagatgcat ctgatctatgctgggaagggcgaggccattcggatcagggcaattctacgctctttaatc ccccttgacgacctgcagggagtcatcggtatcccattccgcatgccgactttagccaaa gatggatccgtggtggagcctgacatgtccggaggcttctgcccagaccacaaggccgcc atggttctgttcctggaccgggtctatgggattgaagatcagaatttcctgctgcacctc ctggaggtgggcttcctgcctgatctccgtgctgcagcttcactcgacacaccagccctg agtgctacagacatggcgctagccttgaaccgctacctgtgcacagctgtgctgcccttg cttactaagtgtgccccactgtttgcgggcacagagccgtacgcctcgctcattgactct ctgctgcacactgtgtaccgcctgtccaagggctgctgcttgaccaaggcccagagggat gccatcgaggagtgtctgctggctgtgtgtggtcaactgaggccctccatgatgcagcat ttactcagaaggctggtgtttgatgttcccctgctgaatgaacacactaaaatgcccctt aaactgttgactaaccactatgaccgctgctggaagtactattgcctgtctggaggttgg ggcaactttggagttgcttctgacgaggagcttcatctctccaggaagctgttctggggg atctttgatgctttgtcgaggaagaagtacgagcaggagctgtttaagctggcgctgccc tgcctgagcgcggtggctggagctctgcccccagactacatggagtccaactatgtggcc cagatggagaagcagtcttctatggatgcagaggggaacttcaacccccagccagttgat actgcaaatgtggttatccctgaaaaactggataatttcatcaccaaatatgcagagcac tcccatgagaggtggtccatggataagttcaccacaggctgggctcatggtgaccaggtc tgtgagtccgccaagacacacccccttctaaaaccatacaaaagcttgtcggagaaggac aaagagatttatcgctggcccataaaggaatccctaaagaccgtcctggcatgggagtgg atcattgagaggtcaagagagggtgacgccaccagcctgcacaaccgcacacgccggatg tctttatcgagtcagcactctatggagggcagtcatggcttcagcccaagaccgatcgac atgagtaatgtgactctctccagagacctgcatgccatggctgaactactcgcagaaaac tatcataacatatgggcgaagaataagaaatctgagctcgaagccaaaggtggagggagc caccctttgctggtaccgtatgacacactaactgccaaagagaagtccagagacagagaa aaagcacaagacatcctgaagttcttccagatcaatggctataatgtgtctaggattaag aaggagcaggagctggacacgccctcaatagagaagcggtttgcttacaccttcctactg cagctcatcacctatgtggaccaggctcatgaacatatgctggaatttgatgccagtgat cagccaaaaggagacaaaatgtgtcatgagcagcagatgaagtttttcggaaaggtggtc ttgcccctagtggatcaatacttcaaaaaccatcacctgtacttcttgtccactgcacta cgccctctcagcagtggtggacacgcctccaacaaggagaaagaaatggtgacgagcctc ttctgcaaacttggagttcttgtcagacataggatatcactgtttggaaatgatgcgact tccattgtgaactgtctccacattcttggacaaacacttgatgccagaacggtgatgaag acggggctggacacagtgaaggcagccctacgggcgttctttgacaactctgctgaggac ttggagaaaactctggagaacctccaccaaggccagttcactcacaccaggactcagccg aagggggtgactcagatcatcaactacaccaccgtggctctgctgccagtgctctcctct ctctttgagcacatcacacagaacatgtttggggaggacatcatacttgatgagattcag gtgtcctgctataggatacttaacagcctgtactcactgggcaccagcaaaagcatgtat gttgaaagacaccgcccagccataggggagtgtctggctgccttctcaggagcgttccct gttgccttcctggaacctcaactcaacaaatataatagtcactccatttacaatgagaag ccctcacgggagagaacaactcttggactccctgctcaggtggaggaagtgtgtcctctc gttccgtctcttgagaagtccttggaggagatcatggagctggcggagtcaggcatgagt tacacccagatgccccatgtgatggaggtggtgttgcccatgctgtgcagctacatgtcg cgctggtgggaccacgggccagagaacaaccctgagcgaacacagagctgctgcacctca