Clupea harengus (Atlantic herring): 105906092 Help Entry 105906092         CDS       T09045                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism char  Clupea harengus (Atlantic herring) Pathway char04020   Calcium signaling pathway char04260   Cardiac muscle contraction char04261   Adrenergic signaling in cardiomyocytes char04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:char00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105906092 (ryr2b)    04020 Calcium signaling pathway     105906092 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     105906092 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     105906092 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:char04040]     105906092 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:char04990]     105906092 (ryr2b) Ion channels [BR:char04040]  Voltage-gated cation channels   Ryanodine receptor    105906092 (ryr2b) Domain-containing proteins not elsewhere classified [BR:char04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    105906092 (ryr2b) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 Motif Other DBs NCBI-GeneID:  105906092 NCBI-ProteinID:  XP_031434601 Ensembl:  ENSCHAG00000010078 UniProt:  A0A6P8GCL9 LinkDB All DBs Position 13 Genome browser AA seq 4960 aa AA seqDB search MTEPGEVEDEIQFLRTNDELVLRCSLAAQQRQQKFCLAAEGFGCRLCFLETTSNSKNVPV DLSICVFVLAQCLSVRALQEMLAKQCDQQTGAVEMGSHRTLLYGQAVLLRHAYSGMYLCC LSTTCSSTDKLAFDVGLQEEIIGEACWWTVEPASKQRSEGEKVRVGDDLILVSVSSERYL HLSLSNCNSSGDEGGGLRVDAAFQQTLWSVASVSSGSGVAQGFLKGGDTFRLLHGHTDEC LTVPPVDHGEEERRSVYFEGGSVSSQAGSLWRLETMRVAWSGSHTQWGQLFRLRHVTTGM YLSLMQEKGLRLIEREKADAKATAFCFRSSKEKLDIVQKKDVDGMGTPEIKYGDSVCFIQ HLGSGLWLTYQTGHGKSGRMAGAPRQAILHLEGHMDDGLTLSRSQTEESRAAQIIRSSVL LFSHFIRGLDDLGQRANLPMTPALPIARVRLSLQDLISYLRPPDEDQGQEERQNNMRALK NRQNLFQEEGIIGYALDCIDRLHAYGSAAHFAEVAGKEAGEECEALLNSLYELLASLIRG NRNNCAQFSGSLEWLIGRLEKLDASSGILEVLHCVLEESPEALNFIKEGHIKSIISLLDK HGRNHKILDVLCSLCVCHGMAVRSNQHYICVNLLPERDLLLQTRLCNQVTSVRPSVFLCM SEDSAQCRKWYFELVVEKAEPFVTAEPTHLRVGWACAEGYCPSPTGGDGWGPNGAGDDLY SYGFDGLHLWAGGIGRRVNSPNQHLLKEDDVVSCCLDLGALCMSFRVNGLPVQGMFENFS TEGLLFPVASFSAGVRVCFLLGGRLGEFKFLPPPGFSPVSEALLPRVRCRVEPCLDFMRH RNSSQQDLLGPWVAPNPPTFTPVPVDTSQVAFPPQLEQIRDELAENLHELWLISMVDQGW IYGPVKEENKKHHPDLVEFSKLPDPEKNLNLQAAQDTLRTLLALGVHIGLLDDHADEKVK YIRLSNKYELWNGYRPAPVDLSHLTLTAAQEAIVDCLAENEHNVWAKERIRQGWSYGPQQ DVKSKRSPHLVPFSLLDERTQRSGSETVRDALCTILAYGYTVEPLDQEQMVLPDAGVALV ENFRIFRVERAYAVLKGKWYFEFEAVTSGEMKVGWARPGSKPDLELGSDDQAFVFDGCKG RIWHQGSEQLGLSWQMGDVVGCMLDLEQCTMMFTLNGELLLNNHGSELAAKQFAVQDGFV PVCSVGVNQVGRLKLGHPGSLRYLSVCGHQEGYQPFAHNMSRDVPLWMSWKQPHFTPVPP DHGHIQVTRLDGTVDRSPCLKVTQKSSGSQVTSGSVSSDIGYYRLSMPIECAEVFSRPAE GAVPCSSTAYYPKRDSEEGDIDSDFEVLMKSARRHAGSRDELNNHKDHGQEKPSRLKQRF