KEGG   Callithrix jacchus (white-tufted-ear marmoset): 100406689
Entry
100406689         CDS       T03264                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
cjc  Callithrix jacchus (white-tufted-ear marmoset)
Pathway
cjc01521  EGFR tyrosine kinase inhibitor resistance
cjc01522  Endocrine resistance
cjc01524  Platinum drug resistance
cjc04012  ErbB signaling pathway
cjc04014  Ras signaling pathway
cjc04015  Rap1 signaling pathway
cjc04024  cAMP signaling pathway
cjc04062  Chemokine signaling pathway
cjc04066  HIF-1 signaling pathway
cjc04068  FoxO signaling pathway
cjc04070  Phosphatidylinositol signaling system
cjc04071  Sphingolipid signaling pathway
cjc04072  Phospholipase D signaling pathway
cjc04081  Hormone signaling
cjc04140  Autophagy - animal
cjc04150  mTOR signaling pathway
cjc04151  PI3K-Akt signaling pathway
cjc04152  AMPK signaling pathway
cjc04210  Apoptosis
cjc04211  Longevity regulating pathway
cjc04213  Longevity regulating pathway - multiple species
cjc04218  Cellular senescence
cjc04360  Axon guidance
cjc04370  VEGF signaling pathway
cjc04380  Osteoclast differentiation
cjc04510  Focal adhesion
cjc04550  Signaling pathways regulating pluripotency of stem cells
cjc04611  Platelet activation
cjc04613  Neutrophil extracellular trap formation
cjc04620  Toll-like receptor signaling pathway
cjc04625  C-type lectin receptor signaling pathway
cjc04630  JAK-STAT signaling pathway
cjc04650  Natural killer cell mediated cytotoxicity
cjc04660  T cell receptor signaling pathway
cjc04662  B cell receptor signaling pathway
cjc04664  Fc epsilon RI signaling pathway
cjc04666  Fc gamma R-mediated phagocytosis
cjc04668  TNF signaling pathway
cjc04670  Leukocyte transendothelial migration
cjc04722  Neurotrophin signaling pathway
cjc04725  Cholinergic synapse
cjc04750  Inflammatory mediator regulation of TRP channels
cjc04810  Regulation of actin cytoskeleton
cjc04910  Insulin signaling pathway
cjc04914  Progesterone-mediated oocyte maturation
cjc04915  Estrogen signaling pathway
cjc04917  Prolactin signaling pathway
cjc04919  Thyroid hormone signaling pathway
cjc04923  Regulation of lipolysis in adipocytes
cjc04926  Relaxin signaling pathway
cjc04929  GnRH secretion
cjc04930  Type II diabetes mellitus
cjc04931  Insulin resistance
cjc04932  Non-alcoholic fatty liver disease
cjc04933  AGE-RAGE signaling pathway in diabetic complications
cjc04935  Growth hormone synthesis, secretion and action
cjc04960  Aldosterone-regulated sodium reabsorption
cjc04973  Carbohydrate digestion and absorption
cjc05010  Alzheimer disease
cjc05017  Spinocerebellar ataxia
cjc05020  Prion disease
cjc05100  Bacterial invasion of epithelial cells
cjc05135  Yersinia infection
cjc05142  Chagas disease
cjc05146  Amoebiasis
cjc05160  Hepatitis C
cjc05161  Hepatitis B
cjc05162  Measles
cjc05163  Human cytomegalovirus infection
cjc05164  Influenza A
cjc05165  Human papillomavirus infection
cjc05166  Human T-cell leukemia virus 1 infection
cjc05167  Kaposi sarcoma-associated herpesvirus infection
cjc05168  Herpes simplex virus 1 infection
cjc05169  Epstein-Barr virus infection
cjc05170  Human immunodeficiency virus 1 infection
cjc05171  Coronavirus disease - COVID-19
cjc05200  Pathways in cancer
cjc05203  Viral carcinogenesis
cjc05205  Proteoglycans in cancer
cjc05206  MicroRNAs in cancer
cjc05207  Chemical carcinogenesis - receptor activation
cjc05208  Chemical carcinogenesis - reactive oxygen species
cjc05210  Colorectal cancer
cjc05211  Renal cell carcinoma
cjc05212  Pancreatic cancer
cjc05213  Endometrial cancer
cjc05214  Glioma
cjc05215  Prostate cancer
cjc05218  Melanoma
cjc05220  Chronic myeloid leukemia
cjc05221  Acute myeloid leukemia
cjc05222  Small cell lung cancer
cjc05223  Non-small cell lung cancer
cjc05224  Breast cancer
cjc05225  Hepatocellular carcinoma
cjc05226  Gastric cancer
cjc05230  Central carbon metabolism in cancer
cjc05231  Choline metabolism in cancer
cjc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cjc05415  Diabetic cardiomyopathy
cjc05417  Lipid and atherosclerosis
cjc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cjc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100406689 (PIK3R2)
   04015 Rap1 signaling pathway
    100406689 (PIK3R2)
   04630 JAK-STAT signaling pathway
    100406689 (PIK3R2)
   04668 TNF signaling pathway
    100406689 (PIK3R2)
   04066 HIF-1 signaling pathway
