KEGG   Cebus imitator (Panamanian white-faced capuchin): 108284538
Entry
108284538         CDS       T08783                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
cimi  Cebus imitator (Panamanian white-faced capuchin)
Pathway
cimi01521  EGFR tyrosine kinase inhibitor resistance
cimi01522  Endocrine resistance
cimi01524  Platinum drug resistance
cimi04012  ErbB signaling pathway
cimi04014  Ras signaling pathway
cimi04015  Rap1 signaling pathway
cimi04024  cAMP signaling pathway
cimi04062  Chemokine signaling pathway
cimi04066  HIF-1 signaling pathway
cimi04068  FoxO signaling pathway
cimi04070  Phosphatidylinositol signaling system
cimi04071  Sphingolipid signaling pathway
cimi04072  Phospholipase D signaling pathway
cimi04081  Hormone signaling
cimi04140  Autophagy - animal
cimi04150  mTOR signaling pathway
cimi04151  PI3K-Akt signaling pathway
cimi04152  AMPK signaling pathway
cimi04210  Apoptosis
cimi04211  Longevity regulating pathway
cimi04213  Longevity regulating pathway - multiple species
cimi04218  Cellular senescence
cimi04360  Axon guidance
cimi04370  VEGF signaling pathway
cimi04380  Osteoclast differentiation
cimi04510  Focal adhesion
cimi04517  IgSF CAM signaling
cimi04550  Signaling pathways regulating pluripotency of stem cells
cimi04611  Platelet activation
cimi04613  Neutrophil extracellular trap formation
cimi04620  Toll-like receptor signaling pathway
cimi04625  C-type lectin receptor signaling pathway
cimi04630  JAK-STAT signaling pathway
cimi04650  Natural killer cell mediated cytotoxicity
cimi04660  T cell receptor signaling pathway
cimi04662  B cell receptor signaling pathway
cimi04664  Fc epsilon RI signaling pathway
cimi04666  Fc gamma R-mediated phagocytosis
cimi04668  TNF signaling pathway
cimi04670  Leukocyte transendothelial migration
cimi04722  Neurotrophin signaling pathway
cimi04725  Cholinergic synapse
cimi04750  Inflammatory mediator regulation of TRP channels
cimi04810  Regulation of actin cytoskeleton
cimi04910  Insulin signaling pathway
cimi04914  Progesterone-mediated oocyte maturation
cimi04915  Estrogen signaling pathway
cimi04917  Prolactin signaling pathway
cimi04919  Thyroid hormone signaling pathway
cimi04923  Regulation of lipolysis in adipocytes
cimi04926  Relaxin signaling pathway
cimi04929  GnRH secretion
cimi04930  Type II diabetes mellitus
cimi04931  Insulin resistance
cimi04932  Non-alcoholic fatty liver disease
cimi04933  AGE-RAGE signaling pathway in diabetic complications
cimi04935  Growth hormone synthesis, secretion and action
cimi04960  Aldosterone-regulated sodium reabsorption
cimi04973  Carbohydrate digestion and absorption
cimi05010  Alzheimer disease
cimi05017  Spinocerebellar ataxia
cimi05020  Prion disease
cimi05100  Bacterial invasion of epithelial cells
cimi05135  Yersinia infection
cimi05142  Chagas disease
cimi05146  Amoebiasis
cimi05160  Hepatitis C
cimi05161  Hepatitis B
cimi05162  Measles
cimi05163  Human cytomegalovirus infection
cimi05164  Influenza A
cimi05165  Human papillomavirus infection
cimi05166  Human T-cell leukemia virus 1 infection
cimi05167  Kaposi sarcoma-associated herpesvirus infection
cimi05168  Herpes simplex virus 1 infection
cimi05169  Epstein-Barr virus infection
cimi05170  Human immunodeficiency virus 1 infection
cimi05171  Coronavirus disease - COVID-19
cimi05200  Pathways in cancer
cimi05203  Viral carcinogenesis
cimi05205  Proteoglycans in cancer
cimi05206  MicroRNAs in cancer
cimi05207  Chemical carcinogenesis - receptor activation
cimi05208  Chemical carcinogenesis - reactive oxygen species
cimi05210  Colorectal cancer
cimi05211  Renal cell carcinoma
cimi05212  Pancreatic cancer
cimi05213  Endometrial cancer
cimi05214  Glioma
cimi05215  Prostate cancer
cimi05218  Melanoma
cimi05220  Chronic myeloid leukemia
cimi05221  Acute myeloid leukemia
cimi05222  Small cell lung cancer
cimi05223  Non-small cell lung cancer
cimi05224  Breast cancer
cimi05225  Hepatocellular carcinoma
cimi05226  Gastric cancer
cimi05230  Central carbon metabolism in cancer
cimi05231  Choline metabolism in cancer
cimi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cimi05415  Diabetic cardiomyopathy
cimi05417  Lipid and atherosclerosis
cimi05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cimi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    108284538 (PIK3R2)
   04014 Ras signaling pathway
    108284538 (PIK3R2)
   04015 Rap1 signaling pathway
    108284538 (PIK3R2)
   04370 VEGF signaling pathway
    108284538 (PIK3R2)
   04630 JAK-STAT signaling pathway
    108284538 (PIK3R2)
   04668 TNF signaling pathway
    108284538 (PIK3R2)
   04066 HIF-1 signaling pathway
    108284538 (PIK3R2)