MLKRPKPELHPSHSSARLLEEVVAIEKDEDKLLSHCSAYYYSVRVLPGQDPSCVWVGWVT SSFHRQQQGFDLERVRRVTVTLGDEQGKVHESVKRCSCFMVCATEAVGQTHSRSSTQLEI GCLVDTATGLLTFTANGKELDTYYQVEPCTKLYPAVFAKATSSDMFQFELGRIKNVMPVS AGMFRDERGNPVAQCPPRLQVQHVVPFRWLRVPDNLPRVEVTRMDERHGWRVQCPSSLQV MTLHVPEENRCVDILELSELDDLLTFHQHTLRLYSALCSHGNTHVAHALCSHVDQSQFLY ALQCRHMPGPLREAYYALLSEVHLNGYAGARRAMTHEYIVPMTRDSRSITLYNSHRRRHS LPGSVRSASLWPRLRFSAPCFIRPDEGANRQPLDGRGGDVQQDSPAFPVELLKTLLVEML EEAVCAAGQCVRDPVGGSVELLLVPLLRLLHTLLLMGVYRGPGLRAALKLILPGVYIQNW AITEDEDGEEFEMDVDRERDEFLGGFPTHGLLRMKLPEAVKLQVCNLLEYLCDCQVRHRV EAVVAFADGFVARLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINLLLNFREE QLECPCPLEIQDLLQEFHSDLMSHCGIEIDEDSEAGDDGDLSVRGRLSGLVEKVNSLKRR LSLCPVESVAVKPVSLRQMISDAMLRWAQEAPMGDPVLVRAVFELLRRQYEGLSAQMAAP LLKAYCITPGSVEDTLSLQSALGRIRSLLRIRMGRQEEALMIQGLGDIMNNKVFYQHPNL MRALGMHETVMEVMVNVLGEGESKEIMFPKMVAHCCRFLCYFCRISRHNQKAMFDHLSYL LDNSNVGLASPSMRGSTPLDVAAASVMDNNELALALTEAALEKVVHYLAGCGLRSCPSLL ARGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENAYVVLRLLIRRPECFGPALQGDGGD GLLATMEEAIRIAADPKRDGRRAAYESNRTLDTLNEEEDDLIHLGHAIMTFYSAFIDLLG RCGPEMHLIEAGKGEAIRIRAILRSLIPLEDLVGVISIPLHLPSLDTGGTVIEPDMSTVF CPDHKAAMVLFLDRVYGIQDQKFLMRLLEVGFLPDLQAAVTMDSSDLAGTDMSLALNRYL CTAVLPLLTKCASLFGGSEAHSQLVDSLLQAVYGISKGSVLTKAQRDAIEECLLSVCGNL RPSVVQPLLHCLVFDVPLLTANTKMPLKLLANHYEHSWRYYCLTGGCGGRGCASAEELHL SRQLFWSTLRALARKPYEADLFWLSLACLSAVARAIPPDHLDPSCRGGLESHQPLDTKGR FCPQPVDTSNVSIPEGLEYVVNRYAEHIHEKWSLDKFASGWVHGDQPCESSKVHPLLKPY RAFSEKDKESYRWAIKEKVKNMLVFGWTIERTKDGEAQEVHNPARRVSQAGQLSFEGAST FSPKPIDMSNVTLSWDQYSMAEQLAESSHNMWAKRKQLELESKGGGSHPLLVPYDSVPAR EKTRIRERAQDILKFFHMSGYNVWRDRKPVDCDSPAIASRFAYGVLQQALTYTDQAQEQL LELEGLQARGQGSKSEQPPPEKQTYFFVKVVLPLVDQYFKCHRCYFLSTSTDLLGNRGHA SNKEKEMVTSLFCKLGALVRRRICLFGNDSPSVTSCLTILASCLDAGSAIRSAAESVRLS LCSFFEEAATDLELTVETLALGPVPPTRGQLRGAGDTVVYTSEVLIPVLTALFHHAAQCQ YGQELIVDTVQASCYRILISMYSLGTSKNIYAERRRPEVGTCLAALTAAFPVTFLEPPVD EHNPYSVYAMSNAEEGVVAVPSHAEEASQLLPSLYQALGEVEELVLAGSAARHALLSRVT EVTLPLLCSYFSRWGGAEGPRESVSSLGPEHTNTLLGHILSIIHNHLGIADGAWMKRLAV VSQPIIGQAEPQLLKSHFLPVMEKLKKRAESVLLEEEHLKTEGRGDTSEAELHIQEKFTV LVRDLYAFYPLLIPYVDLHRVSWLRELTPEAEELFSMVADIFIFWAKSHNFKWEEQNFVV QNEINNTEFLVNISRNTKPTSKRGGALDKERRKLRRKGDRYSTHTSLIVAALKKLLPIGL SVCSAADQEVIAKAKTHLSQKDTEEEVREIIRKGLQKHYMDLFRGAWKIEDLDIERLFGI ARVLFHLDQVERPHRTKKAVWNKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLLGYGK GWIETEGHSFEDKLIEDLTKVGDQELEDPEGEVNNELEGGALCSDPLHQLITLFSQSALT ERRHVSRLQEDRLYMSFAEIMSKSCHGEEEDEDEVKSFEEKETEKQKLLYEQARLHEHGA ANMVLQTISASRGKKGPMVEATLKLGIAILNGGNTSVQQKMLDYLQQKRDVGFFQSLAGL MQSCSVLDLNAFERQNKAEGLGLVTEASSGDKVMADEELTCDLFRFLQLLCEGHNSDFQN YLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDKMDEHGQRHFSKAVSVAKQV FNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSCQIDLLKELMDLQK DMVVMLLSMLEGNVVNGTIGKQMVDMLVESFSNVELILRFFDMFLKLKDLTSSDAFKEFD PDRRGLISKKDIQKAMEACRLYSLSDTEFLLSCMETDDGELLDYQAFVKRFHEPAKDIGF NIAVLLTNLSEHMPGDARLHKFLELAESVLRYFQPHLGRIEILGSAKRIERVYFEISESS RTQWEKPQVKESKRQFIFEVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISGVDAGEGTT EKDEDEDEEEEAERGKPRETSIFSLSAVMYVLLAPVYFLMMLMSLLSVRSLRKHLRKVTL KGLIGVTFSFFLNLLTGLAQVVFCVVSSILYILYLIFINAGIIEMVKDMTLTDLLIDVPD PSLDEASAVHVGLGDGVGKHSDTDSSQEDLSGVDLDMDLSAVSKDPLVATDVFGLRIRKE GTKFRLISHDNSTSLDQLLSGSAELTDAADLRGKQKVSALKTPYCEEKKETVTEKADGED DEKKEERKECKQRWRARQRRCSKQEDEHVQESAFWKTLSSYQRRMLNCFARNFYNMRFLA LFVAFAINFILLFYKVSSSSVAVDEEDPEGSAWSDSPDDVSVEGPMPTVDTPSSDTAPFI LEESSGYMEPSLRLLAIIHTLISFCCIIGYYCLKVPLVIFKREKEVARKLEFDGLYVTEQ PSEDDIRGQWDRLVINTPSFPSNYWDKFVKRKVMDKYGDFYGLARISDLLGLDRAALDFS ALGMERRRPRLSSIDMKYQIWKLGVVFTDNSFLYLAWYMSVSVLGHYNNFFFAAHLLDIA MAFKTLRTILTSVTHNGKQLVLTLGLLAVIVYLYTVVAFNFFRKFYNQSEDGEGVDMKCD DMMTCYMFHMYVGVRAGGGIGDEIEDPAGDESEFYRIIFDITFFFFVIVILLAIIQGLII DAFGELRDQQEQVKEDMETKCFICGIGNEYFDTMPHGFEVHTLQEHNLANYLFFVMYLIN KDETEHTGQESYVWKMYQERCWEFFPVGDCFRKQYEDQLS NT seq 14883 nt NT seq  +upstreamnt  +downstreamnt atgaccgagccgggagaggtagaggatgaaattcagtttctacgaacgaatgatgagctt gtgttgcggtgctccctggccgctcagcagaggcagcagaagttctgtctggctgctgag ggctttggctgcaggctctgctttctggagaccacatccaactcgaaaaatgttccagtg gacctgtccatctgtgtgtttgtactggcccagtgtctgtcagttcgtgccctgcaggaa atgctcgccaaacagtgcgaccagcaaacaggggcggttgagatgggaagtcaccgcact ctcctctacggccaagcggtgctgctgcgtcatgcctacagtggaatgtacctatgctgt ttgtccacaacttgctcctccactgataagctggcatttgacgtagggttgcaagaggaa ataataggcgaggcgtgttggtggactgttgaaccggcctccaagcagagatccgaggga gagaaagttcgagttggggatgacttaatacttgtcagtgtgtcctcagagcgatacctg catttgtccctgagtaactgtaatagttcaggggacgagggcgggggtctgagggtggat gctgccttccagcagactctgtggagtgttgcctccgtctcctccgggagcggagtggct caagggttcctgaagggaggggacacgtttcgcctgttgcacggacacactgatgaatgt ctgaccgttccacctgtggaccacggagaagaagagcggaggtcggtgtactttgaagga ggttctgtttcatcgcaggccggttctctctggaggctggagaccatgcgtgtggcatgg agtgggagtcacacccagtggggtcagctgttccgtctgcggcatgtcaccacggggatg tacctcagcctcatgcaggagaagggactgagactgatagagagggagaaagctgatgcc aaagccactgctttctgcttccgctcctcaaaggagaagcttgacattgtccagaagaag gatgtagatggcatgggcaccccagagataaagtatggagactccgtctgcttcattcag cacttgggcagtggtctttggctgacttaccagactggtcatgggaagagtgggagaatg gccggggcaccacggcaggccattttgcacctggagggccacatggatgacggtctgact ctgtcccgctcccagacggaggagtccagagctgctcagatcataagaagctctgtcctc ctattctcacacttcatcagaggactggatgaccttggtcagagggctaatctaccgatg actccagctctgccaatcgccagagtccgcttgagtctgcaggatctcattagctacctg cggcctcctgatgaagaccagggtcaagaagaaaggcagaacaacatgagggccctgaag aacagacagaacctcttccaagaggaggggataattggctatgcattagactgcattgac cgccttcatgcctacggcagcgctgcccattttgctgaggtcgcaggaaaagaggcagga gaggaatgtgaggctctcctgaactcactgtatgaactccttgcgtctttgatcaggggc