    100406689 (PIK3R2)
   04068 FoxO signaling pathway
    100406689 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    100406689 (PIK3R2)
   04072 Phospholipase D signaling pathway
    100406689 (PIK3R2)
   04071 Sphingolipid signaling pathway
    100406689 (PIK3R2)
   04024 cAMP signaling pathway
    100406689 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    100406689 (PIK3R2)
   04152 AMPK signaling pathway
    100406689 (PIK3R2)
   04150 mTOR signaling pathway
    100406689 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100406689 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100406689 (PIK3R2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100406689 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100406689 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    100406689 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    100406689 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    100406689 (PIK3R2)
   04660 T cell receptor signaling pathway
    100406689 (PIK3R2)
   04662 B cell receptor signaling pathway
    100406689 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    100406689 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    100406689 (PIK3R2)
   04670 Leukocyte transendothelial migration
    100406689 (PIK3R2)
   04062 Chemokine signaling pathway
    100406689 (PIK3R2)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    100406689 (PIK3R2)
   04929 GnRH secretion
    100406689 (PIK3R2)
   04915 Estrogen signaling pathway
    100406689 (PIK3R2)
   04917 Prolactin signaling pathway
    100406689 (PIK3R2)
   04926 Relaxin signaling pathway
    100406689 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    100406689 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    100406689 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100406689 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100406689 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    100406689 (PIK3R2)
   04722 Neurotrophin signaling pathway
    100406689 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100406689 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    100406689 (PIK3R2)
   04380 Osteoclast differentiation
    100406689 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    100406689 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    100406689 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100406689 (PIK3R2)
   05206 MicroRNAs in cancer
    100406689 (PIK3R2)
   05205 Proteoglycans in cancer
    100406689 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    100406689 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    100406689 (PIK3R2)
   05203 Viral carcinogenesis
    100406689 (PIK3R2)
   05230 Central carbon metabolism in cancer
    100406689 (PIK3R2)
   05231 Choline metabolism in cancer
    100406689 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100406689 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100406689 (PIK3R2)
   05212 Pancreatic cancer
    100406689 (PIK3R2)
   05225 Hepatocellular carcinoma
    100406689 (PIK3R2)
   05226 Gastric cancer
    100406689 (PIK3R2)
   05214 Glioma
    100406689 (PIK3R2)
   05221 Acute myeloid leukemia
    100406689 (PIK3R2)
   05220 Chronic myeloid leukemia
    100406689 (PIK3R2)
   05218 Melanoma
    100406689 (PIK3R2)
   05211 Renal cell carcinoma
    100406689 (PIK3R2)
   05215 Prostate cancer
    100406689 (PIK3R2)
   05213 Endometrial cancer
    100406689 (PIK3R2)
   05224 Breast cancer
    100406689 (PIK3R2)
   05222 Small cell lung cancer
    100406689 (PIK3R2)
   05223 Non-small cell lung cancer
    100406689 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100406689 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    100406689 (PIK3R2)
   05161 Hepatitis B
    100406689 (PIK3R2)
   05160 Hepatitis C
    100406689 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    100406689 (PIK3R2)
   05164 Influenza A
    100406689 (PIK3R2)
   05162 Measles
    100406689 (PIK3R2)
   05163 Human cytomegalovirus infection
    100406689 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100406689 (PIK3R2)
   05169 Epstein-Barr virus infection
    100406689 (PIK3R2)
   05165 Human papillomavirus infection
    100406689 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100406689 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    100406689 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100406689 (PIK3R2)