   04068 FoxO signaling pathway
    108284538 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    108284538 (PIK3R2)
   04072 Phospholipase D signaling pathway
    108284538 (PIK3R2)
   04071 Sphingolipid signaling pathway
    108284538 (PIK3R2)
   04024 cAMP signaling pathway
    108284538 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    108284538 (PIK3R2)
   04152 AMPK signaling pathway
    108284538 (PIK3R2)
   04150 mTOR signaling pathway
    108284538 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    108284538 (PIK3R2)
   04517 IgSF CAM signaling
    108284538 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108284538 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    108284538 (PIK3R2)
   04218 Cellular senescence
    108284538 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108284538 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    108284538 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108284538 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    108284538 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    108284538 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    108284538 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    108284538 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    108284538 (PIK3R2)
   04660 T cell receptor signaling pathway
    108284538 (PIK3R2)
   04662 B cell receptor signaling pathway
    108284538 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    108284538 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    108284538 (PIK3R2)
   04670 Leukocyte transendothelial migration
    108284538 (PIK3R2)
   04062 Chemokine signaling pathway
    108284538 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108284538 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    108284538 (PIK3R2)
   04929 GnRH secretion
    108284538 (PIK3R2)
   04915 Estrogen signaling pathway
    108284538 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    108284538 (PIK3R2)
   04917 Prolactin signaling pathway
    108284538 (PIK3R2)
   04926 Relaxin signaling pathway
    108284538 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    108284538 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    108284538 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    108284538 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    108284538 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    108284538 (PIK3R2)
   04722 Neurotrophin signaling pathway
    108284538 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    108284538 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    108284538 (PIK3R2)
   04380 Osteoclast differentiation
    108284538 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    108284538 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    108284538 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108284538 (PIK3R2)
   05206 MicroRNAs in cancer
    108284538 (PIK3R2)
   05205 Proteoglycans in cancer
    108284538 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    108284538 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    108284538 (PIK3R2)
   05203 Viral carcinogenesis
    108284538 (PIK3R2)
   05230 Central carbon metabolism in cancer
    108284538 (PIK3R2)
   05231 Choline metabolism in cancer
    108284538 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108284538 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108284538 (PIK3R2)
   05212 Pancreatic cancer
    108284538 (PIK3R2)
   05225 Hepatocellular carcinoma
    108284538 (PIK3R2)
   05226 Gastric cancer
    108284538 (PIK3R2)
   05214 Glioma
    108284538 (PIK3R2)
   05221 Acute myeloid leukemia
    108284538 (PIK3R2)
   05220 Chronic myeloid leukemia
    108284538 (PIK3R2)
   05218 Melanoma
    108284538 (PIK3R2)
   05211 Renal cell carcinoma
    108284538 (PIK3R2)
   05215 Prostate cancer
    108284538 (PIK3R2)
   05213 Endometrial cancer
    108284538 (PIK3R2)
   05224 Breast cancer
    108284538 (PIK3R2)
   05222 Small cell lung cancer
    108284538 (PIK3R2)
   05223 Non-small cell lung cancer
    108284538 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108284538 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    108284538 (PIK3R2)
   05161 Hepatitis B
    108284538 (PIK3R2)
   05160 Hepatitis C
    108284538 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    108284538 (PIK3R2)
   05164 Influenza A
    108284538 (PIK3R2)
   05162 Measles
    108284538 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    108284538 (PIK3R2)
   05163 Human cytomegalovirus infection
    108284538 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108284538 (PIK3R2)