aacaggaataattgtgcccagttttctggatcgctggagtggttgattggaaggctggag aaactggatgcatcctctggaatccttgaggtgttacattgtgtcctggaggagagccca gaggctctgaactttatcaaagagggacacatcaaatccatcatatctcttttggacaag catggtcgcaatcacaagatcctagatgtgttgtgttcactctgtgtgtgccatgggatg gccgtgcgctctaaccaacactatatctgtgtgaacctgctgccagagcgagacctgctt ctgcagacacgcctctgcaatcaagtcaccagtgtgaggcccagtgtgttcctgtgtatg agtgaagactctgcccagtgcaggaagtggtactttgagctggtggtggagaaggcagag ccattcgtcacggctgagcccactcacctgcgtgtgggctgggcctgtgcggagggctac tgcccctccccaaccggtggagatggctggggtccaaatggagccggggatgacctctac tcttatggctttgatgggcttcacttgtgggcaggtggtattggccggagagtgaactca cccaatcagcaccttctgaaggaggatgatgtggtcagctgttgcctggacctgggggct ctctgcatgtcattcagggtcaatggtctgcctgtccagggcatgtttgaaaacttcagc acagagggcctgctctttcctgtggccagtttctctgctggagtgagggtgtgtttcctg ttggggggtcgtttaggggagtttaaattcctgcccccacctggtttctcgcccgtgtcc gaggctctactgccccgggtcaggtgccgggtggagccgtgtctggacttcatgaggcac cggaacagtagccagcaggacctcctggggccatgggtggcaccgaaccctcctaccttc acccctgttcctgtagacactagtcaggtggccttcccccctcagctagagcagattcga gacgagctcgctgagaacctgcatgaactctggctcatcagtatggtggatcagggctgg atctacgggcctgttaaggaagaaaataagaagcatcatcctgatctggttgagttttcc aaactgccagacccagagaagaatctgaacctccaggctgcacaggataccctcaggaca ctcctggctctcggtgtccacattgggctgttagacgaccatgctgatgagaaagtcaaa tatatccgactctctaacaagtatgagctgtggaatggataccgacccgctcctgtggat ctgtctcatctcaccctgaccgctgcccaggaggccatagtggactgtctggccgagaat gagcacaatgtgtgggccaaagagaggatcagacagggatggagctatgggcctcagcag gatgtgaagagtaagaggagtcctcacttggtgcccttctctctgctggacgagcggacc cagaggtctggcagtgagaccgtgagggatgctctgtgcaccatactagcgtacgggtac acagtggagccgctggaccaggagcagatggtactgccagatgcaggcgttgccctggtc gaaaacttccggatattccgtgttgagcgtgcctatgctgtgctgaaaggaaagtggtac tttgaatttgaagctgtgacctccggggagatgaaggtgggctgggctcgacccggaagt aaaccagacctggagctggggtcagatgaccaggcctttgtctttgatggctgcaagggg cgtatttggcatcagggcagtgagcagctgggcctaagctggcagatgggagatgttgta ggctgcatgctggatcttgaacagtgtactatgatgttcacactaaacggggagcttttg ctgaacaaccatggctctgagcttgctgccaaacagtttgcagtccaagatggcttcgtg cctgtatgcagtgtaggggtgaaccaggtgggtcgtctaaagttgggccaccctggctcc ctgcgttacctcagcgtgtgtgggcaccaggaaggctaccagccattcgctcacaacatg agccgagacgttcccctgtggatgagctggaaacagccccatttcacccctgtgccccca gaccacggccatattcaggtaactcgtctcgatgggacagtggaccgatcaccctgtttg aaggtgacgcagaaatcctcagggtcacaggtcaccagtggctcagtcagttctgacatt ggctattaccggctcagcatgcctatagagtgtgccgaggttttctcccgaccagcagag ggtgctgtcccctgcagcagcactgcttactaccccaagagagattcagaggagggggac attgactctgattttgaggtccttatgaagtcagctcgccgacacgcagggtccagagac gaactgaacaaccataaagaccacggtcaagagaagccttccaggctcaagcagcgtttc atgctgaagcgacccaaaccagagctgcacccaagccactcttctgcacgcctgttagag gaagtggtggctatagagaaggacgaggacaagctcctttcacattgctctgcgtattac