ctcacatccaaccacatgaacacgctgctggggaacatcctgaaaatcatctataacaat ctggggattgatgaaggagcctggatgaagcgtctggcggtcttctctcagccaattatc agcaaggccaagcctcagctgttgaagacacatttcctgcctttgatggagaaactgaag aagaagtcggccatagtgcacgctgatgaggagctgatgaaggctgagggtcgaggagag atgtctgagtcggagcttctcatcctagatgagttcaccgttcttgttcgtgatctatat gctttctatcctctcctcatacgatttgtggattacaacagggcaaaatggcttaaagaa cctaacccggaggcagaggagttgttccgcatggtggcagaaatctttatattttgggca aaatctcataacttcaaaagggaggagcaaaactttgttgttcagaatgagataaacaac atgtctttcctcattacggataccaagtcgaaaatgtcaaagggggcagtgtcagaccag gagaggaagaagaacaagaagaagggagaccggtactcgatgcagacctctcttattgta gctgctctcaagaggttgctgcctgttggcttgaacatctgcgctccaggagatcaagag ctgattggacttgccaagaatcgcttctctcagaaagatacagaggcagaggtacgggag atcatatgcaacaatctccatcttcagggaaaactggaggatcctgctattcgctggcag atggctctatataaggacatgcccaatcgtagtgaggatacctcagacccccagaagact gtggagagggtgcttgatattgcccacgtgcttttccacctggatcaggttgaacatccc cagaggagtaagaaagccgtgtggcacaagctcctgtccaagcagaggaagagagccgta gtggcctgtttcaggatggcacctctctataacctgcccaggcatcgagcagtcaatctc ttcctccagggctacttgagatcctggatagaaacagaagaacactactttgaagacaag cttattgaagacttggcaaaacctggaggagaggaaccatctgaagaggatgaggccacc aaggacatagacccccttcaccagctcatccagctgttcagtagaactgcactgacagag aagtgtaagctggaggaagacgccctctacatggcttatgcagatatcatggcaaagagc tgtcatgatgaagaggatgaagatggtgaggaagtgaaaagttttgaagagaaagagatg gagaagcagaagctcctttaccaacaggcacggcttcatgatcgaggtgctgctgagatg gtccttcaaaccatcagcgcaagtaaaggggagatgggaccaatggtggcatcaacatta aagctgggaattgccggactaaatggaggaaactccaccgtacagcagaaaatgctggac tatctgaaagataagaaagatgtgggcttcttccagagtttggcaggtctcatgcagtcc tgcagtgttctagatctcaacgcatttgagaggcaaaacaaagctgaaggcctggggatg gtgactgaggaaggctcagtcatcagtcatgagcgtggagagaaggtgatgcaagacgac gagttcacctgtgacctctttcgcttcttacaacttctctgtgaaggacataactcagat ttccaaaattatctgagaacacagactggaaacaacacaactgtcaacatcattatatct acagtcgactacctcctcagagtccaggagtctatcagtgatttctactggtattattct ggtaaagatgtcattgatgaacaggggcaacgcaatttctccaaagctatcaatgtagca aagcaagtcttcaacaccctgactgagtatatacaggggccatgcacaggaaaccagcag agtctagcccatagtcgcttatgggacgcagtggtcggctttctgcatgtgttcgctcat atgcagatgaagttgtctcaggattcgagccaaattgatttactgaaggagttaatggat ctccaaaaagacatggttgtgatgttactgtccatgttggaaggcaatgtggtcaatggg accattgggaagcagatggtggacatgctagtggaatcttccaacaatgtggagatgatt ctgaagttctttgacatgttcctcaagctgaaagacctgacgtcctcggatgccttcaaa gaatatgaccccgacgggaaaggggttatctcaaaacgagattttcataaggcaatggag agtcacaaacactacacccaatctgaaacagacttcctgctctcctgtgtagagacagat gagagtgagcttctcgactatgaggagtttgtagaaaggttccatgaaccagcaaaagac attgggtttaatgtggctgtacttttgaccaacctttcagagcatatgccacatgattca cgccttcaaactttcctcgagttggctgagagtgtgcttaattacttccagcctttcttg