KEGG   Capra hircus (goat): 102170135
Entry
102170135         CDS       T02910                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
chx  Capra hircus (goat)
Pathway
chx01521  EGFR tyrosine kinase inhibitor resistance
chx01522  Endocrine resistance
chx01524  Platinum drug resistance
chx04012  ErbB signaling pathway
chx04014  Ras signaling pathway
chx04015  Rap1 signaling pathway
chx04024  cAMP signaling pathway
chx04062  Chemokine signaling pathway
chx04066  HIF-1 signaling pathway
chx04068  FoxO signaling pathway
chx04070  Phosphatidylinositol signaling system
chx04071  Sphingolipid signaling pathway
chx04072  Phospholipase D signaling pathway
chx04081  Hormone signaling
chx04140  Autophagy - animal
chx04145  Phagocytosis
chx04150  mTOR signaling pathway
chx04151  PI3K-Akt signaling pathway
chx04152  AMPK signaling pathway
chx04210  Apoptosis
chx04211  Longevity regulating pathway
chx04213  Longevity regulating pathway - multiple species
chx04218  Cellular senescence
chx04360  Axon guidance
chx04370  VEGF signaling pathway
chx04380  Osteoclast differentiation
chx04510  Focal adhesion
chx04517  IgSF CAM signaling
chx04518  Integrin signaling
chx04550  Signaling pathways regulating pluripotency of stem cells
chx04611  Platelet activation
chx04613  Neutrophil extracellular trap formation
chx04620  Toll-like receptor signaling pathway
chx04625  C-type lectin receptor signaling pathway
chx04630  JAK-STAT signaling pathway
chx04650  Natural killer cell mediated cytotoxicity
chx04660  T cell receptor signaling pathway
chx04662  B cell receptor signaling pathway
chx04664  Fc epsilon RI signaling pathway
chx04666  Fc gamma R-mediated phagosome formation
chx04668  TNF signaling pathway
chx04670  Leukocyte transendothelial migration
chx04722  Neurotrophin signaling pathway
chx04725  Cholinergic synapse
chx04750  Inflammatory mediator regulation of TRP channels
chx04810  Regulation of actin cytoskeleton
chx04910  Insulin signaling pathway
chx04914  Progesterone-mediated oocyte maturation
chx04915  Estrogen signaling pathway
chx04917  Prolactin signaling pathway
chx04919  Thyroid hormone signaling pathway
chx04923  Regulation of lipolysis in adipocytes
chx04926  Relaxin signaling pathway
chx04929  GnRH secretion
chx04930  Type II diabetes mellitus
chx04931  Insulin resistance
chx04932  Non-alcoholic fatty liver disease
chx04933  AGE-RAGE signaling pathway in diabetic complications
chx04935  Growth hormone synthesis, secretion and action
chx04960  Aldosterone-regulated sodium reabsorption
chx04973  Carbohydrate digestion and absorption
chx05010  Alzheimer disease
chx05017  Spinocerebellar ataxia
chx05020  Prion disease
chx05100  Bacterial invasion of epithelial cells
chx05135  Yersinia infection
chx05142  Chagas disease
chx05146  Amoebiasis
chx05160  Hepatitis C
chx05161  Hepatitis B
chx05162  Measles
chx05163  Human cytomegalovirus infection
chx05164  Influenza A
chx05165  Human papillomavirus infection
chx05166  Human T-cell leukemia virus 1 infection
chx05167  Kaposi sarcoma-associated herpesvirus infection
chx05168  Herpes simplex virus 1 infection
chx05169  Epstein-Barr virus infection
chx05170  Human immunodeficiency virus 1 infection
chx05171  Coronavirus disease
chx05200  Pathways in cancer
chx05203  Viral carcinogenesis
chx05205  Proteoglycans in cancer
chx05206  MicroRNAs in cancer
chx05207  Chemical carcinogenesis - receptor activation
chx05208  Chemical carcinogenesis - reactive oxygen species
chx05210  Colorectal cancer
chx05211  Renal cell carcinoma
chx05212  Pancreatic cancer
chx05213  Endometrial cancer
chx05214  Glioma
chx05215  Prostate cancer
chx05218  Melanoma
chx05220  Chronic myeloid leukemia
chx05221  Acute myeloid leukemia
chx05222  Small cell lung cancer
chx05223  Non-small cell lung cancer
chx05224  Breast cancer
chx05225  Hepatocellular carcinoma
chx05226  Gastric cancer
chx05230  Central carbon metabolism in cancer
chx05231  Choline metabolism in cancer
chx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
chx05415  Diabetic cardiomyopathy
chx05417  Lipid and atherosclerosis
chx05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:chx00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102170135 (PIK3R2)
   04014 Ras signaling pathway
    102170135 (PIK3R2)
   04015 Rap1 signaling pathway
    102170135 (PIK3R2)
   04370 VEGF signaling pathway
    102170135 (PIK3R2)
   04630 JAK-STAT signaling pathway
    102170135 (PIK3R2)
   04668 TNF signaling pathway
    102170135 (PIK3R2)
   04066 HIF-1 signaling pathway
    102170135 (PIK3R2)
   04068 FoxO signaling pathway
    102170135 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    102170135 (PIK3R2)