tactccgtgagggtgctccctggccaggacccctcctgtgtctgggtgggctgggtcacc tcgagcttccaccggcagcagcagggcttcgacctggagagagttcgcagagtgactgtg acgcttggggatgagcagggcaaagttcacgagagtgtaaagcgttgtagctgctttatg gtttgtgcaacagaggctgtgggccagactcacagtcgtagcagcacccaactagagatc ggttgtcttgttgacacggcaacaggacttctaaccttcactgctaatggaaaagagctg gacacctattatcaggtggagccatgtacaaagctgtaccctgcagtgtttgccaaagcc acaagctctgacatgtttcagtttgagcttggcagaattaagaatgtgatgcccgtgtct gcgggtatgtttcgggatgagaggggcaaccccgtggcccagtgccctcccaggttacag gtgcagcacgttgtgcccttccgttggctgcgtgtgcctgacaacttacccagggtggag gtgacacgcatggacgagaggcatggatggagagtgcagtgccccagctcgctgcaggtc atgaccctccacgtccctgaggagaacaggtgtgtggatattctcgagctgtcagagctg gacgaccttctgacctttcaccagcacaccctccgtctctactctgccctgtgcagccat ggcaacactcatgtggctcatgccctgtgcagccacgtggaccagtcccagttcctgtac gccctccagtgccgccacatgcccggcccgttacgggaggcctactacgccctcctaagc gaggttcacctcaacggctacgccggtgccagacgggccatgactcacgagtacatagtg cccatgacacgcgacagcagatccatcacgctctataacagccacaggaggcgccactcg ctgccaggcagcgtccgcagtgcctccctctggcccaggctgcgcttcagcgcgccctgc ttcatcaggcctgatgagggggctaacagacagcctctggatggcagagggggggacgtg cagcaggacagcccagcattcccagtggagctgctgaagactctgctggtggagatgcta gaggaggctgtgtgtgcagcgggtcaatgtgtgagggatcctgtagggggcagtgtggag ctgctgctggtgcctctcctgcggctgctgcacaccctcctgctcatgggagtgtatcga ggcccaggcttgagggcagctctcaaactaattttgccaggtgtgtacatacagaactgg gccatcactgaggatgaggatggggaagagtttgagatggatgttgatcgagagcgagat gaatttctgggaggcttcccgacacatggactactgcggatgaaactgcctgaggctgtc aaactgcaagtgtgtaacttgctggagtacctgtgtgactgtcaggtgcgtcacagagtg gaggcagtggtggcgttcgcggatggctttgtggcgcggctccaggacaaccagcgcttc cgctacaatgaggtcatgcaggccctcaacatgtctgctgcccttacggcccgcaagact aaagagttccgctctcctccacaggagcagattaacctgctgctgaacttccgtgaggag cagctggagtgcccatgcccactagagatccaggacctcctccaggagttccacagtgat ctcatgagtcactgcggcattgagattgatgaggactcagaggctggagatgatggagat ctgtccgtcaggggtcggctctccggcctggtggaaaaggtgaacagcctgaagcgaagg ctctccctgtgtcccgtggaatctgtagccgtgaagcctgtgtccctgcggcagatgatc tcggacgccatgctgcgctgggctcaggaggcgcccatgggggaccctgtgctggtgcgc gccgtgttcgagctgctgcgccggcagtacgaggggctgagcgcccagatggccgcgccg ctgctgaaggcgtactgcatcaccccgggctccgtggaggacaccttatcgcttcagagc gccctggggcgcatcaggtccctcctccgcatccgcatgggccgccaggaggaggcgctc atgatccaaggactcggagacatcatgaataataaagtgttttatcagcacccaaacctg atgagagctttggggatgcacgagacagtgatggaggtgatggtcaacgtcttaggagag ggagaatcgaaggaaatcatgtttcctaagatggtcgcccactgctgcagattcctctgt tatttctgccggattagccgacacaaccagaaggccatgtttgaccatctcagctatctg ttggataacagcaatgtcggactagcgtccccttctatgcgggggtccactcctctggat gtggccgctgcctcagtgatggataacaatgagctggccctggccctgacagaggccgcc ctggagaaggtggtccattacctggcaggctgtggtttacggagctgtccctcgctgctg gccaggggctatcctgatattggctggaatccagtggagggggagcgctatttggacttc ctccggtttgctgtattttgtaatggtgagagtgttgaggagaacgcttacgtagtgctg