KEGG   Citrobacter sp. CRE-46: AN232_27650
Entry
AN232_27650       CDS       T05520                                 
Name
(GenBank) trimethoprim-resistant dihydrofolate reductase DfrA12
  KO
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Organism
cie  Citrobacter sp. CRE-46
Pathway
cie00670  One carbon pool by folate
cie00790  Folate biosynthesis
cie01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:cie00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    AN232_27650
   00670 One carbon pool by folate
    AN232_27650
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes [BR:cie01504]
    AN232_27650
Enzymes [BR:cie01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     AN232_27650
Antimicrobial resistance genes [BR:cie01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    AN232_27650
SSDB
Motif
Pfam: DHFR_1 Aq_1974-like
Other DBs
NCBI-ProteinID: AWS98922
UniProt: A0A2Z3XCP4
LinkDB
Position
unnamed1:complement(204660..205157)
AA seq 165 aa
MNSESVRIYLVAAMGANRVIGNGPNIPWKIPGEQKIFRRLTEGKVVVMGRKTFESIGKPL
PNRHTLVISRQANYRATGCVVVSTLSHAIALASELGNELYVAGGAEIYTLALPHAHGVFL
SEVHQTFEGDAFFPMLNETEFELVSTETIQAVIPYTHSVYARRNG
NT seq 498 nt   +upstreamnt  +downstreamnt
atgaactcggaatcagtacgcatttatctcgttgctgcgatgggagccaatcgggttatt
ggcaatggtcctaatatcccctggaaaattccgggtgagcagaagatttttcgcagactc
actgagggaaaagtcgttgtcatggggcgaaagacctttgagtctatcggcaagcctcta
ccgaaccgtcacacattggtaatctcacgccaagctaactaccgcgccactggctgcgta
gttgtttcaacgctgtcgcacgctatcgctttggcatccgaactcggcaatgaactctac
gtcgcgggcggagctgagatatacactctggcactacctcacgcccacggcgtgtttcta
tctgaggtacatcaaaccttcgagggtgacgccttcttcccaatgctcaacgaaacagaa
ttcgagcttgtctcaaccgaaaccattcaagctgtaattccgtacacccactccgtttat
gcgcgtcgaaacggctaa

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