   05169 Epstein-Barr virus infection
    108284538 (PIK3R2)
   05165 Human papillomavirus infection
    108284538 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    108284538 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    108284538 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    108284538 (PIK3R2)
   05142 Chagas disease
    108284538 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108284538 (PIK3R2)
   05017 Spinocerebellar ataxia
    108284538 (PIK3R2)
   05020 Prion disease
    108284538 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108284538 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    108284538 (PIK3R2)
   05415 Diabetic cardiomyopathy
    108284538 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    108284538 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    108284538 (PIK3R2)
   04931 Insulin resistance
    108284538 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    108284538 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108284538 (PIK3R2)
   01524 Platinum drug resistance
    108284538 (PIK3R2)
   01522 Endocrine resistance
    108284538 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cimi04131]
    108284538 (PIK3R2)
Membrane trafficking [BR:cimi04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    108284538 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 SH3_9 Ribosomal_L22e TACC_C ATG11
Other DBs
NCBI-GeneID: 108284538
NCBI-ProteinID: XP_017356771
Ensembl: ENSCCAG00000036359
UniProt: A0A2K5S9D6
LinkDB
Position
Unknown
AA seq 727 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPVPARPRDGASEPGLTLPDLPEQFSP
PDVAPPLLVKLVEVLERTGLDSESYYRPELPALRTDWSLSDVDQWDAAALADGIKSFLLA
LPAPLVTPEASAEARRALWEAGGPVGPALEPPMLPLHRALTLRFLLQHLGRVARRAPTLG
PAVRALGATFGPLLLRLPPPSSPPPGGAPDGSEPSPDFSALLVEKLLQEHLEEQEVAPPA
LPPKPPKAKPVPAGLANGGSPLSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKI
QGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRL
LYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAI
EAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTK
LEQQLRAQASDIREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNET
EDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVV
DGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGP
GPPPAAR
NT seq 2184 nt   +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgcgcgctgtacccgttccgccgggagcggcca
gaggacctggagctgctgcctggcgacgtgctggtggtgagccgggcggccttgcaggca
ctgggcgtggccgagggtggcgagcgctgcccacagagcgtgggctggatgcccggcctc
aatgaacgcacacggcagcgaggtgacttccctggcacctacgtcgagttcctggggcct
gtggccctggcccggcccggccctcgcccacggggcccccgcccagtgcccgccaggccc
cgtgatggggcctctgagccaggcctcaccctccccgacttgccggagcagttctcccca
cctgatgtggcgccccctcttctggtgaagcttgtagaggtcttggaacggacgggactg
gacagcgaatcttactaccggccagagctccccgcactgcgtacagactggtccctgagc
gacgtggatcagtgggatgcagcagccctggccgatggcattaagagcttcctgctggca
ctgcccgcgccgctggtgacccccgaggcctcggccgaggcgcgccgggccctgtgggag
gccggggggcccgtggggccggcgctggagcccccgatgctgccgctgcaccgcgctctc
acgctgcgcttcctgctccagcacctgggccgcgtggcccgccgcgccccgactctgggt
cccgcagttcgggccctgggcgccaccttcgggccgctgctgctgcgcctgccgccgccg
tcctcaccgccgccagggggcgcgcccgacgggagtgagcccagccctgacttctcggcg
ctgctcgtggagaagctgcttcaggaacacctggaagagcaggaggttgcgcccccagcg
ctgccacctaaaccccccaaggcaaagccggtccccgcaggcctggccaatggggggagc
ccattgtccctgcaggatgctgagtggtactggggggacatctcgagggaggaggtgaac
gagaaactccgggacactcccgatggcaccttcctagtccgagatgcttccagcaagatc
cagggcgagtacacgctgaccctcaggaaaggcgggaacaataagctaatcaaggtcttc
caccgagacgggcactatggcttctcggagccgctcaccttctgctccgttgtcgacctc
atcaatcactaccgccacgaatccctggcccagtacaacgccaagctggacacgcggctt
ctctaccctgtgtccaaataccagcaggaccagatcgtcaaggaggacagcgtggaggcg
gtgggcgcccagctcaaggtctatcaccagcagtaccaggacaagagccgcgagtacgac
cagctttatgaggagtacacacggacctcccaggagctgcagatgaagcgtacggcaatc
gaggccttcaatgagactatcaagatcttcgaagagcagggccagacccaggagaagtgc
agcaaggaatacctggagcgcttccggcgtgagggcaacgagaaggagatgcagaggatc
ctgctgaactcagagcggctcaagtcccgcattgccgagatccacgagagccgcacgaag
ctggagcagcagctgcgggcccaggcctcggacatccgcgaaatcgacaagcgcatgaac
agcctcaagccggacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggctc
acccagaaaggtgcccggcagaagaaaatcaatgagtggctggggatcaaaaatgagact
gaggaccagtatgcactgatggaggatgaggatgatcttccccaccacgaggagcgcact
tggtacgtgggcaagatcaaccgcacgcaggcggaggagatgctgagtggcaagcgggac
ggcaccttcctcatccgcgagagcagccagcggggctgctacgcctgctccgtggtggta
gacggcgacaccaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcggag
ccctacaacctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcgctc
gtgcagcacaacgacgcgctcacggtcaccctggcgcacccggtgcgcgccccgggcccc
ggcccgccgcctgccgcccgctga

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