aggttactgattcgtcgaccagagtgctttggccccgccttgcaaggtgatggaggagac ggtctcctagcaaccatggaggaagccatcaggatcgcagccgatccaaagagagatgga cgaagagcagcctacgagtccaacagaactcttgacacactcaatgaagaagaagatgac ctcatccacttggggcatgcaatcatgacgttctattctgcctttatcgacctgcttggg cgctgtggccctgagatgcatctgattgaagctgggaaaggtgaggccatccgtatcagg gccatcctgaggtcactcatcccactagaggatctggtgggggtcatcagcatccccctt cacctaccctcactggacacaggtggcacagtgatagagccagacatgtcgacagtgttc tgtcctgaccacaaggctgctatggtcctgtttctggaccgggtctatgggatccaggac cagaagttcctgatgcgactcctggaagtaggcttcttgccagacctccaagctgctgtc accatggattcatctgatctggcaggcactgacatgtctctggctctcaaccgctatctg tgcacagcagtgctgcccctcctcaccaagtgtgcgtctctgttcggaggctccgaggcc cacagccagctggtggactccctgctccaggcggtctacgggatctccaagggcagcgtg ctcaccaaggcccagagagatgccatcgaggagtgcctgctgtctgtctgtggcaatctc aggccctccgtggtgcagcccctgttacactgcctagtgtttgacgttcctctcctgaca gcgaacacaaagatgcccctcaagctgctggccaatcactatgagcacagctggaggtac tactgtttgaccggaggctgtggaggcaggggctgtgcctcagctgaggagcttcacctg tccagacagctgttctggagcacgctcagggccctggccaggaagccttatgaggctgat ctgttctggctgagtctggcctgcctcagtgccgttgcccgggcgatcccacctgaccac ctggaccccagctgcaggggtggcctggagtcccaccagcctctggacacgaagggacgc ttctgccctcagcctgtggacacctcaaatgtttccatccctgagggactggagtacgtg gtgaatagatatgctgagcacatacatgagaaatggtctcttgacaagtttgccagtggt tgggtccatggagaccagccgtgtgagagttccaaagttcatccccttctgaagccgtat cgagccttctcagagaaggacaaagagagctatcgctgggctatcaaggagaaggtgaag aacatgctggtgtttggctggaccatcgaaagaaccaaggatggagaggcacaggaagtg cataacccagcacgaagagtatcacaggctgggcagctatctttcgaaggcgcctccact ttcagtcccaaacccattgacatgagcaatgtgacgttgtcatgggaccagtattccatg gcagagcagctggcggagagttctcataacatgtgggccaagaggaaacagctggagctg gaatccaaaggaggggggagtcatcccctgctggtgccttatgactctgtgcctgctcgt gagaagaccagaatacgagagagagctcaagacatcctcaagttcttccacatgagtgga tacaatgtgtggagggacagaaagcctgtggattgtgactctccggccatcgccagtcgc ttcgcctatggcgttcttcagcaggctctgacctacaccgaccaggcccaggaacagctg ctggagctggaggggcttcaggctagaggacaaggatccaaatcagaacagcctcctcct gaaaaacaaacctatttctttgtcaaggttgttttacccttggttgatcagtactttaag tgccatcgctgctacttcctgtccacctctacggatctccttggtaacagaggtcatgca tccaacaaagagaaagagatggtaaccagtcttttctgcaagcttggagctcttgtaagg cgtaggatatgtctctttggaaacgattctccttctgtgacaagctgtctgaccattttg gcgtcgtgtttggatgctggaagcgctataagaagcgctgcggagtctgtgcgtctctct ctgtgctccttctttgaggaggcggcgactgatctggagctcaccgtggagaccctggct ctgggcccagtcccccccacccgaggccagctcaggggagcgggcgacaccgtggtctac acctccgaggtgctcatccccgtcctcaccgctctcttccatcacgctgctcagtgtcag tatggccaggagctcatagtggatacagttcaagcctcctgctatagaatcctaatcagc atgtattcactcggcacttccaagaacatctacgctgagaggcggaggccggaggtgggg acgtgtctggctgcgctgacggctgcttttcctgtcacgttcctggagcctcctgtggat gagcacaacccttactctgtctacgccatgagtaatgcagaagaaggggttgtggctgtg