KEGG   PATHWAY: cls00946
Entry
cls00946                    Pathway                                
Name
Degradation of flavonoids - Clostridium sp. SY8519
Description
Flavonoids are polyphenolic compounds with the C6-C3-C6 skeleton structure. Natural flavonoids, including their O-glycoside and C-glycoside forms, are synthesized as plant secondary metabolites and thus ubiquitously found in foods of plant origin. Because of the potential health benefits of dietary flavonoids, there has been much interest in characterizing the involvement of gut microbiome and identifying key metabolites and their interactions. For example, equol metabolized from soy products [MD:M00966] is known to have estrogenic activity.
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
cls00946  Degradation of flavonoids
cls00946

Module
cls_M00967  Flavone degradation, luteolin/apigenin => DHCA/phloretate [PATH:cls00946]
Organism
Clostridium sp. SY8519 [GN:cls]
Gene
CXIVA_10390  hypothetical protein [KO:K26176]
CXIVA_14850  hypothetical protein [KO:K26176]
CXIVA_24790  ACH1; acetyl-CoA hydrolase [KO:K26177]
CXIVA_10380  alpha-glucosidase, family 31 of glycosyl hydrolase [KO:K26177]
CXIVA_20250  hypothetical protein [KO:K26178]
CXIVA_14860  hypothetical protein [KO:K26178]
CXIVA_19050  hypothetical protein [KO:K26178]
CXIVA_00870  hypothetical protein [KO:K22906] [EC:3.7.1.4]
CXIVA_16390  hypothetical protein [KO:K22906] [EC:3.7.1.4]
CXIVA_01400  hypothetical protein [KO:K22906] [EC:3.7.1.4]
CXIVA_03650  hypothetical protein [KO:K22906] [EC:3.7.1.4]
CXIVA_10480  hypothetical protein [KO:K22906] [EC:3.7.1.4]
CXIVA_20190  hypothetical protein [KO:K22906] [EC:3.7.1.4]
Compound
C00036  Oxaloacetate
C00389  Quercetin
C00509  Naringenin
C00642  4-Hydroxyphenylacetate
C00774  Phloretin
C00974  Dihydrokaempferol
C01161  3,4-Dihydroxyphenylacetate
C01477  Apigenin
C01514  Luteolin
C01617  Taxifolin
C01744  Phloretate
C02183  Phloroglucinol
C05623  Isoquercitrin
C05625  Rutin
C05631  Eriodictyol
C05903  Kaempferol
C06563  Genistein
C09099  Naringenin 7-O-beta-D-glucoside
C09126  Genistin
C09789  Naringin
C10208  Daidzein
C10216  Daidzin
C10447  3,4-Dihydroxyphenylpropanoate
C10524  Puerarin
C12088  4-Hydroxycinnamoylmethane
C14131  Equol
C14458  Dihydrogenistein
C22552  Alphitonin
C22553  Maesopsin
C22556  (R)-Dihydrodaidzein
C22557  (S)-Dihydrodaidzein
C22558  (3S,4R)-Tetrahydrodaidzein
C22559  O-Desmethylangolensin
C22560  6'-Hydroxy-O-desmethylangolensin
C22567  3-Hydroxyphloretin
C22568  5,7,8-Trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
C22569  (2E,4E)-2,4-Dihydroxy-4-[6-(4-hydroxyphenyl)-2,4-dioxodihydro-2H-pyran-3(4H)-ylidene]but-2-enoate
C22570  5-(4-Hydroxyphenyl)-3-oxovalero-delta-lactone
C22571  5-Hydroxy-5-(4-hydroxyphenyl)-3-oxopentanoate
C22572  4-Hydroxy-4-(4-hydroxyphenyl)-butan-2-one
Reference
  Authors
Goris T, Cuadrat RRC, Braune A.
  Title
Flavonoid-Modifying Capabilities of the Human Gut Microbiome-An In Silico Study.
  Journal
Nutrients 13:2688 (2021)
DOI:10.3390/nu13082688
Reference
  Authors
Shimada Y, Takahashi M, Miyazawa N, Abiru Y, Uchiyama S, Hishigaki H
  Title
Identification of a novel dihydrodaidzein racemase essential for biosynthesis of equol from daidzein in Lactococcus sp. strain 20-92.
  Journal
Appl Environ Microbiol 78:4902-7 (2012)
DOI:10.1128/AEM.00410-12
Reference
  Authors
Maria Marin A, de la Torre J, Ricardo Marques Oliveira A, Barison A, Satie Chubatsu L, Adele Monteiro R, de Oliveira Pedrosa F, Maltempi de Souza E, Wassem R, Duque E, Ramos JL.
  Title
Genetic and functional characterization of a novel meta-pathway for degradation of naringenin in Herbaspirillum seropedicae SmR1.
  Journal
Environ Microbiol 18:4653-4661 (2016)
DOI:10.1111/1462-2920.13313
Reference
  Authors
Mayo B, Vazquez L, Florez AB.
  Title
Equol: A Bacterial Metabolite from The Daidzein Isoflavone and Its Presumed Beneficial Health Effects.
  Journal
Nutrients 11:E2231 (2019)
DOI:10.3390/nu11092231
Related
pathway
cls00020  Citrate cycle (TCA cycle)
KO pathway
ko00946   
LinkDB

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