   04072 Phospholipase D signaling pathway
    102170135 (PIK3R2)
   04071 Sphingolipid signaling pathway
    102170135 (PIK3R2)
   04024 cAMP signaling pathway
    102170135 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    102170135 (PIK3R2)
   04152 AMPK signaling pathway
    102170135 (PIK3R2)
   04150 mTOR signaling pathway
    102170135 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102170135 (PIK3R2)
   04517 IgSF CAM signaling
    102170135 (PIK3R2)
   04518 Integrin signaling
    102170135 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    102170135 (PIK3R2)
   04140 Autophagy - animal
    102170135 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    102170135 (PIK3R2)
   04218 Cellular senescence
    102170135 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102170135 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102170135 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102170135 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102170135 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    102170135 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    102170135 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    102170135 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    102170135 (PIK3R2)
   04660 T cell receptor signaling pathway
    102170135 (PIK3R2)
   04662 B cell receptor signaling pathway
    102170135 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    102170135 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    102170135 (PIK3R2)
   04670 Leukocyte transendothelial migration
    102170135 (PIK3R2)
   04062 Chemokine signaling pathway
    102170135 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102170135 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    102170135 (PIK3R2)
   04929 GnRH secretion
    102170135 (PIK3R2)
   04915 Estrogen signaling pathway
    102170135 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    102170135 (PIK3R2)
   04917 Prolactin signaling pathway
    102170135 (PIK3R2)
   04926 Relaxin signaling pathway
    102170135 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    102170135 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    102170135 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102170135 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102170135 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    102170135 (PIK3R2)
   04722 Neurotrophin signaling pathway
    102170135 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102170135 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    102170135 (PIK3R2)
   04380 Osteoclast differentiation
    102170135 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    102170135 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    102170135 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102170135 (PIK3R2)
   05206 MicroRNAs in cancer
    102170135 (PIK3R2)
   05205 Proteoglycans in cancer
    102170135 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    102170135 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    102170135 (PIK3R2)
   05203 Viral carcinogenesis
    102170135 (PIK3R2)
   05230 Central carbon metabolism in cancer
    102170135 (PIK3R2)
   05231 Choline metabolism in cancer
    102170135 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102170135 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102170135 (PIK3R2)
   05212 Pancreatic cancer
    102170135 (PIK3R2)
   05225 Hepatocellular carcinoma
    102170135 (PIK3R2)
   05226 Gastric cancer
    102170135 (PIK3R2)
   05214 Glioma
    102170135 (PIK3R2)
   05221 Acute myeloid leukemia
    102170135 (PIK3R2)
   05220 Chronic myeloid leukemia
    102170135 (PIK3R2)
   05218 Melanoma
    102170135 (PIK3R2)
   05211 Renal cell carcinoma
    102170135 (PIK3R2)
   05215 Prostate cancer
    102170135 (PIK3R2)
   05213 Endometrial cancer
    102170135 (PIK3R2)
   05224 Breast cancer
    102170135 (PIK3R2)
   05222 Small cell lung cancer
    102170135 (PIK3R2)
   05223 Non-small cell lung cancer
    102170135 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102170135 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    102170135 (PIK3R2)
   05161 Hepatitis B
    102170135 (PIK3R2)
   05160 Hepatitis C
    102170135 (PIK3R2)
   05171 Coronavirus disease
    102170135 (PIK3R2)
   05164 Influenza A
    102170135 (PIK3R2)
   05162 Measles
    102170135 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    102170135 (PIK3R2)
   05163 Human cytomegalovirus infection
    102170135 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102170135 (PIK3R2)
   05169 Epstein-Barr virus infection
    102170135 (PIK3R2)