ccctctcatgctgaagaggcgagccagctcctgccctccctgtaccaggccctgggtgag gtggaagagctggtgctggcagggtcggccgcccgacatgctctgctgtcccgggtcacc gaggtcacgctccccctgctctgcagttacttctcccgctggggcggcgcagaggggccc agggagagcgtctcctctctcggccccgagcacaccaacacgctgctgggccacatcctc tccatcattcacaatcacctggggatagccgacggagcctggatgaagcgcctggcagtt gtgtctcagccaatcattggccaggcagaaccacagctcctaaagagtcacttcctgccc gtgatggagaagctgaagaaacgggcggagtcagttctcctggaggaggagcatttgaag acagaggggaggggtgatacatcagaggcggagttacacatccaagagaagtttacagtg ttggtccgtgacctgtatgctttttacccactactcattccctatgtggacttacacaga gtaagttggttgagagagctaactcccgaggctgaggagctcttcagtatggtagcagac atcttcatcttctgggctaagtctcataatttcaaatgggaggagcagaattttgtggtc cagaatgaaattaacaacacagagttcctggtcaacatcagcaggaacactaagcctact tcaaagagagggggagcgctggataaagaaaggaggaagttgaggagaaagggggaccgc tactccactcacacctctctcatcgtggccgctctgaagaaactgcttcctattggcctg agcgtctgctctgctgctgaccaggaggttatagccaaggctaagacccacctatctcag aaggatacggaggaggaggtcagagagatcatccgcaaaggccttcagaagcactatatg gatttattcagaggggcttggaaaattgaggatctggatatagagcggctttttggcatt gctcgtgtcttatttcacctggaccaggttgagaggccacataggacaaagaaggctgta tggaacaaactgctgtccaagcagcggaagagagcagtggtggcttgcttcagaatggca cctctatacaatttacccaggcacagagcagtcaatctgttccttctgggttatggaaaa ggatggattgaaacagagggccattcttttgaagataagctaatagaggatttgactaaa gtgggtgatcaagaactggaggatcctgaaggagaagttaataatgagctggaagggggg gcactttgctctgaccctctccatcaactgatcacactcttcagccaaagtgctttgaca gaaaggaggcatgtcagcagactacaggaagacagattgtatatgtcctttgcagagatc atgtctaagagttgccatggtgaagaggaggatgaagatgaggtcaagtcatttgaggag aaggagacggagaagcagaaacttctgtacgagcaggccagactacacgagcacggagca gccaacatggtgctccagaccatcagcgctagcagaggtaagaagggccccatggtggag gctacactcaagcttggaatagctatccttaacggaggaaatacaagtgtgcaacagaaa atgttggattacctgcaacagaagcgagacgtgggattctttcagagcctggcgggcctc atgcagtcgtgcagcgtactggatctcaatgcctttgagcggcagaacaaagcagaggga ttgggcctggtgacggaggccagctcaggtgacaaggtaatggcagacgaggaactgacc tgtgacctgttccgcttcctacagctcttgtgtgagggacacaactcagattttcagaac tatctcaggactcaaacgggcaacaacacaacagtgaacatcatcatatctacagtagac tacctcctcagggtacaggagtccattagtgatttctactggtactactctgggaaagac aagatggatgaacatggacaacggcacttctcaaaggctgttagtgttgccaagcaagtc ttcaacacactcacagaatacattcagggtccttgtacagggaaccagcagagtttggct cacagtcgattatgggatgcagtcgttggattcctgcatgtgtttgcccatatgcaaatg aaactctctcaggattcttgtcagattgatttgctgaaagagttgatggatttacagaaa gacatggttgtgatgcttctctccatgctggaaggaaatgtggtgaacggcactatcggc aaacagatggtggacatgctggtggagtccttcagcaacgtggagctgattctgaggttc tttgacatgttcctgaaactcaaagacctgacctcatctgacgcttttaaagagtttgac cctgaccgaaggggcctcatctccaagaaggacattcagaaggccatggaagcctgccgg ctctattcgctctccgacacagagttcctgctctcctgcatggagacggacgacggggag ctgctggactaccaggcatttgtgaagcgcttccacgagccagccaaagacatcggcttc