ggccgcattgagataatgggtagtgccaggcgcattgaacgtgtttactttgaaattagt gaatctagccgcacacagtgggagaagccacaggtaaaagagtccaaacgacagtttatc tttgatgttgtcaatgaaggaggcgagaaggaaaagatggagctttttgtaaatttctgt gaagacactatttttgagatgcagcttgcagcacaaatgtcggacgctagtgaacgcttg gccagcaaggaggacagcgagcgtggagaaaaacctgaggaggaaagccctgagttaggc ttcttctccgtgaccactgtaaggacagcccttctggctctacgctacaatgtgatgatg ttgatgaaagtgctttccatgaagagtctcaagaaacagatgaagagggccaagaaaatg acactgcaggacttggtaatggcacttgcagccttttactggagtgtgctgattggactt ctgcattttgcgttcagcgtctcacgtggcttcttccgtatcatatacaataccttcctt gggggtagtctgttggatggtgccaagcctttgaaaatgtctgacctcttgaccagccta cctgacccaacacaggaggagttgcgtggggaggctgaggaaggaggtgaaaagaaatca attgaaaagatatcaacaaaggaggacttgtctgacctcgctgttgctccagatgaaaca gaagtcctctcagacatctttggcttagatttacgaagagagggggggcagtataagtta atggctcacaatccaaatgccagtctgacttcacttacctccccgatacctgctcccagt ccctcccctgagcttagaagacgacatgaggttaaagaaacatcaaaggaggaaacagag ggaacagaagcaatcaagtcccagccagagaaagcagaagaagaacatgtggagaaagta gaagataagaaacagctgaagccaaagcagagggtcagacagatccatgtcactaaatca gaggagccggacctgcaggaatcggctctcttcaaaaaaattattatctaccagaggaag cttcttaactactttgccaggaacttctacaacatgaggatgttggcattgtttgtggct tttgccatcaactttatccttctcttctataaggtgtctacatcttcggctgtggtggag gagaaggaggtcttacgaagcccagtagatgctggcctacactggaatcctctgggtgac gaccctgatcgcactatgactgtacacttcgtcctggaggaaagcactggttacatggag cccactctgagaatccttgccatcctgcacacagtcatctctttcttctgcatcatagga tactactgcctgaaggttcccttggtgatcttcaagcgtgaaaaagaggtggctagaaag ctggagtttgatggcctgtacattactgagcagccctcagaggatgacatcaaaggccag tgggataggctggtcatcaatactcagtcatttcctaataattactgggataagtttgtg aaaagaaaggtgatggacaagtatggggagttctatgggcatgatcgcatcagtgagctg ctggggatggacaaagctgccctggacttcagtgatgcgcatgagaagagaaagcccaag aaggacagttcattagctgctgtattaaattccattgatttgaagtaccagatttggaaa ttaggagtcgtcttcacagacaattcctccctgtatctggcctggtacatgaccatgtcc atcctgggacactacaacaacttcttctttgcagcccacctcctggacattgccatgggc ttcaagaccttgagaaccatcctgtcctctgttacccacaatgggaaacagctggtactc acagtcggcttgcttgcagtagtggtttatctttacactgtggtggccttcaacttcttc cgcaaattctacaacaagagtgaggatggggagtccccagacatgaagtgtgatgacatg cttacatgctacatgttccacatgtacgttggcgtgcgggcaggaggaggcattggggac cagatagaggacccagctggggacgaatatgagatctaccgcatcatctttgacatcacc ttcttcttttttgtgattgtcattctgctggccatcattcaaggtctcataatcgatgct tttggtgaactgcgagaccaacaagaacaggtgaaggaggacatggagaccaaatgcttc atctgtggaatagggaatgactactttgatactgtacctcatggctttgaaacacacaca ttgcaggagcacaacttggcaaactatctattttttgtgatgtatctcattaataaagat gaaacagagcacaccggacaggaatcatatgtctggaaaatgtaccaggagcgctgctgg gagtttttccctgcaggagactgtttccgtaaacagtatgaagaccagctcaactag

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