   05142 Chagas disease
    100406689 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100406689 (PIK3R2)
   05017 Spinocerebellar ataxia
    100406689 (PIK3R2)
   05020 Prion disease
    100406689 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100406689 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    100406689 (PIK3R2)
   05415 Diabetic cardiomyopathy
    100406689 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100406689 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    100406689 (PIK3R2)
   04931 Insulin resistance
    100406689 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100406689 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100406689 (PIK3R2)
   01524 Platinum drug resistance
    100406689 (PIK3R2)
   01522 Endocrine resistance
    100406689 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cjc04131]
    100406689 (PIK3R2)
Membrane trafficking [BR:cjc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100406689 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 SH3_9 Ribosomal_L22e TACC_C ATG11
Other DBs
NCBI-GeneID: 100406689
NCBI-ProteinID: XP_002761945
Ensembl: ENSCJAG00000014073
UniProt: F6ZCI2
LinkDB
Position
22:16522827..16541028
AA seq 727 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPVPARPRDGASEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESYYRPDVPALRTDWSLSDVDQWDAAALADGIKSFLLA
LPAPLVTPEASAEARRALWEAGGPVGPALEPPMLPLHRALTLRFLLQHLGRVARRAPALG
PAVRALGATFGPLLLRLPPPSSPPPGGAPDGSEPSPDFSALLVEKLLQEHLEEQEVAPPA
LPPKPPKAKPVPAGLANGGSPLSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKI
QGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRL
LYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAI
EAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTK
LEQQLRAQASDIREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNET
EDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVV
DGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGP
GPPPAAR
NT seq 2184 nt   +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgtgctctgtacccattccgccgggagcggcca
gaggacctggagctgctgcctggcgacgtgctggtggtgagccgggcggccttgcaggca
ctgggtgtggccgagggtggcgagcgctgcccacagagtgtgggctggatgcctggcctc
aatgaacgcacacggcagcgaggtgacttccctggcacctatgtcgagttcctggggcct
gtggccctggcccggcccggccctcgcccacggggcccccgcccagtgcccgccaggccc
cgtgatggggcctctgagccaggcctcacactccctgacttgcctgagcagttctcccca
cctgacgtggcgccccctcttctggtgaagcttgtagaggccattgaacggacagggctg
gacagcgaatcttactaccggccagacgtccccgcactgcgtacagactggtccctgagc
gacgtggatcagtgggacgcggcagccctggccgatggcattaagagcttcctgctggca
ctgcccgcgccgctggtgacccccgaggcctcggccgaggcgcgccgggccctgtgggag
gccgggggacccgtggggccggcgctggagcccccgatgctgccgctgcaccgcgccctc
acgctgcgcttcctgctccagcacctgggccgcgtggcccgccgcgccccggctctaggt
cctgcagtccgggccctgggcgccaccttcgggccgctgctgctgcgcctgccgccgccg
tcctcaccgccgccagggggcgcgcccgacgggagtgagcccagccctgacttctcagcg
ctgctcgtggagaagctgcttcaggaacacttggaagagcaggaggttgcgcccccagcg
ctgccacctaaaccccccaaggcaaagccggtccccgcaggcctggccaatggggggagc
ccactgtccctgcaggatgctgagtggtactggggggacatctcgagggaggaggtgaac
gagaaactccgggacactcccgatggcactttcctagtccgagatgcttctagcaagatc
cagggcgagtacacgctgaccctcaggaaaggcgggaacaataagctaatcaaggtcttc
caccgggacgggcactatggcttctcggagccactcaccttctgctccgtggtggacctc
atcaatcactaccgccacgagtccctggcccagtacaacgccaagctggacacgcggctc
ctctaccctgtgtccaaataccagcaggaccagatcgtcaaggaggacagcgtggaggcg
gtgggtgcccagctcaaggtctatcaccagcagtaccaggacaagagccgcgagtacgac
cagctttatgaggagtacacacggacctcccaggagctgcagatgaagcgtacagcaatt
gaggccttcaatgagactatcaagatcttcgaagagcagggccagactcaggagaagtgc
agcaaggagtacctggagcgcttccggcgtgagggcaacgagaaggagatgcagaggatc
ctgctgaactcagagcggctcaagtcccgcattgctgagatccacgagagccgcacgaag
ctggagcagcagctgcgggcccaggcctcggacatccgggaaatcgacaagcgcatgaac
agcctcaagcctgacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggctc
acccagaaaggtgcccggcagaagaaaatcaacgagtggctggggatcaaaaatgagact
gaggaccagtacgcactgatggaggatgaggatgatcttccccaccacgaggagcgcact
tggtacgtgggcaagatcaaccgcacgcaggcggaggagatgctgagtggcaagcgggac
ggcactttcctcatccgcgagagcagccagcggggctgctacgcctgctccgtagtggta
gatggtgacaccaagcactgcgtcatttaccgcacggccaccggcttcggcttcgcggag
ccctacaacctgtacgggtctctgaaggagctggtgctgcactaccagcacgcctcgctc
gtgcagcacaacgacgcgctcacggtcaccctggcgcacccggtgcgcgccccgggcccc
ggcccgccgcctgccgcccgctga

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