aacatcgccgtgctcctcaccaacctgtccgagcacatgcctggagatgcccgtctgcat aagtttctggaactggcggagagcgttctcaggtacttccagccccaccttggtcgtata gagattctgggcagtgctaagcgcatcgagcgtgtttactttgagatcagcgagtcgagc cggacacagtgggagaaacctcaggtgaaggagtccaagcgccagttcatctttgaagtc gtcaatgaggggggagagaaagagaagatggagctttttgtgaacttctgcgaggacacc atctttgaaatgcagctagctgcgcagatctctggtgttgatgctggcgaagggacgacc gaaaaggacgaggacgaggacgaggaggaggaggctgagaggggaaaacccagagaaacg agtatcttttccctctctgcagtgatgtatgttctcctggcccctgtgtacttcctgatg atgctgatgtcactgctctccgtgaggagcctccggaagcatctaaggaaggtcaccttg aagggtctcataggtgtcactttctcattcttcttaaaccttctcacgggcttggcccaa gtggtcttctgtgtggtctcctccatactctatatactctacctgatcttcatcaacgcg ggcattattgagatggtgaaggacatgaccctcactgacctgttaattgacgtccctgac cccagcctggatgaggcctctgcggtgcacgtcgggttgggggatggagtcggaaaacac tcggacaccgactcctcccaggaggacctgagtggagtggatctggacatggacctctca gctgtgtccaaagacccgctggtcgccacagacgtcttcgggctgcgcataaggaaggag ggcaccaagttcagactcatatctcatgacaacagcaccagcctagatcaacttctctcg ggctccgctgagctcactgacgccgctgaccttagggggaaacaaaaggtgtctgcactc aagacaccgtactgtgaagaaaagaaagagacagtgactgaaaaagcagacggagaggat gatgaaaagaaggaggagaggaaggagtgcaagcagaggtggagagccaggcagcggcgt tgctcaaagcaggaggatgaacatgtccaggagtcagctttttggaaaaccttgagctcc tatcagagaagaatgcttaactgcttcgccaggaacttctacaacatgcgatttctcgcc ctgtttgttgcttttgctatcaatttcatccttctgttttataaggtctcctcatcatct gtggctgtagatgaagaggacccagaggggtctgcgtggtctgacagcccagatgatgtg agcgtggaggggccgatgccgaccgtggacaccccgtcttcagacacggccccttttatc ctggaggagagcagcggctacatggagccctctctgcgtctcctggccatcattcacacc ctcatatccttctgctgtatcatcggctactactgtctgaaggttcccttggtgattttt aagcgggagaaagaagtagcgcgcaagcttgagtttgatggcctctatgtgacggagcag ccctctgaagatgacatcagaggacagtgggacagactcgtcattaatactccgtctttt ccgagtaactactgggataagtttgtgaagaggaaggtgatggataaatatggggatttt tacggcttggcgcggatcagcgacctgctgggtctggatcgagccgctctggacttcagt gccctgggcatggagaggaggagacccaggttgagctccattgacatgaagtaccagata tggaaacttggtgtggtgttcactgataattctttcctgtacctggcttggtatatgtct gtgtctgtccttggccactataacaacttcttctttgctgctcatctgctggacatcgct atggcctttaaaacactgaggaccattctcacctccgtcacacacaatggcaaacagctg gtgttgaccctggggctgctggctgtcatagtctatctctacacagtcgttgcctttaac ttcttccggaagttctacaaccaaagtgaagacggtgaaggtgtggacatgaaatgtgac gatatgatgacatgttacatgttccacatgtacgtgggggtgagagctggggggggcatc ggggatgagattgaggatcccgccggagacgagtcggagttctaccgcatcatcttcgac atcaccttcttctttttcgttatagttatcctgctagcaatcatacaaggtctcatcatt gatgcatttggagagctgagagatcagcaggagcaggtcaaggaggacatggagaccaag tgcttcatctgtggcatcggtaatgagtactttgacaccatgccccatggatttgaagtg cacacgctgcaggaacacaacctggccaactatctattctttgtgatgtacctcatcaac aaggatgaaaccgagcacactggccaggaatcgtatgtatggaagatgtaccaggagcgc tgctgggaattcttcccagtgggagattgtttccgtaaacaatatgaggatcagcttagc taa

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