   05165 Human papillomavirus infection
    102170135 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102170135 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    102170135 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102170135 (PIK3R2)
   05142 Chagas disease
    102170135 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102170135 (PIK3R2)
   05017 Spinocerebellar ataxia
    102170135 (PIK3R2)
   05020 Prion disease
    102170135 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102170135 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    102170135 (PIK3R2)
   05415 Diabetic cardiomyopathy
    102170135 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102170135 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    102170135 (PIK3R2)
   04931 Insulin resistance
    102170135 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102170135 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102170135 (PIK3R2)
   01524 Platinum drug resistance
    102170135 (PIK3R2)
   01522 Endocrine resistance
    102170135 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:chx04131]
    102170135 (PIK3R2)
Membrane trafficking [BR:chx04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102170135 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 ODF2_C Ribosomal_L22e SH3_9 ATG11 Laminin_I
Other DBs
NCBI-GeneID: 102170135
NCBI-ProteinID: XP_017906913
LinkDB
Position
7:103723675..103736411
AA seq 776 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPAGPFCSSSTTWPI
TQGGPTGPGLPLLCARASPPRAKAASNGGCADRERLNTKGLTLPDLPEQFSPPDVAPPIL
VKLVEAIERTGLDSYRPEPPTMRTDWSLGDVEQWDAAALSEGVKSFLLALPAPLVTPEAA
AEAHRALREAAGPVGPALEPPTLPLHHALTLRFLLQHLGRVARRAPAPGPAVRALGATFG
PLLLRAPPPPSPPPGGAPDGAEPTPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKTKPA
PTGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKG
GNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLLYPVSKYQQDQ
IVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFE
EQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQELRAQASD
NREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYSLMEDED
DLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYR
TATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
NT seq 2331 nt   +upstreamnt  +downstreamnt
atggctggccctgagggcttccaataccgtgcattgtacccattccgccgggagcggccg
gaggacctggagctacttccgggtgatgtgctggtggtgagcagggccgccctgcaggcg
ctgggcgtggccgagggcaacgagcgctgcccgcagagcgtcggctggatgcctggcctc
aatgagcgtacccggcaacgcggtgacttccctggcacctatgtggagttcctggggccc
gtggccctggcccggcctggccctcgcccacgtggcccccgcccactgcccgccaggccc
cgagacgggccccctgagccagctgggcctttctgcagctcaagcaccacctggcccatc
actcagggaggccccacaggccctggcttgcccctgctgtgtgccagggcgtccccgcca
agggccaaagctgcatcaaatggtggctgtgccgacagagagcgcctgaacacaaaaggc
ctgacactccctgacctacccgagcagttctccccccctgatgtggctccccctatcctg
gtgaagctggtggaggccattgaacggacagggttggacagctacaggcctgagccaccc
accatgcgcacagactggtccctgggtgatgtggagcagtgggatgcggcagccctgtca
gagggtgtgaaaagcttcctgctggcgctgccggcgcccctcgtgacacccgaggccgcg
gccgaggcacaccgagccctgcgggaggctgcggggcccgtggggccggcgctggagccc
ccgacgctgccactgcaccacgcgctcacgctgcgcttcctgctccagcacctgggccgg
gtggccaggcgcgccccagccccgggccccgcggtccgtgccctgggcgccaccttcggg
ccgctgctgctgcgcgcgccgccgccgccctctccgccgccagggggcgcgcccgacggg
gccgagcccacccccgactttcctgcgctgctggtggagaagctgcttcaggaacacctg
gaggagcaggaggttgcccccccagcactgccaccaaaaccccccaagacaaagccagcc
cccacaggcctggccaatgggggcagcccaccctccctgcaagatgccgagtggtactgg
ggtgacatctccagggaggaggtaaacgagaaactgcgggacacgcccgacggcaccttc
ctggtccgagatgcctccagcaagatccagggagagtacacgctgaccctcaggaagggc
ggaaacaacaagctgatcaaggtcttccaccgagacgggcactacggcttctcggagccg
ctcaccttctgctctgtcgtggacctcatcacccactaccgccatgagtcactggcccag
tacaacgccaagctggacacgcggctcctctacccggtgtccaagtaccaacaggaccag
atcgtcaaggaggacagcgtggaggcggtgggtgcccagctcaaggtctaccaccagcag
taccaggacaagagccgcgagtacgaccagctctacgaggagtacacgcgcacctcccag
gaactgcagatgaagcgcacagccatcgaagccttcaatgagaccatcaagatctttgaa
gagcagggccagacgcaggagaagtgcagcaaggagtatctggagcgcttccgacgtgag
ggcaatgagaaagaaatgcagaggatcctgctcaactcggagcggctcaagtctcgcatt
gctgagatccatgagagccgcacaaagctggagcaggagctgcgggcacaggcctctgac
aaccgagagatcgacaagcgcatgaacagcctcaagccagacctcatgcagttgcgcaag
atccgagaccagtaccttgtgtggctcactcagaaaggtgcccggcagaagaaaatcaac
gaatggttggggatcaagaacgagactgaggaccagtactcactgatggaggatgaggat
gacctcccccaccacgaggaacgcacatggtatgtaggcaagatcaaccgcacccaagct
gaggaaatgctgagtggcaagcgggacggtaccttcctcatccgtgagagcagccagcgg
ggttgctacgcctgttctgtggtggtggacggcgataccaagcactgcgtcatctaccgc
acggccacgggcttcggcttcgcggagccctacaacctgtacgggtccctgaaggagctc
gtcctccactaccagcacgcctccctggtgcagcacaatgacgcgctgaccgtcacgctc
gctcaccccgtgcgcgcccccgggcctgggcccccgcccgctgctcgctga

DBGET integrated database retrieval system